1,183 results match your criteria entering lungs

Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy.

ACS Pharmacol Transl Sci 2021 Apr 1;4(2):870-887. Epub 2021 Apr 1.

Department of Clinical Pharmacy, University of Michigan College of Pharmacy, 428 Church Street, Room 4565 NUB, Ann Arbor, Michigan 48109, United States.

Nucleoside and nucleotide analogs are an essential class of antivirals for COVID-19 treatment. Several nucleoside/nucleotide analogs have shown promising effects against SARS-CoV-2 ; however, their efficacy is limited. Nucleoside/nucleotide analogs are often formed as ester prodrugs to improve pharmacokinetics (PK) performance. Read More

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Surgeon Knowledge of the Pulmonary Arterial System and Surgical Plan Confidence Is Improved by Interactive Virtual 3D-CT Models of Lung Cancer Patient Anatomies.

Front Surg 2021 29;8:652428. Epub 2021 Mar 29.

Department of Thoracic Surgery, Guy's & St Thomas' Hospital, London, United Kingdom.

Interactive three-dimensional virtual models of pulmonary structures (3D-CT) may improve the safety and accuracy of robotic-assisted thoracic surgery (RATS). The aim of this study was to evaluate the impact of 3D-CT models as an imaging adjunct on surgical confidence and anatomical assessment for lobectomy planning. We retrospectively analyzed the response of 10 specialist thoracic surgeons who each reviewed 10 pre-operative images of patients undergoing robotic-assisted lobectomy lung cancer cases from June to November 2018 in our institute, resulting in 100 data points. Read More

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Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells.

Cell Rep 2021 Apr 5:109020. Epub 2021 Apr 5.

Nuffield Department of Medicine, University of Oxford, Oxford, UK; Chinese Academy of Medical Sciences (CAMS) Oxford Institute (COI), University of Oxford, Oxford, UK.

COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment, and one important factor to consider is oxygen tension, in which hypoxia inducible factor (HIF) regulates transcriptional responses to hypoxia. SARS-CoV-2 primarily infects cells of the respiratory tract, entering via its spike glycoprotein binding to angiotensin-converting enzyme 2 (ACE2). Read More

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Potential antiviral activity of isorhamnetin against SARS-CoV-2 spike pseudotyped virus in vitro.

Drug Dev Res 2021 Apr 13. Epub 2021 Apr 13.

School of Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Coronavirus Disease 2019 (COVID-19) cases and deaths are still rising worldwide, there is currently no effective treatment for severe inflammation and acute lung injury caused by new coronavirus (SARS-COV-2) infection. Therapies to prevent or treat COVID-19, including antiviral drug and several vaccines, are still being development. Human angiotensin-converting enzyme 2 (ACE2), expressing in lung, has been confirmed to be a receptor for SARS-COV-2 infection, interventions for attachment of spike protein of SARS-CoV-2 to ACE2 may be a potential approach to prevent viral infections and it is considered as a potential target for drug development. Read More

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Modeling Diagnostic Strategies to Manage Toxic Adverse Events following Cancer Immunotherapy.

Med Decis Making 2021 Apr 5:272989X211002756. Epub 2021 Apr 5.

Health Technology and Services Research Department, Technical Medical Centre, University of Twente, Enschede, Overijssel, the Netherlands.

Background: Although immunotherapy (IMT) provides significant survival benefits in selected patients, approximately 10% of patients experience (serious) immune-related adverse events (irAEs). The early detection of adverse events will prevent irAEs from progressing to severe stages, and routine testing for irAEs has become common practice. Because a positive test outcome might indicate a clinically manifesting irAE that requires treatment to (temporarily) discontinue, the occurrence of false-positive test outcomes is expected to negatively affect treatment outcomes. Read More

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Health Literacy Among Patients With Chronic Lung Disease Entering Pulmonary Rehabilitation and Their Resident Loved Ones.

J Cardiopulm Rehabil Prev 2021 Mar 26. Epub 2021 Mar 26.

Departments of Research and Development (Ms Coenjaerds and Drs Spruit, Franssen, Wouters, and Janssen) and Psychology (Dr Cleutjens), CIRO, Horn, the Netherlands; Department of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, the Netherlands (Ms Coenjaerds and Drs Spruit and Franssen); Reval Rehabilitation Research, Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium (Dr Spruit); Department of Medical Psychology, Maastricht UMC+, School for Mental Health and Neurosciences (MHeNS), Maastricht, the Netherlands (Dr Ponds); Department of Respiratory Medicine, Maastricht UMC+, Maastricht, the Netherlands, and Ludwig Boltzmann Institute for Lung Health, Vienna, Austria (Dr Wouters); and Department of Health Services Research, Care and Public Health Research Institute, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands (Dr Janssen).

Purpose: The objective of this study was determine the prevalence of low health literacy (HL) and low reading ability among patients with chronic lung disease referred for pulmonary rehabilitation (PR) in the Netherlands and their loved ones; and to understand whether low HL or low reading ability influence PR outcomes.

Methods: Health literacy was measured using the Health Literacy Survey-Europe Q16 (HLS-EU-Q16). Reading ability and cognitive functioning were measured using the Rapid Estimate of Adult Literacy in Medicine-Dutch (REALM-D) and the Montreal Cognitive Assessment. Read More

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Systematic Review of Interventions to Reduce Operating Time in Lung Cancer Surgery.

Clin Med Insights Oncol 2021 1;15:1179554920987105. Epub 2021 Feb 1.

Department of Cardiothoracic Surgery, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Introduction: Operating rooms are a scarce resource but often used inefficiently. Operating room efficiency emerges as an important part of maximizing surgical capacity and productivity, minimizing delays, and optimizing lung cancer outcomes. The operative time (time between patient entering and leaving the operating room) is discrete and the one that the surgical team can most directly influence. Read More

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February 2021

SARS-CoV-2 variants reveal features critical for replication in primary human cells.

PLoS Biol 2021 03 24;19(3):e3001006. Epub 2021 Mar 24.

Institute of Medical Virology, University of Zurich, Zurich, Switzerland.

Since entering the human population, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2; the causative agent of Coronavirus Disease 2019 [COVID-19]) has spread worldwide, causing >100 million infections and >2 million deaths. While large-scale sequencing efforts have identified numerous genetic variants in SARS-CoV-2 during its circulation, it remains largely unclear whether many of these changes impact adaptation, replication, or transmission of the virus. Here, we characterized 14 different low-passage replication-competent human SARS-CoV-2 isolates representing all major European clades observed during the first pandemic wave in early 2020. Read More

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lncRNA‑CASC15 promotes osteosarcoma proliferation and metastasis by regulating epithelial‑mesenchymal transition via the Wnt/β‑catenin signaling pathway.

Oncol Rep 2021 May 24;45(5). Epub 2021 Mar 24.

Department of Bone and Soft Tissue Surgery, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China.

Osteosarcoma (OS) is a rare type of tumor and mostly occurs in children and adolescents. Approximately 10‑25% of patients with OS have lung metastases, and lung damage caused by lung metastasis is the main cause of mortality. Therefore, studying the growth and metastasis of OS is key in reducing OS mortality and improving prognosis. Read More

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Haemodynamics and cerebral oxygenation of neonatal piglets in the immediate ex utero period supported by mechanical ventilation or ex utero oxygenator.

J Physiol 2021 Mar 21. Epub 2021 Mar 21.

Early Origins of Adult Health Research Group, Health and Biomedical Innovation, UniSA: Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.

Key Points: The margin of human viability has extended to the extremes of gestational age (<24 weeks) when the lungs are immature and ventilator-induced lung injury is common. Artificial placenta technology aims to extend gestation ex utero in order to allow the lungs additional time to develop prior to entering an air-breathing environment. We compared the haemodynamics and cerebral oxygenation of piglets in the immediate period post-oxygenator (OXY) transition against both paired in utero measures and uniquely against piglets transitioned onto mechanical ventilation (VENT). Read More

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Effects of metal nanoparticles on tight junction-associated proteins via HIF-1α/miR-29b/MMPs pathway in human epidermal keratinocytes.

Part Fibre Toxicol 2021 Mar 19;18(1):13. Epub 2021 Mar 19.

Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA.

Background: The increasing use of metal nanoparticles in industry and biomedicine raises the risk for unintentional exposure. The ability of metal nanoparticles to penetrate the skin ranges from stopping at the stratum corneum to passing below the dermis and entering the systemic circulation. Despite the potential health risks associated with skin exposure to metal nanoparticles, the mechanisms underlying the toxicity of metal nanoparticles on skin keratinocytes remain unclear. Read More

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[Spatial and temporal distribution and predictive value of chest CT scoring in patients with COVID-19].

Zhonghua Jie He He Hu Xi Za Zhi 2021 Mar;44(3):230-236

Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.

To explore a modified CT scoring system, its feasibility for disease severity evaluation and its predictive value in coronavirus disease 2019 (COVID-19) patients. This study was a multi-center retrospective cohort study. Patients confirmed with COVID-19 were recruited in three medical centers located in Beijing, Wuhan and Nanchang from January 27, 2020 to March 8, 2020. Read More

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Drug Repurposing Strategy (DRS): Emerging Approach to Identify Potential Therapeutics for Treatment of Novel Coronavirus Infection.

Front Mol Biosci 2021 26;8:628144. Epub 2021 Feb 26.

CSIR-Central Scientific Instruments Organization, Chandigarh, India.

Drug repurposing is also termed as drug repositioning or therapeutic switching. This method is applied to identify the novel therapeutic agents from the existing FDA approved clinically used drug molecules. It is considered as an efficient approach to develop drug candidates with new pharmacological activities or therapeutic properties. Read More

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February 2021

Malfeasance of KRAS mutations in carcinogenesis.

Clin Exp Med 2021 Mar 12. Epub 2021 Mar 12.

Department of Medical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India.

Activating mutations in the KRAS gene (Kirsten rat sarcoma 2 viral oncogene homolog gene) are commonly seen across the various solid organ and hematolymphoid neoplasms. With the likelihood of the mutation specific KRAS inhibitor entering clinical practice, the present studies profiled the landscape of these mutations in the Indian population to add to databases and posit the clinical utility of its emerging inhibitors. This study included 489 formalin fixed paraffin-embedded (FFPE) tissue samples from consecutive patients during a 5-year period (2015-2019). Read More

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Isolation and Pathogenic Characterization of Pigeon Paramyxovirus Type 1 via Different Inoculation Routes in Pigeons.

Front Vet Sci 2020 17;7:569901. Epub 2021 Feb 17.

National Research Center for Wildlife-Borne Diseases, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Pigeon paramyxovirus type I (PPMV-1) causes regular outbreaks in pigeons and even poses a pandemic threat among chickens and other birds. The birds infected with PPMV-1 mainly show a pathological damage in the respiratory system, digestive system, and nervous system. However, there were few reports on the efficiency of the virus entering the host routes of different systems. Read More

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February 2021

Transbronchial lung cryobiopsy by twin bronchoscopes (kissing technique).

Indian J Tuberc 2021 Jan 2;68(1):16-19. Epub 2020 Nov 2.

Dr. Baba Saheb Ambedkar Hospital, Rohini, Delhi, India.

Objective: To introduce a new & novel method of obtaining big lung tissue samples by transbronchial lung cryobiopsy by twin bronchoscopes (kissing technique) in an advanced interventional pulmonology suite.

Methods: In patients of diffuse parenchymal lung diseases, transbronchial lung cryobiopsy were taken using this novel approach using simultaneously two bronchoscopes under C- arm guidance under conscious sedation. First, a standard fibreoptic bronchoscope was inserted intranasally and fixed just above the area to be biopsied, then fogarty's catheter was introduced through FOB's suction channel and protruded it at the biopsy site. Read More

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January 2021

To unifocalize or not to unifocalize?: A comparison of retro-esophageal versus anterior collaterals.

Ann Thorac Surg 2021 Feb 22. Epub 2021 Feb 22.

Stanford University School of Medicine, Divisions of Pediatric Cardiac Surgery and Pediatric Cardiology, Lucile Packard Children's Hospital Stanford, Stanford, California.

Background: The anatomy of major aortopulmonary collateral arteries (MAPCAs) can be highly variable with regard to number, anatomic origin, course, and relationship to the native pulmonary arteries. Some MAPCAs travel behind the esophagus (retro-esophageal) and bronchus before entering the lung parenchyma. The purpose of this study was to compare the physiologic and surgical characteristics of retro-esophageal versus anterior located MAPCAs. Read More

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February 2021

Lorlatinib in pretreated ALK- or ROS1-positive lung cancer and impact of TP53 co-mutations: results from the German early access program.

Ther Adv Med Oncol 2021 9;13:1758835920980558. Epub 2021 Feb 9.

Department Internal Medicine-Oncology, Pius Hospital, Oldenburg, Germany.

Introduction: We report on the results of the German early access program (EAP) with the third-generation ALK- and ROS1-inhibitor lorlatinib.

Patients And Methods: Patients with documented treatment failure of all approved ALK/ROS1-specific therapies or with resistance mutations not covered by approved inhibitors or leptomeningeal carcinomatosis were enrolled and analyzed.

Results: In total, 52 patients were included [median age 57 years (range 32-81), 54% female, 62% never smokers, 98% adenocarcinoma]; 71% and 29% were ALK- and ROS1-positive, respectively. Read More

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February 2021

Natural Derived Nasal Spray; a Proposed Approach for COVID-19 Disease Control.

Infect Disord Drug Targets 2021 02 18. Epub 2021 Feb 18.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Considering the importance of COVID-19 disease pandemic, emerged by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in line with other studies to find appropriate prevention or treatment methods for this virus infection, proposing the use of natural derived ingredients as an approach for COVID-19 disease control was our study objective. Here we reviewed previous studies on natural derived nasal sprays and found that some known natural derived ingredients have antiviral properties, so their topical use as a nasal spray is effective in reducing the symptoms of respiratory infections, and it also has potential of decreasing viral load including titer of coronaviruses, in the nasal cavity. It seems that use of carrageenan or other herbal ingredients nasal spray may block the SARS-CoV-2 virus entering to the lung cells of a contaminated person and also can prevent virus transmission to other susceptible persons. Read More

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February 2021

A comparative study of chest CT findings regarding the effects of regional dust exposure on patients with COPD living in urban areas and rural areas near cement plants.

Respir Res 2021 Feb 6;22(1):43. Epub 2021 Feb 6.

Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, Republic of Korea.

Background: The clinical and radiological presentation of chronic obstructive pulmonary disease (COPD) is heterogenous depending on the characterized sources of inflammation. This study aimed to evaluate COPD phenotypes associated with specific dust exposure.

Methods: This study was designed to compare the characteristics, clinical outcomes and radiological findings between two prospective COPD cohorts representing two distinguishing regions in the Republic of Korea; COPD in Dusty Area (CODA) and the Korean Obstructive Lung Disease (KOLD) cohort. Read More

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February 2021

Pharmacokinetics profiles of polyphyllin II and polyphyllin VII in rats by liquid chromatography with tandem mass spectrometry.

Biomed Chromatogr 2021 Feb 5:e5083. Epub 2021 Feb 5.

Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.

Polyphyllin II (PII) and polyphyllin VII (PVII) are the main active ingredients in Paris Polyphylla with an excellent antitumor effect in vitro and in vivo. In this study, a rapid and precise LC-MS/MS method was developed and validated for the separation and simultaneous determination of PII and PVII in rat plasma, tissues, feces and urine using ginsenoside Rg3 as the internal standard. Positive linearity ranged from 1 to 1,000 ng/ml in samples. Read More

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February 2021

When things go wrong: Exploring possible mechanisms driving the progressive fibrosis phenotype in interstitial lung diseases.

Eur Respir J 2021 Feb 4. Epub 2021 Feb 4.

Facultad de Ciencias, Universidad Nacional Autónoma de Mexico, Mexico City, Mexico.

Interstitial lung diseases (ILD) comprise a large and heterogeneous group of disorders of known and unknown etiology characterised by diffuse damage of the lung parenchyma. In the past years, it has become evident that patients with different types of ILD are at risk of developing progressive pulmonary fibrosis known as pulmonary fibrosing ILD (PF-ILD). This is a phenotype behaving similar to idiopathic pulmonary fibrosis, the archetypical example of progressive fibrosis. Read More

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February 2021

A fatal outcome from SARS-CoV-2 infection: One case report of a young man with multiple organ damage.

Radiol Infect Dis 2020 Dec 31;7(4):208-212. Epub 2020 Jul 31.

Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China.

The coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China on December 2019 and has become a severe public health issue worldwide. A 36-year-old man was presented to the hospital staff with a fever that had already persisted for a three-day period, general weakness and diarrhea. He had no chronic diseases and was tested positive for COVID-19 with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid. Read More

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December 2020

COVID-19 vaccination in our transplant recipients: The time is now.

J Heart Lung Transplant 2021 03 2;40(3):169-171. Epub 2021 Jan 2.

Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio.

We are entering 2021 with an expanding and effective COVID-19 vaccine armamentarium. Recent interim results from COVID-19 vaccine trials, including more than 80,000 participants worldwide, demonstrate remarkable efficacy and low rate of serious adverse events. Based on experience with other vaccines in transplant recipients and knowing the risk of severe COVID-19 in this population, we believe that COVID-19 vaccines provide potential benefit with minimal risk. Read More

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Lung transplantation during the outbreak of Coronavirus Disease 2019 in China.

J Thorac Cardiovasc Surg 2020 Dec 1. Epub 2020 Dec 1.

Wuxi Lung Transplant Center, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China; Center for Lung Transplantation, China-Japan Friendship Hospital, Beijing, China. Electronic address:

Objectives: The study objectives were to illustrate our workflow for lung donation and transplantation during the Coronavirus Disease 2019 crisis and to report our preliminary experience with perioperative care.

Methods: We retrospectively analyzed data in the China Lung Transplantation Registration from January 23, 2020, to March 23, 2020 (2020 cohort), compared with the same period in 2019 (2019 cohort). Pre- and post-lung transplantation management strategies, including measures aiming to prevent severe acute respiratory syndrome coronavirus 2 infection, were applied to all recipients, including 5 post-Coronavirus Disease 2019 transplants during the Coronavirus Disease 2019 pandemic period in China. Read More

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December 2020

Short Preirradiation of TiO Nanoparticles Increases Cytotoxicity on Human Lung Coculture System.

Chem Res Toxicol 2021 Mar 17;34(3):733-742. Epub 2021 Jan 17.

Mines Saint-Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS, F-42023 Saint-Etienne, France.

Anatase titanium dioxide nanoparticles (TiO NPs) are used in a large range of industrial applications mainly due to their photocatalytic properties. Before entering the lung, virtually all TiO NPs are exposed to some UV light, and lung toxicity of TiO NPs might be influenced by photoexcitation that is known to alter TiO surface properties. Although the TiO NPs toxicity has been extensively investigated, limited data are available regarding the toxicity of TiO NPs that have been pre-exposed to UV light, and their impact on humans remains unknown. Read More

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Biochemical transformation of bacterial lipopolysaccharides by acyloxyacyl hydrolase reduces host injury and promotes recovery.

J Biol Chem 2020 12;295(51):17842-17851

Department of Immunology and Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China. Electronic address:

Animals can sense the presence of microbes in their tissues and mobilize their own defenses by recognizing and responding to conserved microbial structures (often called microbe-associated molecular patterns (MAMPs)). Successful host defenses may kill the invaders, yet the host animal may fail to restore homeostasis if the stimulatory microbial structures are not silenced. Although mice have many mechanisms for limiting their responses to lipopolysaccharide (LPS), a major Gram-negative bacterial MAMP, a highly conserved host lipase is required to extinguish LPS sensing in tissues and restore homeostasis. Read More

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December 2020

Entering the era of highly effective modulator therapies.

Pediatr Pulmonol 2021 Feb;56 Suppl 1:S79-S89

Departments of Cystic Fibrosis and Paediatric Respiratory Medicine, Royal Brompton & Harefield Foundation Trust, London, UK.

Since the discovery of the gene responsible for cystic fibrosis (CF) in 1989, hopes have been pinned on a future with novel therapies tackling the basis of the disease rather than its symptoms. These have become a reality over the last decade with the development through to the clinic of CF transmembrane conductance regulator (CFTR) modulators. These are oral drugs which improve CFTR protein function through either increasing the time the channel pore is open (potentiators) or facilitating its trafficking through the cell to its location on the cell membrane (correctors). Read More

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February 2021

ACE-2-interacting Domain of SARS-CoV-2 (AIDS) Peptide Suppresses Inflammation to Reduce Fever and Protect Lungs and Heart in Mice: Implications for COVID-19 Therapy.

J Neuroimmune Pharmacol 2021 03 11;16(1):59-70. Epub 2021 Jan 11.

Department of Neurological Sciences, Rush University Medical Center, 1735 West Harrison St Suite Cohn 310, Chicago, IL, 60612, USA.

COVID-19 is an infectious respiratory illness caused by the virus strain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and until now, there is no effective therapy against COVID-19. Since SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) for entering into host cells, to target COVID-19 from therapeutic angle, we engineered a hexapeptide corresponding to the ACE2-interacting domain of SARS-CoV-2 (AIDS) that inhibits the association between receptor-binding domain-containing spike S1 and ACE-2. Accordingly, wild type (wt), but not mutated (m), AIDS peptide inhibited SARS-CoV-2 spike S1-induced activation of NF-κB and expression of IL-6 in human lungs cells. Read More

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Chaperonin-Containing TCP-1 Promotes Cancer Chemoresistance and Metastasis through the AKT-GSK3β-β-Catenin and XIAP-Survivin Pathways.

Cancers (Basel) 2020 Dec 21;12(12). Epub 2020 Dec 21.

Institute of Biochemical Sciences, National Taiwan University, Taipei 10617, Taiwan.

Chaperonin-containing TCP-1 (CCT) is a chaperonin composed of eight subunits that participates in intracellular protein folding. Here, we showed that increased levels of subunits of CCT, particularly CCT-β, were significantly correlated with lower survival rates for cancer patients. Endogenously high expression of CCT-β was found in cancer cell lines, such as the triple-negative breast cancer cell line MDA-MB-231 and the highly metastatic non-small-cell lung cancer cell line CL1-5. Read More

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December 2020