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Is it safe to place implants in patients at risk of MRONJ?

Evid Based Dent 2021 Jan;22(3):108-109

Restorative Dentistry DCT3, Aberdeen Dental Hospital, Aberdeen, UK.

Data sources Four electronic databases, namely PubMed, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials, were searched from their inception to 16 July 2019. The OpenGrey database was also used to identify unpublished studies.Study selection Eligible study designs included randomised controlled trials, cohort studies, case-control studies and case series with a retrospective, cross-sectional or prospective design related to implant placement in patients with a history of anti-angiogenic or antiresorptive medications. Read More

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January 2021

Barriers and facilitators of rendering HIV services by community health workers in sub-Saharan Africa: a meta-synthesis.

Fam Med Community Health 2021 Sep;9(4)

Faculty of Health Sciences, University of Pretoria, Johannesburg, Gauteng, South Africa.

Objectives: To synthesise qualitative studies that address the barriers to and facilitators of providing HIV services by community health workers (CHWs) in sub-Saharan Africa (SSA).

Design: This meta-synthesis was guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We included studies that were published between 2009 and 2019. Read More

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September 2021

Primary Septic Arthritis in Children Demonstrates Presumed and Confirmed Varieties Which Require Age-specific Evaluation and Treatment Strategies.

J Pediatr Orthop 2021 Sep 27. Epub 2021 Sep 27.

Children's Health System of Texas Department of Orthopedics, Texas Scottish Rite Hospital for Children Department of Orthopedics and Pediatrics, University of Texas Southwestern, Dallas, TX.

Background: There is uncertainty involved in the evaluation and treatment of children suspected to have septic arthritis particularly when no causative pathogen is confirmed. This study evaluates children with primary septic arthritis to refine the processes of evaluation and treatment and improve the rate of pathogen confirmation.

Methods: Children suspected to have septic arthritis from 2009 to 2019 were retrospectively studied. Read More

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September 2021

Anterior decompression through a posterior approach for thoracic myelopathy caused by ossification of the posterior longitudinal ligament: a novel concept in anterior decompression and technical notes with the preliminary outcomes.

J Neurosurg Spine 2021 Sep 24:1-11. Epub 2021 Sep 24.

2Department of Orthopaedic Surgery, Tohoku Medical and Pharmaceutical University, Sendai, Japan.

Objective: Various surgical procedures are used to manage thoracic myelopathy due to ossification of the posterior longitudinal ligament (OPLL). However, the outcomes of surgery for thoracic OPLL are generally unfavorable in comparison to surgery for cervical OPLL. Previous studies have shown a significant risk of perioperative complications in surgery for thoracic OPLL. Read More

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September 2021

Uniportal thoracoscopic anterior and lingular (S3+4+5) segmentectomy of the left upper lobe using intravenous indocyanine green.

Multimed Man Cardiothorac Surg 2021 Sep 22;2021. Epub 2021 Sep 22.

Department of General Thoracic Surgery, Japanese Red Cross Maebashi Hospital.

Although an anterior and lingular (S3+4+5) segmentectomy of the left upper lobe is rarely performed, this type of segmentectomy is very useful to ensure a sufficient margin when the tumor is located at the border between the anterior segment (S3) and the superior lingular segment (S4). However, it might be technically difficult to perform this unusual segmentectomy via a uniportal approach because of the limited angulation and exposure of the peripheral vessels/bronchi. We present the successful results of a patient undergoing uniportal thoracoscopic S3+4+5 segmentectomy of the left upper lobe and describe some technical details. Read More

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September 2021

Breast cancer and pregnancy: Why special considerations prior to treatment are needed in multidisciplinary care.

Biosci Trends 2021 Sep 23. Epub 2021 Sep 23.

Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Breast cancer diagnosed during pregnancy poses ethical and professional challenges. Clinical management of that condition should ensure the safety of both the mother and fetus. Clinical trials on breast cancer exclude pregnant women, so sufficient evidence with which to formulate guidelines for the management of these patients is lacking. Read More

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September 2021

Safety of elective abdominal and vascular surgery during the COVID-19 pandemic: a retrospective single-center study.

Eur J Med Res 2021 Sep 23;26(1):112. Epub 2021 Sep 23.

Department of General, Visceral, Transplantation, Vascular and Pediatric Surgery, University Hospital Wuerzburg, Oberduerrbacher Str. 6, 97080, Wuerzburg, Germany.

Background: Patients with coronavirus disease 2019 (COVID-19) who undergo surgery have impaired postoperative outcomes and increased mortality. Consequently, elective and semi-urgent operations on the increasing number of patients severely affected by COVID-19 have been indefinitely postponed.in many countries with unclear implications on disease progression and overall survival. Read More

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September 2021

Pinning multisynchronization of delayed fractional-order memristor-based neural networks with nonlinear coupling and almost-periodic perturbations.

Neural Netw 2021 Sep 8;144:372-383. Epub 2021 Sep 8.

School of Automation Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, PR China. Electronic address:

This paper concerns the multisynchronization issue for delayed fractional-order memristor-based neural networks with nonlinear coupling and almost-periodic perturbations. First, the coexistence of multiple equilibrium states for isolated subnetwork is analyzed. By means of state-space decomposition, fractional-order Halanay inequality and Caputo derivative properties, the novel algebraic sufficient conditions are derived to ensure that the addressed networks with arbitrary activation functions have multiple locally stable almost periodic orbits or equilibrium points. Read More

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September 2021

A 10 J shock impedance in sinus rhythm correlates with a 65 J defibrillation impedance during subcutaneous defibrillator implantation using an inter-muscular technique.

J Cardiovasc Electrophysiol 2021 Sep 23. Epub 2021 Sep 23.

Division of Cardiovascular Medicine, Department of Internal Medicine, the Ohio State University Wexner Medical Center, Columbus, OH, USA.

Introduction: Defibrillation testing (DT) is recommended during the subcutaneous defibrillator (S-ICD) placement. We sought to compare 10 J shock impedance in sinus rhythm (SR) with 65 J defibrillation impedance and evaluate device position on a post-implant chest x-ray (CXR) using an inter-muscular (IM) technique.

Methods: Consecutive S-ICD implantations between 12/2019 and 12/2020 at The Ohio State University were reviewed. Read More

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September 2021

Emergency food supplies and food security in Wuhan and Nanjing, China during the COVID-19 pandemic: Evidence from a field survey.

Dev Policy Rev 2021 Jul 2. Epub 2021 Jul 2.

Department of Geography and Environmental Management University of Waterloo Canada.

Motivation: Detailed empirical work on the impact of the COVID-19 pandemic on food security is scant. Local management of food security has received little attention.

Purpose: This paper describes emergency food policies in Wuhan and Nanjing, China during lockdown in 2020 and their implications for household food security in the two cities. Read More

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Bipartite synchronization of signed networks via aperiodically intermittent control based on discrete-time state observations.

Neural Netw 2021 Sep 7;144:307-319. Epub 2021 Sep 7.

Department of Mathematics, Harbin Institute of Technology (Weihai), Weihai 264209, PR China. Electronic address:

In this paper, bipartite synchronization of signed networks with stochastic disturbances via aperiodically intermittent control is investigated. The aperiodically intermittent control presented is based on discrete-time state observations rather than continuous-time ones. To formulate signed networks and exhibit the competitive relation, a structurally balanced signed network is built and all the units are divided into two subcommunities. Read More

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September 2021

The protein kinase SlCIPK23 boosts K and Na uptake in tomato plants.

Plant Cell Environ 2021 Sep 20. Epub 2021 Sep 20.

Departamento de Nutrición Vegetal, Centro de Edafología y Biología Aplicada del Segura- CSIC, Murcia, Spain.

Regulation of root transport systems is essential under fluctuating nutrient supply. In the case of potassium (K ), HAK/KUP/KT K transporters and voltage-gated K channels ensure root K uptake in a wide range of K concentrations. In Arabidopsis, the CIPK23/CBL1-9 complex regulates both transporter- and channel-mediated root K uptake. Read More

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September 2021

Vestibular testing in children - The suppression head impulse (SHIMP) test.

Int J Pediatr Otorhinolaryngol 2021 Sep 4;151:110921. Epub 2021 Sep 4.

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Germany. Electronic address:

Introduction: The incidence of vestibular disorders and vertigo during childhood is increasing and pediatric clinicians have become more sensitive to children's balance disorders; thus, there is a need for appropriate detection test procedures for peripheral vestibular hypofunction. In order to ensure a reliable diagnosis and minimize misdiagnosis, a standardized clinical procedure via careful history and clinical examination is recommended. However, children, especially, are often unable to verbalize "vertigo" in a concrete manner, which often necessitates a consultation with a pediatrician holding nonspecific symptoms. Read More

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September 2021

High Energy Density Solid State Lithium Metal Batteries Enabled by Sub-5 µm Solid Polymer Electrolytes.

Adv Mater 2021 Sep 18:e2105329. Epub 2021 Sep 18.

Shanghai Key Lab of Advanced High-Temperature Materials and Precision Forming, State Key Laboratory of Metal Matrix Composites, School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China.

Solid-state batteries (SSBs) are considered as the most promising next-generation high-energy-density energy storage devices due to their ability in addressing the safety concerns from organic electrolytes and enabling energy dense lithium anodes. To ensure the high energy density of SSBs, solid-state electrolytes (SSEs) are required to be thin and light-weight, and simultaneously offer a wide electrochemical window to pair with high-voltage cathodes. However, the decrease of SSE thickness and delicate structure may increase the cell safety risks, which is detrimental for the practical application of SSBs. Read More

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September 2021

[Care atlas rheumatology : Approaches and concepts for improving care in outpatient rheumatology].

Z Rheumatol 2021 Sep 17. Epub 2021 Sep 17.

Rheumatologie Baden-Baden GbR, Tätigkeitsschwerpunkt Klinische Immunologie, Medical Center Baden-Baden, Baden-Baden, Deutschland.

Inflammatory rheumatic diseases affect 1.5 million adults and an estimated 20,000 children and adolescents throughout Germany. The successful treatment of these patients is largely based on the availability of high-quality medical care. Read More

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September 2021

Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study).

Pulm Ther 2021 Sep 17. Epub 2021 Sep 17.

General Practitioners Research Institute, Professor Enno Dirk Wiersmastraat 5, 9713 GH, Groningen, The Netherlands.

Introduction: Dry powder inhalers (DPIs), a commonly prescribed inhaler type for respiratory diseases, require patients to generate sufficient peak inspiratory flow (PIF) to ensure optimal drug delivery to the airways. Effectiveness of therapy also requires a good inhalation technique and adequate medication adherence. For patients with chronic obstructive pulmonary disease (COPD), recent studies conducted in tertiary care suggest that DPI users with suboptimal PIF have poorer COPD-related health status and increased exacerbation risk versus those with optimal PIF. Read More

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September 2021

Combining DNA metabarcoding and ecological networks to inform conservation biocontrol by small vertebrate predators.

Ecol Appl 2021 Sep 16:e02457. Epub 2021 Sep 16.

CIBIO-InBIO, Research Center in Biodiversity and Genetic Resources, University of Porto, 4485-661, Vairão, Portugal.

In multifunctional landscapes, diverse communities of flying vertebrate predators provide vital services of insect pest control. In such landscapes, conservation biocontrol should benefit service-providing species to enhance the flow, stability, and resilience of pest control services supporting the production of food and fibre. However, this would require identifying key service providers, which may be challenging where multiple predators interact with multiple pests. Read More

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September 2021

Single-isocenter stereotactic non-coplanar arc treatment of 200 patients with brain metastases: multileaf collimator size and setup uncertainties.

Strahlenther Onkol 2021 Sep 15. Epub 2021 Sep 15.

Department of Oncology, Radiotherapy Research Unit (52AA), Herlev & Gentofte Hospital, University of Copenhagen, Borgmester Ib Juuls vej 7, 2730, Herlev, Denmark.

Purpose: The purpose of this study was to evaluate our 2 years' experience with single-isocenter, non-coplanar, volumetric modulated arc therapy (VMAT) for brain metastasis (BM) stereotactic radiosurgery (SRS).

Methods: A total of 202 patients treated with the VMAT SRS solution were analyzed retrospectively. Plan quality was assessed for 5 mm (120) and 2. Read More

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September 2021

The quality of medical products for cardiovascular diseases: a gap in global cardiac care.

BMJ Glob Health 2021 Sep;6(9)

Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao People's Democratic Republic

Objective: Good quality cardiovascular medicines and devices are crucial in the prevention and management of the ever-growing threats of cardiovascular diseases (CVDs) globally. Yet our current understanding of the extent and impact of substandard and falsified (SF) cardiovascular medical products is poor. Our objective was to review the available literature on SF cardiovascular medicines/devices, with a focus on prevalence studies to discuss their impacts on public health. Read More

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September 2021

Ensuring Student Practice Readiness: Mapping Course Assessments to Canadian Pharmacy Educational Outcomes.

Am J Pharm Educ 2021 Sep 14:8724. Epub 2021 Sep 14.

University of Toronto, Leslie Dan Faculty of Pharmacy, Toronto, Ontario.

The entry-to-practice PharmD program is designed to meet the Association of Faculties of Pharmacy of Canada (AFPC) Educational Outcomes (EOs). We set out to evaluate how assessment strategies in a 'capstone' course align with AFPC EOs, their respective key and enabling competencies, and whether there are a sufficient number of assessments for students to demonstrate achievement of competencies prior to embarking on advanced pharmacy practice experiences. Each assessment's objectives, content and methods were mapped to key and enabling competencies of each role. Read More

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September 2021

Simulation research on the protection performance of fall protection net at the end of truck escape ramp.

Sci Prog 2021 Jul-Sep;104(3):368504211039615

College of Mechanical Engineering, 12664Guangxi University, China.

Introduction: Although the fall protection net installed at the end of the truck escape ramp has a protective effect on trucks and drivers, but lacks sufficient theoretical basis and verification method.

Objectives: The primary objective of this paper was to design a fall protection net that meets the regulations and research its protection performance.

Methods: The finite-element method was used to design the overall size, material, mesh length, mesh type, shape, and supporting structure of the fall protection net installed at the end of truck escape ramp, then dummy and truck models were used to impact the fall protection net to verify the rationality of the design. Read More

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September 2021

Maternal immunization with Group B Streptococcus six-valent polysaccharide conjugate vaccine supported by lack of toxicity in rat and rabbit fertility and developmental toxicity studies.

Birth Defects Res 2021 Sep 13. Epub 2021 Sep 13.

Drug Safety Research and Development, Pfizer Worldwide Research and Development, Groton, Connecticut, USA.

A maternal Group B Streptococcus (GBS) six-valent polysaccharide conjugate vaccine (GBS6) is being developed to protect neonates and infants up to 3 months of age through passive transfer of antibodies from the mother to the infant. Fertility and developmental toxicity studies were conducted in female Sprague Dawley rats and New Zealand White rabbits with GBS6 (20 μg capsular polysaccharide/serotype formulated with or without AlPO , the highest clinical dose). Females were administered the full human dose of the GBS6 formulation intramuscularly twice prior to mating and twice during gestation, to ensure that high antibody levels were maintained throughout gestation and lactation. Read More

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September 2021

Distinct responses of growth and respiration to growth temperatures in two mangrove species.

Ann Bot 2021 Sep 11. Epub 2021 Sep 11.

School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Horinouchi Hachioji, Tokyo, Japan.

Background And Aims: Mangrove plants are mostly found in tropical and sub-tropical tidal flats, and their limited distribution may be related to their responses to growth temperatures. However, the mechanisms underlying these responses have not been clarified. Here, we measured the dependencies of the growth parameters and respiration rates of leaves and roots on growth temperatures in typical mangrove species. Read More

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September 2021

Small studies, big decisions: the role of pilot/feasibility studies in incremental science and premature scale-up of behavioral interventions.

Pilot Feasibility Stud 2021 Sep 10;7(1):173. Epub 2021 Sep 10.

Arnold School of Public Health, University of South Carolina, Columbia, USA.

Background: Careful consideration and planning are required to establish "sufficient" evidence to ensure an investment in a larger, more well-powered behavioral intervention trial is worthwhile. In the behavioral sciences, this process typically occurs where smaller-scale studies inform larger-scale trials. Believing that one can do the same things and expect the same outcomes in a larger-scale trial that were done in a smaller-scale preliminary study (i. Read More

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September 2021

Results from the German registry for refractory celiac disease.

Z Gastroenterol 2021 Sep 10;59(9):944-953. Epub 2021 Sep 10.

Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.

Refractory celiac disease (RCD) refers to a rare subgroup of patients with celiac disease who show clinical signs of malabsorption despite a gluten-free diet. RCD is divided into an autoimmune phenotype (RCD type I) and pre-lymphoma (RCD type II). To reflect the clinical reality in managing this disease in Germany, a national register was established based on a questionnaire developed specifically for this purpose. Read More

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September 2021

[Preparation of dual-functional composite magnetic nanomaterials modified with different metals/aptamers and their performance in exosome enrichment].

Se Pu 2021 Oct;39(10):1128-1136

Shanghai Key Laboratory of Functional Materials Chemistry, School of Chemistry & Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China.

Exosomes, which are extracellular vesicles with sizes of 30-150 nm, contain proteins, lipids, RNA, etc., which can reflect important information about parental cells. They also have unique structures and can perform characteristic biological functions. Read More

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October 2021

Arthroscopic Rotator Cuff Repair Augmented with Autologous Subacromial Bursa Tissue, Concentrated Bone Marrow Aspirate, Platelet-Rich Plasma, Platelet-Poor Plasma, and Bovine Thrombin.

Arthrosc Tech 2021 Sep 2;10(9):e2053-e2059. Epub 2021 Aug 2.

Department of Orthopaedic Surgery, UConn Health Center, Farmington, Connecticut 06030 U.S.A.

As recurrent rotator cuff tears following repair remain a significant problem, improving healing potential using biologic adjuvants, including concentrated bone marrow aspirate (cBMA), platelet-rich plasma (PRP), or subacromial bursa tissue (SBT), has become increasingly popular in recent years. In an attempt to combine the benefits of these various biologic adjuvants and maximize the healing potential of the repaired tendon, an arthroscopic rotator cuff repair technique biologically augmented with autologous SBT, cBMA, PRP, platelet-poor plasma (PPP), and bovine thrombin has been developed. The created clot is used as a biologic scaffold for sufficient delivery, and it is stabilized using bovine thrombin in order to ensure maximum stability and retainment of the applied biologic augments at the repair site. Read More

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September 2021

Medical cannabis or cannabinoids for chronic pain: a clinical practice guideline.

BMJ 2021 09 8;374:n2040. Epub 2021 Sep 8.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada.

Clinical Question: What is the role of medical cannabis or cannabinoids for people living with chronic pain due to cancer or non-cancer causes?

Current Practice: Chronic pain is common and distressing and associated with considerable socioeconomic burden globally. Medical cannabis is increasingly used to manage chronic pain, particularly in jurisdictions that have enacted policies to reduce use of opioids; however, existing guideline recommendations are inconsistent, and cannabis remains illegal for therapeutic use in many countries.

Recommendation: The guideline expert panel issued a weak recommendation to offer a trial of non-inhaled medical cannabis or cannabinoids, in addition to standard care and management (if not sufficient), for people living with chronic cancer or non-cancer pain. Read More

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September 2021

Cilium induction triggers differentiation of glioma stem cells.

Cell Rep 2021 Sep;36(10):109656

Institute of Human Genetics, University Hospital Düsseldorf, Heinrich-Heine-Universität, Universitätsstr. 1, 40225 Düsseldorf, Germany. Electronic address:

Glioblastoma multiforme (GBM) possesses glioma stem cells (GSCs) that promote self-renewal, tumor propagation, and relapse. Understanding the mechanisms of GSCs self-renewal can offer targeted therapeutic interventions. However, insufficient knowledge of GSCs' fundamental biology is a significant bottleneck hindering these efforts. Read More

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September 2021