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Phthalates In Children Toys Available In Malaysian Market: Quantification And Potential Human Health Risk.

J Steroid Biochem Mol Biol 2021 Jul 23:105955. Epub 2021 Jul 23.

Department of Environmental and Occupational Health, Faculty Of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor Darul Ehsan, Malaysia.

In Malaysia, inexpensive toys are sold in various urban and rural shops. Although safety regulations for toys are available in Malaysia there are limited reports about the chemicals in toys. Thus, this study aimed to assess the levels of phthalates (bis-[2-ethylhexyl] phthalate [DEHP], diethyl phthalate [DEP], diisobutyl phthalate [DiBP] and dibutyl phthalate [DBP]) in inexpensive toys sold at local markets in Kuala Lumpur (Malaysia) and its health risks to children. Read More

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Evolution and Plasticity of Genome-Wide Meiotic Recombination Rates.

Annu Rev Genet 2021 Jul 26. Epub 2021 Jul 26.

Plant Evolutionary Genetics, Institute of Molecular Plant Biology, Department of Biology, ETH Zürich, 8092 Zürich, Switzerland; email:

Sex, as well as meiotic recombination between homologous chromosomes, is nearly ubiquitous among eukaryotes. In those species that use it, recombination is important for chromosome segregation during gamete production, and thus for fertility. Strikingly, although in most species only one crossover event per chromosome is required to ensure proper segregation, recombination rates vary considerably above this minimum and show variation within and among species. Read More

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Engaging Youth in Citizen-Led Advocacy and Accountability for Adolescent Sexual and Reproductive Health.

East Afr Health Res J 2019 29;3(2):85-87. Epub 2019 Nov 29.

White Ribbon Alliance Kenya.

The White Ribbon Alliance Kenya is an autonomous, locally registered nongovernmental organisation in Kenya with a vision to ensure that all women and girls realise their right to quality health and well-being. It is among 14 other national alliances affiliated with the White Ribbon Alliance Global Secretariat, based in Washington, DC. White Ribbon Alliance Kenya recognises that even though the Kenyan government has policies in place to improve adolescent sexual and reproductive health outcomes, proper implementation and commitment is still needed. Read More

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November 2019

Global Transcriptomics Uncovers Distinct Contributions From Splicing Regulatory Proteins to the Macrophage Innate Immune Response.

Front Immunol 2021 9;12:656885. Epub 2021 Jul 9.

Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health, Bryan, TX, United States.

Pathogen sensing pattern recognition receptors triggers massive reprogramming of macrophage gene expression. While the signaling cascades and transcription factors that activate these responses are well-known, the role of post-transcriptional RNA processing in modulating innate immune gene expression remains understudied. Given their crucial role in regulating pre-mRNA splicing and other RNA processing steps, we hypothesized that members of the SR/hnRNP protein families regulate innate immune gene expression in distinct ways. Read More

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Scenario-based preference modeling to examine the robustness of airport mega projects initiatives.

Sci Total Environ 2021 Jul 20;797:149142. Epub 2021 Jul 20.

Industrial Engineering Department, College of Engineering and Petroleum, Kuwait University, P.O. Box 5969 SAFAT, Kuwait 13109, Kuwait.

Airports are a high complex type of projects that are exposed to many disruptiveness. Proper management between airport expansion projects and airport operations is needed to ensure safety and efficiency of the project and the aviation. Scenario-based preference modeling is one of the robustness analysis techniques that describes the influence of disruptive scenarios on the project initiatives across different criteria. Read More

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Implementation Science Strategies Promote Fidelity in The Food, Feeding, and Your Family Study.

J Nutr Educ Behav 2021 Jul 21. Epub 2021 Jul 21.

US Department of Agriculture, Agricultural Research Service, Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX.

Objective: Use of implementation science strategies to promote fidelity in the Food, Feeding, and Your Family study.

Design: Cluster randomized controlled trial with 3 conditions: control, in-class, or online, delivered in English or Spanish. Observations of 20% of classes. Read More

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Evaluation of functional outcomes following rectus diastasis repair-an up-to-date literature review.

Hernia 2021 Jul 24. Epub 2021 Jul 24.

Department of Clinical Science and Education, Södersjukhuset, and Department of Surgery, Södersjukhuset, Karolinska Institute, Sjukhusbacken 10, 11883, Stockholm, Sweden.

Introduction: Over the last decade rectus diastasis has gained attention as a condition that may benefit from surgery. Numerous surgical techniques have been presented but scientifically proper studies reporting functional outcome are few and evidence is incomplete. The aim of this up-to-date review is to analyse the outcomes of rectus diastasis repair in recently published papers, focusing on functional changes following surgery. Read More

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Oxidative stress parameters as biomarkers of bladder cancer development and progression.

Sci Rep 2021 Jul 23;11(1):15134. Epub 2021 Jul 23.

Department of General Biochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Pomorska 141/143, 90-236, Lodz, Poland.

The epidemiological studies confirm that the overproduction of free radical is an important factor of cancer induction as well as development, and loss of antioxidant systems efficiency is associated with an increased risk of carcinogenesis. While bladder cancer is the fourth most common type of cancer all over the world, there is little evidence of the advancing changes in oxidative/nitrative stress during the progression of bladder cancer. Our study aimed to investigate the plasma levels of typical markers of oxidative/nitrative stress depending on the clinical classification of bladder cancer differentiation and infiltration degree. Read More

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Iron-Based Water Treatment Residuals: Phase, Physicochemical Characterization, and Textural Properties.

Materials (Basel) 2021 Jul 14;14(14). Epub 2021 Jul 14.

Faculty of Geology, Geophysics and Environmental Protection, AGH University of Science and Technology, A. Mickiewicza 30, 30-059 Kraków, Poland.

Groundwater treatment residuals (GWTRs) are safe waste materials generated during drinking water treatment. GWTRs are mainly deposited in landfills, but the preferred solution should be reused or utilized for some components. To ensure proper sludge management, it is important to provide quality, chemical composition, and texture characteristics of GWTRs. Read More

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Fast Eccentric Movement Tempo Elicits Higher Physiological Responses than Medium Eccentric Tempo in Ice-Hockey Players.

Int J Environ Res Public Health 2021 Jul 20;18(14). Epub 2021 Jul 20.

Institute of Sport Sciences, Jerzy Kukuczka Academy of Physical Education in Katowice, 40-065 Katowice, Poland.

Background: Resistance training is a significant part of ice-hockey players' conditioning, where optimal loading should ensure strength development and proper recovery. Therefore, this study aimed to compare the acute physiological responses to fast and medium movement tempo resistance exercises in ice-hockey players.

Methods: Fourteen ice-hockey players (26. Read More

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Multi-Dimensional Impact of Chronic Low Back Pain among Underserved African American and Latino Older Adults.

Int J Environ Res Public Health 2021 Jul 6;18(14). Epub 2021 Jul 6.

Department of Psychiatry, UCLA, Los Angeles, CA 90095, USA.

Chronic low back pain is one of the most common, poorly understood, and potentially disabling chronic pain conditions from which older adults suffer. The existing low back pain research has relied almost exclusively on White/Caucasian participant samples. This study examines the correlates of chronic low back pain among a sample of underserved urban African American and Latino older adults. Read More

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Expression of Rad51 and the histo-morphological evaluation of testis of the sterile male cattle-yak.

Theriogenology 2021 Jul 9;172:239-254. Epub 2021 Jul 9.

Laboratory of Animal Anatomy & Tissue Embryology, Department of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Gansu Agricultural University, Lanzhou, China.

Meiotic recombination is key to the repair of DNA double-strand break damage, provide a link between homologs for proper chromosome segregation as well as ensure genetic diversity in organisms. Defects in recombination often lead to sterility. The ubiquitously expressed Rad51 and the meiosis-specific DMC1 are two closely related recombinases that catalyze the key strand invasion and exchange step of meiotic recombination. Read More

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Actigraphy: Metrics reveal it is not a valid tool for determining sleep in neonates.

J Sleep Res 2021 Jul 22:e13444. Epub 2021 Jul 22.

Department of Pediatrics, University of Massachusetts Medical School, Worcester, MA, USA.

Study of emerging sleep-wake patterns in neonates is important for promptly identifying and treating abnormal sleep behaviours to ensure healthy infant development and neurobehavioral outcomes. Current methods to assess sleep are costly, labour intensive, and particularly difficult to implement in fragile, hospitalised infants requiring intensive medical care. The aim of the present study was to assess the validity of actigraphy as a tool for detecting sleep in preterm infants, using polysomnography (PSG) as the "gold standard". Read More

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Identification and Quantification of Bu Shen Yi Sui Capsule by UPLC-LTQ-Orbitrap-MSn and UPLC-QTOF-MS/MS.

J Chromatogr Sci 2021 Jul 21. Epub 2021 Jul 21.

School of Traditional Chinese Medicine, Beijing Key Lab of TCM Collateral Disease Theory Research, Capital Medical University, Beijing 100069, China.

Traditional Chinese medicines (TCMs) have been considered as important alternative therapeutics because of their significant medicinal benefits in specific diseases. Chinese herb formula is characterized by a vast molecule that differs in routine medicines. Due to TCMs chemical complexity, proper quality control has been a great challenge. Read More

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Development, Characterization, and Evaluation of SLN-Loaded Thermoresponsive Hydrogel System of Topotecan as Biological Macromolecule for Colorectal Delivery.

Biomed Res Int 2021 3;2021:9968602. Epub 2021 Jul 3.

Nanomedicine Research Group, Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

Background: Chemotherapeutic drugs cause severe toxicities if administered unprotected, without proper targeting, and controlled release. In this study, we developed topotecan- (TPT-) loaded solid lipid nanoparticles (SLNs) for their chemotherapeutic effect against colorectal cancer. The TPT-SLNs were further incorporated into a thermoresponsive hydrogel system (TRHS) (TPT-SLNs-TRHS) to ensure control release and reduce toxicity of the drug. Read More

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Future Care Planning: Concerns of Elderly Parents Caring for a Person With Serious Mental Illness.

Psychiatr Serv 2021 Jul 20:appips201900267. Epub 2021 Jul 20.

Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bengaluru, India (Sivakumar, Philip, Chandra); Department of Psychiatry, All India Institute of Medical Sciences, Bhopal, India (Jain); Semel Institute on Neuroscience and Human Behavior, University of California, Los Angeles, and VA Greater Los Angeles Healthcare System at West Los Angeles, Los Angeles (Glynn).

Although recent advances in early treatment of people with serious mental illness have brought new hope to family members, parents of service users are still often left to worry about their loved one's future care. Without judicious planning, a parent''s death can be a catastrophic event that leaves an adult with serious mental illness without supports. This Open Forum emphasizes the benefits of mental health professionals being proactive and helping families and service users address concerns with future care planning. Read More

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Employing telehealth strategies for opioid addiction during COVID-19: implications for social work health care.

Soc Work Health Care 2021 Jul 18:1-10. Epub 2021 Jul 18.

School of Social Work, University of Central Florida, Orlando, Florida, USA.

As the COVID-19 global pandemic continues, more than 40 states have reported increases in opioid-related mortality. The issue of service access and delivery poses a major concern for those struggling with mental illness and substance use disorders in the United States. To ensure the continuity of health care during the pandemic and the co-occurring opioid crisis, the United States continues to adapt its healthcare delivery strategies, which include the introduction of telehealth. Read More

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Surgical treatment of locally recurrent rectal cancer: a narrative review.

Zhaoya Gao Jin Gu

Ann Transl Med 2021 Jun;9(12):1026

Department of Gastrointestinal Surgery, Peking University Shougang Hospital, Beijing, China.

Objective: To summarize the recent literature on surgical treatment of locally recurrent rectal cancer (LRRC).

Background: LRRC is a heterogeneous disease that requires a multidisciplinary treatment approach. The treatment and prognosis depend on the site and type of recurrence. Read More

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SNP-Based Genotyping Provides Insight Into the West Asian Origin of Russian Local Goats.

Front Genet 2021 1;12:708740. Epub 2021 Jul 1.

L.K. Ernst Federal Science Center for Animal Husbandry, Podolsk, Russia.

Specific local environmental and sociocultural conditions have led to the creation of various goat populations in Russia. National goat diversity includes breeds that have been selected for down and mohair production traits as well as versatile local breeds for which pastoralism is the main management system. Effective preservation and breeding programs for local goat breeds are missing due to the lack of DNA-based data. Read More

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Regulation of the nucleic acid-sensing Toll-like receptors.

Nat Rev Immunol 2021 Jul 16. Epub 2021 Jul 16.

Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.

Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that receptor activation unequivocally indicates the presence of something foreign. However, a subset of TLRs recognizes nucleic acids, which are present in both the host and foreign microorganisms. This specificity enables broad recognition by virtue of the ubiquity of nucleic acids but also introduces the possibility of self-recognition and autoinflammatory or autoimmune disease. Read More

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Generalized energy-conserving dissipative particle dynamics revisited: Insight from the thermodynamics of the mesoparticle leading to an alternative heat flow model.

Phys Rev E 2021 Jun;103(6-1):062128

Weapons and Materials Research Directorate, U.S. Army CCDC Army Research Laboratory, Aberdeen Proving Ground, Maryland 21005, USA.

Recently we introduced the generalized energy-conserving dissipative particle dynamics method (GenDPDE) [J. Bonet Avalos, M. Lísal, J. Read More

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High-Performance Cathode Materials for Potassium-Ion Batteries: Structural Design and Electrochemical Properties.

Adv Mater 2021 Jul 16:e2100409. Epub 2021 Jul 16.

CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, and Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing, 100190, P. R. China.

Due to the obvious advantage in potassium reserves, potassium-ion batteries (PIBs) are now receiving increasing research attention as an alternative energy storage system for lithium-ion batteries (LIBs). Unfortunately, the large size of K makes it a challenging task to identify suitable electrode materials, particularly cathode ones that determine the energy density of PIBs, capable of tolerating the serious structural deformation during the continuous intercalation/deintercalation of K . It is therefore of paramount importance that proper design principles of cathode materials be followed to ensure stable electrochemical performance if a practical application of PIBs is expected. Read More

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Improved DEMATEL-ISM integration approach for complex systems.

Jih-Kuang Chen

PLoS One 2021 16;16(7):e0254694. Epub 2021 Jul 16.

Economics and Management College, Zhaoqing University, Zhaoqing, China.

Purpose: Decision Making Trial and Evaluation Laboratory (DEMATEL) and Interpretive Structural Modeling (ISM) are commonly used separately, but also may be combined per their common characteristics to identify causal relationships and hierarchical structure among factors in complex systems with a relatively small computational burden. The purpose of this study is to establish an improved DEMATEL-ISM integration approach to remedy the disadvantages of the traditional DEMATEL-ISM integration method. A case study was conducted to compare the proposed improved integration approach against the traditional integration method, and to validate its feasibility and effectiveness. Read More

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Monitoring Antihypertensive Medication Adherence by LC-MS/MS: Method Establishment and Clinical Application.

J Cardiovasc Pharmacol 2021 Jul 9. Epub 2021 Jul 9.

Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China, 210029 Fu Foundation School of Engineering and Applied Science, Columbia University, NY, USA, 10027 Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi, China, 030009 Department of Cardiology, East Hospital Affiliated Tongji University, Shanghai, China, 200120 Frontage Labs, Shanghai, 201203 Hangzhou Calibra Diagnostic Ltd., Hangzhou, China, 310030 Division of Cardiology, Department of Medicine, College of Physicians & Surgeons, Columbia University, NY, USA, 10032.

Abstract: Proper medication compliance is critical for the integrity of clinical practice, directly related to the success of clinical trials to evaluate both pharmacological and device-based therapies. Here, we established a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to accurately detect 55 chemical entities in human urine sample, which accounting for the most commonly used 172 antihypertensive drugs in China. The established method had good accuracy, intra-day and inter-day precision for all analyses in both bench tests and validated in 21 hospitalized patients. Read More

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Large cell anaplastic lymphoma associated with breast implant: a rare case report presentation and discussion of possible management.

Gland Surg 2021 Jun;10(6):2076-2080

Centre Hospitalier Universitaire Bichat Claude-Bernard, Paris, France.

Anaplastic large cell lymphomas (ALCL) are a rare type of primary breast lymphoma. The association between breast implants and ALCL was first described in 1997. Breast implant associated (BIA)-ALCL arises from the inflammatory T cells surrounding the fibrous capsule, and most tumors are . Read More

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Food Safety and Employee Health Implications of COVID-19.

J Food Prot 2021 Jul 15. Epub 2021 Jul 15.

Cornell University Assistant Professor 411 Tower Rd 362 Stocking Hall UNITED STATES Ithaca NY 14853.

The COVID-19 pandemic has greatly impacted the US food supply and consumer behavior. Food production and processing are being disrupted as illnesses, proactive quarantines, and government-mandated movement restrictions cause labor shortages. In this environment, the food industry has been required to adopt new, additional practices to minimize the risk of COVID-19 cases and outbreaks among its workforce. Read More

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Comparative cross-sectional assessment of knowledge, attitude and practice among university students and employees towards the use of the microbiology laboratory equipment.

F1000Res 2021 16;10:117. Epub 2021 Feb 16.

College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Continuous evaluation of students and employee's knowledge and attitude in clinical laboratories is mandatory to ensure a high level of competency, proper practice and to assess the need for training, which shall be reflected on the quality of laboratory results. The aim of the present study was to evaluate the knowledge, attitude, and practice in microbiology laboratories among employees (at King Fahd Hospital of the University) and clinical laboratory students (at Imam Abdulrahman Bin Faisal University)    This was a cross-sectional survey of 30 2 year students, 26 3 year students, 24 4 year students in the Clinical Laboratory Sciences department, and 30 employees. Participants completed a survey comprising 30 questions to assess their knowledge and attitude towards the use of equipment and practice in the microbiology laboratory. Read More

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WDR47 protects neuronal microtubule minus ends from katanin-mediated severing.

Cell Rep 2021 Jul;36(2):109371

Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, 3584 Utrecht, the Netherlands; Department of Neuroscience, Genentech, Inc., South San Francisco, CA 94080, USA. Electronic address:

Axons and dendrites are long extensions of neurons that contain arrays of noncentrosomal microtubules. Calmodulin-regulated spectrin-associated proteins (CAMSAPs) bind to and stabilize free microtubule minus ends and are critical for proper neuronal development and function. Previous studies have shown that the microtubule-severing ATPase katanin interacts with CAMSAPs and limits the length of CAMSAP-decorated microtubule stretches. Read More

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Shaping the root system: the interplay between miRNA regulatory hubs and phytohormones.

J Exp Bot 2021 Jul 14. Epub 2021 Jul 14.

Laboratory of Molecular Genetics of Plant Development, Department of Biological Sciences, Luiz de Queiroz College of Agriculture, University of Sao Paulo, Piracicaba, Sao Paulo, Brazil.

The root system commonly lies underground, where it provides anchorage to the aerial organs, as well as nutrients and water. Both endogenous and environmental cues contribute to the establishment of the root system. Among the endogenous cues, microRNAs (miRNAs), transcription factors and phytohormones modulate root architecture. Read More

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