J Cardiovasc Pharmacol 2021 Jul 9. Epub 2021 Jul 9.
Jiangsu Province Hospital, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China, 210029 Fu Foundation School of Engineering and Applied Science, Columbia University, NY, USA, 10027 Taiyuan Central Hospital of Shanxi Medical University, Taiyuan, Shanxi, China, 030009 Department of Cardiology, East Hospital Affiliated Tongji University, Shanghai, China, 200120 Frontage Labs, Shanghai, 201203 Hangzhou Calibra Diagnostic Ltd., Hangzhou, China, 310030 Division of Cardiology, Department of Medicine, College of Physicians & Surgeons, Columbia University, NY, USA, 10032.
Abstract: Proper medication compliance is critical for the integrity of clinical practice, directly related to the success of clinical trials to evaluate both pharmacological and device-based therapies. Here, we established a liquid chromatography tandem mass spectrometry (LC-MS/MS) method to accurately detect 55 chemical entities in human urine sample, which accounting for the most commonly used 172 antihypertensive drugs in China. The established method had good accuracy, intra-day and inter-day precision for all analyses in both bench tests and validated in 21 hospitalized patients. Read More