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Predictive factors for postpartum glucose intolerance in women with gestational diabetes mellitus.

J Obstet Gynaecol Res 2022 Jan 20. Epub 2022 Jan 20.

Department of Obstetrics and Gynecology, Kobe University Graduate School of Medicine, Kobe, Japan.

Aim: The aim of this prospective cohort study was to evaluate the risk factors for postpartum glucose intolerance (GI) in women with gestational diabetes mellitus (GDM).

Method: A total of 140 women with GDM were enrolled. Of these, 115 underwent a 75-g oral glucose tolerance test (OGTT) at 12 weeks after delivery. Read More

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January 2022

Characterization and Utility of Remote Interpretation of Visual Field Diagnostic Testing in an Academic Center.

J Neuroophthalmol 2022 Jan 17. Epub 2022 Jan 17.

Mayo Clinic Alix School of Medicine (FFK, TTX), Mayo Clinic, Rochester, Minnesota; Departments of Ophthalmology (JAL, VIL, MTB, JJC) and Neurology (JAL, MTB, JJC), Mayo Clinic, Rochester, Minnesota; Circle City Neuro-Ophthalmology (KEL), Carmel, Indiana; Neuro-Ophthalmology Section (KEL), Midwest Eye Institute, Carmel, Indiana; Ophthalmology Service (KEL), Richard L. Roudebush Veterans Administration Medical Center, Indianapolis, Indiana; and Departments of Ophthalmology (KEL, MWK) and Neurology and Neurosurgery (MWK), Indiana University School of Medicine, Indianapolis, Indiana.

Background: The use of remote interpretation of data has risen in neuro-ophthalmology to increase efficiency and maintain social distancing due to the coronavirus disease-19 pandemic. The purpose of this study is to characterize the use and efficiency of remote interpretation of visual fields (VFs) in an academic center and to determine how often the VF interpretation was consistent with the patient's clinical history and imaging at the time of the consult.

Methods: This is a retrospective study at a single academic center that enrolled all patients receiving a remote interpretation of VF from January 1, 2012, through December 31, 2012. Read More

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January 2022

Relationship Between Carotid Artery Angle and Plaque Morphology in Acute Cerebral Infarction Patients.

Neurologist 2022 Jan 20. Epub 2022 Jan 20.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University China National Clinical Research Center for Neurological Diseases Department of Neurology, People's Hospital of Daxing District, Beijing, China.

Background: High-resolution magnetic resonance imaging (HRMRI) can be used to clearly distinguish the luminal structure of the carotid artery (CA); measure the lumen, vessel wall, and total blood vessel area; and accurately describe the morphologic features of plaques.

Methods: This study used HRMRI to investigate the relationship between geometric features and volume and composition of carotid atherosclerotic plaques. Patients (n=81) who had experienced acute cerebral infarction (CI) within 7±3 days before admission to the Neurology Department of Beijing Tiantan Hospital between November 2011 and June 2012 were enrolled in the study. Read More

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January 2022

Ketamine Associated Intraoperative Electroencephalographic Signatures of Elderly Patients With and Without Preoperative Cognitive Impairment.

Anesth Analg 2022 Jan 20. Epub 2022 Jan 20.

Department of Anesthesiology, Columbia University Medical Center New York Presbyterian Hospital, New York, New York.

Background: Ketamine is typically used by anesthesiologists as an adjunct for general anesthesia and as a nonopioid analgesic. It has been explored for prevention of postoperative delirium, although results have been contradictory. In this study, we investigated the association of ketamine with postoperative delirium and specific encephalographic signatures. Read More

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January 2022

Validation of Continuous Noninvasive Blood Pressure Monitoring Using Error Grid Analysis.

Anesth Analg 2022 Jan 20. Epub 2022 Jan 20.

From the Department of Anesthesiology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Background: Error grid analysis was recently proposed to compare blood pressure obtained by 2 measurement methods. This study aimed to compare continuous noninvasive blood pressure (CNBP) with invasive blood pressure (IBP) using the error grid analysis and investigate the confounding risk factors attributable to the differences between CNBP and IBP.

Methods: Sixty adult patients undergoing general anesthesia were prospectively enrolled. Read More

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January 2022

Severe Intraoperative Hyperglycemia and Infectious Complications After Elective Brain Neurosurgical Procedures: Prospective Observational Study.

Anesth Analg 2022 Jan 20. Epub 2022 Jan 20.

Department of Anesthesiology, Critical Care and Pain Medicine, Sapienza University, Rome, Italy.

Background: Postoperative infections after brain surgery are a serious complication potentially worsening the outcome of surgical treatment. Severe intraoperative hyperglycemia (SIH) contributes to both infectious and noninfectious postoperative complications. However, there are a lack of data on the incidence of SIH in patients undergoing elective neurosurgical brain procedures and its association with the risk of postoperative infections. Read More

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January 2022

Prognostic impact of inflammation-based scores for extrahepatic cholangiocarcinoma.

Dig Surg 2022 Jan 20. Epub 2022 Jan 20.

Introduction: Although the relationship between systemic inflammatory responses and prognosis has been known in various cancers, it remains unclear which scores are most valuable for determining the prognosis of extrahepatic cholangiocarcinoma. We aimed to verify the usefulness of various inflammation-based scores as prognostic factors in patients with resected extrahepatic cholangiocarcinoma.

Methods: We analyzed consecutive patients undergoing surgical resection for extrahepatic cholangiocarcinoma at our institution between January 2000 and December 2019. Read More

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January 2022

Female Reproductive Ageing and Chromosomal Abnormalities in a Large Series of Women Undergoing IVF.

Cytogenet Genome Res 2022 Jan 20:1-5. Epub 2022 Jan 20.

Genesis Genoma Lab, Genetic Diagnosis, Clinical Genetics & Research, Athens, Greece.

Chromosomal abnormalities are often detected in women with reproductive problems. This study aimed to investigate the presence and type of chromosomal aberrations in peripheral blood of women undergoing in vitro fertilization (IVF) and their possible association with advanced maternal age (AMA). A total of 1,837 women undergoing IVF between 2016 and 2019 were enrolled in the study. Read More

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January 2022

Oral Abundance of Actinomyces spp. in Breast Cancer Patients.

Oncology 2022 Jan 20. Epub 2022 Jan 20.

Objectives: Pathophysiology of medication-related osteonecrosis of the jaw (MRONJ) is still unclear and disease development is associated with adverse reaction of bisphosphonates and denosumab, and Actinomyces spp. as well. In this study we evaluated the abundance of Actinomyces spp. Read More

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January 2022

Negatively interactive effect of chromium and cadmium on obesity: Evidence from adults living near ferrochromium factory.

Ecotoxicol Environ Saf 2022 Jan 17;231:113196. Epub 2022 Jan 17.

Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China. Electronic address:

Background: Researchers have reported that chromium (Cr) exposure may be associated with metabolism of glucose and lipids in residents living in a long-term Cr polluted area. Previous statistical analysis is mainly focused on individual chromium exposure. Furtherly, we aim to investigated the independent, combined, and interaction effects of the co-exposure of urine Cr (UCr) with cadmium (UCd), lead (UPb) and manganese (UMn) on body mass index (BMI), waist circumference, and the risk of overweight and abdominal obesity. Read More

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January 2022

Diffusion-weighted imaging-gadolinium enhancement mismatch sign in diffuse midline glioma.

Eur J Radiol 2021 Dec 13;147:110103. Epub 2021 Dec 13.

Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address:

Background: Diffuse midline glioma (DMG), H3 K27M-mutant including diffuse intrinsic pontine glioma (DIPG) is a disease with dismal prognosis. We focused on diffusion-weighted imaging (DWI) and gadolinium enhanced T1WI (Gd), especially high intensity on DWI at non-enhanced lesion, i.e. Read More

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December 2021

Prevalence of fatty liver disease after liver transplantation and risk factors for recipients and donors.

Ann Hepatol 2022 Jan 17:100670. Epub 2022 Jan 17.

Institute of Gastroenterology, Department of Internal Medicine, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Introduction And Objectives: Fatty liver disease (FLD) may develop in liver transplant recipients. We investigated the recipient and donor risk factors for FLD development after liver transplantation (LT).

Methods: A total of 108 liver transplant recipients (54 men [50. Read More

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January 2022

Knowledge, attitudes and practices of undergraduate and dentists about dental prenatal care.

Eur J Dent Educ 2022 Jan 20. Epub 2022 Jan 20.

Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of São Paulo, Bauru, São Paulo, Brazil.

This study aimed to evaluate the knowledge, attitudes, practices of undergraduate and professionals, both from the public and from private sectors in Brazil, regarding dental prenatal care. This study corresponded to an online questionnaire survey, via Google Forms, consisting of 17 general questions for undergraduates (n = 103) and 16 for professionals (n = 227) for demographic and school mapping, and 18 specific questions about the importance and protocol of dental prenatal care. T test, Mann-Whitney U test and multiple linear regression were adopted (p <0. Read More

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January 2022

Dietary folate intake and fecundability in two preconception cohorts.

Hum Reprod 2022 Jan 20. Epub 2022 Jan 20.

Department of Clinical Epidemiology, Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.

Study Question: To what extent is dietary folate intake and total folate intake (dietary and supplemental intakes) associated with fecundability, the per cycle probability of conception?

Summary Answer: Preconception dietary folate intake was positively associated with fecundability in a monotonic pattern.

What Is Known Already: Supplemental folic acid has been associated with improved fertility, but little is known about the relation between dietary folate and fecundability.

Study Design, Size, Duration: A prospective cohort study including 9559 women trying to conceive without fertility treatment and enrolled in the period 2013-2020. Read More

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January 2022

A prospective cohort study of COVID-19 vaccination, SARS-CoV-2 infection, and fertility.

Am J Epidemiol 2022 Jan 20. Epub 2022 Jan 20.

Some reproductive-aged individuals remain unvaccinated against COVID-19 due to concerns about potential adverse effects on fertility. We examined the associations of COVID-19 vaccination and SARS-CoV-2 infection with fertility among couples trying to conceive spontaneously using data from an internet-based preconception cohort study. We enrolled 2,126 self-identified females residing in the U. Read More

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January 2022

Effect of a multi-domain lifestyle intervention on cardiovascular risk in older people: the FINGER trial.

Eur Heart J 2022 Jan 20. Epub 2022 Jan 20.

Department of Public Health and Welfare, Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.

Aims: Joint prevention of cardiovascular disease (CVD) and dementia could reduce the burden of both conditions. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated a beneficial effect on cognition (primary outcome) and we assessed the effect of this lifestyle intervention on incident CVD (pre-specified secondary outcome).

Methods And Results: FINGER enrolled 1259 individuals aged 60-77 years (ClinicalTrials. Read More

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January 2022

Human Papillomavirus (HPV) seroprevalence, cervical HPV prevalence, genotype distribution and cytological lesions in solid organ transplant recipients and immunocompetent women in Sao Paulo, Brazil.

PLoS One 2022 20;17(1):e0262724. Epub 2022 Jan 20.

Departamento de Molestias Infecciosas e Parasitarias da Faculdade de Medicina da Universidade de Sao Paulo (FMUSP), Sao Paulo, Brazil.

Introduction: Solid organ transplant (SOT) recipients are at increased risk of Human Papillomavirus (HPV) persistent infection and disease. This study aimed to evaluate HPV seroprevalence, cervical HPV prevalence, genotype distribution, and frequency of HPV-related cervical lesions in SOT recipients in comparison to immunocompetent women.

Methods: Cross-sectional study including SOT and immunocompetent women aged 18 to 45 years who denied previous HPV-related lesions. Read More

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January 2022

Perception of students on factors contributing to overweight and obesity among high school students in Kiribati: A qualitative study.

PLoS One 2022 20;17(1):e0260900. Epub 2022 Jan 20.

School of Public Health and Primary Care, Fiji National University, Suva, Fiji.

Background: Overweight and obesity among high school students is a growing distress not only to the individual wellbeing of a person but also to the productivity of communities and economic expense of both developed and developing nations. This study aimed to determine factors contributing to overweight and obesity among high school students in Kiribati through the perception of students.

Methods: This qualitative study was conducted in four (4) randomly selected senior high schools on South Tarawa, Kiribati from August to November, 2020. Read More

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January 2022

Results of a phase 1, randomized, placebo-controlled first-in-human trial of griffithsin formulated in a carrageenan vaginal gel.

PLoS One 2022 20;17(1):e0261775. Epub 2022 Jan 20.

Center for Biomedical Research, Population Council, New York, New York, United States of America.

HIV pre-exposure prophylaxis (PrEP) is dominated by clinical therapeutic antiretroviral (ARV) drugs. Griffithsin (GRFT) is a non-ARV lectin with potent anti-HIV activity. GRFT's preclinical safety, lack of systemic absorption after vaginal administration in animal studies, and lack of cross-resistance with existing ARV drugs prompted its development for topical HIV PrEP. Read More

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January 2022

Effect of Ultrasound-Guided Partial Release of the Transverse Carpal Ligament with a Needle in Patients with Refractory Carpal Tunnel Syndrome.

Pain Physician 2022 Jan;25(1):E141-E145

Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Korea.

Background: Neuropathic pain in the hands due to carpal tunnel syndrome (CTS) disturbs sleep and affects the quality of life.

Objectives: We evaluated the effect of ultrasound (US)-guided partial release of the transverse carpal ligament (TCL) using an 18-G needle in patients with refractory CTS.

Study Design: A prospective outcome study. Read More

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January 2022

Multi-waveform Spinal Cord Stimulation with High Frequency Electromagnetic Coupled (HF-EMC) Powered Implanted Electrode Array and Receiver for the Treatment of Chronic Back and Leg Pain (SURF Study).

Pain Physician 2022 Jan;25(1):67-76

Stimwave Technologies Inc., Pompano Beach, FL.

Background: Novel externally powered spinal cord stimulation technology can be fully implanted when trialing the effectiveness of the therapy, since no percutaneous leads are needed, and the trial period lasted 30 days. Multiple tests of different stimulation modalities and parameters are possible, thus improving the chances that the therapy will lead to effective pain reduction.

Objectives: The objective of this study was to analyze the effectiveness of the Freedom Spinal Cord Stimulator System (Stimwave LLC, Pompano Beach, FL) for the treatment of failed back surgery syndrome due to postlaminectomy syndrome utilizing multiple waveforms. Read More

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January 2022

Do Patients Accurately Recall Their Pain Levels Following Epidural Steroid Injection? A Cohort Study of Recall Bias in Patient-Reported Outcomes.

Pain Physician 2022 Jan;25(1):59-66

University of Michigan, Ann Arbor, MI.

Background: Although patient-reported outcomes (PROs) have become important in the evaluation of spine surgery patients, the accuracy of patient recall of pre- or post-intervention  symptoms following epidural steroid injection remains unknown.

Objectives: The purpose of this study was to: 1) characterize the accuracy of patient recollection of back/leg pain following epidural steroid injection; 2) characterize the direction and magnitude of recall bias; and 3) characterize factors that impact patient recollection.

Study Design: A prospective cohort study. Read More

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January 2022

Clinical Effects and Safety of the Use of Methylene Blue for the Treatment of Lumbar Facet Joint Syndrome.

Pain Physician 2022 Jan;25(1):E15-E26

Department of Pain, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Background: Lumbar facet joint syndrome (LFJS) has been suggested to be a main source of low back pain. Methylene blue (MB), an inhibitor of nitric oxide synthesis with potential analgesic and anti-inflammatory properties, has been widely applied for a variety of pain-related diseases. However, no studies have been conducted on the treatment of LFJS patients using MB. Read More

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January 2022

Video-Urodynamic Characteristics and Predictors of Switching from Botulinum Neurotoxin a Injection to Augmentation Enterocystoplasty in Spinal Cord Injury Patients.

Toxins (Basel) 2022 Jan 10;14(1). Epub 2022 Jan 10.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien 970374, Taiwan.

Botulinum neurotoxin type A (BoNT-A) injection and augmentation enterocystoplasty (AE) are alternative and effective management strategies for neurogenic detrusor overactivity (NDO) refractory to pharmacotherapy. A great majority of patients with spinal cord injury (SCI) may, however, prefer BoNT-A injections to AE, due to the less invasive characteristics. In this study we evaluated the influence of various video-urodynamic study (VUDS) parameters in SCI patients who continuously received repeat BoNT-A detrusor injections or switched to AE to improve their bladder conditions. Read More

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January 2022

Effectiveness of Botulinum Toxin on Pain in Stroke Patients Suffering from Upper Limb Spastic Dystonia.

Toxins (Basel) 2022 Jan 5;14(1). Epub 2022 Jan 5.

Academic Neurology Unit, Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04019 Terracina, Italy.

This observational study aimed at investigating pain in stroke patients with upper limb spastic dystonia. Forty-one consecutive patients were enrolled. A 0-10 numeric rating scale was used to evaluate pain at rest and during muscle tone assessment. Read More

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January 2022

Weight Surveillance and Heart Failure Self-assessment in Patients with Chronic Leg Wounds: A Pilot Study.

Adv Skin Wound Care 2022 Feb;35(2):1-6

Julia Stecker, DNP, CWCN, FNP-NP-C, is a family nurse practitioner, Seattle, Washington. Jessica Schwinck, DNP, RN, CEN, ACCNS-AG, AGACNP-BC, FNP-BC, is Clinical Assistant Professor of Nursing, Pacific Lutheran University, Tacoma, Washington. Acknowledgments: The HRSA-ANEW Grant Trainee has partially funded this work. The grant funded study materials for the implementation of this project. The authors have disclosed no other financial relationships related to this article. Submitted May 17, 2021; accepted in revised form July 26, 2021.

Objective: To determine if a weight check and heart failure symptom evaluation with each wound care visit could impact wound healing in patients with heart failure and chronic leg wounds.

Methods: This was a descriptive, correlational study at an outpatient wound healing center in the Pacific Northwest. A convenience sample of individuals currently enrolled at the center with leg wounds and heart failure was identified from standardized electronic medical records. Read More

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February 2022

Mutations in Circulating Tumor DNA and Clinical Outcomes of Rechallenge Treatment With Anti-EGFR Antibodies in Patients With Metastatic Colorectal Cancer.

JCO Precis Oncol 2020 Nov;4:898-911

Division of Medical Oncology, Showa University Fujigaoka Hospital, Yokohama, Japan.

Purpose: Several trials have evaluated the efficacy of rechallenge treatment with anti-epidermal growth factor receptor (EGFR) monoclonal antibody (mAb) in patients with metastatic colorectal cancer (mCRC). A recent trial indicated that status in circulating tumor DNA (ctDNA) may potentially predict patients with wild-type mCRC resistant to anti-EGFR mAb who would benefit from rechallenge treatment, and the findings should be further investigated.

Material And Methods: We enrolled patients whose plasma samples were collected in prospective phase II trials, the JACCRO CC-08 (n = 36) and CC-09 (n = 25), which evaluated rechallenge chemotherapy with anti-EGFR mAb for wild-type mCRC. Read More

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November 2020

Palbociclib in Patients With Non-Small-Cell Lung Cancer With Alterations: Results From the Targeted Agent and Profiling Utilization Registry Study.

JCO Precis Oncol 2020 Nov;4:757-766

American Society of Clinical Oncology, Alexandria, VA.

Purpose: The Targeted Agent and Profiling Utilization Registry (TAPUR) Study is a phase II pragmatic basket trial evaluating antitumor activity of commercially available targeted agents in patients with advanced cancer with genomic alterations known to be drug targets. Results in a cohort of patients with non-small-cell lung cancer (NSCLC) with alterations treated with palbociclib are reported.

Methods: Eligible patients were ≥ 18 years old with advanced NSCLC, no remaining standard treatment options, measurable disease, Eastern Cooperative Oncology Group performance status of 0 to 2, and adequate organ function. Read More

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November 2020

Teaching Parents Read, Ask, Answer, Prompt Strategies via Telepractice: Effects on Parent Strategy Use and Child Communication.

Lang Speech Hear Serv Sch 2022 Jan 20:1-19. Epub 2022 Jan 20.

Department of Pediatrics, Oregon Health & Science University, Portland.

Purpose: This study aimed to explore the feasibility of a telepractice communication partner intervention for children who use augmentative and alternative communication (AAC) and their parents.

Method: Five children (aged 3;4-12;9 [years;months]) with severe expressive communication impairments who use AAC and their parents enrolled in a randomized, multiple-probe design across participants. A speech-language pathologist taught parents to use a least-to-most prompting procedure, Read, Ask, Answer, Prompt (RAAP), during book reading with their children. Read More

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January 2022

Multicenter phase II study of trifluridine/tipiracil for esophageal squamous carcinoma refractory/intolerant to 5-fluorouracil, platinum compounds, and taxanes: the ECTAS study.

Esophagus 2022 Jan 20. Epub 2022 Jan 20.

Department of Therapeutic Oncology, Graduate School of Medicine, Kyoto University, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: The standard treatment for unresectable advanced/recurrent esophageal cancer in Japan is 5-fluorouracil plus platinum-containing drugs as first-line chemotherapy and taxanes as second-line chemotherapy. However, the standard regimen after patients become refractory to these treatments remains to be established. Therefore, we investigated the efficacy of trifluridine/tipiracil (FTD/TPI) in patients with esophageal cancer who are refractory or intolerant to 5-fluorouracil, platinum-containing drugs, and taxanes. Read More

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January 2022