94,315 results match your criteria enhanced presence


Coordination of nitrogen uptake and assimilation favours the growth and competitiveness of moso bamboo over native tree species in high-NH environments.

J Plant Physiol 2021 Sep 7;266:153508. Epub 2021 Sep 7.

College of Landscape and Art, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China; Jiangxi Provincial Key Laboratory for Bamboo Germplasm Resources and Utilization, Jiangxi Agricultural University, Nanchang, Jiangxi, 330045, China. Electronic address:

Phenotypic plasticity and competitive strength are major mechanisms determining the success of invasive species and are influenced by abiotic factors. A rise in the ratio of ammonium (NH) to nitrate (NO) in soils is frequently associated with the invasion of bamboo into broad-leaved evergreen forests. However, the influence of soil nitrogen (N) chemistry on plant growth and interspecific competition in the context of invasion remains insufficiently studied. Read More

View Article and Full-Text PDF
September 2021

Bacillus siamensis CNE6- a multifaceted plant growth promoting endophyte of Cicer arietinum L. having broad spectrum antifungal activities and host colonizing potential.

Microbiol Res 2021 Sep 11;252:126859. Epub 2021 Sep 11.

Mycology and Plant Pathology Laboratory, Department of Botany, Visva-Bharati, Santiniketan, 731235, India. Electronic address:

Exploration of endophytic bacteria with multiple plant growth promoting (PGP) attributes is considered as an eco-friendly and cost-effective alternative to agricultural chemicals for increasing crop productivity. In the present endeavor, healthy chickpea plants (Cicer arietinum L.) collected from district Birbhum, West Bengal, India were subjected for the isolation of endophytic bacteria having multifarious PGP properties. Read More

View Article and Full-Text PDF
September 2021

Sirolimus loaded chitosan functionalized poly (lactic-co-glycolic acid) (PLGA) nanoparticles for potential treatment of age-related macular degeneration.

Int J Biol Macromol 2021 Sep 15. Epub 2021 Sep 15.

Department of Pharmaceutics, School of Pharmaceutical Education & Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

The usefulness of sirolimus (SIR) in the treatment of diseases that involve retinal degeneration like age-related macular degeneration (AMD) has been well documented. However, the problem still remains probably owing to the peculiar environment of the eye and/or unfavourable physiochemical profile of SIR. In the present work, we aimed to fabricate sirolimus loaded PLGA nanoparticles (SIR-PLGA-NP) and chitosan decorated PLGA nanoparticles (SIR-CH-PLGA-NP) to be administered via non-invasive subconjunctival route. Read More

View Article and Full-Text PDF
September 2021

Effect of Revtech thermal processing on volatile organic compounds and chemical characteristics of split yellow pea (Pisum sativum L.) flour.

J Food Sci 2021 Sep 17. Epub 2021 Sep 17.

Department of Food and Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada.

Yellow pea (Pisumsativum L.) is an economically rich source of nutrients with health-promoting effects. However, the consumption of pea ingredients is minimal due to their off-flavor characteristics. Read More

View Article and Full-Text PDF
September 2021

A general in-situ reduction method to prepare core-shell liquid-metal / metal nanoparticles for photothermally enhanced catalytic cancer therapy.

Biomaterials 2021 Sep 10;277:121125. Epub 2021 Sep 10.

Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, 215123, China. Electronic address:

Gallium indium (GaIn) alloy as a kind of liquid metal (LM) with unique chemical and physical properties has attracted increasing attention for its potential biomedical applications. Herein, a series of core-shell [email protected] (Metal: Pt, Au, Ag, and Cu) heterogeneous nanoparticles (NPs) are obtained by a simple in-situ reduction method. Take core-shell [email protected] NPs for example, the synthesized [email protected] NPs after Pt growth on their surface showed significantly improved photothermal conversion efficiency (PCE) and thermal stability under near-infrared (NIR) II light irradiation. Read More

View Article and Full-Text PDF
September 2021

Antimicrobial Activity of Synthetic Antimicrobial Peptides Loaded in Poly-Ɛ-Caprolactone Nanoparticles Against Mycobacteria and their Functional Synergy with Rifampicin.

Int J Pharm 2021 Sep 14:121097. Epub 2021 Sep 14.

Experimental Animal Facility, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra, India-282004. Electronic address:

Tuberculosis (TB) treatment has become a challenge because of the natural presence of multilayered cell wall rich in lipids which restrict antibiotic permeability within the bacteria. The development of mutations conferring resistance has aggravated the situation. Consequently, maximum pharmaceutical efforts are required to improve the treatment, and antimicrobial peptides (AMPs) with antimycobacterial activity can be exploited as a new treatment strategy against TB. Read More

View Article and Full-Text PDF
September 2021

Repetitive spikes of glucose and lipid induce senescence-like phenotypes of bone marrow stem cells through H3K27me3 demethylase-mediated epigenetic regulation.

Am J Physiol Heart Circ Physiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Medicine II, grid.410783.9Kansai Medical University, Osaka, Hirakata, Osaka, Japan.

Bone marrow-derived endothelial progenitor cells (EPCs) contribute to endothelial repair and angiogenesis. Reduced number of circulating EPCs is associated with future cardiovascular events. We tested whether dysregulated glucose and/or triglyceride (TG) metabolism has an impact on EPC homeostasis. Read More

View Article and Full-Text PDF
September 2021

Improved Spatial Resolution Achieved by Chromatic Intensity Interferometry.

Phys Rev Lett 2021 Sep;127(10):103601

Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei 230026, China.

Interferometers are widely used in imaging technologies to achieve enhanced spatial resolution, but require that the incoming photons be indistinguishable. In previous work, we built and analyzed color erasure detectors, which expand the scope of intensity interferometry to accommodate sources of different colors. Here we demonstrate experimentally how color erasure detectors can achieve improved spatial resolution in an imaging task, well beyond the diffraction limit. Read More

View Article and Full-Text PDF
September 2021

Achieving Enhanced Photochromic Property of Diarylethene Through Host-Guest Interaction in Aqueous Solution.

Chemistry 2021 Sep 17. Epub 2021 Sep 17.

Wuhan University of Science and Technology, School of Chemistry and Chemical Engineering, 947# Heping Road, 430081, Wuhan, CHINA.

Diarylethene (DTE) has been widely used in fluorescence probes, molecular logic gates, optical data-storage devices owing to the excellent photochromic property, while constructing high-performance photochromic DTE in aqueous media remains a big challenge. Herein we present several host-guest systems formed between cucurbit[ n ]uril (CB[ n ], n = 7, 8, 10) and two water-soluble DTE derivatives 1 and 2 . It was found that host-guest interactions not only affect the photophysical properties of photochromic guests, also make great differences on the photoreaction process. Read More

View Article and Full-Text PDF
September 2021

Urofaecal glucocorticoid metabolite concentrations in African penguin () chick populations experiencing different levels of human disturbance.

Conserv Physiol 2021 14;9(1):coab078. Epub 2021 Sep 14.

Department of Biodiversity and Conservation Biology, University of the Western Cape, Bellville, 7535, South Africa.

Despite the importance of ecotourism in species conservation, little is known about the industry's effects on wildlife. In South Africa, some African penguin () colonies have become tourist attractions. The species is globally endangered, with population sizes decreasing over the past 40 years. Read More

View Article and Full-Text PDF
September 2021

Preparation of immobilized arylsulfatase on magnetic FeO nanoparticles and its application for agar quality improvement.

Food Sci Nutr 2021 Sep 7;9(9):4952-4962. Epub 2021 Jul 7.

College of Food and Biological Engineering Jimei University Xiamen China.

The presence of sulfate groups in agar compromises the agar quality by affecting the crosslinking during gelling process. Some arylsulfatases can catalyze the hydrolysis of sulfate bonds in agar to improve the agar quality. Immobilized arylsulfatases prove beneficial advantages for their industrial applications. Read More

View Article and Full-Text PDF
September 2021

Reservoir quality and its controlling diagenetic factors in the Bentiu Formation, Northeastern Muglad Basin, Sudan.

Sci Rep 2021 Sep 16;11(1):18442. Epub 2021 Sep 16.

School of Earth Sciences, Northeast Petroleum University, Daqing, 163318, China.

The Abu Gabra and Bentiu formations are widely distributed within the interior Muglad Basin. Recently, much attention has been paid to study, evaluate and characterize the Abu Gabra Formation as a proven reservoir in Muglad Basin. However, few studies have been documented on the Bentiu Formation which is the main oil/gas reservoir within the basin. Read More

View Article and Full-Text PDF
September 2021

R-Ras subfamily proteins elicit distinct physiologic effects and phosphoproteome alterations in neurofibromin-null MPNST cells.

Cell Commun Signal 2021 Sep 16;19(1):95. Epub 2021 Sep 16.

Department of Pathology and Laboratory Medicine (SMW, AP, JFL, SLC), MUSC Medical Scientist Training Program (SMW), Medical University of South Carolina, 171 Ashley Avenue, MSC 908, Charleston, SC, 29425-9080, USA.

Background: Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-Ras, N-Ras, K-Ras), M-Ras, and R-Ras (R-Ras, R-Ras2/TC21) subfamily proteins. We have shown that classic Ras proteins promote proliferation and survival, but not migration, in malignant peripheral nerve sheath tumor (MPNST) cells. Read More

View Article and Full-Text PDF
September 2021

Solvent induced conformational changes for the altered activity of laccase: A molecular dynamics study.

J Hazard Mater 2021 Sep 5;423(Pt B):127123. Epub 2021 Sep 5.

P.K. Sinha Centre for Bioenergy and Renewables, Indian Institute of Technology Kharagpur, West Bengal 721302, India; School of Energy Science and Engineering, Indian Institute of Technology Kharagpur, West Bengal 721302, India. Electronic address:

The growing demands of solvent-based industries like paint, pharmaceutical, petrochemical, paper and pulp, etc., have directly increased the release of effluents that are rich in hazardous aromatic compounds in the environment. A sustainable biotechnological approach utilizing laccases as biocatalyst enable in biodegradation of these aromatic toxin-rich effluents. Read More

View Article and Full-Text PDF
September 2021

Gas-filled Protein Nanostructures as Cavitation Nuclei for Molecule-Specific Sonodynamic Therapy.

Acta Biomater 2021 Sep 13. Epub 2021 Sep 13.

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, PR China. Electronic address:

Sonodynamic therapy (SDT) is a promising alternative for cancer therapy, understood to exert cytotoxicity through cavitation and subsequent production of large amounts of reactive oxygen species (ROS). Gas-filled protein nanostructures (gas vesicles or GVs) produced by cyanobacteria have a hollow structure similar to microbubbles and have demonstrated comparable enhancement of ultrasound imaging contrast. We thus hypothesized that GVs may act as stable nuclei for inertial cavitation to enhance SDT with improved enhanced permeability and retention (EPR) effects due to their nanometer scale. Read More

View Article and Full-Text PDF
September 2021

Features from MRI texture analysis associated with survival outcomes in triple-negative breast cancer patients.

Breast Cancer 2021 Sep 16. Epub 2021 Sep 16.

Department of Radiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi, 466-8550, Japan.

Purpose: The purpose of the study is to evaluate the associations between intratumoral or peritumoral textural features derived from pretreatment magnetic resonance imaging (MRI) and recurrence-free survival (RFS) in triple-negative breast cancer (TNBC) patients.

Methods: Forty-three patients with TNBC who underwent preoperative MRI between February 2008 and March 2014 were included. We performed two-dimensional texture analysis on the intratumoral or peritumoral region of interest (ROI) on axial of T2-weighted image (T2WI), dynamic contrast-enhanced (DCE)-MRI and DCE-MRI subtraction images. Read More

View Article and Full-Text PDF
September 2021

Enhanced esterase activity during the degradation of dibutyl phthalate by Fusarium species in liquid fermentation.

J Ind Microbiol Biotechnol 2021 Sep 16. Epub 2021 Sep 16.

Laboratory of Biotechnology, Research Centre for Biological Sciences, Universidad Autónoma de Tlaxcala, Ixtacuixtla, CP. 90062, Tlaxcala, Mexico.

Dibutyl phthalate (DBP) is one of the most abundantly produced and used plasticizers and is incorporated into plastic to make it more flexible and malleable. DBP has been found to be an environmental contaminant and reported as an endocrine disruptor. Therefore, it is crucial to develop ecofriendly alternatives to eliminate phthalate pollution. Read More

View Article and Full-Text PDF
September 2021

Performance of the Enhanced Liver Fibrosis Test to Estimate Advanced Fibrosis Among Patients With Nonalcoholic Fatty Liver Disease.

JAMA Netw Open 2021 Sep 1;4(9):e2123923. Epub 2021 Sep 1.

Center for Outcomes Research in Liver Diseases, Washington, District of Columbia.

Importance: The most important surrogate for increased risk of adverse clinical outcomes among patients with nonalcoholic fatty liver disease (NAFLD) is the patient's stage of liver fibrosis. There is a significant barrier to risk-stratifying patients in clinical practice owing to the need for liver biopsy.

Objective: To determine the performance of the enhanced liver fibrosis (ELF) test as a noninvasive test for assessment of liver fibrosis among patients with NAFLD. Read More

View Article and Full-Text PDF
September 2021

Derivatization-assisted enzyme-linked immunosorbent assay for identifying hallucinogenic mushrooms with enhanced sensitivity.

Anal Methods 2021 Sep 16;13(35):3954-3962. Epub 2021 Sep 16.

Kobe Pharmaceutical University, 4-19-1, Motoyama-Kitamachi, Higashinada-ku, Kobe 658-8558, Japan.

A sensitive immunochemical method for identifying hallucinogenic mushrooms (magic mushrooms) is required for regulating their illicit use. We have previously generated a monoclonal antibody (mAb) that targets psilocin (Psi), the major psychoactive compound in hallucinogenic mushrooms, and developed an enzyme-linked immunosorbent assay (ELISA). However, this ELISA failed to achieve the expected low-picomole-range sensitivity, as a result of insufficient affinity of the mAb to Psi. Read More

View Article and Full-Text PDF
September 2021

Catalyzing Bond-Dissociation in Graphene via Alkali-Iodide Molecules.

Small 2021 Sep 16:e2102037. Epub 2021 Sep 16.

Max Planck Institute for Solid State Research, Heisenberstr.1, 70569, Stuttgart, Germany.

Atomic design of a 2D-material such as graphene can be substantially influenced by etching, deliberately induced in a transmission electron microscope. It is achieved primarily by overcoming the threshold energy for defect formation by controlling the kinetic energy and current density of the fast electrons. Recent studies have demonstrated that the presence of certain species of atoms can catalyze atomic bond dissociation processes under the electron beam by reducing their threshold energy. Read More

View Article and Full-Text PDF
September 2021

Treating Chronic Wounds Using Photoactive Metabolites: Data Mining the Chinese Pharmacopoeia for Potential Lead Species.

Planta Med 2021 Sep 15. Epub 2021 Sep 15.

Research Group "Pharmacognosy and Phytotherapy", UCL School of Pharmacy, London, UK.

Efficient wound treatment that addresses associated infections and inflammation remains one of the big unmet needs, especially in low- and middle-income countries. One strategy for securing better healthcare can be using medicinal plants if sufficient evidence on their safety and therapeutic benefits can be ascertained. A unique novel opportunity could be photo-enhanced wound treatment with a combination of light-sensitive plant preparations and local exposure to daylight. Read More

View Article and Full-Text PDF
September 2021

Enhanced intestinal permeability and intestinal co-morbidities in heat strain: A review and case for autodigestion.

Temperature (Austin) 2021 12;8(3):223-244. Epub 2021 Jul 12.

Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.

Enhanced intestinal permeability is a pervasive issue in modern medicine, with implications demonstrably associated with significant health consequences such as sepsis, multiorgan failure, and death. Key issues involve the trigger mechanisms that could compromise intestinal integrity and increase local permeability allowing the passage of larger, potentially dangerous molecules. Heat stress, whether exertional or environmental, may modulate intestinal permeability and begs interesting questions in the context of global climate change, increasing population vulnerabilities, and public health. Read More

View Article and Full-Text PDF

Metanephric adenoma: association between the imaging features of contrast-enhanced ultrasound and clinicopathological characteristics.

Gland Surg 2021 Aug;10(8):2490-2499

Department of Ultrasound, The Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen, China.

Background: This study aimed to improve the understanding of metanephric adenoma (MA) by retrospective analysis of contrast-enhanced ultrasound (CEUS) findings and clinicopathological characteristics of MAs.

Methods: Gray-scale ultrasound (US) and CEUS findings of 7 adult MA patients, confirmed by postoperative pathology, were summarized via collection of clinicopathological and ultrasonographic imaging data, including tumor location, size, echo intensity, color flow, presence or absence of calcification, and liquefactive necrosis, contrast-enhanced pattern, enhancement characteristics, and contrast wash-out compared with adjacent parenchyma, and the presence or absence of a pseudocapsule. Histopathological analyses, including hematoxylin and eosin (HE) and immunohistochemical (IHC) staining, were conducted with the EnVision method. Read More

View Article and Full-Text PDF

Clinical Significance of Hyperdense Lesions on Non-enhanced Brain CT Obtained Immediately after Arterial Revascularization in Acute Ischemic Stroke Patients.

Comput Math Methods Med 2021 3;2021:1562502. Epub 2021 Sep 3.

Department of Neurology, Shandong Provincial Third Hospital, Cheeloo College of Medicine, Shandong University, No. 12, Wuyingshan Middle Road, Tianqiao District, Jinan 250031, China.

Purpose: To analyze the characteristics of hyperdense lesions on brain CT conducted immediately after arterial revascularization (AR) in patients with acute ischemic stroke (AIS), track the outcome of those lesions and investigate their clinical significance.

Materials And Methods: 97 AIS patients were enrolled in our study. Among them, 52 patients showed hyperdense lesions and were divided into three categories: type I, type II and type III according to the morphologic characteristics of hyperdense lesions. Read More

View Article and Full-Text PDF
September 2021

Efficacy of Δ -Tetrahydrocannabinol (THC) Alone or in Combination With a 1:1 Ratio of Cannabidiol (CBD) in Reversing the Spatial Learning Deficits in Old Mice.

Front Aging Neurosci 2021 30;13:718850. Epub 2021 Aug 30.

Institute of Molecular Psychiatry, Medical Faculty, University of Bonn, Bonn, Germany.

Decline in cognitive performance, an aspect of the normal aging process, is influenced by the endocannabinoid system (ECS). Cannabinoid receptor 1 (CB1) signaling diminishes with advancing age in specific brain regions that regulate learning and memory and abolishing CB1 receptor signaling accelerates cognitive aging in mice. We recently demonstrated that prolonged exposure to low dose (3 mg/kg/day) Δ-tetrahydrocannabinol (THC) improved the cognitive performances in old mice on par with young untreated mice. Read More

View Article and Full-Text PDF

Rational design of a new antibiotic class for drug-resistant infections.

Nature 2021 Sep 15. Epub 2021 Sep 15.

Entasis Therapeutics, Waltham, MA, USA.

The development of new antibiotics to treat infections caused by drug-resistant Gram-negative pathogens is of paramount importance as antibiotic resistance continues to increase worldwide. Here we describe a strategy for the rational design of diazabicyclooctane inhibitors of penicillin-binding proteins from Gram-negative bacteria to overcome multiple mechanisms of resistance, including β-lactamase enzymes, stringent response and outer membrane permeation. Diazabicyclooctane inhibitors retain activity in the presence of β-lactamases, the primary resistance mechanism associated with β-lactam therapy in Gram-negative bacteria. Read More

View Article and Full-Text PDF
September 2021

Toward enhanced catalytic activity of magnetic nanoparticles integrated into 3D reduced graphene oxide for heterogeneous Fenton organic dye degradation.

Sci Rep 2021 Sep 15;11(1):18343. Epub 2021 Sep 15.

POLYMAT, Facultad de Ciencias, Químicas, University of the Basque Country UPV/EHU, Joxe Mari Korta, Center - Avda. Tolosa, 72, 20018, San Sebastian, Spain.

Composite Fenton nanocatalyst was prepared by water-based in situ creation of FeO nanoparticles integrated within the self-assembly 3D reduced graphene oxide (rGO) aerogel. The hybrid applied for the degradation of Acid Green 25 (AG-25) organic dye in an aqueous solution, in the presence of HO. By investigating the conditions that maximize the dye adsorption by the 3D composite, it was found that the pH of the solution should be adjusted between the pKa of the functional groups present on the rGO surface (carboxylic acid) and that of the dye (sulfonic acid) to promote electrostatic interactions dye-3D structure. Read More

View Article and Full-Text PDF
September 2021

Dexamethasone enhances the efficacy of atorvastatin in inhibiting excessively inflammation-induced abnormal angiogenesis by regulating macrophages.

J Neuroinflammation 2021 Sep 15;18(1):203. Epub 2021 Sep 15.

Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin, 300052, China.

Background: We have recently showed that atorvastatin (ATO) combined with low dose of dexamethasone (DEX) was more efficacious in treating patients with chronic subdural haematoma (CSDH) than ATO monotherapy. This study was designed to investigate the underlying mechanisms of the improved efficacy of this combined therapy.

Methods: Mass spectrometry was performed to quantitatively detect drugs in haematoma fluids and serum samples from CSDH patients and also in cultured macrophages after treatment with either ATO alone or in combination with DEX. Read More

View Article and Full-Text PDF
September 2021

Postmortem diagnosis of pulmonary tumor thrombotic microangiopathy with rapid exacerbation in a patient with gastric cancer: a case report.

Int J Emerg Med 2021 Sep 15;14(1):53. Epub 2021 Sep 15.

Advanced Critical Care Center, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan.

Background: Pulmonary tumor thrombotic microangiopathy (PTTM) is a condition that involves the development of pulmonary hypertension due to the presence of microscopic tumor emboli of the peripheral pulmonary arteries. Here, we report a case of rapidly exacerbating PTTM associated with gastric cancer that was identified postmortem through pathological autopsy.

Case Presentation: A 52-year-old Asian woman who experienced anterior chest pain while coughing visited the orthopedic department of the Gifu University Hospital. Read More

View Article and Full-Text PDF
September 2021

Decrease in Cell Viability of Breast Cancer Cells by a Di-Hydroxylated Derivative of N-(2-hydroxyphenyl)-2-Propylpentanamide.

Anticancer Agents Med Chem 2021 Sep 14. Epub 2021 Sep 14.

Laboratorio de Diseño y Desarrollo de Nuevos Fármacos e Innovación Biotecnológica (Laboratory for the Design and Development of New Drugs and Biotechnological Innovation). Escuela Superior de Medicina, Instituto Politécnico Nacional. Plan de San Luis y Salvador Díaz Mirón s/n, Casco de Santo Tomás, Ciudad de México 11340. Mexico.

Background: A preliminary study of the biotransformation by cytochrome P450 enzymes (CYP) of N-(2-hydroxyphenyl)-2-propylpentanamide (HO-AAVPA), an HDAC inhibitor, led to the synthesis of two hydroxylated derivatives: N-(2,4-dihydroxyphenyl)-2-propylpentanamide (5a) and N-(2,5-dihydroxyphenyl)-2-propylpentanamide (5b).

Objective: The study aims to evaluate the anti-proliferative activity of these di-hydroxylated derivatives in breast cancer cell lines.

Methods: MTT assays were conducted in MCF-7 and MDA-MB-231 cell lines. Read More

View Article and Full-Text PDF
September 2021