358,308 results match your criteria english japanese


Low serum 25-hydroxyvitamin D levels are associated with obesity and atherogenesis in adolescent boys.

Ann Pediatr Endocrinol Metab 2021 Oct 17. Epub 2021 Oct 17.

Department of Pediatrics, Dokkyo Medical University, Shimotsuga, Japan.

Purpose: We investigated the relationship of 25-hydroxyvitamin D (25(OH)D) levels with obesity and atherosclerosis in Japanese adolescents.

Methods: We examined 492 children (247 boys and 245 girls) aged 12-13 years. The serum 25(OH)D levels were compared among underweight, healthy weight, and overweight children. Read More

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October 2021

Pharmacokinetics and safety of cenobamate, a novel antiseizure medication, in healthy Japanese, and an ethnic comparison with healthy non-Japanese.

Clin Transl Sci 2021 Oct 20. Epub 2021 Oct 20.

Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

Cenobamate (XCOPRI and ONTOZRY) is a novel antiseizure medication for the treatment of focal-onset seizures. Nonetheless, there is limited information on the pharmacokinetics (PKs), safety, and efficacy of cenobamate in Asian people, including Japanese people. This study aimed to evaluate the PKs and safety of cenobamate after a single oral dose in healthy Japanese subjects and to compare the PKs with that reported in non-Japanese subjects. Read More

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October 2021

Structural validity of the Japanese Orthopedic Association back pain evaluation questionnaire in individuals with chronic low back pain.

Rev Assoc Med Bras (1992) 2021 Aug;67(8):1087-1092

Universidade Federal do Maranhão, Departamento de Educação Física - São Luís (MA), Brazil.

Objective: The main aim of this study was to evaluate the structural validity of the Brazilian version of the Japanese Orthopedic Association Back Pain Evaluation Questionnaire (JOABPEQ).

Methods: Individuals with chronic low back pain were included. The data collection of the study occurred by means of online platform. Read More

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Temperature increase drives critical slowing down of fish ecosystems.

PLoS One 2021 20;16(10):e0246222. Epub 2021 Oct 20.

Institute of Environment and Ecology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, China.

Fish ecosystems perform ecological functions that are critically important for the sustainability of marine ecosystems, such as global food security and carbon stock. During the 21st century, significant global warming caused by climate change has created pressing challenges for fish ecosystems that threaten species existence and global ecosystem health. Here, we study a coastal fish community in Maizuru Bay, Japan, and investigate the relationships between fluctuations of ST, abundance-based species interactions and salient fish biodiversity. Read More

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October 2021

The impact of second-hand smoke on ear, nose, and throat diseases and head and neck cancers in Japan: a cross-sectional study using a questionnaire and secondary data from the national health and nutrition survey.

Acta Otolaryngol 2021 Oct 20:1-5. Epub 2021 Oct 20.

Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Shinjuku, Japan.

Background: The risk of head and neck cancers (HNCs) and ear, nose, and throat (ENT) diseases due to second-hand smoke (SHS) have not been fully assessed.

Objective: To determine which ENT diseases or HNCs are associated with SHS.

Material And Methods: Data from a survey of a cross-sectional sample of ENT patients ( = 1228) on SHS exposure were compared to control-subject data ( = 6598) from a Japan National Health Survey. Read More

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October 2021

Mortality from Leukemia, Cancer and Heart Disease among U.S. Nuclear Power Plant Workers, 1957-2011.

Int J Radiat Biol 2021 Oct 20:1-67. Epub 2021 Oct 20.

Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Background: The aim of the Million Person Study (MPS) of Low Dose Health Effects is to examine the level of radiation risk for chronic exposures received gradually over time and not acutely as was the case for the Japanese atomic bomb survivors. Nuclear power plant (NPP) workers comprise nearly 15 percent of the MPS. Leukemia, selected cancers, Parkinson's disease, ischemic heart disease (IHD) and other causes of death are evaluated. Read More

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October 2021

A Million Persons, A Million Dreams: A Vision For A National Center Of Radiation Epidemiology And Biology.

Int J Radiat Biol 2021 Oct 20:1-50. Epub 2021 Oct 20.

Memorial Sloan Kettering Cancer Center, New York, NY.

Background: Epidemiologic studies of radiation-exposed populations form the basis for human safety standards. They also help shape public health policy and evidence-based health practices by identifying and quantifying health risks of exposure in defined populations. For more than a century, epidemiologists have studied the consequences of radiation exposures, yet the health effects of low levels delivered at a low-dose rate remain equivocal. Read More

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October 2021

Motor unit firing patterns on increasing force during force and position tasks.

J Neurophysiol 2021 Oct 20. Epub 2021 Oct 20.

Laboratory of Neuromuscular Biomechanics, School of Health and Sport Sciences, grid.411620.0Chukyo University, Toyota, Japan.

Different neurophysiological strategies are used to perform angle adjustments during motor tasks such as car driving and force-control tasks using a fixed-rigid pedal. However, the difference in motor unit behavior in response to an increasing exerted force between tasks is unknown. This study aimed to investigate the difference in motor unit responsiveness on increasing force between force and position tasks. Read More

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October 2021

Relationship between serum zinc level and sepsis-induced coagulopathy.

Int J Hematol 2021 Oct 20. Epub 2021 Oct 20.

Department of Emergency and Critical Care Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180, Japan.

Background: We investigated whether a decrease in the serum zinc level (SZL) among patients with sepsis admitted to the intensive care unit (ICU) was related to sepsis-induced coagulopathy.

Methods: All patients (≥20 years) with a diagnosis of sepsis defined by Sepsis-3 criteria, presenting to the ICU between June 2016 and July 2017, were enrolled. Demographic characteristics and the Sequential Organ Failure Assessment (SOFA) and Japanese Association of Acute Medicine (JAAM) disseminated intravascular coagulation (DIC) scores were recorded. Read More

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October 2021

Health problems associated with single, multiple, and the frequency of months of objectively measured long working hours: a cohort study by the National Institute of Occupational Safety and Health, Japan.

Int Arch Occup Environ Health 2021 Oct 20. Epub 2021 Oct 20.

Faculty of Human Sciences, University of Tsukuba, Tokyo, Japan.

Purpose: We aimed to examine the prospective associations of monthly working hours measured in a month, the 6-month averaged hours, and the frequency of long working hours (≥ 205 h/month) during the past 6 months with health indicators.

Methods: This study included 6,806 Japanese company workers (response rate = 86.6%). Read More

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October 2021

Racial and Ethnic Disparities in Rates of Invasive Second Breast Cancer Among Women With Ductal Carcinoma In Situ in Hawai'i.

JAMA Netw Open 2021 Oct 1;4(10):e2128977. Epub 2021 Oct 1.

University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu.

Importance: Women with ductal carcinoma in situ (DCIS) may develop a subsequent invasive second breast cancer (SBC). Understanding the association of racial and ethnic factors with the development of invasive SBC may help reduce overtreatment and undertreatment of women from minority groups.

Objective: To evaluate risk factors associated with developing invasive ipsilateral SBC (iiSBC) and invasive contralateral SBC (icSBC) among women with an initial diagnosis of DCIS who are from racial and ethnic minority populations. Read More

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October 2021

Effect of anti-attention-deficit hyperactivity disorder (ADHD) medication on clinical seizures and sleep EEG: A retrospective study of Japanese children with ADHD.

Neuropsychopharmacol Rep 2021 Oct 20. Epub 2021 Oct 20.

Department of Developmental Disorders, National Institute of Mental Health, NCNP, Kodaira, Japan.

Aims: Patients with attention-deficit hyperactivity disorder (ADHD) often exhibit basic or paroxysmal wave abnormalities on electroencephalography (EEG). Methylphenidate (MPH), an anti-ADHD stimulant, has been reported to lower the seizure threshold. However, there have been no reports comparing EEG changes before and after administration of the central nervous system (CNS) stimulant MPH, or atomoxetine (ATX) hydrochloride, a non-CNS stimulant. Read More

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October 2021

Effects of forest cover on richness of threatened fish species in Japan.

Conserv Biol 2021 Oct 20. Epub 2021 Oct 20.

Hokkaido University, Faculty of Fisheries Sciences, Hakodate, Japan.

Estuaries - one of the most vulnerable ecosystems globally - face anthropogenic threats, including biodiversity loss and the collapse of sustainable fisheries. Determining the factors contributing to the maintenance of estuarine biodiversity, especially that of fish, is vital for promoting estuarine conservation and sustainability. We used environmental DNA metabarcoding analysis to determine fish species composition in 22 estuaries around Japan and measured watershed-scale land-use factors (e. Read More

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October 2021

First Report of Beech Leaf Disease, Caused by Litylenchus crenatae mccannii, on American Beech (Fagus grandifolia) in Virginia.

Plant Dis 2021 Oct 20. Epub 2021 Oct 20.

USDA ARS, 17123, Mycology and Nematology, Beltsville, Maryland, United States;

Beech leaf disease (BLD) was first reported in 2012 in Lake County, Ohio on American beech trees (Fagus grandifolia Ehrh.). Since then, it spread across the Northeastern United States and has been reported from Ohio, Pennsylvania, New York, New Jersey, Connecticut, Rhode Island, Maine, West Virginia, and Ontario, Canada (Carta et al. Read More

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October 2021

Application of Triggered EMG in the Intraoperative Neurophysiological Monitoring of Posterior Percutaneous Endoscopic Cervical Discectomy.

Orthop Surg 2021 Oct 19. Epub 2021 Oct 19.

Department of Spinal and Spinal Cord surgery, Henan Provincial People's Hospital, Zhengzhou, China.

Objective: To describe the rationale and application of triggered EMG (T-EMG) in intraoperative neurophysiological monitoring, and to explore the efficacy and safety of posterior percutaneous endoscopic cervical discectomy (PPECD) in the treatment of cervical spondylotic radiculopathy (CSR) under multimodal intraoperative neurophysiological monitoring (IOM).

Methods: This study was a retrospective cohort control study. The clinical data of 74 patients with single-segment CSR from June 2015 to August 2018 were analyzed retrospectively, of whom 35 underwent IOM-assisted PPECD with triggered EMG (T-EMG group), while 39 were subjected to IOM-assisted PPECD alone (IOM group). Read More

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October 2021

Management of major venous bleeding during minimally invasive pelvic surgery: A proposed protocol for "What should we do next?"

Int J Urol 2021 Oct 19. Epub 2021 Oct 19.

Department of Urology, Jikei University School of Medicine, Kashiwa Hospital, Chiba, Japan.

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October 2021

Woman with neck pain and odynophagia.

J Am Coll Emerg Physicians Open 2021 Oct 11;2(5):e12466. Epub 2021 Oct 11.

Department of Infectious Diseases Japanese Red Cross Ise Hospital Ise Mie Japan.

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October 2021

Subtotal Nasal Reconstruction in a 91-year-old Patient: Expanded Double Forehead Flaps and Costal Cartilage.

Plast Reconstr Surg Glob Open 2021 Oct 15;9(10):e3868. Epub 2021 Oct 15.

Department of Plastic and Reconstructive Surgery, Japanese Red Cross Society Nagano Hospital, Nagano, Japan.

Nasal reconstruction in very elderly patients is challenging. We attempted subtotal nasal reconstruction with an expanded double forehead flap and autologous costal cartilage support in a 91-year-old woman presenting with subtotal nasal defects after sebaceous carcinoma resection. Only small parts of the bilateral alae and the columella base remained after resection, and the frontal area of the septum was also resected. Read More

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October 2021

Phosphoglycerate kinase 1 silencing by a novel microRNA microRNA-4523 protects human osteoblasts from dexamethasone through activation of Nrf2 signaling cascade.

Cell Death Dis 2021 Oct 19;12(11):964. Epub 2021 Oct 19.

Spinal Surgery, Sino-Japanese Friendship Hospital, Beijing, China.

Nuclear-factor-E2-related factor 2 (Nrf2) cascade activation can ameliorate dexamethasone (DEX)-induced oxidative injury and death in human osteoblasts. Phosphoglycerate kinase 1 (PGK1) depletion is shown to efficiently activate Nrf2 signaling by inducing methylglyoxal modification of Kelch-like ECH-associated protein 1 (Keap1). We here identified a novel PGK1-targeting microRNA: microRNA-4523 (miR-4523). Read More

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October 2021

Eosinophilic bronchiolitis successfully treated with benralizumab.

BMJ Case Rep 2021 Oct 19;14(10). Epub 2021 Oct 19.

Department of Respiratory Medicine, Tsuboi Hospital, Koriyama, Japan.

A 53-year-old non-smoking Japanese woman was admitted to our hospital with a 20-year history of wet cough and dyspnoea on exertion. Bronchial asthma (BA) had been diagnosed 20 years earlier. Although she has been treated with high-dose inhaled corticosteroid, she had experienced frequent exacerbation of BA, and short-term oral corticosteroid bursts were occasionally administered. Read More

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October 2021

Giant cell arteritis with cervical radiculopathy mimicking polymyalgia rheumatica and elderly-onset rheumatoid arthritis: a case report.

J Med Case Rep 2021 Oct 20;15(1):527. Epub 2021 Oct 20.

Department of Respiratory Medicine and Clinical Immunology, Suita Municipal Hospital, 5-7 Kishibeshinmachi, Suita, Osaka, 564-8567, Japan.

Background: Giant cell arteritis has a wide variety of clinical symptoms, one of them being cervical radiculopathy, which mainly involves the C5 nerve root. If the patient does not develop typical clinical symptoms of giant cell arteritis but has C5 radiculopathy, it may be misdiagnosed as polymyalgia rheumatica or elderly-onset rheumatoid arthritis due to old age, high serum inflammatory markers, and difficulty in raising both upper limbs.

Case Presentation: A 72-year-old Japanese man with a month-long history of dyspnea on exertion and with difficulty in raising both upper limbs was referred to our hospital because of elevated serum C-reactive protein (12. Read More

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October 2021

The impact that family members' health care experiences have on patients' trust in physicians.

BMC Health Serv Res 2021 Oct 19;21(1):1122. Epub 2021 Oct 19.

Department of Clinical Epidemiology, Graduate School of Medicine, Fukushima Medical University, Fukushima, Japan.

Background: A family member's negative experiences with medical care have long-term effects on a patient's attitudes and emotions. However, the impact of family members' experiences on patients' trust in their own physicians and in physicians generally is poorly understood. This study aims to quantify these associations. Read More

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October 2021

Genetic Characteristics of the Japanese Serow in the Kii Mountain Range, Central Japan.

Zoolog Sci 2019 Aug;36(4):306-315

Faculty of Bioresources, Mie University, Tsu, Mie 514-8507, Japan,

The Japanese serow, , is an indigenous bovid species exclusively inhabiting mountain regions in the main Japanese islands, excepting Hokkaido. It had decreased in abundance to its lowest level due to overhunting and deforestation, with its distribution severely fragmented from the middle of the 20th century, many populations of currently facing the risk of extinction. The Kii Mountain Range (KM) on Honshu is one such location that has seen a drastic population decline of . Read More

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Post-Anesthesia Evaluation Shows No Relationship Between Body Conditions and Salinity-Choice Propensities in Glass Eels.

Zoolog Sci 2019 Aug;36(4):267-272

Nikko Branch, National Research Institute of Fisheries Science, Japan Fisheries Research and Education Agency, Nikko, Tochigi 321-1661, Japan.

Anguillid eels generally exhibit catadromous migration between oceanic spawning grounds and freshwater growth habitats, but some individuals remain in coastal or estuarine saline waters for growth. This migratory plasticity had been considered to be a conditional strategy based on individual energetic status during the glass eel stage. Several studies have examined whether salinity-based habitat selection is linked to individual body conditions, but while frozen specimens of European eels showed this relationship, anesthetized samples of American eels did not. Read More

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Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia.

Blood Cancer Discov 2020 Jul 10;1(1):82-95. Epub 2020 Jun 10.

Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

The cellular context that integrates gene expression, signaling, and metabolism dictates the oncogenic behavior and shapes the treatment responses in distinct cancer types. Although chimeric fusion proteins involving transcription factors (TF) are hallmarks of many types of acute lymphoblastic leukemia (ALL), therapeutically targeting the fusion proteins is a challenge. In this work, we characterize the core regulatory circuitry (CRC; interconnected autoregulatory loops of TFs) of B-ALL involving MEF2D-fusions and identify MEF2D-fusion and SREBF1 TFs as crucial CRC components. Read More

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Classification of drugs for evaluating drug interaction in drug development and clinical management.

Drug Metab Pharmacokinet 2021 Jul 8;41:100414. Epub 2021 Jul 8.

Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shin-machi, Nishitokyo-shi, Tokyo, 202-8585, Japan. Electronic address:

During new drug development, clinical drug interaction studies are carried out in accordance with the mechanism of potential drug interactions evaluated by in vitro studies. The obtained information should be provided efficiently to medical experts through package inserts and various information materials after the drug's launch. A recently updated Japanese guideline presents general procedures that are considered scientifically valid at the present moment. Read More

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The three-dimensional quadriceps vector is most parallel to the spherical axis in Japanese varus osteoarthritic knees.

Knee 2021 Oct 16;33:200-209. Epub 2021 Oct 16.

Division of Orthopaedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background: The quadriceps femoris may be a reliable reference to proper alignment in total knee arthroplasty (TKA). We previously showed the quadriceps vector (QV) to be the most parallel to the spherical axis (SA-center hip to center medial condyle) for healthy knees. The purpose of this study was to determine whether the QV is the most parallel to the SA in knees with varus osteoarthritis (OA). Read More

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October 2021

Associations of frequent emollient use with wheeze and asthma in young Japanese children: A survey of well-child visits.

Clin Exp Allergy 2021 Oct 19. Epub 2021 Oct 19.

Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Allergic diseases are a disorder of the immune system characterized by complex networks among multiple organs. Young children have shown variations of allergic symptoms. Previously, we reported the complex relationships among serum multiple cytokines/chemokines and allergic signs and symptoms of atopic dermatitis and asthma in a birth cohort using the artificial intelligence (AI) technique. Read More

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October 2021

Association between mild cognitive impairment and lumbar degenerative disease in a Japanese community: A cross-sectional study.

PLoS One 2021 19;16(10):e0258852. Epub 2021 Oct 19.

Department of Orthopaedic Surgery, Graduate School of Medicine, Hirosaki University, Hirosaki, Aomori, Japan.

Lumbar degenerative disease and dementia are increasing in super-aging societies and are both related to physical dysfunction and pain. However, the relationship between these diseases remains unclear. This cross-sectional study aimed to investigate the comorbidity rates of lumbar spinal canal stenosis (LSS) and mild cognitive impairment (MCI) and clarify the association between LSS presence, lumbar symptoms, and quality of life (QOL) related to low back pain and cognitive impairment in the Japanese population. Read More

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October 2021

Analysis of risk factors and treatment outcome in patients presenting with neglected congenital spinal deformity and neurological deficit.

Spine Deform 2021 Oct 19. Epub 2021 Oct 19.

Ganga Hospital, 313, Mettupalayam Road, Coimbatore, 641043, India.

Purpose: Congenital spinal deformities (CSD) are uncommon; and usually present during early childhood. Rarely, patients have been reported to present with neglected CSD in association with myelopathy. The current study reports the largest series of patients with neglected CSD and major neuro-deficit; and discusses their long-term outcome. Read More

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October 2021