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MBNM: Multi-branch network based on memory features for long-tailed medical image recognition.

Comput Methods Programs Biomed 2021 Oct 2;212:106448. Epub 2021 Oct 2.

Hebei Eye Hospital, Hebei, 054001, China. Electronic address:

Background And Objectives: Deep learning algorithms show revolutionary potential in computer-aided diagnosis. These computer-aided diagnosis techniques often rely on large-scale, balanced standard datasets. However, there are many rare diseases in real clinical scenarios, which makes the medical datasets present a highly imbalanced long-tailed distribution, leading to the poor generalization ability of deep learning models. Read More

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October 2021

A HET-CAM based vascularized intestine tumor model as a screening platform for nano-formulated photosensitizers.

Eur J Pharm Sci 2021 Oct 17:106046. Epub 2021 Oct 17.

Fraunhofer Institute for Biomedical Engineering, Department Bioprocessing & Bioanalytics, Joseph-von-Fraunhofer-Weg 1, 66280 Sulzbach (Germany). Electronic address:

The development of new tumor models for anticancer drug screening is a challenge for preclinical research. Conventional cell-based in vitro models such as 2D monolayer cell cultures or 3D spheroids allow an initial assessment of the efficacy of drugs but they have a limited prediction to the in vivo effectiveness. In contrast, in vivo animal models capture the complexity of systemic distribution, accumulation, and degradation of drugs, but visualization of the individual steps is challenging and extracting quantitative data is usually very difficult. Read More

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October 2021

Incidental findings in UK healthy volunteers screened for a COVID-19 vaccine trial.

Clin Transl Sci 2021 Oct 20. Epub 2021 Oct 20.

University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.

The safety of novel therapeutics and vaccines are typically assessed in early phase clinical trials involving "healthy volunteers." Abnormalities in such individuals can be difficult to interpret and may indicate previously unrecognized medical conditions. The frequency of incidental findings (IFs) in healthy volunteers who attend for clinical trial screening is unclear. Read More

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October 2021

webTWAS: a resource for disease candidate susceptibility genes identified by transcriptome-wide association study.

Nucleic Acids Res 2021 Oct 20. Epub 2021 Oct 20.

Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou, China.

The development of transcriptome-wide association studies (TWAS) has enabled researchers to better identify and interpret causal genes in many diseases. However, there are currently no resources providing a comprehensive listing of gene-disease associations discovered by TWAS from published GWAS summary statistics. TWAS analyses are also difficult to conduct due to the complexity of TWAS software pipelines. Read More

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October 2021

Decision making by health professionals during COVID-19: an integrative review.

Rev Bras Enferm 2021 18;75(suppl 1):e20210067. Epub 2021 Oct 18.

Universidade Federal da Bahia. Salvador, Bahia, Brazil.

Objective: To analyze the scientific production on the decision making of health workers during the COVID-19 pandemic.

Methods: Integrative review in the databases CINAHL, MEDLINE, Scopus, ScienceDirect, WoS, and BVS. Inclusion criteria: original articles available in full, in any language, related to the object investigated. Read More

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October 2021

Development and characterization of an adaptable aerosolized methylene diphenyl diisocyanate generation system.

Environ Sci Process Impacts 2021 Oct 20;23(10):1500-1508. Epub 2021 Oct 20.

Université du Québec à Montréal (UQAM), Chemistry Department, Qc, Canada.

Reactive semivolatile contaminants, such as isocyanates, can be particularly difficult to assess in occupational environments. While standard methods exist for isocyanates, there are still significant differences between the results they provide for various occupational environments or processes. This study presents the validation of a laboratory system for the generation of controlled atmospheres of isocyanates. Read More

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October 2021

An improved deep learning model for hierarchical classification of protein families.

PLoS One 2021 20;16(10):e0258625. Epub 2021 Oct 20.

Department of Computer Science, University of Ruhuna, Matara, Sri Lanka.

Although genes carry information, proteins are the main role player in providing all the functionalities of a living organism. Massive amounts of different proteins involve in every function that occurs in a cell. These amino acid sequences can be hierarchically classified into a set of families and subfamilies depending on their evolutionary relatedness and similarities in their structure or function. Read More

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October 2021

Nine-Year Follow-Up of a Huge Retroperitoneal Alveolar Soft-Part Sarcoma: A Case Report.

Am J Case Rep 2021 Oct 20;22:e932514. Epub 2021 Oct 20.

Department of Vascular, General and Transplantation Surgery, Wrocław Medical University, Wrocław, Poland.

BACKGROUND Alveolar soft-part sarcoma is an uncommon mesenchymal tumor accounting for approximately 0.7% of soft tissue sarcomas in adults. It mainly affects young adults, with a peak incidence between 15 and 35 years old. Read More

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October 2021

Molecular genotyping of adrenocortical carcinoma: a systematic analysis of published literature 2019-2021.

Curr Opin Oncol 2021 Oct 19. Epub 2021 Oct 19.

Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, ASST Spedali Civili Section of Pharmacology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.

Purpose Of Review: comprehensive molecular characterization of adrenocortical carcinoma (ACC) through next-generation sequencing and bioinformatics analyses is expanding the number of targets with potential prognostic and therapeutic value. We performed a critical review of recent published literature on genotyping of ACC.

Recent Findings: 423 studies were published between 2019 and 2021. Read More

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October 2021

A soft sensor model of cell concentration based on IBDA-RELM.

Prep Biochem Biotechnol 2021 Oct 20:1-9. Epub 2021 Oct 20.

Jiangsu University, Zhenjiang, China.

For fermentation process with multi-operating conditions, it is difficult to predict the cell concentration under the new operating conditions by the soft sensor model established under the specific operating conditions. Inspired by the idea of transfer learning, a method based on an improved balanced distribution adaptive regularization extreme learning machine (IBDA-RELM) was proposed to solve the problem. The domain adaptation (DA) method in transfer learning is developed to reduce distribution distance by transforming data. Read More

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October 2021

Photoactivatable Nitric Oxide-Releasing Gold Nanocages for Enhanced Hyperthermia Treatment of Biofilm-Associated Infections.

ACS Appl Mater Interfaces 2021 Oct 20. Epub 2021 Oct 20.

Frontiers Science Center for Flexible Electronics (FSCFE), Xi'an Institute of Flexible Electronics (IFE) & Xi'an Institute of Biomedical Materials and Engineering (IBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi'an, Shaanxi 710072, P. R. China.

With the increasing clinical use of invasive medical devices, various healthcare-associated infections (HAIs) caused by bacterial biofilm colonization of biomedical devices have posed serious threats to patients. The formation of biofilms makes it much more difficult and costly to treat infections. Here, we report a nitric oxide (NO)-releasing gold nanocage ([email protected]) that is stimulated by near-infrared (NIR) irradiation to deliver NO and generate hyperthermia for biofilm elimination. Read More

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October 2021

[Evaluation of the effectiveness of organ preservation treatment of choroidal melanomas by optical coherence tomography findings].

Authors:
A S Stoyukhina

Vestn Oftalmol 2021 ;137(5. Vyp. 2):189-200

Research Institute of Eye Diseases, Moscow, Russia.

Achieving local tumor control is generally considered to be the criterion of effectiveness of organ preservation treatment. In most cases it can be assessed by ophthalmoscopy and ultrasonography. However, in presence of pigmentation areas, it can be difficult to interpret the ophthalmoscopy and ultrasonography findings. Read More

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January 2021

[Scanning electron microscopy results of the vitreous body in asteroid hyalosis].

Vestn Oftalmol 2021 ;137(5. Vyp. 2):181-188

Research Institute of Eye Diseases, Moscow, Russia.

Purpose: To evaluate the structure of vitreous body in asteroid hyalosis by low vacuum scanning electron microscopy.

Material And Methods: The material of the study was samples of the vitreous body obtained from 7 patients aged from 62 to 72 years with vitreomacular traction syndrome during vitrectomy. In all cases, clinical manifestations of asteroid hyalosis (the presence of multiple point-like echo-positive inclusions) were identified during the preoperative examination. Read More

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January 2021

[Droghe d'abuso e rene].

G Ital Nefrol 2021 Sep 7;38(Suppl 77). Epub 2021 Sep 7.

Struttura Complessa di Nefrologia e Dialisi Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), Ospedali di Cattinara e Maggiore di Trieste, Trieste, Italy.

Here we present a case of acute renal failure needing dialysis in a heroin addict patient chronically treated with Metadone. This give us the opportunity to review the renal effects of the main drugs of abuse, highlighting the shift occured from the four "old sisters" (Marijuana, Cocaine, Heroin and Amphetamine) to the news synthetic drugs (chiefly Synthetic Cathinones and Cannabinoids), that poses problems due to large diffusion, easy procurement, legal non-regulation and difficult analytical identification, raising medical and forensic questions. From a Nephrological point of view is essential to take great care over the need to diagnose this kind of pathology and to widen the search trying anyway to recognize the substances potentially involved. Read More

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September 2021

Minimally invasive aortic valve repair using geometric ring annuloplasty.

J Card Surg 2021 Oct 20. Epub 2021 Oct 20.

Department of Cardiac Surgery, Klinikum Nürnberg Cardiovascular Center, Paracelsus Medical University, Nuremberg, Germany.

Objectives: As aortic valve repair (AVr) for aortic insufficiency (AI) expands, minimally invasive (Mi) approaches are increasingly being applied. Cardiac surgical techniques can be more difficult through small incisions, and this report analyzes medium-term outcomes for MiAVr facilitated by geometric ring annuloplasty.

Methods: Since 2013, 58 patients were selected for AVr through upper sternotomy third-interspace incisions. Read More

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October 2021

Cancer of the vagina: 2021 update.

Int J Gynaecol Obstet 2021 Oct;155 Suppl 1:19-27

Division of Obstetrics and Gynecology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Diagnosis of a primary vaginal cancer is rare, as most vaginal tumors are metastatic from another primary site. Although cancer of the vagina is more common in postmenopausal women, an increase in young women being diagnosed with primary vaginal cancer has been reported, especially in countries with a high HIV prevalence. This is associated with persistence of high-risk HPV infection. Read More

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October 2021

Cascading loss and loss risk multipliers amid a changing climate in the Pacific Islands.

Ambio 2021 Oct 20. Epub 2021 Oct 20.

United Nations Environment Programme, Nairobi, Kenya.

Human society has experienced, and will continue to experience, extensive loss and damage from worsening anthropogenic climate change. Despite our natural tendencies to categorise and organise, it can be unhelpful to delineate clean boundaries and linear understandings for complex and messy concepts such as loss and damage. Drawing on the perspectives of 42 local and regional Pacific Islander stakeholders, an underexplored resource for understanding loss and damage, we explore the complexity and interconnectedness of non-economic loss and damage (NELD). Read More

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October 2021

Structural Distinctive 26SK, a Ribosome-Inactivating Protein from Jatropha curcas and Its Biological Activities.

Appl Biochem Biotechnol 2021 Oct 20. Epub 2021 Oct 20.

Department of Biochemistry, Faculty of Science, Kasetsart University, 50 Ngamwongwan Rd., Bangkok, 10900, Thailand.

Ribosome-inactivating proteins (RIPs) are a group of proteins exhibiting N-glycosidase activity leading to an inactivation of protein synthesis. Thirteen predicted Jatropha curcas RIP sequences could be grouped into RIP types 1 or 2. The expression of the RIP genes was detected in seed kernels, seed coats, and leaves. Read More

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October 2021

Above- and belowground biomass allocation and its regulation by plant density in six common grassland species in China.

J Plant Res 2021 Oct 20. Epub 2021 Oct 20.

College of Urban and Environmental Sciences, and Key Laboratory for Earth Surface Processes of the Ministry of Education, Institute of Ecology, Peking University, Beijing, 100871, China.

Above- and belowground biomass allocation is an essential plant functional trait that reflects plant survival strategies and affects belowground carbon pool estimation in grasslands. However, due to the difficulty of distinguishing living and dead roots, estimation of biomass allocation from field-based studies currently show large uncertainties. In addition, the dependence of biomass allocation on plant species, functional type as well as plant density remains poorly addressed. Read More

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October 2021

Understanding patient-reported knowledge of hernia surgery: a quantitative study.

Hernia 2021 Oct 20. Epub 2021 Oct 20.

Department of General and Digestive Surgery, Hospital Universitario del Mar, Parc de Salut Mar, Barcelona, Spain.

Purpose: The objective of this study was to gather information on patient-reported knowledge (PRK) in the field of hernia surgery.

Methods: A prospective quantitative study was designed to explore different aspects of PRK and opinions regarding hernia surgery. Patients referred for the first time to a surgical service with a presumed diagnosis of hernia and eventual hernia repair were eligible, and those who gave consent completed a simple self-assessment questionnaire before the clinical visit. Read More

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October 2021

Potent Induction of Envelope-Specific Antibody Responses by Virus-Like Particle (VLP) Immunogens Based on HIV-1 Envelopes from Patients with Early Broadly Neutralizing Responses.

J Virol 2021 Oct 20:JVI0134321. Epub 2021 Oct 20.

Institute of Health Carlos III, ISCIII, National Microbiology Centre, Madrid, Spain.

Longitudinal studies in HIV-1 infected individuals have indicated that 2-3 years of infection are required to develop broadly neutralizing antibodies. However, we have previously identified individuals with broadly neutralizing activity (bNA) in early HIV-1 infection, indicating that a vaccine may be capable of bNA induction after short periods of antigen exposure. Here, we describe 5 HIV-1 envelope sequences from individuals who have developed bNA within the first 100 days of infection (early neutralizers) and selected two of them to design immunogens based on HIV-1-Gag virus like particles (VLPs). Read More

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October 2021

Self-Assembly Dual-Responsive NO Donor Nanoparticles for Effective Cancer Therapy.

ACS Appl Mater Interfaces 2021 Oct 20. Epub 2021 Oct 20.

Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai 201203, People's Republic of China.

Drug resistance and the serious side effects caused by classical chemotherapy drugs necessitate the development of novel targeted drug delivery systems. The high lipophilicity and short half-life of nitric oxide (NO), a gas with strong antitumor activity, make it difficult to reach the tumor site and result in a poor therapeutic effect . In order to overcome the deficiencies of the existing NO donors and NO delivery vehicles, a novel strategy was proposed to deliver NO for cancer chemotherapy by the prodrug dimer self-assembly nanoparticles of NO donors. Read More

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October 2021

Characterization of the Depth of Discharge-Dependent Charge Transfer Resistance of a Single LiFePO Particle.

Anal Chem 2021 Oct 20. Epub 2021 Oct 20.

Division of Electrical Engineering and Computer Science, Kanazawa University, Kanazawa 920-1192, Japan.

The discharged state affects the charge transfer resistance of lithium-ion secondary batteries (LIBs), which is referred to as the depth of discharge (DOD). To understand the intrinsic charge/discharge property of LIBs, the DOD-dependent charge transfer resistance at the solid-liquid interface is required. However, in a general composite electrode, the conductive additive and organic polymeric binder are unevenly distributed, resulting in a complicated electron conduction/ion conduction path. Read More

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October 2021

Transfer Learning Strategy Based on Unsupervised Learning and Ensemble Learning for Breast Cancer Molecular Subtype Prediction Using Dynamic Contrast-Enhanced MRI.

J Magn Reson Imaging 2021 Oct 20. Epub 2021 Oct 20.

School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai, China.

Background: Imaging-driven deep learning strategies focus on training from scratch and transfer learning. However, the performance of training from scratch is often impeded by the lack of large-scale labeled training data. Additionally, owing to the differences between source and target domains, analyzing medical image tasks satisfactorily via transfer learning based on ImageNet is difficult. Read More

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October 2021

Separating the contributions of SLC26A9 and CFTR to anion secretion in primary human bronchial epithelia (HBE).

Am J Physiol Lung Cell Mol Physiol 2021 Oct 20. Epub 2021 Oct 20.

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

Aberrant anion secretion across the bronchial epithelium is associated with airway disease, most notably in cystic fibrosis. While the cystic fibrosis transmembrane conductance regulator (CFTR) is recognized as the primary source of airway anion secretion, alternative anion transport mechanisms play a contributing role. An alternative anion transporter of growing interest is SLC26A9, a constitutively active chloride channel which has been shown to interact with CFTR and may also contribute to bicarbonate secretion. Read More

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October 2021

Accelerated Electron Transfer in Nanostructured Electrodes Improves the Sensitivity of Electrochemical Biosensors.

Adv Sci (Weinh) 2021 Oct 19:e2102495. Epub 2021 Oct 19.

Department of Electrical Engineering, Stanford University, Stanford, CA, 94305, USA.

Electrochemical biosensors hold the exciting potential to integrate molecular detection with signal processing and wireless communication in a miniaturized, low-cost system. However, as electrochemical biosensors are miniaturized to the micrometer scale, their signal-to-noise ratio degrades and reduces their utility for molecular diagnostics. Studies have reported that nanostructured electrodes can improve electrochemical biosensor signals, but since the underlying mechanism remains poorly understood, it remains difficult to fully exploit this phenomenon to improve biosensor performance. Read More

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October 2021

Accurate Placement of Cannulated Screws in Femoral Neck Fractures: Screw and Guide Wire Combined Technique.

Orthop Surg 2021 Oct 19. Epub 2021 Oct 19.

Department of Traumatology, Hebei Medical University Third Affiliated Hospital, Shijiazhuang, China.

Cannulated screw fixation is widely used in the treatment of femoral neck fractures. During surgery, we often face the situation that a guide wire needs to be adjusted because of poor positioning in the femoral neck. It is difficult to adjust the direction of the guide wire in the neck of the femur due to its elasticity. Read More

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October 2021

Long bone fractures in fibrous dysplasia/McCune-Albright Syndrome: prevalence, natural history, and risk factors.

J Bone Miner Res 2021 Oct 20. Epub 2021 Oct 20.

Metabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA.

Fibrous dysplasia/McCune-Albright Syndrome (FD/MAS) is a rare bone and endocrine disorder arising along a broad spectrum. Long bone fractures are a common, painful, and potentially disabling complication. However, fracture prevalence and risk factors have not been well-established, making it difficult to predict which patients are at-risk for a severe course. Read More

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October 2021

What is unknown in using Microbiota as a Therapeutic?

J Gastroenterol Hepatol 2021 Oct 19. Epub 2021 Oct 19.

Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.

Faecal microbiota transplantation (FMT) has been used extensively in the treatment of various gastrointestinal and extra-intestinal conditions, despite that there are still a lot of missing gaps in our knowledge in the gut microbiota and its behaviour. This article describes the unknowns in microbiota biology (undetected microbes, uncertain colonization, unclear mechanisms of action, uncertain indications, unsure long-term efficacy, or side effects). We discuss how these unknowns may affect the therapeutic uses of FMT, and the potentials and caveats of other related microbiota-based therapies. Read More

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October 2021

Patch Testing Versus Interferon-Gamma Release Assay in Evaluation of Drug Eruptions.

Fundam Clin Pharmacol 2021 Oct 19. Epub 2021 Oct 19.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Background: Delayed-onset T-cell-mediated cutaneous adverse drug reactions are an uncommon, but potentially serious result of medication exposures. Identification of culprit medications is crucial but clinical diagnosis is often difficult. Patch tests and interferon-gamma release assays (IFNγ-RA) were previously reported as potentially useful ancillary tests, while rechallenges remain the reference standard test. Read More

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October 2021