47,483 results match your criteria engagement treatment


Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Agency with the participation of the Food and Drug Administration.

Eur J Cancer 2021 Sep 15;157:198-213. Epub 2021 Sep 15.

Hospital for Sick Children, Toronto, Canada.

The first (2017) and sixth (2021) multistakeholder Paediatric Strategy Forums focused on anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies. ALK is an important oncogene and target in several paediatric tumours (anaplastic large cell lymphoma [ALCL], inflammatory myofibroblastic tumour [IMT], neuroblastoma and hemispheric gliomas in infants and young children) with unmet therapeutic needs. ALK tyrosine kinase inhibitors have been demonstrated to be active both in ALK fusion-kinase positive ALCL and IMT. Read More

View Article and Full-Text PDF
September 2021

Barriers and facilitators to using vaporised nicotine products as smoking cessation aids among people receiving treatment for substance use disorder.

Addict Behav 2021 Aug 24;124:107097. Epub 2021 Aug 24.

The University of Newcastle, Faculty of Health and Medicine, School of Medicine and Public Health, 1 University Drive, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, Lot 1 Kookaburra Circuit, New Lambton Heights, NSW 2305, Australia; Flinders University, College of Medicine & Public Health, Level 5 Flinders Medical Centre, Bedford Park, SA 5042, Australia.

Introduction: Vaporised nicotine products (VNPs) may be useful smoking cessation aids for people in alcohol and other drug (AOD) treatment, a population with high tobacco-related morbidity and mortality rates. This qualitative study aimed to examine the barriers and facilitators of using VNPs as part of a clinical trial to reduce or quit smoking among people in AOD treatment.

Methods: Thirteen people in AOD treatment who were participating in a trial of VNPs for smoking cessation (QuitENDs) completed a brief semi-structured interview examining experiences of using VNPs to reduce or quit smoking. Read More

View Article and Full-Text PDF

The effect of immunosuppression therapy on activities of daily living and comfort level after liver transplantation.

Transpl Immunol 2021 Sep 15:101468. Epub 2021 Sep 15.

Surgical Nursing Department, Health Sciences Faculty, Gaziosmanpasa University, Erbaa Campus, Tokat, Turkey. Electronic address:

Objectives: This study was carried out to investigate the effect of immunosuppression therapy on activities of daily living and comfort level after liver transplantation.

Materials And Methods: This study was conducted in a descriptive and correlational type with the participation of 148 liver transplant patients hospitalized in the liver transplant center of a university hospital. Personal Information Form, Katz Activities of Daily Living Scale and General Comfort Questionnaire were used in data collection. Read More

View Article and Full-Text PDF
September 2021

PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism: Drp1-dependent mechanism.

Mol Oncol 2021 Sep 17. Epub 2021 Sep 17.

Department of Biology, University of Rome Tor Vergata, 00133, Rome, Italy.

Programmed cell death-1 (PD-1) signaling downregulates the T cell response, promoting an exhausted state in tumor-infiltrating T cells, through mostly unveiled molecular mechanisms. Dynamin-related protein-1 (Drp1)-dependent mitochondrial fission plays a crucial role in sustaining T cell motility, proliferation, survival, and glycolytic engagement. Interestingly, such processes are exactly those inhibited by PD-1 in tumor-infiltrating T cells. Read More

View Article and Full-Text PDF
September 2021

Accounts of health risk assessment survey administration in the Catch a Break Program: the social construction of osteoporosis risk identification and need for intervention.

Arch Osteoporos 2021 Sep 17;16(1):136. Epub 2021 Sep 17.

Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta, 2J2.00 WC Mackenzie Health Sciences Centre, 8440 112 St. NW, Edmonton, AB, T6G 2R7, Canada.

Catch a Break staff conducting the organizational work of delivering secondary fracture prevention screening conversations drew on cultural and organizational resources to determine eligibility of individuals. They encountered and navigated their way through interactional troubles as they requested participation, assessed trauma risk, and provided lifestyle information.

Purpose: We investigated delivery of a population-based type C fracture liaison service for non-hip fractures. Read More

View Article and Full-Text PDF
September 2021

Deconstructing the Pharmacological Contribution of Sphingosine-1 Phosphate Receptors to Mouse Models of Multiple Sclerosis Using the Species Selectivity of Ozanimod, a Dual Modulator of Human Sphingosine-1 Phosphate Receptor Subtypes 1 and 5.

J Pharmacol Exp Ther 2021 Sep 17. Epub 2021 Sep 17.

Neuroscience TRC, Bristol Myers Squibb, United States.

Ozanimod, a sphingosine-1 phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P) and 5 (S1P), is approved for the treatment of relapsing multiple sclerosis (MS) in multiple countries. Ozanimod profiling revealed a species difference in its potency for S1P in mouse, rat, and canine compared with that for human and monkey. Site-directed mutagenesis identified amino acid alanine at position 120 to be responsible for loss of activity for mouse, rat, and canine S1P and mutation back to threonine as in human/monkey S1P restored activity. Read More

View Article and Full-Text PDF
September 2021

Predicting pain and function outcomes in people consulting with shoulder pain: the PANDA-S clinical cohort and qualitative study protocol.

BMJ Open 2021 Sep 17;11(9):e052758. Epub 2021 Sep 17.

School of Medicine, Keele University, Keele, UK.

Introduction: People presenting with shoulder pain considered to be of musculoskeletal origin is common in primary care but diagnosing the cause of the pain is contentious, leading to uncertainty in management. To inform optimal primary care for patients with shoulder pain, the study aims to (1) to investigate the short-term and long-term outcomes (overall prognosis) of shoulder pain, (2) estimate costs of care, (3) develop a prognostic model for predicting individuals' level and risk of pain and disability at 6 months and (4) investigate experiences and opinions of patients and healthcare professionals regarding diagnosis, prognosis and management of shoulder pain.

Methods And Analysis: The Prognostic And Diagnostic Assessment of the Shoulder (PANDA-S) study is a longitudinal clinical cohort with linked qualitative study. Read More

View Article and Full-Text PDF
September 2021

Prehabilitation services for people diagnosed with cancer in Scotland - Current practice, barriers and challenges to implementation.

Surgeon 2021 Sep 14. Epub 2021 Sep 14.

Professor of Public Health Nutrition, Centre for Research Into Cancer Prevention and Screening, Level 7, Mailbox 7, University of Dundee, Ninewells Hospital and Medical School, Dundee, DD1 9SY, UK. Electronic address:

Background: Prehabilitation is the practice of enhancing a patient's functional and psychological capacity before treatment commences. It is of interest in the cancer context because of the impact of treatments on quality of life and cancer survivorship. This work aims to document current practice, barriers and challenges to implementing prehabilitation to inform the development of a national framework. Read More

View Article and Full-Text PDF
September 2021

In search of the last malaria cases: ethnographic methods for community and private-sector engagement in malaria elimination in Vietnam, Laos, and Cambodia.

Malar J 2021 Sep 17;20(1):370. Epub 2021 Sep 17.

Socio-Ecological Health Research Unit, Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Background: Despite significant strides made in reducing malaria morbidity and mortality in the Greater Mekong Subregion, malaria transmission continues amongst the most 'hard-to-reach', such as forest-goers and mobile and migrant populations, who face access obstacles to malaria diagnosis and treatment. As such, regional malaria elimination strategies endeavour to incorporate the private sector and local communities in improving surveillance and detection of the last malaria cases in remote forested areas. The question remains, however, whether such strategies can reach these hard-to-reach populations and effectively reduce their disproportionate burden of malaria. Read More

View Article and Full-Text PDF
September 2021

Eating disorder behaviors and treatment seeking in self-identified military personnel and veterans: Results of the National Eating Disorders Association online screening.

Eat Behav 2021 Sep 7;43:101562. Epub 2021 Sep 7.

Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objective: To characterize disordered eating behaviors, eating disorder (ED) risk and diagnosis, and treatment seeking behaviors in active-duty military personnel/veterans compared with civilians.

Method: Self-selecting participants (n = 113,388; 1744 were military personnel/veterans) 18+ years old completed the National Eating Disorders Association's online screen. Engagement in and frequencies of disordered eating behaviors were compared across military/veteran and civilian groups and were stratified by gender. Read More

View Article and Full-Text PDF
September 2021

Heavy episodic drinking and HIV disclosure by HIV treatment status among People with HIV in IeDEA Cameroon.

Int J Drug Policy 2021 Sep 14;98:103431. Epub 2021 Sep 14.

University of North Carolina at Chapel Hill, United States.

Background: Heavy alcohol use is common among people with HIV (PWH), leading to sub-optimal HIV care outcomes. Yet, heavy episodic drinking (HED) is not routinely addressed within most HIV clinics in sub-Saharan Africa. HIV disclosure may provide social support, potentially reducing HED to cope with HIV. Read More

View Article and Full-Text PDF
September 2021

Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength.

Immunity 2021 Sep 13. Epub 2021 Sep 13.

Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK. Electronic address:

How T cell receptor (TCR) signal strength modulates T cell function and to what extent this is modified by immune checkpoint blockade (ICB) are key questions in immunology. Using Nr4a3-Tocky mice, we characterized early quantitative and qualitative changes that occur in CD4 T cells in relation to TCR signaling strength. We captured how dose- and time-dependent programming of distinct co-inhibitory receptors rapidly recalibrates T cell activation thresholds and visualized the immediate effects of ICB on T cell re-activation. Read More

View Article and Full-Text PDF
September 2021

The impact of integrated care in community-based substance use treatment in Brazil: A longitudinal study.

Health Soc Care Community 2021 Sep 17. Epub 2021 Sep 17.

Nursing School of Lisbon, Lisbon, Portugal.

Integrated care (outpatient-inpatient) plays a vital function in community care for people with drug use problems. Its recent and innovative treatment model is representing a challenge for the deinstitutionalisation process. The purpose of this study was to assess the impact of integrated care using biopsychosocial indicators. Read More

View Article and Full-Text PDF
September 2021

An Overview of Social Participation in Older Adults: Concepts and Assessments.

Phys Ther Res 2021 13;24(2):85-97. Epub 2021 Jul 13.

Department of Physical Therapy, School of Health Sciences, Kyorin University, Japan.

In older adults, social participation is an important component of rehabilitation and health promotion. Several studies have attempted to describe the definition and concepts of social participation, and there were many outcomes to measure social participation. This overview provides information about representative social participation and related concepts that have been defined in the literature. Read More

View Article and Full-Text PDF

Returning the Favor? Feeling Obliged and Reported Participation in Discretionary Safety Activities.

Front Psychol 2021 31;12:674110. Epub 2021 Aug 31.

Human Resources Development Unit, University of Liège, Liège, Belgium.

Recent research has shown that the reported participation of employees in voluntary safety activities is related to the prevention of accidents and injuries. Encouraging such participation, then, is beneficial to organizations. A key question, therefore, is why employees should choose to report that they engage in such activities: what is their motivation given such activities are not compulsory? We used social exchange theory (SET) and organizational support theory (OST) to develop a model linking perceived organizational support to reports of safety participation. Read More

View Article and Full-Text PDF

Gender, Maltreatment and Psychiatric Symptoms among Adolescents in Outpatient Substance Abuse Treatment.

Child Adolesc Social Work J 2020 Aug 14;37(4):385-396. Epub 2019 Sep 14.

American University.

Childhood maltreatment experiences are risk factors for externalizing and internalizing symptoms, as well as substance abuse problems during adolescence. In the present study, we administered structured interviews to 394 adolescents receiving outpatient substance abuse treatment services (280 males; =16.33; =1. Read More

View Article and Full-Text PDF

Chimeric antigen receptor T-cells in New Zealand: challenges and opportunities.

N Z Med J 2021 Sep 17;134(1542):96-108. Epub 2021 Sep 17.

Cancer Immunotherapy Programme, Malaghan Institute of Medical Research, Wellington, New Zealand; Clinical Human Immunology Laboratory, Malaghan Institute of Medical Research, Wellington, New Zealand.

Chimeric antigen receptor (CAR) T-cells are a personalised cell and gene therapy for cancer that are becoming an international standard of care for some refractory B-cell leukaemias, non-Hodgkin lymphomas and myeloma. A single CAR T-cell administration can result in durable complete response for some recipients. Domestic CAR T-cell manufacturing capability was established for Aotearoa New Zealand's first CAR T-cell trial (ENABLE, ClinicalTrials. Read More

View Article and Full-Text PDF
September 2021

Six Stages of Engagement in ADHD Treatment Described by Diverse, Urban Parents.

Pediatrics 2021 Sep 16. Epub 2021 Sep 16.

Pediatrics, Boston University School of Medicine, Boston, Massachusetts.

Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition in children. Although ADHD is treatable, barriers remain to engagement in treatment, especially among socioeconomically disadvantaged and racial and ethnic minority families. Our goal was to examine the process by which families engage in ADHD treatment and to identify targets for an intervention to improve engagement in care. Read More

View Article and Full-Text PDF
September 2021

Primary school students' poetic malaria messages from Jimma zone, Oromia, Ethiopia: a qualitative content analysis.

BMC Public Health 2021 Sep 16;21(1):1688. Epub 2021 Sep 16.

Department of Health, Behavior, and Society, Jimma University, Jimma, Oromia, Ethiopia.

Background: The engagement of schools in malaria control is an emerging strategy. Little is known about the involvement of students in the development of malaria messages. This study evaluated the message content of primary school students' malaria poems. Read More

View Article and Full-Text PDF
September 2021

Healthcare Provider Perspectives on the Use of a Digital Behavioral Health App to Support Patients: Qualitative Study.

JMIR Form Res 2021 Sep 13. Epub 2021 Sep 13.

UPMC Health Plan, U.S. Steel Tower600 Grant Street, Pittsburgh, US.

Background: Despite the growing evidence indicating the efficacy of digital interventions for behavioral health treatment, broad and consistent use of such interventions has been limited by knowledge obtained in real-world settings, including factors that impact provider uptake/referral. Engaging providers early in the implementation process offers an opportunity to explore their needs and behaviors, integrate interventions into workflows, and better understand provider setting capabilities.

Objective: To assess providers' views on the feasibility and acceptability of delivering a Cognitive Behavioral Therapy (CBT)-based mobile application (app) in multiple care settings. Read More

View Article and Full-Text PDF
September 2021

Experiences of patients with facioscapulohumeral dystrophy with facial weakness: a qualitative study.

Disabil Rehabil 2021 Sep 16:1-8. Epub 2021 Sep 16.

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.

Purpose: This study focuses on the functional and psychosocial consequences of facial weakness of patients with facioscapulohumeral muscular dystrophy (FSHD) and how they manage their daily lives.

Materials And Methods: We conducted a qualitative study. Sixteen FSHD patients with varying degrees of facial weakness were interviewed using a semi-structured interview guide. Read More

View Article and Full-Text PDF
September 2021

PBX1: a key character of the hallmarks of cancer.

J Mol Med (Berl) 2021 Sep 16. Epub 2021 Sep 16.

Laboratory of Human Cytogenetics and Oncogenetics, Department of Genetics, Postgraduate Program in Genetics, Universidade Federal Do Paraná, Rua Coronel Francisco Heráclito Dos Santos, 100, Jardim das AméricasCuritiba, CEP, 81531-980, Brazil.

Pre-B-cell leukemia homeobox transcription factor 1 (PBX1) was first identified as part of a fusion protein resulting from the chromosomal translocation t(1;19) in pre-B cell acute lymphoblastic leukemias. Since then, PBX1 has been associated with important developmental programs, and its expression dysregulation has been related to multifactorial disorders, including cancer. As PBX1 overexpression in many cancers is correlated to poor prognosis, we sought to understand how this transcription factor contributes to carcinogenesis, and to organize PBX1's roles in the hallmarks of cancer. Read More

View Article and Full-Text PDF
September 2021

Designing User-Centered Mobile Health Initiatives to Promote Healthy Behaviors for Children With Disabilities: Development and Usability Study.

JMIR Form Res 2021 09 16;5(9):e23877. Epub 2021 Sep 16.

McGill University, Montreal, QC, Canada.

Background: The gap between research and its practical application in community settings limits its impact on public health. Closing this gap has the potential to improve the well-being of underserved groups, such as children with disabilities. Mobile health has the potential to improve access to community resources and support for underserved populations, thereby encouraging improved health behaviors. Read More

View Article and Full-Text PDF
September 2021

Communication partner engagement: A relevant factor for functional outcomes in speech language therapy for aphasic dementia.

J Gerontol B Psychol Sci Soc Sci 2021 Sep 16. Epub 2021 Sep 16.

Mesulam Center for Cognitive Neurology and Alzheimer's Disease Northwestern University, Chicago, IL, USA.

Objectives: Previous reports established the feasibility of a telehealth model for delivering speech-language therapy via Internet videoconferencing, which connects individuals with primary progressive aphasia (PPA) to an expert speech and language pathologist for treatment. This study reports feasibility of the same telehealth intervention in a larger set of progressive aphasia participants and explores factors potentially influencing functional intervention outcomes.

Methods: Participants with PPA or progressive aphasia in the context of a neurodegenerative dementia syndrome and their communication partners were enrolled into an 8-session intervention, with 3 evaluations (Baseline, 2- and 6-months post-enrollment). Read More

View Article and Full-Text PDF
September 2021

Systematising Pharmacovigilance Engagement of Patients, Healthcare Professionals and Regulators: A Practical Decision Guide Derived from the International Risk Governance Framework for Engagement Events and Discourse.

Drug Saf 2021 Sep 15. Epub 2021 Sep 15.

Team Pharmacoepidemiology, Bordeaux University, INSERM, U1219 BPH Research Center, Bordeaux, France.

Introduction: Input from patients and healthcare professionals to regulatory assessments is essential for benefit-risk management of medicines. How to best obtain input in different risk scenarios is uncertain.

Objectives: The objective of this study was to investigate whether the International Risk Governance Council (IRGC) Framework is applicable to pharmacovigilance and can guide selecting engagement mechanisms for optimising stakeholder input. Read More

View Article and Full-Text PDF
September 2021

Evaluating Community Engagement Strategies to Manage Stigma in Two African Genomics Studies Involving People Living with Schizophrenia or Rheumatic Heart Disease.

Glob Health Epidemiol Genom 2021 26;2021:9926495. Epub 2021 Jun 26.

Department of Medicine, University of Cape Town, Cape Town, South Africa.

In global health research and genomics research specifically, community engagement has gained prominence in enhancing ethical conduct, particularly in managing the risk of stigmatization, but there is minimal scientific evidence on how to do this effectively. This article reports on community engagement evaluation strategies in two African genomics studies: the Stigma in African Genomics Research study and the Genomics of Schizophrenia in South African Xhosa People (SAX) study. Within the Stigma in African Genomics Research study, a self-report rating scale and open-ended questions were used to track participant responses to an experiential theatre workshop. Read More

View Article and Full-Text PDF

Identifying and understanding the contextual factors that shaped mid-implementation outcomes during the COVID-19 pandemic in organizations implementing mental health recovery innovations into services.

Implement Sci Commun 2021 Sep 15;2(1):101. Epub 2021 Sep 15.

Douglas Mental Health University Institute, 6875, boul. LaSalle, Montréal, Québec, H4H 1R3, Canada.

Background: Seven housing and health services organizations were guided through a process of translating Chapter Six of the Canadian Guidelines for Recovery-Oriented Practice into a recovery-oriented innovation and plan for its implementation. At the time of the COVID-19 outbreak and lockdown measures, six of the seven organizations had begun implementing their chosen innovation (peer workers, wellness recovery action planning facilitator training, staff training and a family support group). This mid-implementation study used the Consolidated Framework for Implementation Research (CFIR) to identify contextual factors that influenced organizations to continue or postpone implementation of recovery-oriented innovations in the early months of the COVID-19 pandemic. Read More

View Article and Full-Text PDF
September 2021

Connection During COVID-19: Pilot Study of a Telehealth Group Parenting Intervention.

Am J Psychother 2021 Sep 16:appipsychotherapy20210005. Epub 2021 Sep 16.

Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Montefiore Medical Center, New York City (all authors); Division of Clinical Research, Nathan S. Kline Institute for Psychiatric Research, Orangeburg, New York (Gabbay).

Objective: The COVID-19 pandemic has resulted in considerable stress for families, placing parents at risk for heightened psychological distress, while prompting widespread changes in mental health service delivery. This study evaluated treatment engagement, acceptability, and psychiatric distress among participants in the telehealth adaptation of the Connecting and Reflecting Experience (CARE) program after the onset of COVID-19.

Methods: CARE is a transdiagnostic, bigenerational, mentalizing-focused group parenting intervention based out of an outpatient child mental health clinic in an underserved urban community. Read More

View Article and Full-Text PDF
September 2021

Burden of Renal Cysts Imaging: A Survey of Patients among the Greater Plains Collaborative.

Urol Int 2021 Sep 15:1-7. Epub 2021 Sep 15.

Division of Nephrology and Hypertension, Department of Medicine, University of Kansas Medical Center, Kansas City, Kansas, USA.

Purpose: Renal cysts are a frequent incidental finding on cross-sectional radiographic imaging. While most cysts are indolent, individuals with such cysts are frequently monitored for interval growth and potential malignant transformation, which is ultimately rare. In this study, we aimed to assess patients' values and preferences (believes and attitudes) about renal cysts. Read More

View Article and Full-Text PDF
September 2021