142,448 results match your criteria endothelial growth

Estrogen promotes resistance to bevacizumab in murine models of non-small cell lung cancer.

J Thorac Oncol 2021 Jul 23. Epub 2021 Jul 23.

Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77130.

Subgroup analyses from clinical studies have suggested that among metastatic non-small cell lung cancer (NSCLC) patients receiving chemotherapy, females may derive less benefit from the addition of the vascular endothelial growth factor (VEGF) monoclonal antibody bevacizumab than males. This has raised the question of whether estrogen may impact the response to anti-angiogenic therapy. To address this, we investigated the effects of estrogen on tumor growth, angiogenesis, and the response to bevacizumab in human xenograft models of NSCLC. Read More

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Corneal lymphangiogenesis in dry eye disease is regulated by substance P/neurokinin-1 receptor system through controlling expression of vascular endothelial growth factor receptor 3.

Ocul Surf 2021 Jul 23. Epub 2021 Jul 23.

Department of Cornea, External Disease & Refractive Surgery, HanGil Eye Hospital, Incheon, Republic of Korea; Department of Ophthalmology, Catholic Kwandong University College of Medicine, Gangneung-si, Republic of Korea. Electronic address:

Purpose: To evaluate the role of substance P (SP)/neurokinin-1 receptor (NK1R) system in the regulation of pathologic corneal lymphangiogenesis in dry eye disease (DED).

Methods: Immunocytochemistry, angiogenesis assay, and western blot analysis of human dermal lymphatic endothelial cells (HDLECs) were conducted to assess the involvement of SP/NK1R system in lymphangiogenesis. DED was induced in wild-type C57BL/6J mice using controlled-environment chamber without scopolamine. Read More

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The Distinct Roles of Exosomes in Tumor-Stroma Crosstalk within Gastric Tumor Microenvironment.

Pharmacol Res 2021 Jul 23:105785. Epub 2021 Jul 23.

Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, Sichuan, China; South Sichuan Institute of Translational Medicine, Luzhou 646000, Sichuan, China. Electronic address:

Gastric cancer (GC) development is a complex process displaying polytropic cell and molecular landscape within gastric tumor microenvironment (TME). Stromal cells in TME, including fibroblasts, endothelial cells, mesenchymal stem cells, and various immune cells, support tumor growth, metastasis, and recurrence, functioning as the soil for gastric tumorigenesis. Importantly, exosomes secreted by either stromal cells or tumor cells during tumor-stroma crosstalk performed as crucial transporter of agents including RNAs and proteins for cell-cell communication in GC pathogenesis. Read More

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Systemic Immunosuppression and Risk of Endophthalmitis After Intravitreal Anti-Vascular Endothelial Growth Factor Injections.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(S1):S17-S22. Epub 2021 Jul 1.

Background And Objective: To evaluate the impact of systemic immunosuppressive therapy on the rates and outcomes of endophthalmitis following intravitreal anti-vascular endothelial growth factor (VEGF) injections.

Patients And Methods: A retrospective, single-center, comparative cohort study examining eyes undergoing intravitreal anti-VEGF injections from January 2016 to September 2019. Cohorts were created based on concurrent immunosuppressive therapy at time of injection. Read More

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Lactate Consumption via Cascaded Enzymes Combined VEGF siRNA for Synergistic Anti-Proliferation and Anti-Angiogenesis Therapy of Tumors.

Adv Healthc Mater 2021 Jul 26:e2100799. Epub 2021 Jul 26.

Department of Pharmaceutics, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China.

Lactate, as the most abundant component with concentrations of 4-40 mm in tumors, contributes to the regulation of metabolic pathways, angiogenesis, and immunosuppression, exhibiting remarkable potential in cancer treatment. Therefore, a codelivery strategy that combined the cascaded enzymes Lactate oxidase/Catalase (LOx/CAT) and vascular endothelial growth factor (VEGF) siRNA (siVEGF) to suppress tumor proliferation and angiogenesis synergistically is creatively proposed. In brief, the cationic liposomes (LIP) encapsulated with LOx/CAT and siVEGF via hydrophilic interaction and electrostatic adsorption followed by coating with PEGylated phenylboronic acid (PP) is established ([email protected][LOX+CAT]). Read More

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Mammary Epithelial and Endothelial Cell Spheroids as a Potential Functional In vitro Model for Breast Cancer Research.

J Vis Exp 2021 Jul 12(173). Epub 2021 Jul 12.

Department of Reproductive Endocrinology, Wagistrasse 14, University of Zurich and University Hospital Zurich; Department of Pharmacology and Chemical Biology, University of Pittsburgh;

Breast cancer is the leading cause of mortality in women. The growth of breast cancer cells and their subsequent metastasis is a key factor for its progression. Although the mechanisms involved in promoting breast cancer growth have been intensively studied using monocultures of breast cancer cells such as MCF-7 cells, the contribution of other cell types, such as vascular and lymphatic endothelial cells that are intimately involved in tumor growth, has not been investigated in depth. Read More

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Effect of temperature manipulation during incubation on body weight, plasma parameters, muscle histology, and expression of myogenic genes in breast muscle of embryos and broiler chickens from two commercial strains.

Br Poult Sci 2021 Jul 26. Epub 2021 Jul 26.

Ege University, Faculty of Agriculture, Department of Animal Science, İzmir, Turkey.

This study evaluated the effect of a higher incubation temperature on body weight, plasma profile, histology and expression of myogenin (MYOG), insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor A (VEGFA) genes in breast muscle of embryos and broilers from two commercial strains.A total of 784 eggs from Ross 308 and Cobb 500 broiler breeder flocks were used. Half of the eggs per strain were incubated at control temperature (37. Read More

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Resolution of Foveal Lipid Deposition in Adult-Onset Coats Disease With Combined Focal Laser Photocoagulation and Anti-VEGF Therapy.

Ophthalmic Surg Lasers Imaging Retina 2021 Jul 1;52(7):396-399. Epub 2021 Jul 1.

A major cause of poor visual prognosis in Coats disease is the formation of fibrovascular changes following dense foveal lipid deposition. The authors document the multimodal imaging findings of a 38-year-old woman and a 23-year-old man with adult-onset Coats disease who presented with macular edema and foveal lipid accumulation. Thermal laser targeting individual capillary macroaneurysms combined with intravitreal anti-vascular endothelial growth factor (VEGF) therapy was performed. Read More

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Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus.

J Am Heart Assoc 2021 Jul 26:e019437. Epub 2021 Jul 26.

Department of Pediatrics Yale University School of Medicine New Haven CT.

Background Proteinuria and glomerular segmental fibrosis are inevitable complications of diabetic nephropathy though their mechanisms are poorly understood. Understanding the clinical characteristics and pathogenesis of proteinuria and glomerular segmental fibrosis in diabetic nephropathy is, therefore, urgently needed for patient management of this severe disease. Methods and Results Diabetes mellitus was induced in podocyte-specific glucocorticoid receptor knockout (GR) mice and control littermates by administration of streptozotocin. Read More

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Vascular Endothelial Growth Factor Receptor Expression in Orbital Cavernous Malformations and Lymphatic Malformations.

Ophthalmol Vis Care 2021 31;1(1). Epub 2021 Mar 31.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, FL.

Purpose: To investigate the presence of vascular endothelial growth factor receptors (VEGFR) in orbital cavernous malformations and lymphatic malformations to further understand the feasibility of anti-VEGF treatment.

Methods: This study was a single-center retrospective chart review performed at the Bascom Palmer Eye Institute of patients who underwent surgical excision of orbital cavernous malformations and lymphangiomas from 2000 - 2017. Immunohistochemical staining of these lesions for VEGFR1 and VEGFR2 expression was performed. Read More

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American Society of Retina Specialists Clinical Practice Guidelines on the Management of Nonproliferative and Proliferative Diabetic Retinopathy without Diabetic Macular Edema.

J Vitreoretin Dis 2020 Mar 6;4(2):125-135. Epub 2020 Jan 6.

Retina Consultants of Houston, Blanton Eye Institute, Houston Methodist Hospital, Weill Cornell Medical College, Houston, TX.

Purpose: Nonproliferative (NPDR) and proliferative diabetic retinopathy (PDR) without diabetic macular edema (DME) affect millions of individuals living with diabetes throughout the world. There is increasing data on various management strategies for such patients, but there is limited consensus on how the data should be adopted into clinical practice.

Methods: This literature review and editorial presents and synthesizes the current evidence for various management paradigms for NPDR and PDR without DME. Read More

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Ameliorating effect of melatonin on mercuric chloride-induced neurotoxicity in rats.

Heliyon 2021 Jul 6;7(7):e07485. Epub 2021 Jul 6.

Department of Pharmacology and Therapeutics, College of Medicine, Jouf University, Sakaka, Saudi Arabia.

Mercury is a highly toxic metal. It induces its toxicity via production of reactive oxygen species. Brain tissues are more susceptible to oxidative damage. Read More

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Upregulated expression of hypoxia reactive genes in peripheral blood mononuclear cells from chronic liver disease patients.

Biochem Biophys Rep 2021 Sep 14;27:101068. Epub 2021 Jul 14.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Liver fibrosis induces intrahepatic microcirculation disorder and hypoxic stress. Hypoxic stress has the potential for an increase in the possibility of more liver fibrosis and carcinogenesis. Liver biopsy is a standard method that evaluates of intrahepatic hypoxia, however, is invasive and has a risk of bleeding as a complication. Read More

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September 2021

The 100 most-cited papers on age-related macular degeneration: a bibliographic perspective.

BMJ Open Ophthalmol 2021 5;6(1):e000823. Epub 2021 Jul 5.

Ophthalmology, Meir Medical Center, Kfar Saba, Israel.

The 100 most-cited papers on age-related macular degeneration (AMD) were analysed using a bibliographic study. The bibliographic databases of the Institute for Scientific Information Web of Knowledge were searched, limited to research articles published between 1965 and 2020 in peer-reviewed journals. The papers were ranked in order of number of citations since publication. Read More

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Adipose-derived mesenchymal stem cells preserve cardiac function via ANT-1 in dilated cardiomyopathy hamster model.

Regen Ther 2021 Dec 9;18:182-190. Epub 2021 Jul 9.

Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Suita, Japan.

Introduction: Idiopathic dilated cardiomyopathy (DCM) is associated with abnormalities in cytoskeletal proteins, mitochondrial ATP transporter, microvasculature, and fibrosis. Mesenchymal stem cells (MSCs) can ameliorate distressed mitochondrial and structural proteins, as well as fibrosis, via the paracrine effect of cytokines. This study aimed to investigate whether the transplantation of adipose tissue-derived MSCs (ADSCs) reverses histological and functional abnormalities in the distressed myocardium of DCM-like hamsters by modulating the expression of adenine nucleotide translocase 1 (ANT-1). Read More

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December 2021

LncRNA NORAD Promotes Vascular Endothelial Cell Injury and Atherosclerosis Through Suppressing Gene Transcription Enhancing H3K9 Deacetylation by Recruiting HDAC6.

Front Cell Dev Biol 2021 9;9:701628. Epub 2021 Jul 9.

Department of Radiology, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou, China.

Coronary artery disease (CAD) is a major atherosclerotic cardiovascular disease and the leading cause of mortality globally. Long non-coding RNAs (lncRNAs) play crucial roles in CAD development. To date, the effect of lncRNA non-coding RNA activated by DNA damage (NORAD) on atherosclerosis in CAD remains unclear. Read More

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Adipose-Derived Stem Cells Based on Electrospun Biomimetic Scaffold Mediated Endothelial Differentiation Facilitating Regeneration and Repair of Abdominal Wall Defects HIF-1α/VEGF Pathway.

Front Bioeng Biotechnol 2021 7;9:676409. Epub 2021 Jul 7.

Department of General Surgery, Hernia and Abdominal Wall Surgery Center of Shanghai Jiao Tong University, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Application of synthetic or biological meshes is the main therapy for the repair and reconstruction of abdominal wall defects, a common disease in surgery. Currently, no ideal materials are available, and there is an urgent need to find appropriate ones to satisfy clinical needs. Electrospun scaffolds have drawn attention in soft tissue reconstruction. Read More

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Management of Refractory Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia with Bevacizumab.

Case Rep Gastrointest Med 2021 29;2021:2242178. Epub 2021 Jun 29.

Department of Gastroenterology and Hepatology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder resulting in vascular malformations of several organs including the pulmonary, cerebral, and gastrointestinal systems. One sequela is recurrent gastrointestinal (GI) bleeding. Bevacizumab (Bev) is emerging as an effective treatment of recurrent gastrointestinal bleeding in HHT. Read More

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Application of CT and MRI combined with VEGF-C and EGFR in the identification of endometrial cancer stages.

Am J Transl Res 2021 15;13(6):7164-7171. Epub 2021 Jun 15.

Department of Radiology, Hanchuan People's Hospital/Wuhan University People's Hospital of Hanchuan Hospital Hanchuan, Hubei Province, China.

Objective: To explore the application of computed tomography (CT) and magnetic resonance imaging (MRI) in combination with vascular endothelial growth factor-C (VEGF-C) and epidermal growth factor receptor (EGFR) in the identification of endometrial cancer stages.

Methods: Clinical data of 84 patients with endometrial cancer who underwent surgery in our hospital were retrospectively analyzed. Before surgery, they were received inspection by CT and MRI and examination by VEGF-C and EGFR measurement. Read More

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Huperzine A combined with hyperbaric oxygen on the effect on cognitive function and serum hypoxia-inducible factor-1α Level in elderly patients with vascular dementia.

Am J Transl Res 2021 15;13(6):6897-6904. Epub 2021 Jun 15.

Encephalopathy Department, Wuxi No. 2 Chinese Medicine Hospital China.

Objective: To explore the clinical effect of huperzine A combined with hyperbaric oxygen on cognitive function and serum hypoxia-inducible factor-1α (HIF-1α) level in elderly patients with vascular dementia (VD).

Methods: 120 elderly VD patients admitted to our hospital from February 2018 to March 2020 were selected and divided into two groups according to the treatment method (n = 60 each). They were administered for huperzine A and huperzine A combined with hyperbaric oxygen, respectively. Read More

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Effects of ginkgo diterpene lactone on brain inflammation and oxidative stress in rats with cognitive impairment of cerebral small vessel disease.

Am J Transl Res 2021 15;13(6):6382-6390. Epub 2021 Jun 15.

Department of Encephalopathy, Lianyungang Affiliated Hospital of Nanjing University of Traditional Chinese Medicine Lianyungang 222004, Jiangsu Province, China.

Purpose: This study aims to investigate the effects of ginkgo diterpene lactone on brain inflammation and oxidative stress in rats with cognitive impairment of cerebral small vessel disease (CSVD).

Methods: We equally assigned 40 Sprague Dawley (SD) rats to the observation group (OG) and the control group (CG) and modeled them for cognitive impairment of CSVD. Rats in OG were given ginkgo diterpene lactone for treatment, while those in CG were injected with the same amount of normal saline. Read More

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Effects of 8-Amino-Isocorydine, a Derivative of Isocorydine, on Gastric Carcinoma Cell Proliferation and Apoptosis.

Curr Ther Res Clin Exp 2021 4;94:100624. Epub 2021 Mar 4.

Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Gansu, China.

Background: Isocorydine (ICD) has anticancer effects; however, its suboptimal bioactivity has driven the production of ICD derivatives, including 8-amino-isocorydine (8-NICD).

Objective: This study explored the antitumor effects of 8-NICD on a variety of tumor cell lines to detect tumors sensitive to 8-NICD and investigated the mechanisms by which it suppresses tumor cell growth.

Methods: Human gastric carcinoma (GC) cells (MGC-803) were used to evaluate the effects of 8-NICD on cell proliferation and apoptosis. Read More

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Linn. Extract Improves Cognitive Deficits in Olfactory Bulbectomized Mice via the Enhancement of Central Cholinergic Systems and VEGF Expression.

Evid Based Complement Alternat Med 2021 30;2021:6627648. Epub 2021 Jun 30.

Center for Supporting Pharmaceutical Education, Daiichi University of Pharmacy, Fukuoka 815-8511, Japan.

This study aimed to clarify the antidementia effects of ethanolic extract of Linn. (OS) and its underlying mechanisms using olfactory bulbectomized (OBX) mice. OBX mice were treated daily with OS or a reference drug, donepezil (DNP). Read More

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Y-Box Binding Protein 1 Regulates Angiogenesis in Bladder Cancer via miR-29b-3p-VEGFA Pathway.

J Oncol 2021 1;2021:9913015. Epub 2021 Jul 1.

Institute of Urology, Lanzhou University Second Hospital, Key Laboratory of Urological Diseases in Gansu Province, Gansu Nephro-Urological Clinical Center, Lanzhou 730030, Gansu, China.

Angiogenesis plays a vital role in the development of bladder cancer (BC). The Y-box-binding protein 1 (YB-1) is a well-known oncoprotein which is closely related to angiogenesis of tumors, but the relationship and mechanism of YB-1 and angiogenesis in BC remain unclear. Based on 56 clinical BC specimens, this study found that high expression of YB-1 samples demonstrated a higher expression of vascular endothelial growth factor A (VEGFA) than those of YB-1 low expression. Read More

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Mechanisms and Clinical Trials of Hepatocellular Carcinoma Immunotherapy.

Front Genet 2021 8;12:691391. Epub 2021 Jul 8.

Laboratory of Oncology, Center for Molecular Medicine, School of Basic Medicine, Faculty of Medicine, Yangtze University, Jingzhou, China.

Hepatocellular carcinoma (HCC), one of the most common and lethal tumors worldwide, is usually not diagnosed until the disease is advanced, which results in ineffective intervention and unfavorable prognosis. Small molecule targeted drugs of HCC, such as sorafenib, provided only about 2.8 months of survival benefit, partially due to cancer stem cell resistance. Read More

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Identification of MX2 as a Novel Prognostic Biomarker for Sunitinib Resistance in Clear Cell Renal Cell Carcinoma.

Front Genet 2021 9;12:680369. Epub 2021 Jul 9.

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Antiangiogenic agents that specifically target vascular endothelial growth factor receptor (VEGFR), such as sunitinib, have been utilized as the standard therapy for metastatic clear cell renal cell carcinoma (ccRCC) patients. However, most patients eventually show no responses to the targeted drugs, and the mechanisms for the resistance remain unclear. This study is aimed to identify pivotal molecules and to uncover their potential functions involved in this adverse event in ccRCC treatment. Read More

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Non-invasive Biomarkers of Liver Inflammation and Cell Death in Response to Alcohol Detoxification.

Front Physiol 2021 7;12:678118. Epub 2021 Jul 7.

Center for Alcohol Research, University of Heidelberg, Heidelberg, Germany.

Introduction: Alcohol-related liver disease (ALD) represents the most common liver disease worldwide, however, the underlying molecular mechanisms are still poorly understood. Namely centrilobular inflammation and programmed cell death are characteristic to ALD and it remains to be elucidated why they persist despite the absence of alcohol.

Aims: To study the effects of alcohol withdrawal in a cohort of heavy drinkers and the role of cirrhosis by using non-invasive biomarkers such as cytokines, apoptotic and angiogenic markers. Read More

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Effect of a Topical Nonsteroidal Anti-Inflammatory Drug (0.1% Pranoprofen) on VEGF and COX-2 Expression in Primary Pterygium.

Front Pharmacol 2021 9;12:709251. Epub 2021 Jul 9.

Department of Ophthalmology, Nanjing Lishui District People's Hospital, Lishui Branch of Southeast University Affiliated Zhongda Hospital, Nanjing, China.

To evaluate the effect of a topical nonsteroidal anti-inflammatory drug (0.1% pranoprofen) on the expression of VEGF and Cox-2 in primary pterygium. This was a prospective, randomized study. Read More

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Precision medicine: Uses and challenges.

Med J Armed Forces India 2021 Jul 3;77(3):258-265. Epub 2021 Jul 3.

Professor & Head, Department of Pharmacology, Armed Forces Medical College, Pune, India.

Precision medicine has brought in many changes to the practise of medicine. The omics-based development of biomarkers and pharmaco-omics-based drug development programmes are evidences for the advancement. However, the field where it has proved to be most useful is in the development of various modalities of treatment in oncology. Read More

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Commentary: Are we there yet? Role of anti-vascular endothelial growth factor and laser in the management of retinopathy of prematurity.

Indian J Ophthalmol 2021 Aug;69(8):2176-2177

Vitreo-Retina Services, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Pondicherry, India.

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