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Otolaryngol Head Neck Surg 2021 Apr 13:1945998211006930. Epub 2021 Apr 13.

Division of Otolaryngology, Department of Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA.

Objective: Corticosteroid-eluting stents (CESs) are increasingly used after endoscopic sinus surgery to reduce the need for revision surgery, but their use is not without risks. The objective of this study is to describe adverse events related to CESs.

Study Design: Retrospective cross-sectional study. Read More

J Aerosol Med Pulm Drug Deliv 2021 Apr 13. Epub 2021 Apr 13.

Department of Otorhinolaryngology, Faculty of Medicine and Dentistry, Medical University of Warsaw, Warsaw, Poland.

Chronic rhinosinusitis (CRS) is a disease that can significantly reduce patients' quality of life (QoL). Intranasal steroid therapy is the most commonly used treatment for CRS. There are many evaluation tools dedicated to assessing CRS patients' QoL, but none of them evaluates QoL during local steroid therapy. Read More

Wien Klin Wochenschr 2021 Apr 12. Epub 2021 Apr 12.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Graz, Auenbruggerplatz 26, 8036, Graz, Austria.

Background: Sinonasal mucosal melanoma (SNMM) is a rare disease entity comprising 0.4-1.3% of all melanomas. Read More

Eur J Ophthalmol 2021 Apr 10:11206721211009450. Epub 2021 Apr 10.

Depatment of Radiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To report two cases of COVID-19 under treatment with a corticosteroid; in one case rhino-orbitocerebral mucormycosis and in another one rhino-orbital mucormycosis developed.

Case Presentation: A 40-year old woman and a 54-year old man with severe COVID-19 underwent corticosteroid therapy for immune-related lung injuries. The first case presented with a bilateral visual loss and complete ophthalmoplegia of the right eye. Read More

Am J Transl Res 2021 15;13(3):1840-1846. Epub 2021 Mar 15.

Department of Otolaryngology, The First Affiliated Hospital of Anhui Medical University Hefei 238000, Anhui Province, China.

Objective: To explore the effects of desloratadine citrate disodium on the postoperative complications and inflammatory markers in patients with chronic sinusitis undergoing endoscopic sinus surgery.

Methods: From June 2019 to December 2020, the patients with chronic sinusitis who received treatment in our hospital were selected and divided into the control group (CG) and experimental group (EG). In both groups, patients were given endoscopic sinus surgery. Read More

J Craniofac Surg 2021 Apr 5. Epub 2021 Apr 5.

Department of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Chonnam National University Hwasun Hospital, Jeonnam, South Korea.

Objective: The purpose of this study was to analyze the clinical characteristics and treatment outcomes of patients who underwent endoscopic surgery for a maxillary sinus organized hematoma during a 15-year period in our hospital.

Methods: The authors analyzed 25 patients who underwent endoscopic surgery for a maxillary sinus organized hematoma from January 2004 to December 2019.

Results: Twenty-five patients with a maxillary sinus organized hematoma underwent endoscopic surgical treatment and complete removal of the maxillary sinus organized hematoma was achieved in all cases. Read More

Intern Med 2021 Apr 12. Epub 2021 Apr 12.

Department of Otorhinolaryngology, Asahi General Hospital, Japan.

Ann Otol Rhinol Laryngol 2021 Apr 12:34894211005940. Epub 2021 Apr 12.

Department of Otolaryngology-Head and Neck Surgery, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.

Objectives: Topical vasoconstrictors and intravenous tranexamic acid (IV TXA) are safe and efficacious to decrease bleeding and improve the surgical field during endoscopic sinus surgery (ESS). The purpose of this study was to investigate practice patterns, awareness of clinical evidence, and comfort levels among anesthesia providers regarding these hemostatic agents for ESS.

Methods: A total of 767 attending anesthesiologists, residents, and certified registered nurse anesthetists (CRNAs) at 5 United States academic centers were invited to participate in a survey regarding their experience with IV TXA and 3 topical vasoconstrictor medications (oxymetazoline, epinephrine, and cocaine) during ESS. Read More

Am J Otolaryngol 2021 Mar 31;42(5):103024. Epub 2021 Mar 31.

Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objective: In this study we aimed to determine whether Desmopressin (DDAVP) can alter bleeding and improves surgeon visual field and decrease operation time or lessen use of anesthesiology medication in a clinical trial study.

Method: This study is a randomized clinical trial using the permuted block randomization method. 44 patients were enrolled in study and divided into two equal intervention-control groups. Read More

World Neurosurg 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurological Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Department of Physiology, Anatomy and Genetics, University of Oxford, UK. Electronic address:

The pterygopalatine fossa (PPF) is an inverted, pyramid-shaped space immediately behind the posterior wall of the maxillary sinus and lesions arising here include juvenile angiofibromas, schwannomas and, in exceptionally rare cases, malignant peripheral nerve sheath tumours. Surgical access to the PPF is challenging and been historically achieved via an open transmaxillary approach associated with facial scaring/deformity as well as potential injury to facial and infraorbital nerve branches. We present the case of a 67-year-old female with facial numbness secondary to a presumed trigeminal schwannoma in the right PPF on MRI. Read More

Rev Esp Anestesiol Reanim 2021 Apr 6. Epub 2021 Apr 6.

Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Valladolid, Valladolid, España.

Kartagener's syndrome (KS) is a rare genetic disease characterized by the triad of sinusitis, bronchiectasis, and situs inversus. This syndrome is associated with an increased risk of respiratory complications. Therefore, both the anesthetic technique and the agents used must be carefully chosen according to the type of intervention and the patient's baseline condition. Read More

Am J Otolaryngol 2021 Mar 31;42(5):103025. Epub 2021 Mar 31.

Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, PA, United States of America.

Purpose: This study evaluated whether stratified preoperative, pre- aspirin desensitization (AD) sinonasal symptom scores predict postoperative, post-AD outcomes in Aspirin exacerbated respiratory disease (AERD).

Materials And Methods: Retrospective chart review of patients with aspirin challenge-proven AERD who underwent endoscopic sinus surgery followed by AD was performed. Preoperative, postoperative/pre-AD, and postoperative/post-AD sinonasal symptom scores were collected (22-item Sino-Nasal Outcomes Test, SNOT-22). Read More

Tokai J Exp Clin Med 2021 Apr 20;46(1):17-21. Epub 2021 Apr 20.

Department of Otolaryngology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Most maxillary sinus papillomas are confirmed when they have extended beyond the nasal cavity and are rarely found while localized in the maxillary sinus. We experienced two cases of localized papilloma in the maxillary sinus. Case 1 was a 69-year-old man with a localized left maxillary sinus lesion detected during a routine imaging examination. Read More

Ann Otol Rhinol Laryngol 2021 Apr 9:34894211007240. Epub 2021 Apr 9.

Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle WA, USA.

Objectives: There is a paucity of data on postoperative infections after endoscopic sinus surgery and associated risk factors. Our objective was to evaluate a cohort of patients undergoing endoscopic sinus surgery (ESS) for chronic rhinosinusitis to determine which perioperative factors may be associated with infection in the 30-day postoperative period.

Methods: A retrospective cohort study of adults who underwent ESS at a tertiary academic medical center from 2015 to 2018 was performed. Read More

Cureus 2021 Mar 4;13(3):e13689. Epub 2021 Mar 4.

Hematology and Medical Oncology, Saint Joseph Mercy Oakland Hospital, Pontiac, USA.

Neuroendocrine tumors (NETs) have a heterogeneous pathology and indolent behavior, with the most common location being the gastrointestinal tract and then the lungs. The head and neck are rare sites of NET presentation with varied clinical signs and symptoms, which occasionally delay the diagnosis, thereby leading to an advanced stage at presentation. We present a rare case of paranasal sinus small cell neuroendocrine tumor and perform a review of the literature. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;56(4):414-415

Department of Otorhinolaryngology, Zibo Municipal Hospital, Zibo 255400, Shandong Province, China.

Ear Nose Throat J 2021 Apr 8:1455613211003802. Epub 2021 Apr 8.

Department of Otolaryngology, Head and Neck Surgery, 37803Medical University of Warsaw, Banacha, Warsaw, Poland.

Objectives: The possibility of visualization of the frontal sinus during endoscopic surgery depends on 3-dimensional configuration of the frontal sinus opening (FSO). We aimed to determine the prevalence of unfavorable angulation of the lower part of the posterior wall of the frontal sinus and its relation to FSO diameter.

Methods: One hundred and twenty-eight computed tomography (CT) scans were retrospectively reviewed to measure (1) the angle between the nasal floor and the plane tangent to the posterior table of the frontal sinus above the most posterior aspect of the anterior buttress (frontal angle, FA) and (2) dimensions of the FSO. Read More

Acta Neurochir (Wien) 2021 Apr 7. Epub 2021 Apr 7.

Department of Neurological Surgery, The Ohio State University Medical Center, N-1049 Doan Hall, 410 West 10th Avenue, Columbus, OH, 43210, USA.

Background: Superb knowledge of surgical anatomy and nuances to remove the natural barriers preventing full access to the paramedian skull base determines the ease of using the expanded sellar/parasellar approaches as the main gateway for all the parasagittal modules during endoscopic endonasal access (EEA) to pituitary tumors with cavernous sinus (CS) invasion.

Methods: Throughout stepwise-cadaveric dissections and pertinent intraoperative analysis, we describe surgical pearls and pitfalls of the parasellar-EEA with special references to the utility of various lines/classifications on neuroimaging correlated with strategies to enhance surgical safety and tumor resection.

Conclusion: EEA to invasive parasellar pathologies needs to address strict bleeding control and displacement of neurovascular structures inside the CS, posing a chance for neurologic morbidities/ICA injury. Read More

Acta Otolaryngol 2021 Apr 7:1-9. Epub 2021 Apr 7.

Hackensack University Medical Center, Hackensack, NJ, USA.

Background: Eosinophilic Otitis Media (EOM) is a relatively newly defined entity of recurrent and resistant otitis media.

Objective: To perform a systematic review of otologic manifestations, diagnosis and management of eosinophilic otitis media (EOM).

Methods: 393 patients diagnosed with EOM of 26 studies met inclusion criteria and were assessed for demographics, otologic manifestations, diagnostic criteria fulfilled, and medical and surgical treatments. Read More

Rhinology 2021 Apr 6. Epub 2021 Apr 6.

Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: Low-dose macrolides (LDM) are anti-inflammatory agents with antineutrophilic activity, but patient selection for LDM therapy in treating chronic rhinosinusitis (CRS) is controversial. This study aimed to assess factors which predict LDM responders.

Methodology: A prospective cohort study was performed. Read More

Clin Otolaryngol 2021 Apr 4. Epub 2021 Apr 4.

Queen Mary University of London, Barts and The London School of Medicine and Dentistry.

-Surgical repair is required for persistent CSF leaks due to trauma or following endoscopic skull base resections -The endoscopic endonasal approach is associated with low morbidity and high success rates; 90% at first attempt and overall in 97% -A variety of materials are used for the reconstruction and closure of CSF leaks with no overall consensus; the multilayered approach to defect closure is currently deemed best practice -The anterior ethmoid septal flap can be successfully utilized for frontal CSF leak repair -Anterior ethmoid flap is conveniently located for frontal sinus defects; and so provides excellent final layer of multilayer reconstruction when septum is intact. Read More

Pituitary 2021 Apr 3. Epub 2021 Apr 3.

Department of Neurosurgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, 390-8621, Japan.

Purpose: Acromegaly is an acquired disorder usually caused by growth hormone-secreting pituitary adenoma, resolution of which requires correction of the excess hormone production. Recently, intraoperative magnetic resonance imaging (iMRI) was reported to be useful during the endoscopic endonasal approach (EEA) for pituitary adenoma. The present study was performed to quantitatively assess the role of iMRI in improving surgical outcomes in EEA for acromegaly. Read More

Am J Otolaryngol 2020 Jul 8;42(5):102644. Epub 2020 Jul 8.

1(st) Department of Otorhinolaryngology - Head & Neck Surgery, University of Athens, 'Hippocration' General Hospital, 114 Vasilissis Sofias Avenue, 115 27 Athens, Greece.

Background: Surgical excision represents the unequivocal treatment modality for symptomatic paranasal sinus osteomas. However, the optimal surgical approach and the extent of the surgery, as well as the management stance in the case of an asymptomatic tumor, remain controversial.

Methods: The MeSH terms 'Osteoma', 'Nasal Cavity', and 'Paranasal Sinuses' were used to retrieve articles concerning the management of paranasal sinus osteomas that were published in the last 30 years, the vast majority of which comprised case reports of one or two cases. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;35(4):328-332

Department of Otolaryngology Head and Neck Surgery，Qilu Hospital（Qingdao），Cheeloo College of Medicine，Shandong University，Qingdao，266035，China.

The aim of this study is to investigate the pathological characteristics of unilateralmaxillary sinus fungus ball（UMFB） in order to improve the accuracy of clinical diagnosis. A total of 86 patients with unilateral maxillary sinus lesions who underwent nasal endoscopic surgery in Qilu Hospital of Shandong University（Qingdao） from January 2017 to June 2019 were included. Those patients were confirmed UMFB or unilateral chronic maxillary sinusitis（UCMS） by pathology. Read More

Ear Nose Throat J 2021 Mar 30:145561320973773. Epub 2021 Mar 30.

Department of Otolaryngology-Head and Neck Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.

Although the diagnosis of chronic invasive fungal sinusitis relies chiefly on identification of invasive fungi on histology, the insidious nature of the disease can preclude detection of fungal organisms. Here, we present a case of chronic invasive fungal sinusitis with negative histopathologic findings and a definitive diagnosis made through fungal DNA detection. Clinicians should consider polymerase chain reaction an important complement to histology and culture in the diagnosis of chronic invasive fungal sinusitis. Read More

Am J Otolaryngol 2021 Mar 24;42(5):102998. Epub 2021 Mar 24.

Otorhinolaryngology, Faculty of Medicine, Kafrelsheikh University, Egypt. Electronic address:

Background: Frontal sinusotomy is a challenging procedure that needs meticulous handling due to its unique anatomical position. Postoperative middle turbinate lateralization is critical comorbidity for the success rate, and many techniques are adopted to prevent it. The study aimed to compare the effect of middle turbinate bolgerization and partial resection on the postoperative endoscopic scores and assess their impact on the middle meatus and the frontal recess outcome. Read More

Clin Otolaryngol 2021 Mar 29. Epub 2021 Mar 29.

Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Objective: Patient reported outcome measures (PROMs) for assessment of chronic rhinosinusitis (CRS) employ a variety of recall periods and response scales for reporting CRS symptom burden. CRS patient perspective is unknown with respect to recall periods and response scales in PROMs.

Design: Cross-sectional study. Read More

Cureus 2021 Feb 20;13(2):e13457. Epub 2021 Feb 20.

Otolaryngology - Head and Neck Surgery, King Fahad Specialist Hospital, Dammam, SAU.

Introduction Cerebrospinal fluid (CSF) rhinorrhea is the result of a bony defect at the skull base with disruption of the arachnoid, dura mater, and sinonasal mucosa that leads to an active CSF leak and flow of clear fluid from the nose. The endoscopic repair of CSF leaks and skull defects have been used by an increasing number of surgeons and is the standard of care for repairing CSF leaks. Materials and methods We conducted a retrospective study of all cases of CSF leaks managed via the endonasal endoscopic approach from 2010 to 2020 at a tertiary referral hospital of King Fahad Specialist Hospital, Dammam (KFSH-D). Read More

Indian J Anaesth 2021 Feb 10;65(2):121-127. Epub 2021 Feb 10.

Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Zagazig University, Zagazig, Alsharqiah, Egypt.

Background And Aims: Appropriate premedication can optimise haemodynamics and hence surgical field visibility during endoscopic sinus surgery (ESS). This study aimed to compare the intraoperative effect of gabapentin 1200 mg versus bisoprolol 2.5 mg, given 2 hours before ESS. Read More

Clin Otolaryngol 2021 Mar 26. Epub 2021 Mar 26.

Department of Otorhinolaryngology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.