1,010 results match your criteria endometrium bone

Stem Cells and the Endometrium: From the Discovery of Adult Stem Cells to Pre-Clinical Models.

Cells 2021 Mar 8;10(3). Epub 2021 Mar 8.

IVI Foundation, Health Research Institute La Fe, 46026 Valencia, Spain.

Adult stem cells (ASCs) were long suspected to exist in the endometrium. Indeed, several types of endometrial ASCs were identified in rodents and humans through diverse isolation and characterization techniques. Putative stromal and epithelial stem cell niches were identified in murine models using label-retention techniques. Read More

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Characterization of highly proliferative decidual precursor cells during the window of implantation in human endometrium.

Stem Cells 2021 Mar 25. Epub 2021 Mar 25.

Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, UK.

Pregnancy depends on the wholesale transformation of the endometrium, a process driven by differentiation of endometrial stromal cells (EnSC) into specialist decidual cells. Upon embryo implantation, decidual cells impart the tissue plasticity needed to accommodate a rapidly growing conceptus and invading placenta, although the underlying mechanisms are unclear. Here we characterize a discrete population of highly proliferative mesenchymal cells (hPMC) in midluteal human endometrium, coinciding with the window of embryo implantation. Read More

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Endometrial osseous metaplasia in a patient with secondary infertility referred for hysterosalpingogram with ultrasound.

J Med Imaging Radiat Oncol 2021 Mar 17. Epub 2021 Mar 17.

Fertility Associates, Auckland, New Zealand.

Endometrial osseous metaplasia is a rare entity resulting in the formation of trabecular bone fragments within the uterine cavity and frequently presents as secondary infertility with a history of previous pregnancy loss or termination. The unusual transvaginal ultrasound appearances are important to recognise, as fertility is often restored after hysteroscopic removal of the bone fragments from the uterine cavity. Read More

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Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women.

J Clin Endocrinol Metab 2021 Feb 24. Epub 2021 Feb 24.

Department of Metabolism, Digestion and Reproduction, Imperial College London, UK.

Context: The ideal therapy for endometriosis (EM) and uterine fibroids (UF) would suppress estrogenic drive to the endometrium and myometrium, whilst minimizing vasomotor symptoms and bone loss associated with current treatments. An integrated neurokinin-kisspeptin system involving Substance P and neurokinin B acting at the neurokinin (NK) receptors 1 and 3, respectively, modulates reproductive hormone secretion and represents a therapeutic target.

Objective: To assess the effects of the novel NK1,3 antagonist elinzanetant on reproductive hormone levels in healthy women. Read More

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February 2021

Microenvironment-Protected Exosome-Hydrogel for Facilitating Endometrial Regeneration, Fertility Restoration, and Live Birth of Offspring.

Small 2021 Mar 16;17(11):e2007235. Epub 2021 Feb 16.

Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.

Thin endometrium is a primary cause of failed embryo transfer, resulting in long-term infertility and negative family outcomes. While hormonal treatments have greatly improved fertility results for some women, these responses remain unsatisfactory due to damage and infection of the complex endometrial microenvironment. In this study, a multifunctional microenvironment-protected exosome-hydrogel is designed for facilitating endometrial regeneration and fertility restoration via in situ microinjection and endometrial regeneration. Read More

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Optimized culture system to maximize ovarian cell growth and functionality in vitro.

Cell Tissue Res 2021 Feb 13. Epub 2021 Feb 13.

Wake Forest Institute for Regernative Medicine, Wake Forest School of Medicine, Medical Center Boulvard, Winston Salem, NC, 27157, USA.

Ovaries are the primary physiological source of female sex hormones, which play a crucial role in maintaining ovarian cycle, determining secondary sexual characteristics and preparing the endometrium for implantation. In vitro follicle engineering has been used to investigate follicle development, including ovarian hormone production and gamete maturation. To engineer functional follicles, culture and expansion of the primary ovarian cells are essential. Read More

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February 2021

Mesenchymal stem cells for restoring endometrial function: An infertility perspective.

Reprod Med Biol 2021 Jan 20;20(1):13-19. Epub 2020 Jul 20.

Department of Obstetrics and Gynecology Faculty of Medicine Chulalongkorn University Bangkok Thailand.

Background: Mesenchymal stem cells (MSCs) can be derived from several tissues such as bone marrow, placenta, adipose tissue, or endometrial tissue. MSCs gain a lot of attention for cell-based therapy due to their characteristics including differentiation ability and immunomodulatory effect. Preclinical and clinical studies demonstrated that MSCs can be applied to treat female infertility by improving of the functions of ovary and uterus. Read More

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January 2021

Transplantation of bone marrow-derived mesenchymal stem cells with silencing of microRNA-138 relieves pelvic organ prolapse through the FBLN5/IL-1β/elastin pathway.

Aging (Albany NY) 2021 01 16;13(2):3045-3059. Epub 2021 Jan 16.

Department of Gynaecology and Obstetrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, PR China.

Nondegradable transvaginal polypropylene meshes for treating pelvic organ prolapse (POP) are now generally unavailable or banned due to serious adverse events. New tissue engineering approaches combine degradable scaffolds with mesenchymal stem/stromal cells from human endometrium (eMSC). In this study, we investigate effect of microRNA-138 (miR-138) regulation on bone marrow-derived mesenchymal stem cells (BMSCs) and the efficacy of BMSC transplantation therapy in a rat POP model. Read More

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January 2021

Endometriosis stromal cells induce bone marrow mesenchymal stem cell differentiation and PD-1 expression through paracrine signaling.

Mol Cell Biochem 2021 Apr 11;476(4):1717-1727. Epub 2021 Jan 11.

Department of Obstetrics, Gynecology and Reproductive Sciences, Yale School of Medicine, 310 Cedar Street, New Haven, CT, 06510, USA.

Endometriosis is an estrogen-dependent, inflammatory gynecological disorder characterized by the growth of endometrial cells in lesions outside the uterus. Bone marrow-derived cells (BMDCs) engraft lesions and increase lesion size. Do endometriosis cells regulate differentiation of engrafted BMDCs in the pathogenesis and growth of endometriosis? Here, we report endometriosis derived stromal cells promote the differentiation of BMDCs to stromal, epithelial and leukocyte cell fates through paracrine signaling. Read More

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Low-grade Endometrial Stromal Sarcoma Presenting as a Sigmoid Mass.

Korean J Gastroenterol 2020 12;76(6):322-326

Department of Surgery, Wonkwang University Hospital, Iksan, Korea.

Low-grade endometrial stromal sarcoma (LG-ESS) is a very rare mesenchymal neoplasm of the uterus. LG-ESS can recur or metastasize to extrauterine sites, such as the pelvis, peritoneal cavity, and vagina, but rarely to the lung, liver, heart, bone, and colon. A 42-year-old female patient was transferred from an outside clinic for an evaluation of constipation. Read More

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December 2020

Sleep disorders and cancer: State of the art and future perspectives.

Sleep Med Rev 2021 Apr 28;56:101409. Epub 2020 Nov 28.

Sleep Research Centre, Department of Neurology I.C., Oasi Research Institute, IRCCS, Troina 94018, Italy. Electronic address:

A bidirectional connection between sleep and cancer exists; however, the specific associations between individual sleep disorders and particular tumors are not very clear. An accurate assessment of sleep disorders in cancer patients is necessary to improve patient health, survival, response to therapy, quality of life, reduction of comorbidities/complications. Indeed, recent scientific evidence shows that knowledge and management of sleep disorders offer interesting therapeutic perspectives for the treatment of cancer. Read More

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Cryptococcemia According to Immune Status: An Analysis of 65 Critical Cases.

Infect Dis Ther 2021 Mar 16;10(1):363-371. Epub 2020 Dec 16.

Department of Infectious Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.

Introduction: Cryptococcemia is associated with poor prognosis among patients with cryptococcosis. However, there are limited data on the clinical features of cryptococcemia, particularly among patients with different immune statuses. This study assessed the largest number of cases diagnosed with cryptococcemia, to the best of our knowledge. Read More

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Comparing the Effect of TGF-β Receptor Inhibition on Human Perivascular Mesenchymal Stromal Cells Derived from Endometrium, Bone Marrow and Adipose Tissues.

J Pers Med 2020 Dec 1;10(4). Epub 2020 Dec 1.

The Ritchie Centre, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.

Rare perivascular mesenchymal stromal cells (MSCs) with therapeutic properties have been identified in many tissues. Their rarity necessitates extensive in vitro expansion, resulting in spontaneous differentiation, cellular senescence and apoptosis, producing therapeutic products with variable quality and decreased potency. We previously demonstrated that A83-01, a transforming growth factor beta (TGF-β) receptor inhibitor, maintained clonogenicity and promoted the potency of culture-expanded premenopausal endometrial MSCs using functional assays and whole-transcriptome sequencing. Read More

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December 2020

miR-29a in Exosomes from Bone Marrow Mesenchymal Stem Cells Inhibit Fibrosis during Endometrial Repair of Intrauterine Adhesion.

Int J Stem Cells 2020 Nov;13(3):414-423

Department of Gynecology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background And Objectives: Bone marrow mesenchymal stem cells (BMSCs) is an ideal source of stem cells in the treatment of intrauterine adhesion. Exosomes are a type of membrane vesicle and the diameter is 30∼100 nm. Exosomes can take their contents into the target cells, releasing and exerting their functions. Read More

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November 2020

Stem cell-based therapeutic strategies for corneal epithelium regeneration.

Tissue Cell 2021 Feb 19;68:101470. Epub 2020 Nov 19.

Department of Materials Science and Engineering, Golpayegan University of Technology, Golpayegan, Iran.

Any significant loss of vision or blindness caused by corneal damages is referred to as corneal blindness. Corneal blindness is the fourth most common cause of blindness worldwide, representing more than 5% of the total blind population. Currently, corneal transplantation is used to treat many corneal diseases. Read More

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February 2021

Uterine Stem Cells and Benign Gynecological Disorders: Role in Pathobiology and Therapeutic Implications.

Stem Cell Rev Rep 2020 Nov 5. Epub 2020 Nov 5.

Department of Gynecology & Obstetrics, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD, 21205, USA.

Stem cells in the endometrium and myometrium possess an immense regenerative potential which is necessary to maintain the menstrual cycle and support pregnancy. These cells, as well as bone marrow stem cells, have also been implicated in the development of common benign gynecological disorders including leiomyomas, endometriosis and adenomyosis. Current evidence suggests the conversion of uterine stem cells to tumor initiating stem cells in leiomyomas, endometriosis stem cells, and adenomyosis stem cells, acquiring genetic and epigenetic alterations for the progression of each benign condition. Read More

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November 2020

The regulation of IGFBP3 by BMP2 has a role in human endometrial remodeling.

FASEB J 2020 Nov 25;34(11):15462-15479. Epub 2020 Sep 25.

Department of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada.

In mammals, bone morphogenetic protein 2 (BMP2) is a critical regulator of endometrial decidualization and early implantation. Insulin-like growth factor-binding protein 3 (IGFBP3) is highly expressed in the endometrium and at the maternal-fetal interface in multiple species, including humans. BMP2-induced IGFBP3 signaling has been confirmed to have a role in trophoblast cell invasion; however, the involvement of this signaling pathway in endometrial remodeling remains poorly understood. Read More

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November 2020

Fecundity is impaired in a mouse model of osteogenesis imperfecta.

Mol Reprod Dev 2020 09 31;87(9):927-929. Epub 2020 Aug 31.

Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri.

Osteogenesis imperfecta (OI), or brittle bone disease, is most often caused by mutations in genes encoding type I collagen or proteins that process it. Women with OI have a small, but significant increase in risk of serious pregnancy complications including uterine rupture. Here, the OI mouse, Col1a2 , was used to examine the effects of collagen mutation on establishment and maintenance of pregnancy. Read More

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September 2020

Comparative Analysis of Mouse Decidualization Models at the Molecular Level.

Genes (Basel) 2020 08 13;11(8). Epub 2020 Aug 13.

Guangdong Laboratory for Lingnan Modern Agriculture, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, Guangdong, China.

The mouse is widely used to study decidualization and there are three well-established mouse models of decidualization, namely natural pregnancy decidualization (NPD), artificial decidualization (AD), and in vitro decidualization (IVD). However, the extent of similarity and difference between these models at the molecular level remains largely unknown. Here, we performed a comparative analysis using the RNA-seq approach. Read More

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17β-estradiol promotes bone marrow mesenchymal stem cell migration mediated by chemokine upregulation.

Biochem Biophys Res Commun 2020 09 13;530(2):381-388. Epub 2020 Aug 13.

Shanghai Ji Ai Genetics & IVF Institute, Obstetrics and Gynecology Hospital Affiliated with Fudan University, Shanghai, 200011, China; Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, China. Electronic address:

Bone marrow-derived cells engraft to the uterine endometrium and contribute to endometriosis. This study sought to further confirm that estrogen can promote the migration of bone marrow mesenchymal stem cells (BMSCs) and to investigate the function of estrogen on the secretion of chemokines during BMSC migration. BMSCs were treated with or without 17β-estradiol, cultured with or without endometrial stromal cells (ESCs), or pretreated with or without AMD 3100 (an antagonist of the SDF-1α receptor) before co-culture. Read More

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September 2020

Endometrial and Menstrual Blood Mesenchymal Stem/Stromal Cells: Biological Properties and Clinical Application.

Front Cell Dev Biol 2020 9;8:497. Epub 2020 Jul 9.

The Ritchie Centre, Hudson Institute of Medical Research, Melbourne, VIC, Australia.

A highly proliferative mesenchymal stem/stromal cell (MSC) population was recently discovered in the dynamic, cyclically regenerating human endometrium as clonogenic stromal cells that fulfilled the International Society for Cellular Therapy (ISCT) criteria. Specific surface markers enriching for clonogenic endometrial MSC (eMSC), CD140b and CD146 co-expression, and the single marker SUSD2, showed their perivascular identity in the endometrium, including the layer which sheds during menstruation. Indeed, cells with MSC properties have been identified in menstrual fluid and commonly termed menstrual blood stem/stromal cells (MenSC). Read More

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IFNs Drive Development of Novel IL-15-Responsive Macrophages.

J Immunol 2020 08 20;205(4):1113-1124. Epub 2020 Jul 20.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;

Disruption in homeostasis of IL-15 is linked to poor maternal and fetal outcomes during pregnancy. The only cells described to respond to IL-15 at the early maternal-fetal interface have been NK cells. We now show a novel population of macrophages, evident in several organs but enriched in the uterus of mice and humans, expressing the β-chain of the IL-15R complex (CD122) and responding to IL-15. Read More

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Combination of Red Clover and Hops Extract Improved Menopause Symptoms in an Ovariectomized Rat Model.

Evid Based Complement Alternat Med 2020 23;2020:7941391. Epub 2020 May 23.

Natural Product Team, Naturech Co, Ltd., Chungcheongnam-do 31257, Republic of Korea.

Red clover and hops are already known for their alternative menopausal therapies; however, their combination has not yet been studied. This study aimed to evaluate the efficacy of the combination of red clover and hops extract (RHEC) for treating menopausal symptoms for the first time. A high-performance liquid chromatography (HPLC) method for RHEC was developed and validated for the analysis of biochanin A in red clover extract and xanthohumol in hops extract. Read More

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Autologous Bone Marrow-Derived Stem Cell Therapy for Asherman's Syndrome and Endometrial Atrophy: A 5-Year Follow-up Study.

J Hum Reprod Sci 2020 Jan-Mar;13(1):31-37. Epub 2020 Apr 7.

Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Delhi, India.

Background: Based on the role of bone marrow (BM) stem cells in regeneration of endometrium, refractory cases of Asherman's syndrome (AS) and endometrial atrophy (EA) may benefit with BM-derived intrauterine stem cell instillation. Aims and Objectives: To evaluate the role of BM-derived autologous stem cell therapy in endometrial regeneration and restoration of menstruation and fertility in refractory cases of AS and EA.

Setting: This study was conducted at a tertiary care center. Read More

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Selective estrogen receptor modulators (SERMS): keys to understanding their function.

James H Liu

Menopause 2020 10;27(10):1171-1176

Departments of Obstetrics and Gynecology and Reproductive Biology, University Hospitals MacDonald Women's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH.

Selective estrogen receptor modulators (SERMs) are an increasingly important therapeutic modality that are used by clinicians on a daily basis. Unfortunately, clinicians have a limited understanding regarding the underlying mechanism(s) of how SERMs function and their increasingly useful role in the treatment of estrogen-responsive target tissues such as the breast, bone, vagina, uterine endometrium, and brain. This review will provide a basic understanding of our current knowledge of SERM pharmacodynamics and will highlight the clinical applications of Food and Drug Administration-approved SERMs in the treatment of vasomotor symptoms, osteoporosis, genitourinary syndrome of menopause, infertility, and breast cancer and its prevention. Read More

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October 2020

Comparison of the regenerative effects of bone marrow/adipose-derived stem cells in the Asherman model following local or systemic administration.

J Assist Reprod Genet 2020 Aug 14;37(8):1861-1868. Epub 2020 Jun 14.

Department of Anatomy, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Purpose: Cell therapy is a promising strategy for the treatment of Asherman's syndrome (AS), but the origin of these cells and injection route influence the therapeutic effect and complications of cell therapy. Herein, we compared the effects of systemic or local intrauterine injection of bone marrow or adipose-derived mesenchymal stem cells (BMSCs/AMSCs) on the endometrium in a rat model of AS.

Methods: After induction of AS in adult Wistar rats, the CM-Dil-positive BMSCs or AMSCs were injected either locally or intravenously. Read More

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Effects of GW1929 on uterus, ovary and bone metabolism function in perimenopause rats.

Am J Transl Res 2020 15;12(5):1884-1893. Epub 2020 May 15.

Department of Gynecology and Obstetrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University Chengdu 610041, P. R. China.

This study was aimed to investigate the effect of GW1929, a novel peroxisome proliferator-activated receptors gamma (PPARγ) agonist, in perimenopause rats. Female Sprague-Dawley (SD) rats were treated with 4-vinylcyclohexene diepoxide (VCD) to induce perimenopause rat model. Then they were given GW1929 in low, middle and high dosage. Read More

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Tibolone as Hormonal Therapy and Neuroprotective Agent.

Trends Endocrinol Metab 2020 10 5;31(10):742-759. Epub 2020 Jun 5.

Department of Biological Sciences, School of Natural Sciences, University of Limerick, Limerick, Ireland; Health Research Institute, University of Limerick, Limerick, Ireland. Electronic address:

Tibolone (TIB), a selective tissue estrogenic activity regulator (STEAR) in clinical use by postmenopausal women, activates hormonal receptors in a tissue-specific manner. Estrogenic activity is present mostly in the brain, vagina, and bone, while the inactive forms predominate in the endometrium and breast. Conflicting literature on TIB's actions has been observed. Read More

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October 2020

The midlife transition and the risk of cardiovascular disease and cancer Part I: magnitude and mechanisms.

Am J Obstet Gynecol 2020 12 1;223(6):820-833. Epub 2020 Jun 1.

Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

Heart disease and cancer are the leading causes of death in the United States. In women, the clinical appearance of both entities-coronary heart disease and cancer (breast, endometrium, and ovary)-escalate during the decades of the midlife transition encompassing the menopause. In addition to the impact of aging, during the interval between the age of 40 and 65 years, the pathophysiologic components of metabolic syndrome also emerge and accelerate. Read More

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December 2020

An update on stem cell therapy for Asherman syndrome.

J Assist Reprod Genet 2020 Jul 22;37(7):1511-1529. Epub 2020 May 22.

Eunice Kennedy Shriver National Institute for Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

The current treatment for Asherman syndrome is limited and not very effective. The aim of this review is to summarize the most recent evidence for stem cells in the treatment of Asherman syndrome. The advent of stem cell therapy has propagated experimentation on mice and humans as a novel treatment. Read More

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