Reprod Sci 2021 Apr 20. Epub 2021 Apr 20.
Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, BJC Institute of Health - 10th Floor, RM 10606, 425 S. Euclid Avenue, Campus Box 8064, St. Louis, MO, 63110, USA.
Autophagy is a conserved fundamental cellular process with a primary function of catabolizing harmful or surplus cellular contents such as protein aggregates, dysfunctional/long-lived organelles, intracellular pathogens, and storage nutrients. An increasing body of evidence reveals that basal autophagy is essential for maintaining endometrial homeostasis and mediating endometrial-specific functions, including menstrual cycle, embryo implantation, and decidualization. However, perturbed levels of autophagy can lead to severe endometrial pathologies, including endometriosis, endometrial hyperplasia, endometrial cancer, adenomyosis, and leiomyoma. Read More