6,737 results match your criteria endometrial hyperplasia


Endometrial endometrioid carcinoma, G1, is more aggressive in the elderly than in the young.

Histopathology 2021 May 13. Epub 2021 May 13.

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Aims: The aim of this study was to characterize endometrioid carcinoma, G1, in the elderly, using clinicopathological features and immunohistochemical features of surrogate markers of molecular subtypes.

Methods And Results: We retrospectively analyzed tumour samples from 268 patients with endometrioid carcinoma, G1 (<40 years: n=24, 40-59 years: n=169, ≥60 years: n=75), for whom long-term clinical follow-up data were available. Endometrioid carcinoma, G1, in the elderly (≥60 years) was characterized by frequent deep myometrial invasion, less frequent endometrioid intraepithelial neoplasia (EIN), lack of benign hyperplasia (BH), less frequent squamous differentiation and occasional aberrant p53 expression. Read More

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A rare cause of postmenopausal bleeding: chronic lymphocytic leukemia.

Climacteric 2021 May 6:1-3. Epub 2021 May 6.

Department of Pathology, Umraniye Training and Research Hospital, Istanbul, Turkey.

Objective: Postmenopausal bleeding has been reported in about 4-11% of menopausal women. The most common cause of postmenopausal bleeding is atrophy of the vaginal mucosa or endometrium. Endometrial hyperplasia, endometrial polyps, submucous leiomyomas and endometrial cancers are also known causes of postmenopausal bleeding. Read More

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Clinical Efficacy of Hormonal and Nonhormonal Agents in the Treatment of Vulvovaginal Atrophy.

J Menopausal Med 2021 Apr;27(1):15-23

Department of Biostatistics, Sakarya University School of Medicine, Sakarya, Turkey.

Objectives: Symptomatic local treatment of vaginal atrophy (VA) in menopausal women includes hormonal and nonhormonal preparations. Some women may be reluctant to use vaginal estradiol preparations because of the concern for developing breast cancer and endometrial hyperplasia. Therefore, it is necessary to compare the therapeutic effectiveness of alternative vaginal drugs, such as promestriene, an estrogen agonist, and sodium hyaluronate (NaH), a nonhormonal, water-based agent. Read More

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Survey on Reporting of Endometrial Biopsies From Women on Progestogen Therapy for Endometrial Atypical Hyperplasia/Endometrioid Carcinoma.

Int J Gynecol Pathol 2021 May 3. Epub 2021 May 3.

Department of Cellular Pathology, Birmingham Women's Hospital, Birmingham (R.G.) Department of Pathology, Belfast Health and Social Care Trust, Belfast (W.G.M.), UK Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada (C.B.G.) Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY (R.A.S.).

Histologic assessment of response to progestogen therapy is a cornerstone of nonsurgical management of atypical hyperplasia/low-grade endometrioid carcinoma. Pathologists are required to assess whether there is ongoing preneoplastic or neoplastic change in the biopsies (often multiple) taken during therapy. There have been few studies documenting the specific histologic changes induced by therapeutic progestogens and currently there are no guidelines on terminology used in this scenario. Read More

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Fibroblast Growth Factor Receptor 2 Isoforms Detected via Novel RNA ISH as Predictive Biomarkers for Progestin Therapy in Atypical Hyperplasia and Low-Grade Endometrial Cancer.

Cancers (Basel) 2021 Apr 3;13(7). Epub 2021 Apr 3.

School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Translational Research Institute, Princess Alexandra (PA) Hospital Campus, 37 Kent St., Woolloongabba, Brisbane, Queensland 4102, Australia.

Women with atypical hyperplasia (AH) or well-differentiated early-stage endometrioid endometrial carcinoma (EEC) who wish to retain fertility and/or with comorbidities precluding surgery, are treated with progestin. Clinically approved predictive biomarkers for progestin therapy remain an unmet need. The objectives of this study were to document the overall response rate (ORR) of levonorgestrel intrauterine device (LNG-IUD) treatment, and determine the association of FGFR2b and FGFR2c expression with treatment outcome. Read More

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Clinicopathological and ultrasound features of endometrial cancer in postmenopausal women: a retrospective study in a single institute in South Korea.

Pan Afr Med J 2021 10;38:148. Epub 2021 Feb 10.

Department of Occupational and Environmental Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University College of Medicine, Changwon, Korea.

Introduction: endometrial cancer is the most common type of cancer in the female genital tract. Most patients are diagnosed during postmenopausal periods. This study aimed to investigate the demographic characteristics as well as cutoff value of endometrial thickness and ultrasound characteristics of endometrial cancer in postmenopausal patients. Read More

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Spectroscopic evaluation of carcinogenesis in endometrial cancer.

Sci Rep 2021 Apr 27;11(1):9079. Epub 2021 Apr 27.

Institute of Physics, College of Natural Sciences, University of Rzeszow, Pigonia 1, 35-310, Rzeszow, Poland.

Carcinogenesis is a multifaceted process of cancer formation. The transformation of normal cells into cancerous ones may be difficult to determine at a very early stage. Therefore, methods enabling identification of initial changes caused by cancer require novel approaches. Read More

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Morphological changes in bitches endometrium affected by cystic endometrial hyperplasia - pyometra complex - the value of histopathological examination.

BMC Vet Res 2021 Apr 26;17(1):174. Epub 2021 Apr 26.

Department of Diagnostics and Clinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Toruń, Poland.

Background: Cystic endometrial hyperplasia-pyometra complex (CEH-P) is one of the most common uteropathies in bitches. In diseases with mild or obscure clinical signs and normal uterine size, a diagnosis based on a clinical assessment might be incorrect. The main aim of the research was to determine the morphological variables accompanying uterine diseases in bitches in microscopic evaluation. Read More

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Illuminating the "Black Box" of Progesterone-Dependent Embryo Implantation Using Engineered Mice.

Front Cell Dev Biol 2021 7;9:640907. Epub 2021 Apr 7.

Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX, United States.

Synchrony between progesterone-driven endometrial receptivity and the arrival of a euploid blastocyst is essential for embryo implantation, a prerequisite event in the establishment of a successful pregnancy. Advancement of embryo implantation within the uterus also requires stromal fibroblasts of the endometrium to transform into epithelioid decidual cells, a progesterone-dependent cellular transformation process termed decidualization. Although progesterone is indispensable for these cellular processes, the molecular underpinnings are not fully understood. Read More

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Pyelonephritis and Cystic Endometrial Hyperplasia in a Captive Sunda Pangolin (Manis javanica).

J Comp Pathol 2021 Apr 10;184:101-105. Epub 2021 Apr 10.

Conservation, Research & Veterinary Department, Wildlife Reserves Singapore, Singapore.

The Sunda pangolin (Manis javanica) is one of the most trafficked animal species globally, and is listed as Critically Endangered by the IUCN. There is limited information on reproductive biology or pathology of this species. We now document the clinical and pathological features of pyelonephritis and cystic endometrial hyperplasia in one of these animals. Read More

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Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia-pyometra.

Acta Vet Hung 2021 Apr 22. Epub 2021 Apr 22.

1Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Ondokuz Mayis,Samsun, Turkey.

The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)-pyometra complex. Group 1 (n = 10) included bitches with open cervix pyometra, while Group 2 (n = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. Read More

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Hysterectomy and bilateral adnexectomy using transvaginal natural orifice transluminal endoscopic surgery: The role of multichannel abdominal PORT and vaginal support ring.

J Obstet Gynaecol Res 2021 Apr 21. Epub 2021 Apr 21.

Department of Gynecology & Obstetrics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

Background: Although transvaginal natural orifice transluminal endoscopic surgery (NOTES) is gaining importance, knowledge on transvaginal NOTES procedures in gynecologic practice is limited.

Objective: We aimed at evaluating the feasibility and safety of performing hysterectomy and bilateral adnexectomy (or bilateral salpingectomy) via transvaginal NOTES using a self-developed multichannel abdominal port and vaginal support ring.

Study Design: A prospective, single-center, cohort pilot study was conducted from May to December 2017 in patients with benign uterine diseases or endometrial atypical hyperplasia or cervical intraepithelial neoplasia (n = 30) scheduled for laparoscopic hysterectomy. Read More

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The Multifaceted Role of Autophagy in Endometrium Homeostasis and Disease.

Reprod Sci 2021 Apr 20. Epub 2021 Apr 20.

Center for Reproductive Health Sciences, Department of Obstetrics and Gynecology, Washington University School of Medicine, BJC Institute of Health - 10th Floor, RM 10606, 425 S. Euclid Avenue, Campus Box 8064, St. Louis, MO, 63110, USA.

Autophagy is a conserved fundamental cellular process with a primary function of catabolizing harmful or surplus cellular contents such as protein aggregates, dysfunctional/long-lived organelles, intracellular pathogens, and storage nutrients. An increasing body of evidence reveals that basal autophagy is essential for maintaining endometrial homeostasis and mediating endometrial-specific functions, including menstrual cycle, embryo implantation, and decidualization. However, perturbed levels of autophagy can lead to severe endometrial pathologies, including endometriosis, endometrial hyperplasia, endometrial cancer, adenomyosis, and leiomyoma. Read More

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FOXA1 is associated with high tumor grade, myometrial invasion and lymph node invasion in endometrial endometrioid carcinoma.

Ginekol Pol 2021 Apr 12. Epub 2021 Apr 12.

University of Health Sciences, Antalya Education and Research Hospital, Department of Pathology, Antalya, Turkey.

Objectives: FOXA1 expression has been demonstrated in several hormone-dependent cancers. However, data are limited concerning the role of FOXA1 in endometrial cancers. The present study aimed to investigate FOXA1 expression via the microarray technique in benign hyperplasia, endometrial intraepithelial neoplasia, and endometrial endometrioid carcinoma. Read More

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Differential Expression of Androgen Receptor in Type I and Type II Endometrial Carcinomas: A Clinicopathological Analysis and Correlation with Outcome.

Oman Med J 2021 Mar 31;36(2):e245. Epub 2021 Mar 31.

Faculty of Medicine,University of Jordan, Amman, Jordan.

Objectives: Endometrial carcinomas (EC) are the most common gynecological malignancies and are conventionally divided into type I and type II due to diagnostic and prognostic considerations. Female hormone expression in EC is extensively studied; however, data about androgen receptor (AR) expression in EC are sparse. We aimed to study AR expression in different types of EC at our institute and whether it had an impact on patient outcomes. Read More

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Uptake and Outcomes of Sentinel Lymph Node Mapping in Women With Atypical Endometrial Hyperplasia.

Obstet Gynecol 2021 05;137(5):924-934

Columbia University College of Physicians and Surgeons, the Joseph L. Mailman School of Public Health, Columbia University, the Herbert Irving Comprehensive Cancer Center, and New York Presbyterian Hospital, New York, New York.

Objective: To examine the utilization, morbidity, and cost of sentinel lymph node mapping in women undergoing hysterectomy for complex atypical endometrial hyperplasia.

Methods: Women with complex atypical endometrial hyperplasia who underwent hysterectomy from 2012 to 2018 in the Perspective database were examined. Perioperative morbidity, mortality, and cost were examined based on performance of sentinel lymph node mapping, lymph node dissection or no nodal evaluation. Read More

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Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol.

Adv Ther 2021 May 8;38(5):2717-2731. Epub 2021 Apr 8.

Gynecology Department, Hospital El Pilar, Barcelona, Spain.

Introduction: Endometrial cancer is the fifth most common cancer in women and atypical endometrial hyperplasia is a precancerous lesion. Obesity is an important risk factor for endometrioid endometrial adenocarcinoma and endometrial hyperplasia. Progesterone is recommended as first-line treatment in endometrial cancer or atypical endometrial hyperplasia in women who wish to preserve fertility, but optimal treatment schedules have not been defined. Read More

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The use of hysteroscopic endometrectomy in the conservative treatment of early endometrial cancer and atypical hyperplasia in fertile women.

Arch Gynecol Obstet 2021 Apr 8. Epub 2021 Apr 8.

Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.

Objective: To illustrate the effectiveness of hysteroscopic endometrial resection in conservative treatment of early endometrial cancer/atypical hyperplasia in women of reproductive age.

Methods: Review of outcomes of women of reproductive age who underwent fertility sparing treatment (hysteroscopic superficial endometrectomy followed by progestin therapy) in early endometrial cancer.

Results: Eight women with Stage I endometrial cancer and three with atypical endometrial hyperplasia underwent hysteroscopic superficial endometrial resection, followed by 1-year treatment with oral megestrol acetate. Read More

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Prominent decidualization following progestin treatment for endometrial hyperplasia and carcinoma as a mimic of large residual tumor: A cautionary tale.

Gynecol Oncol Rep 2021 May 16;36:100747. Epub 2021 Mar 16.

University of Wisconsin Carbone Cancer Center, USA.

Objective: Progestin-based therapy is common for patients with endometrial neoplasia who desire fertility preservation, but some patients ultimately require surgery. Intraoperative assessment, which can use gross lesion size, may impact the extent of surgery performed. We sought to characterize the extent to which grossly identified lesions in the setting of progestin therapy correspond to microscopic findings. Read More

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MORPHOLOGICAL CHANGES OF THE ENDOMETRIUM IN HYPERPLASTIC PROCESS IN WOMEN OF REPRODUCTIVE AGE.

Wiad Lek 2021 ;74(3 cz 1):388-394

I. YA. HORBACHEVSKY TERNIOPIL NATIONAL MEDICAL UNIVERSITY, TERNOPIL, UKRAINE.

Objective: The aim: To conduct a morphological study of endometrial tissue to identify changes characteristic of viral lesions to develop improved antirelapse treatment of HPE in women of reproductive age.

Patients And Methods: Materials and methods: We surveyed 90 patients of the gynecological department who sought medical for hyperplastic processes of the endometrium in reproductive age. All women underwent hysteroscopy, the resulting material was subjected to morphological examination. Read More

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Mismatch repair-deficiency specifically predicts recurrence of atypical endometrial hyperplasia and early endometrial carcinoma after conservative treatment: A multi-center study.

Gynecol Oncol 2021 Mar 31. Epub 2021 Mar 31.

Department of Public Health, University of Naples Federico II, Naples, Italy.

Objective: Deficient expression of mismatch repair proteins (MMR) has been suggested to be a predictor of resistance of atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EEC) to conservative treatment.

Aims: To assess the predictive value of MMR immunohistochemistry in patients conservatively treated for AEH and EEC, and to calculate its predictive accuracy.

Materials And Methods: All patients with AEH or EEC conservatively treated with hysteroscopic resection plus progestins in two referral centers from January 2004 to July 2019 were retrospectively assessed. Read More

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Risk Assessment of Endometrial Hyperplasia or Endometrial Cancer with Simplified Ultrasound-Based Scoring Systems.

Diagnostics (Basel) 2021 Mar 4;11(3). Epub 2021 Mar 4.

Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland.

Background: Abnormal uterine bleeding (AUB) represents a common diagnostic challenge, as it might be related to both benign and malignant conditions. Endometrial cancer may not be detected with blind uterine cavity sampling by dilatation and curettage or suction devices. Several scoring systems using different ultrasound image characteristics were recently proposed to estimate the risk of endometrial cancer (EC) in women with AUB. Read More

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Pseudo-Placentational Endometrial Hyperplasia in the Bitch: Case Series.

Animals (Basel) 2021 Mar 6;11(3). Epub 2021 Mar 6.

Department of Veterinary Medicine and Animal Production, University of Naples, Federico II, 80137 Naples, Italy.

Canine pseudo-placentational endometrial hyperplasia differs from the classical form of cystic endometrial hyperplasia for the well-organized tissue architecture resembling the canine placenta. After the discovery, it has been inconstantly reported. The present work reports the clinicopathological details of six spontaneous cases retrieved retrospectively from a large database. Read More

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Automated system for diagnosing endometrial cancer by adopting deep-learning technology in hysteroscopy.

PLoS One 2021 31;16(3):e0248526. Epub 2021 Mar 31.

Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Endometrial cancer is a ubiquitous gynecological disease with increasing global incidence. Therefore, despite the lack of an established screening technique to date, early diagnosis of endometrial cancer assumes critical importance. This paper presents an artificial-intelligence-based system to detect the regions affected by endometrial cancer automatically from hysteroscopic images. Read More

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Preoperative Factors of Endometrial Carcinoma in Patients Undergoing Hysterectomy for Atypical Endometrial Hyperplasia.

J Obstet Gynaecol Can 2021 Mar 27. Epub 2021 Mar 27.

Department of Obstetrics and Gynaecology, Kingston Health Sciences Centre, Kingston, ON. Electronic address:

Objective: To identify clinicopathological preoperative factors associated with concurrent endometrial carcinoma in patients undergoing surgical management of atypical endometrial hyperplasia.

Methods: The records of all patients who underwent hysterectomy for preoperatively diagnosed atypical endometrial hyperplasia at a tertiary care hospital from April 2017 to April 2020 were retrospectively reviewed. Clinicopathological characteristics of patients were extracted. Read More

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'The horror stories put me off!': exploring women's acceptability of the Levonorgestrel IntraUterine System (LNG-IUS) for endometrial protection.

J Prim Health Care 2021 03;13(1):55-62

Department of Obstetrics, Gynaecology and Women's Health, University of Otago, Wellington, New Zealand.

INTRODUCTION There are few studies of user perceptions of the Levonorgestrel Intrauterine System (LNG-IUS; Mirena™), which now has the potential to play an important role in the treatment of women with hyperplasia or early stage endometrial cancer. There is limited evidence on how well the Mirena™ is perceived and accepted by women in this context. AIM To gain an understanding of New Zealand women's views on the use of the Mirena™ contraceptive device to inform policies in endometrial cancer prevention. Read More

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Prolonged atrazine exposure beginning and adult uterine morphology in mice.

J Dev Orig Health Dis 2021 Mar 30:1-10. Epub 2021 Mar 30.

School of BioSciences, University of Melbourne, Parkville, Australia.

Through drinking water, humans are commonly exposed to atrazine, a herbicide that acts as an endocrine and metabolic disruptor. It interferes with steroidogenesis, including promoting oestrogen production and altering cell metabolism. However, its precise impact on uterine development remains unknown. Read More

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A Randomized Clinical Trial of Levonorgestrel Intrauterine System with or without Metformin for Treatment of Endometrial Hyperplasia without Atypia in Indian Women.

Asian Pac J Cancer Prev 2021 Mar 1;22(3):983-989. Epub 2021 Mar 1.

Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Background: Endometrial cancer is the second most frequent genital malignancy in women, which is showing a constant rise all over world. Endometrial hyperplasia is the precursor of endometrial cancer. Levonorgestrel intrauterine system is the first line management in patients with endometrial hyperplasia without atypia. Read More

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Guizhi Fuling Capsule ameliorates endometrial hyperplasia through promoting p62-Keap1-NRF2-mediated ferroptosis.

J Ethnopharmacol 2021 Jun 24;274:114064. Epub 2021 Mar 24.

Department of Gynecology, Tongde Hospital of Zhejiang Province, 234 Gucui Road, Hangzhou, 310012, China; Center for Uterine Cancer Diagnosis & Therapy Research in Zhejiang Province, Hangzhou, 310012, China. Electronic address:

Ethnopharmacological Relevance: Guizhi Fuling Capsule (GFC) is a classical traditional Chinese medicine officially recorded in Synopsis of the Golden Chamber and has long been used to treat gynecological diseases in China. However, scientific evidence for the anti-endometrial hyperplasia potential of GFC used in traditional medicine is lacking.

Aim Of The Study: This study evaluated whether GFC protects against endometrial hyperplasia and its potential mechanism in mice. Read More

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Molecular evidence for a clonal relationship between synchronous uterine endometrioid carcinoma and ovarian clear cell carcinoma: a new example of "precursor escape"?

J Mol Med (Berl) 2021 Mar 25. Epub 2021 Mar 25.

Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital Linkou Medical Center and Chang Gung University College of Medicine, 5 Fushin St., Guishan, Taoyuan, 333, Taiwan.

Synchronous endometrial and ovarian carcinomas (SEOCs) that share the same endometrioid histology are generally considered as the result of metastatic spread from one organ to another. However, SEOCs with different histologies are regarded as distinct primary lesions that arise independently from each other. This study was undertaken to compare the mutational landscape of SEOCs with different histologies to confirm or refute the hypothesis of an independent origin. Read More

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