42,029 results match your criteria endometrial cancer


Clinical issues of surgery for uterine endometrial cancer in Japan.

Jpn J Clin Oncol 2022 Jan 15. Epub 2022 Jan 15.

Objective: The mainstay of treatment for uterine endometrial cancer is surgery, and recurrent-risk cases require multidisciplinary treatment, including surgery, chemotherapy and radiation therapy.

Methods: The standard surgery for uterine endometrial cancer is hysterectomy and bilateral salpingooophorectomy, with additional retroperitoneal lymph node dissection and omentectomy, depending on the case. The appropriate treatment is determined based on the risk classification, such as the depth of invasion into the myometrium, diagnosis of histological type and grade, and risk assessment of lymph node metastasis. Read More

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January 2022

Comparison of total and endometrial circulating cell-free DNA in women with and without endometriosis.

Reprod Biomed Online 2021 Nov 13. Epub 2021 Nov 13.

Gynaecological Cancer Research Group, Adult Cancer Program, School of Women's and Children's Health, Faculty of Medicine and Health, University of New South Wales, Sydney NSW, Australia. Electronic address:

Research Question: Do women with laparoscopically confirmed endometriosis have higher plasma concentrations of circulating cell-free DNA (cirDNA) than those without endometriosis?

Design: Prospective study of women aged 18-45 years undergoing benign gynaecological laparoscopy at two tertiary hospitals. Venous blood was collected immediately before surgery, and women were allocated to the endometriosis or control groups based on surgical findings. Total plasma cirDNA and cirDNA integrity were measured by quantitative polymerase chain reaction (qPCR) targeting short (115 bases) and long (247 bases) ALU segments. Read More

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November 2021

A single-site laparoendoscopic staging surgery for endometrial cancer (stage IA, G3): Effective suture-suspension skills and conservative management of chylous fistula.

Asian J Surg 2022 Jan 12. Epub 2022 Jan 12.

From the Department of Gynecologic Oncology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China; From Key Laboratory of Obstetrics and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.

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January 2022

Association of Hormonal Contraceptive Use With Adverse Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials and Cohort Studies.

JAMA Netw Open 2022 Jan 4;5(1):e2143730. Epub 2022 Jan 4.

Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City.

Importance: Meta-analyses have reported conflicting data on the safety of hormonal contraception, but the quality of evidence for the associations between hormonal contraceptive use and adverse health outcomes has not been quantified in aggregate.

Objective: To grade the evidence from meta-analyses of randomized clinical trials (RCTs) and cohort studies that assessed the associations between hormonal contraceptive use and adverse health outcomes among women.

Data Sources: MEDLINE, Embase, and the Cochrane Database of Systematic Reviews were searched from database inception to August 2020. Read More

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January 2022

Clinicopathological characteristics and treatment of patients with high-grade endometrial stromal sarcoma: A retrospective study of 40 cases.

Medicine (Baltimore) 2022 Jan;101(2):e28490

Department of Pathology, the Affiliated Hospital Qingdao University, Qingdao, China.

Abstract: To investigate the clinicopathological characteristics of patients with high-grade endometrial stromal sarcoma (HG-ESS).The clinicopathological characteristics, treatments, and prognostic information of consecutive HG-ESS patients were collected from medical records and then evaluated.A total of 40 women were included in the analysis. Read More

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January 2022

Primary low-grade extrauterine endometrial stromal sarcoma: analysis of 10 cases with a review of the literature.

World J Surg Oncol 2022 Jan 13;20(1):17. Epub 2022 Jan 13.

National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Pan Jia Yuan Street, Chao Yang District, Beijing, 100021, China.

Background: This study aimed to analyze the clinical and pathological features of extrauterine endometrial stromal sarcoma (EESS) and explore an effective therapeutic regimen to reduce the recurrence rate in low-grade EESS patients.

Methods: Ten LG-EESS patients who were treated at the Chinese Academy of Medical Sciences Cancer Institute and Hospital from June 1999 to June 2019 were collected and analyzed.

Results: (1) Patient demographics are summarized in manuscript. Read More

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January 2022

Annual report of the Committee on Gynecologic Oncology, the Japan Society of Obstetrics and Gynecology: Annual Patient Report for 2018 and Annual Treatment Report for 2013.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Gynecology and Obstetrics, Tohoku University Graduate School of Medicine, Sendai, Japan.

To provide information including the trend of gynecological malignancies in Japan, we hereby present the Annual Patient Report for 2018 and the Annual Treatment Report for 2013, on the outcomes of patients who started treatment in 2013. The Japan Society of Obstetrics and Gynecology maintains an annual tumor registry, where information on gynecological malignancies from various participating institutions is gathered. The data of patients whose treatment with gynecologic malignancies was initiated in 2018 were analyzed retrospectively. Read More

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January 2022

Short stay laparoscopic hysterectomy: An evaluation of feasibility and patient satisfaction.

Facts Views Vis Obgyn 2021 Dec;13(4):377-385

Background: Short-stay total laparoscopic hysterectomy (TLH) could lead to reduced hospital costs and decrease complications associated with hospitalisation such as hospital acquired-infection and venous thromboembolism.

Objective: To evaluate the feasibility, safety and patient satisfaction of a novel short 'less than 23-hour' stay TLH protocol.

Material And Methods: Prospective cohort study, at Birmingham Women's Hospital, United Kingdom including eligible women undergoing TLH for benign indications or early stage cervical/endometrial cancer. Read More

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December 2021

Epithelial-mesenchymal transition process during embryo implantation.

Cell Tissue Res 2022 Jan 13. Epub 2022 Jan 13.

Laboratory of Molecular Reproduction, Research Institute of Agriculture, Tokai University, Kumamoto, 862-8652, Japan.

The epithelial to mesenchymal transition (EMT) in endometrial epithelial and trophectoderm cells is essential for the progression of embryo implantation and its impairment could cause implantation failure. Therefore, EMT should be tightly regulated in both embryonic and endometrial cells during implantation. Studies reported the involvement of numerous factors in EMT regulation, including hormones, growth factors, transcription factors, microRNAs, aquaporins (AQPs), and ion channels. Read More

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January 2022

Nucleic acids and proteins carried by exosomes of different origins as potential biomarkers for gynecologic cancers.

Mol Ther Oncolytics 2022 Mar 9;24:101-113. Epub 2021 Dec 9.

Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 Xueyuan Xi Road, Wenzhou, Zhejiang 325027, China.

Exosomes are extracellular vesicles with a diameter of 30-150 nm that function in mediating intercellular communication and intercellular material exchange. The liposomal membrane of exosomes protects the cargo carried by exosomes from degradation and assists in transporting cargo to recipient cells to regulate a variety of physiological and pathological processes. The incidence of gynecologic cancers is increasing annually, which is extremely harmful to the lives and health of women because such cancers are challenging to detect at the early stage. Read More

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Predictors of uncommon location of sentinel nodes in endometrial and cervical cancers.

Gynecol Oncol Rep 2022 Feb 26;39:100917. Epub 2021 Dec 26.

Gynecologic Oncology Division, Department of Obstetrics and Gynecology, Meir Medical Center, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objective: Sentinel node mapping is widely used in the treatment of gynecologic cancers. The current study aimed to identify predictors of uncommon sentinel lymph node (SLN) locations.

Methods: The current study included women who were operated for endometrial or cervical cancer with attempted sentinel lymph node mapping during surgical staging. Read More

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February 2022

The accuracy and clinical impact of intraoperative frozen section in determining the extent of surgical intervention in patients with early stage endometrial cancer.

J Obstet Gynaecol 2022 Jan 12:1-8. Epub 2022 Jan 12.

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Beirut, Lebanon.

The aim of this study was to compare intraoperative frozen section (FS) with the final pathology (FP), and determine its clinical impact in clinically apparent early stage endometrial cancer (EC) at the American University of Beirut Medical Center (AUBMC). Data for patients 18 years or older, with clinically apparent early stage, grade 1 or 2, endometrioid EC, who underwent hysterectomy ± lymph node dissection (LND) at AUBMC between January 1 1996 and June 30 2016 were retrospectively reviewed. 70 patients were included. Read More

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January 2022

Chromatin topology defines estradiol-primed progesterone receptor and PAX2 binding in endometrial cancer cells.

Elife 2022 Jan 12;11. Epub 2022 Jan 12.

Biology and Experimental Medicine Institute, Buenos Aires, Argentina.

Estrogen (E2) and Progesterone (Pg), via their specific receptors (ERalpha and PR), are major determinants in the development and progression of endometrial carcinomas, However, their precise mechanism of action and the role of other transcription factors involved are not entirely clear. Using Ishikawa endometrial cancer cells, we report that E2 treatment exposes a set of progestin-dependent PR binding sites which include both E2 and progestin target genes. ChIP-seq results from hormone-treated cells revealed a non-random distribution of PAX2 binding in the vicinity of these estrogen-promoted PR sites. Read More

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January 2022

Distress screening in endometrial cancer leads to disparity in referral to support services.

Gynecol Oncol 2022 Jan 8. Epub 2022 Jan 8.

Division of Gynecologic Oncology, Duke University School of Medicine, DUMC Box 3079, Durham, NC, 27710, USA. Electronic address:

Objectives: Racial disparities in survival from endometrial cancer (EC) are well known. Cancer distress has also been associated with worse clinical outcomes. We characterized the association between race/ethnicity, patient distress reported on the National Comprehensive Cancer Network Distress Thermometer and Problem List (NCCN DT & PL), referral to support services, time to surgery, and acceptance of adjuvant therapy in patients with EC. Read More

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January 2022

Urinary Phytoestrogen Levels Are Associated with Female Hormonal Cancers: An Analysis of NHANES Data From 1999 to 2010.

Nutr Cancer 2022 Jan 11:1-9. Epub 2022 Jan 11.

Department of Public Health, California State University, Fullerton, Fullerton, CA.

Phytoestrogens are plant-derived compounds that are structurally similar to endogenous estrogens. Studies have shown phytoestrogens to have possible health benefits although they could also act as endocrine disruptors. This is particularly relevant for estrogen-dependent cancers since estrogens increase risk of breast, endometrial, and ovarian cancer. Read More

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January 2022

Clinicopathologic characteristics and risk factors for endometrial malignancy in postmenopausal women with endometrial thickening.

Menopause 2022 Jan 10. Epub 2022 Jan 10.

Department of Obstetrics and Gynecology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objective: To evaluate the clinicopathological characteristics and risk factors for endometrial malignancy in postmenopausal women with endometrial thickening.

Methods: This was a retrospective study. Postmenopausal women with endometrial thickening (defined as the thickest endometrial portion in the sagittal uterine plane was greater than or equal to 5 mm) through transvaginal ultrasound in our outpatient department, and further referred to the gynecology department at Xuanwu Hospital for hysteroscopic diagnostic curettage assessment between January 2018 and March 2021 were included. Read More

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January 2022

Update on hormone therapy for the management of postmenopausal women.

Biosci Trends 2022 Jan 10. Epub 2022 Jan 10.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Hormone therapy (HT) has been used in postmenopausal women for decades in clinical practice. With further analysis and newer studies, the benefits and risks of HT have been repeatedly verified and discussed. HT is recommended for the treatment of vasomotor symptoms (VMS), genitourinary syndrome of menopause (GSM) and the prevention of osteoporosis. Read More

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January 2022

Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer.

Genome Med 2022 Jan 10;14(1). Epub 2022 Jan 10.

School of Biomedical Sciences, Queensland University of Technology located at the Translational Research Institute, Brisbane, QLD, Australia.

Background: Endometrial cancer (EC) is a major gynecological cancer with increasing incidence. It comprises four molecular subtypes with differing etiology, prognoses, and responses to chemotherapy. In the future, clinical trials testing new single agents or combination therapies will be targeted to the molecular subtype most likely to respond. Read More

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January 2022

Circulating inflammatory cytokines and risk of five cancers: a Mendelian randomization analysis.

BMC Med 2022 Jan 11;20(1). Epub 2022 Jan 11.

Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland.

Background: Epidemiological and experimental evidence has linked chronic inflammation to cancer aetiology. It is unclear whether associations for specific inflammatory biomarkers are causal or due to bias. In order to examine whether altered genetically predicted concentration of circulating cytokines are associated with cancer development, we performed a two-sample Mendelian randomisation (MR) analysis. Read More

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January 2022

Contemporary Fertility-Sparing Management Options of Early Stage Endometrioid Endometrial Cancer in Young Nulliparous Patients.

J Clin Med 2021 Dec 30;11(1). Epub 2021 Dec 30.

Department of Medicine, School of Medicine, Nazarbayev University, Nur-Sultan 010000, Kazakhstan.

Incidence of endometrial cancer (EC) has been increasing in recent years, especially in high-income countries. The disease commonly affects peri- and postmenopausal women; however, about 5% of women are diagnosed with EC in their reproductive age. Due to both the increasing incidence of EC among reproductive age women and trends to delayed childbearing, fertility-sparing treatment for young patients with EC has become extremely important for researchers and practitioners. Read More

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December 2021

Conservative Surgery in Endometrial Cancer.

J Clin Med 2021 Dec 29;11(1). Epub 2021 Dec 29.

Department of Public Health, School of Medicine, University of Naples Federico II, 80131 Naples, Italy.

Endometrial cancer (EC) is the sixth most common female cancer worldwide. The median age of diagnosis is 65 years. However, 4% of women diagnosed with EC are younger than 40 years old, and 70% of these women are nulliparous. Read More

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December 2021

Multiple Primary Malignancies in Patients with Gynecologic Cancer.

J Clin Med 2021 Dec 26;11(1). Epub 2021 Dec 26.

Department of Obstetrics and Gynecology, KonKuk University Hospital, Seoul 05030, Korea.

Objective: To investigate the prevalence and oncologic outcomes of patients with multiple primary malignant tumors (MPMT) with gynecologic cancer.

Methods: This retrospective study included 1929 patients diagnosed with gynecologic cancer at a tertiary medical center between August 2005 and April 2021. The clinical data included cancer location, age at primary malignancy diagnosis, interval between primary and secondary cancer, stage of cancer, family history of cancer, genetic testing, dates of last follow-up, recurrence, and death. Read More

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December 2021

Essentiality of Trace Elements in Pregnancy, Fertility, and Gynecologic Cancers-A State-of-the-Art Review.

Nutrients 2021 Dec 31;14(1). Epub 2021 Dec 31.

Chair and Department of Anatomy, Medical University of Lublin, ul. Jaczewskiego 4, 20-090 Lublin, Poland.

Gynecological neoplasms pose a serious threat to women's health. It is estimated that in 2020, there were nearly 1.3 million new cases worldwide, from which almost 50% ended in death. Read More

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December 2021

Metabolic Activity of Visceral Adipose Tissue Is Associated with Metastatic Status of Lymph Nodes in Endometrial Cancer: A F-FDG PET/CT Study.

Int J Environ Res Public Health 2021 Dec 22;19(1). Epub 2021 Dec 22.

Department of Nuclear Medicine, Korea University Anam Hospital, Seoul 02841, Korea.

Obesity contributes to increased cancer incidence and aggressiveness in patients with endometrial cancer. Inflamed metabolic activity of visceral adipose tissue (VAT) is regarded as a key underlying mechanism of adverse consequences of obesity. The aim of this study was to investigate the association between inflammatory metabolic activity of VAT evaluated by F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) and metastatic status of lymph nodes (LN) in patients with endometrial cancer. Read More

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December 2021

Palmitate Enhances the Efficacy of Cisplatin and Doxorubicin against Human Endometrial Carcinoma Cells.

Int J Mol Sci 2021 Dec 22;23(1). Epub 2021 Dec 22.

Graduate Institute of Life Sciences, National Defense Medical Center, Taipei City 114, Taiwan.

Endometrial cancer is the most common gynecological cancer worldwide. At present there is no effective screening test for its early detection and no curative treatment for women with advanced-stage or recurrent disease. Overexpression of fatty acid synthase is a common molecular feature of a subgroup of sex steroid-related cancers associated with poor prognoses, including endometrial cancers. Read More

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December 2021

Understanding the Role and Clinical Applications of Exosomes in Gynecologic Malignancies: A Review of the Current Literature.

Cancers (Basel) 2021 Dec 29;14(1). Epub 2021 Dec 29.

Sylvester Comprehensive Cancer Center, Division of Gynecologic Oncology, University of Miami, Miami, FL 33136, USA.

Background: Gynecologic malignancies are those which arise in the female reproductive organs of the ovaries, cervix, and uterus. They carry a great deal of morbidity and mortality for patients, largely due to challenges in diagnosis and treatment of these cancers. Although advances in technology and understanding of these diseases have greatly improved diagnosis, treatment, and ultimately survival for patients with gynecologic malignancies over the last few decades, there is still room for improvements in diagnosis and treatment, for which exosomes may be the key. Read More

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December 2021

Does an Endometrial Cancer Diagnosis among Asymptomatic Patients Improve Prognosis?

Cancers (Basel) 2021 Dec 27;14(1). Epub 2021 Dec 27.

Department of Gynecology and Obstetrics, University Hospital Brno and Faculty of Medicine, Masaryk University, 60200 Brno, Czech Republic.

Background: Endometrial cancer is the most common gynecological malignancy in developed countries with no screening available. There is still a tendency to provide invasive bioptic verification in asymptomatic women with abnormal ultrasound findings to diagnose carcinoma in a preclinical phase; even though, it is not supported by European guidelines. Our goal was to determine DFS (disease-free survival), OS (overall survival), and DSS (disease-specific survival) differences between symptom-free and symptomatic (bleeding, or spotting) endometrial cancer patients with similar stage and tumor/clinical characteristics. Read More

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December 2021

Prognostic Role of the Removed Vaginal Cuff and Its Correlation with L1CAM in Low-Risk Endometrial Adenocarcinoma.

Cancers (Basel) 2021 Dec 22;14(1). Epub 2021 Dec 22.

Dipartimento Scienze della Salute della Donna, del Bambino, e di Sanità Pubblica, Ginecologia Oncologica, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.

Objective: The aim of our study was to investigate the role of the excised vaginal cuff length as a prognostic factor in terms of DFS and recurrence rate/site, in low-risk endometrial cancer (EC) patients. Moreover, we correlated the recurrence with the expression of L1CAM.

Material And Methods: From March 2001 to November 2016, a retrospective data collection was conducted of women undergoing surgical treatment for low-risk EC according to ESMO-ESGO-ESTRO consensus guidelines. Read More

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December 2021

Pregnancy-specific glycoproteins: evolution, expression, functions, and disease associations.

Reproduction 2022 Jan 1. Epub 2022 Jan 1.

G Dveksler, Pathology, Uniformed Services University of the Health Sciences, Bethesda, 20814-4712, United States.

Pregnancy-specific glycoproteins (PSGs) are members of the immunoglobulin superfamily and are closely related to the predominantly membrane-bound CEACAM proteins. PSGs are produced by placental trophoblasts and secreted into the maternal bloodstream at high levels where they may regulate maternal immune and vascular functions through receptor binding and modulation of cytokine and chemokine expression and activity. PSGs may have autocrine and paracrine functions in the placental bed, and PSGs can activate soluble and extracellular matrix bound TGF-β, with potentially diverse effects on multiple cell types. Read More

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January 2022

Patient experiences of conservative treatment for early stage endometrial cancer and endometrial hyperplasia with atypia using levonorgestrel intrauterine device: A qualitative study.

Gynecol Oncol Rep 2022 Feb 22;39:100914. Epub 2021 Dec 22.

Queensland Centre for Gynaecological Cancer, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.

Objective: The aim of the study was to obtain an in-depth understanding of the experience of women who received non-surgical treatment for endometrial adenocarcinoma (EAC) or endometrial hyperplasia with atypia (EHA). Enhanced understanding of women's experiences of non-surgical treatment is essential to inform counselling of the growing number of patients in this field.

Methods: Individual semi-structured interviews were conducted with 21 women who received conservative (non-surgical hormonal) treatment for early stage EAC or EHA using the levonorgestrel intrauterine device (LNG-IUD) as part of the feMMe trial (NCT01686126). Read More

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February 2022