1,070,647 results match your criteria endocrine disorders


Thyroid disorders and cardiovascular manifestations: an update.

Endocrine 2022 Jan 15. Epub 2022 Jan 15.

3rd Department of Cardiology, Sotiria Chest Disease Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Cardiovascular disease (CVD) remains the leading cause of death worldwide, representing a major health, social, and economic issue. Thyroid disorders are very common and affect >10% of the adult population in total. The aim of this review is to describe the physiologic role of thyroid hormones on cardiovascular system, to present cardiovascular manifestations in patients with thyroid disorders, emphasizing in molecular mechanisms and biochemical pathways, and to summarize current knowledge of treatment options. Read More

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January 2022

Psychological intervention in women with Mayer-Rokitansky-Küster-Hauser syndrome after artificial vaginoplasty: a prospective study.

Int Urogynecol J 2022 Jan 14. Epub 2022 Jan 14.

Obstetrics and Gynecology Hospital, Fudan University, Huangpu District, Fangxie Road 419, Shanghai, 200011, China.

Introduction And Hypothesis: The negative psychological impact on women with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is long-lasting, resulting from not only the disease itself, but also the cumbersome and painful treatment process. However, little is known about the postoperative psychological status of these patients and related interventions to improve mental health. Here, in our study, we postulated that mental disorders exist in MRKH patients with a surgical neovagina and that psychological intervention will be helpful. Read More

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January 2022

Effect of high dose vitamin D supplementation on indices of sarcopenia and obesity assessed by DXA among older adults: A randomized controlled trial.

Endocrine 2022 Jan 14. Epub 2022 Jan 14.

Department of Internal Medicine, Division of Endocrinology, Calcium Metabolism and Osteoporosis Program, WHO Collaborating Center for Metabolic Bone Disorders, American University of Beirut Medical Center, Beirut, Lebanon.

Background: Hypovitaminosis D is associated with Sarcopenic Obesity (SO), but evidence from randomized Vitamin D 3 (VD3) trials is scarce.

Objective: Compare the effect of VD3 supplementation, at two doses, on SO indices at 12 months.

Methods: Overweight older adults (>65 years) with baseline 25-hydroxyvitamin D (25OHD) of 10-30 ng/mL were recruited in this double-blind, randomized, controlled multicenter trial (clinicaltrial. Read More

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January 2022

Art of prevention: The importance of dermatologic care when using aromatase inhibitors.

Int J Womens Dermatol 2021 Dec 17;7(5Part B):769-773. Epub 2021 Jul 17.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.

As of January 2021, there are more than 3.8 million women in the United States with a history of breast cancer. The current standard of care for breast cancer involves surgical resection, radiation therapy, adjuvant endocrine therapy, and/or adjuvant chemotherapy. Read More

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December 2021

Leptin hormone and its effectiveness in reproduction, metabolism, immunity, diabetes, hopes and ambitions.

J Med Life 2021 Sep-Oct;14(5):600-605

Department of Family Medicine, University of Baghdad, Baghdad, Iraq.

Leptin is a hormone derived from adipose tissue and the small intestine, mainly in enterocytes; it helps regulate the energy balance by suppressing hunger, resulting in decreased fat mass in adipocytes. Leptin has specific receptors in the ventromedial and arcuate nuclei and other parts of the hypothalamus and the feeding center in the ventral tegmental area. It also plays a role in regulatory aspects other than fat cells, such as obesity, which is linked to a loss of sensitivity of leptin receptors, resulting in an inability to produce satiety and an increase in food intake. Read More

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Differential expression profiles and function prediction of tRNA-derived fragments in fibrous dysplasia.

Arch Oral Biol 2022 Jan 7;135:105347. Epub 2022 Jan 7.

Jiangsu Province Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing 210029, China; Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing 210029, China; Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China. Electronic address:

Objective: Fibrous dysplasia (FD) is a bone disease featuring that normal bone matrix is replaced by fibrous tissue and immature bone tissue. Transfer RNA-derived RNA fragments (tRFs) and tRNA halves (tiRNAs) are types of small non-coding RNA that produced by specific shearing of mature tRNA. Here, we conducted a comparative analysis of the expression of tRFs/tiRNAs in BMSCs and FD BMSCs. Read More

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January 2022

Multi modular toxicity assessment of nephrotoxicity in podophyllotoxin exposure rats on account of toxicological evidence chain (TEC) concept.

Ecotoxicol Environ Saf 2022 Jan 10;231:113157. Epub 2022 Jan 10.

School of Chinese Materia Medica, Beijing University of Chinese Medicine, Fangshan District, Beijing 102488, China. Electronic address:

Early diagnosis of kidney injuries caused by herbs is necessary to enable effective treatments, prevent kidney failure and promote the internationalization and modernization of herbal medicine. Whereas the toxic assessment evidence has not integrated yet, and the evaluation method has not been unanimously agreed. For example, the gold standard assessing toxicity in animals remains to be histopathology, but serum biochemical indexes are the primary measures for monitoring organs dysfunction in humans. Read More

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January 2022

Eradicating Racism: An Endocrine Society Policy Perspective.

J Clin Endocrinol Metab 2022 Jan 13. Epub 2022 Jan 13.

The Ohio State University College of Medicine, Division of Endocrinology, Diabetes and Metabolism, Columbus, Ohio 43210, USA.

The Endocrine Society recognizes racism as a root cause of the health disparities that affect racial/ethnic minority communities in the United States and throughout the world. In this policy perspective, we review the sources and impact of racism on endocrine health disparities and propose interventions aimed at promoting an equitable, diverse, and just healthcare system. Racism in the healthcare system perpetuates health disparities through unequal access and quality of health services, inadequate representation of health professionals from racial/ethnic minority groups, and the propagation of the erroneous belief that socially constructed racial/ethnic groups constitute genetically and biologically distinct populations. Read More

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January 2022

A retroperitoneal bronchogenic cyst clinically mimicking an adrenal mass: three case reports and a literature review.

J Int Med Res 2022 Jan;50(1):3000605211072664

Department of Radiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China.

Bronchogenic cysts are a congenital primitive foregut-derived developmental malformation, generally occurring in the posterior mediastinum. Their development in the retroperitoneum is extremely rare. Imaging techniques, such as multidetector computed tomography (MDCT), are typically effective in the detection of these lesions. Read More

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January 2022

Interleukin-17 and vascular endothelial growth factor: new biomarkers for the diagnosis of papillary thyroid carcinoma in patients with Hashimoto's thyroiditis.

J Int Med Res 2022 Jan;50(1):3000605211067121

Department of Ultrasonography, Longyan First Affiliated Hospital of Fujian Medical University, Longyan 364000, China.

Objective: The incidences of papillary thyroid carcinoma (PTC) and Hashimoto's thyroiditis (HT) have shown increasing trends. Numerous studies have shown a close relationship between the two diseases, but the exact mechanism linking PTC with HT is still unclear. Interleukin-17 (IL-17) plays an important role in the development of malignant tumors. Read More

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January 2022

Associations between immune-related thyroid dysfunction and efficacy of immune checkpoint inhibitors: a systematic review and meta-analysis.

Cancer Immunol Immunother 2022 Jan 13. Epub 2022 Jan 13.

Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Ave, RFB-2, Boston, MA, 02115, USA.

Background: There is growing evidence suggesting that the occurrence of immune-related adverse events (irAEs) may be a predictor of immune checkpoint inhibitor efficacy. Whether this association extends to all irAEs or just those within particular organs/systems is yet to be resolved. As immune-related thyroid dysfunction (thyroid irAE) is one of the most commonly reported irAEs, this study aims to summarize the available data and determine if thyroid irAE is a surrogate marker for improved cancer outcomes during ICI therapy. Read More

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January 2022

The effect of wet-cupping therapy (hijama) in modulating autoimmune activity of Hashimoto's thyroiditis: A pilot controlled study.

Saudi Med J 2022 Jan;43(1):45-52

From the Department of YAJ chair for Prophetic medical applications (Obeid, Alsayyad), Cupping Therapy Clinics; from the Department of Hematology (Aljaouni), Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, from the Department of Medicine (Qari); from the Department of Physiology (Rohaiem); From the Faculty of Medicine (Alsayyad), King Abdulaziz University, Jeddah, from the Department of Communicable Diseases Prevention and Control (Okmi), Public Health Authority, Riyadh, Kingdom of Saudi Arabia, and from the Department of Radiology (Elsayed), The Royal Wolverhampton Trust, New Cross Hospital, London, United Kingdom.

Objectives: To investigate the possible effects of wet-cupping therapy (hijama) on autoimmune activity and thyroid hormonal profiles of Hashimoto's disease (HD) patients.

Methods: A prospective pilot controlled trial was carried out among adult females following HD at the Endocrinology Clinic of King Abdulaziz University Hospital, Jeddah, Saudi Arabia, from February 2014 until March 2017. A total of 13 patients (intervention group) underwent 3 hijama sessions at 3-week interval with a 6-month follow-up. Read More

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January 2022

Relationship between housing insecurity, diabetes processes of care, and self-care behaviors.

BMC Health Serv Res 2022 Jan 13;22(1):61. Epub 2022 Jan 13.

Division of General Internal Medicine, Department of Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd., WI, 53226-3596, Milwaukee, USA.

Background: The aim of this analysis was to examine the influence of housing insecurity on diabetes processes of care and self-care behaviors and determine if that relationship varied by employment status or race/ethnicity.

Methods: Using nationally representative data from the Behavioral Risk Factor Surveillance System (2014-2015), 16,091 individuals were analyzed for the cross-sectional study. Housing insecurity was defined as how often respondents reported being worried or stressed about having enough money to pay rent/mortgage. Read More

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January 2022

The impact of bisphenol a (BPA) on the placenta.

Biol Reprod 2022 Jan 8. Epub 2022 Jan 8.

Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011, USA.

Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that is used in a wide-variety of plastic and common house-hold items. Therefore, there is potential continual exposure to this compound. BPA exposure has been linked to certain placenta-associated obstetric complications such as preeclampsia, fetal growth restriction, miscarriage, and preterm birth. Read More

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January 2022

Clinical significance of gene polymorphisms for hereditary predisposition to breast and ovarian cancer (review of literature).

Klin Lab Diagn 2021 Dec;66(12):760-767

Medical Academy named after S.I. Georgievsky of Vernadsky CFU.

The review presents classical and modern views on the molecular genetic causes underlying hereditary predisposition to breast and ovarian cancer. A computerized literature search was carried out in the electronic databases MEDLINE, Scopus, and Web of Science, published between January 1994 and May 2021, using the keywords: «hereditary breast and ovarian cancer», «BRCA» and «DNA repair». Current views on the role of germline mutations in genes for susceptibility to breast cancer (BC): BRCA1, BRCA2, PALB2, TP53, CHEK2, PTEN, ATM, and PPM1D are presented. Read More

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December 2021

Chronic vomiting: Rare causes not to be missed.

Indian J Gastroenterol 2022 Jan 12. Epub 2022 Jan 12.

Department of Medical Gastroenterology, Dr. Rela Institute and Medical Center, No. 7 CLC Works Road, Chromepet, Chennai, 600 044, India.

Establishing the cause of vomiting can be challenging in 10% of patients. In such situations, the clinicians need to consider non-gastrointestinal causes including metabolic and endocrine disorders. Clinical and laboratory clues may prompt further relevant tests that will lead to the correct diagnosis. Read More

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January 2022

[Bilateral adrenal incidentaloma in a patient with acute appendicitis].

Rev Med Inst Mex Seguro Soc 2021 Aug 2;59(4):352-357. Epub 2021 Aug 2.

Hospital Nacional Edgardo Rebagliati Martins, Servicio de Endocrinología. Lima, Perú.

Background: Adrenal incidentalomas are tumors that are usually detected in imaging studies indicated without suspicion of adrenal disease. Pheochromocytoma is a neuroendocrine tumor that can occur sporadically or associated with genetic syndromes, having been described in 0.1-5% of patients with type 1 neurofibromatosis, which is a progressive multisystemic disease of autosomal dominant inheritance that affects 1 / 2600-3000 individuals . Read More

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Monitoring of blood glucose levels, ketones and insulin bolus advice using 4SURE products and app-based technology.

Authors:
Paula Johnston

Br J Nurs 2022 Jan;31(1):34-39

Lead Diabetes Specialist Nurse, University Hospital Southampton and RCN Diabetes forum committee member and Diabetes Inpatient Specialist Nurse forum committee member.

With more people being diagnosed with diabetes and requiring insulin therapy as they live longer, an increasing number of individuals are needing access to blood and ketone monitoring that is simple to use and provides accurate results. Having access to a bolus advisor is equally important in order for people with diabetes to calculate accurate insulin doses based on the foods that they are eating. The use of app-based technology for healthcare purposes has increased over recent years and now includes the Diabetes:M application that can be used in conjunction with the 4SURE smart meters with no additional cost to the individual. Read More

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January 2022

IS THE WAIST/HEIGHT RATIO A BETTER PARAMETER THAN BMI IN DETERMINING THE CARDIOMETABOLIC RISK PROFILE OF OBESE PEOPLE?

Arq Bras Cir Dig 2022 5;34(3):e1610. Epub 2022 Jan 5.

Mackenzie Evangelical Faculty of Paraná, Curitiba, PR, Brazil.

Background: The increased prevalence of obesity has led to a significant increase in the occurrence of metabolic syndrome, a recognized risk factor for increased morbidity and mortality from cardiovascular diseases. Hyperglycemia or type 2 diabetes mellitus, dyslipidemia and arterial hypertension are its main components. Since 2015, international guidelines have recognized the benefits of bariatric surgery in each isolated factor of this syndrome. Read More

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January 2022

Association of blood groups/Rh and diabetes mellitus in Karachi city, Pakistan.

Braz J Biol 2022 7;84:e252952. Epub 2022 Jan 7.

Federal Urdu University of Arts, Science, and Technology, Department of Zoology, Gulshan -e-Iqbal, Karachi, Pakistan.

The main purpose of this study was to find out a possible association between ABO blood groups or Rh and diabetes mellitus (DM) in the local population of eight (8) different towns of Karachi, Pakistan. For this purpose a survey was carried out in Karachi to have a practical observation of these towns during the period of 9 months from June 2019 to Feb. 2020. Read More

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January 2022

The potential impact of COVID-19 and diabetes on intervertebral disc degeneration.

Einstein (Sao Paulo) 2022;19:eCE6911. Epub 2022 Jan 5.

Universidade Federal de São Paulo, São Paulo, SP, Brazil.

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January 2022

Importance of Primary Healthcare in prognosis of individuals with diabetes mellitus and/or hypertension.

Einstein (Sao Paulo) 2022;19:eCE6773. Epub 2022 Jan 5.

Centro Universitário Alfredo Nasser, Goiânia, GO, Brazil.

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January 2022

Sport-Related Concussion Preceding Adrenal Insufficiency and Hypopituitarism.

Curr Sports Med Rep 2022 Jan;21(1):15-17

Department of Neurosurgery, University of North Carolina, NC.

Abstract: A 49-year-old woman with a history of daily inhaled corticosteroid use for asthma presented to a concussion clinic 7 wk after sport-related head injury with headache, visual blurring, dizziness, nausea, fatigue, polydipsia, and polyuria. Examination revealed difficulty with vestibulo-occulomotor testing due to nausea and visual straining. Cranial CT/MR imaging was unremarkable. Read More

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January 2022

[On the anniversary of Galina A. Melnichenko, Academician of the Russian Academy of Sciences].

Probl Endokrinol (Mosk) 2021 Dec 15;67(6):4-5. Epub 2021 Dec 15.

Endocrinology Research Centre, Moscow, Russian Federation.

Galina A. Melnichenko is a famous Russian scientist-endocrinologist, one of the leading in the country, author and head of fundamental and applied research. G. Read More

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December 2021

Assessment of diabetes self-management amongst Nigerians using the diabetes self-management questionnaire: a cross-sectional study.

Pan Afr Med J 2021 24;40:178. Epub 2021 Nov 24.

Department of Internal Medicine, University of Benin Teaching Hospital, Benin City, Nigeria.

Introduction: self-management is probably the most important factor contributing to achieving euglycaemia. The Diabetes Self-Management Questionnaire (DSMQ) is an instrument that shows favourable prospects compared to older measures. This study aimed to investigate the association between self-management and glycaemic control using the DSMQ, and determine factors that affect glycaemic control in patients living with diabetes mellitus. Read More

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January 2022

Association between hyperuricemia and glycated hemoglobin in type 2 diabetes at the District Hospital of Dschang.

Pan Afr Med J 2021 22;40:177. Epub 2021 Nov 22.

University of Dschang, Dschang, Cameroon.

Introduction: given the difficulty to obtain glycemic control in type 2 diabetes, the exploration of others pathophysiological hypotheses could improve the understanding of this phenomenon. We conducted this study to search for an association between uric acid and uncontrolled diabetes.

Methods: it was a cross-sectional study in a population of type 2 diabetes with normal postprandial and fast blood sugar for the last three months at the District Hospital of Dschang. Read More

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January 2022

Benign multicystic peritoneal mesothelioma in a postmenopausal woman complicated with an ovarian cyst: a case report.

Pan Afr Med J 2021 19;40:171. Epub 2021 Nov 19.

Department of Obstetrics and Gynecology, University Hospital of Larissa, Larissa, Thessaly, Greece.

Benign multicystic peritoneal mesothelioma is a rare cystic neoplasm, characterized by subtle symptoms, that occurs predominantly in reproductive-aged women. The pathogenesis and etiology of the disease are yet to be determined. We herein present a 71-year-old woman presented to our clinic with persistent low back pain. Read More

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January 2022

Predictive role of neutropenia under crizotinib treatment in ALK-rearranged nonsmall cell lung cancer patients: A single-institution retrospective analysis.

Indian J Cancer 2021 Sep 30. Epub 2021 Sep 30.

Department of Medical Oncology, Ege University School of Medicine, Tulay Aktas Oncology Hospital, Izmir, Turkey.

Background: Anaplastic lymphoma kinase (ALK)-rearranged nonsmall cell lung cancer (NSCLC) represents a molecular subgroup with high sensitivity to ALK inhibitors. Tyrosine kinase inhibitor crizotinib, an anticancer drug acting as an ALK inhibitor, has shown remarkable response in ALK-positive NSCLC. The aim of our study is to explore the adverse events (AEs) of patients on crizotinib therapy and analyze the predictability of AEs for better survival or response on NSCLC patients. Read More

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September 2021

Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.

BMC Med 2022 Jan 12;20(1). Epub 2022 Jan 12.

Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Background: Genetic and lifestyle factors have considerable effects on obesity and related diseases, yet their effects in a clinical cohort are unknown. This study in a patient biobank examined associations of a BMI polygenic risk score (PRS), and its interactions with lifestyle risk factors, with clinically measured BMI and clinical phenotypes.

Methods: The Mass General Brigham (MGB) Biobank is a hospital-based cohort with electronic health record, genetic, and lifestyle data. Read More

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January 2022

Development and validation of the diagnostic scale of traditional Chinese medicine syndrome elements for diabetic kidney disease.

Ann Palliat Med 2021 Dec;10(12):12291-12299

Department of Endocrinology and Nephrology, Renal Research Institute of Beijing University of Chinese Medicine, Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, Beijing, China.

Background: To construct a traditional Chinese medicine (TCM) syndrome elements diagnostic scale for diabetic kidney disease (DKD).

Methods: A total of 492 DKD patients were included in the study. TCM symptoms, signs and tongue manifestation information of the patients were collected, which constituted the items of the TCM syndrome elements diagnostic scale. Read More

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December 2021