603,271 results match your criteria endocrine


Disorders of Puberty in Girls.

Semin Reprod Med 2021 Sep 24. Epub 2021 Sep 24.

Division of Endocrinology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Puberty is the process through which reproductive competence is achieved and comprises gonadarche and adrenarche. Breast development is the initial physical finding of pubertal onset in girls and typically occurs between 8 and 13 years. Menarche normally occurs 2 to 3 years after the onset of breast development. Read More

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September 2021

Metastatic Patterns of Duodenopancreatic Neuroendocrine Tumors in Patients With Multiple Endocrine Neoplasia Type 1.

Am J Surg Pathol 2021 Sep 23. Epub 2021 Sep 23.

Department of Pathology, University Medical Center Utrecht, Utrecht University Department of Endocrine Surgical Oncology, University Medical Center Utrecht Department of Endocrine Oncology, University Medical Center Utrecht Cancer Center, Utrecht Department of Endocrinology and Internal Medicine, Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Patients with multiple endocrine neoplasia 1 syndrome (MEN1) often develop multifocal duodenopancreatic neuroendocrine tumors (dpNETs). Nonfunctional pancreatic neuroendocrine tumors (PanNETs) and duodenal gastrinomas are the most frequent origins of metastasis. Current guidelines recommend surgery based on tumor functionality, size ≥2 cm, grade or presence of lymph node metastases. Read More

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September 2021

Dose to neuroanatomical structures surrounding pituitary adenomas and the effect of stereotactic radiosurgery on neuroendocrine function: an international multicenter study.

J Neurosurg 2021 Sep 24:1-9. Epub 2021 Sep 24.

20Centro Gamma Knife Dominicano and Radiology Department, CEDIMAT, Santo Domingo, Dominican Republic.

Objective: Stereotactic radiosurgery (SRS) provides a safe and effective therapeutic modality for patients with pituitary adenomas. The mechanism of delayed endocrine deficits based on targeted radiation to the hypothalamic-pituitary axis remains unclear. Radiation to normal neuroendocrine structures likely plays a role in delayed hypopituitarism after SRS. Read More

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September 2021

[Environmental endocrine disruptors and fertility.]

Gynecol Obstet Fertil Senol 2021 Sep 21. Epub 2021 Sep 21.

Univ Montpellier, INSERM 1203, Développement Embryonnaire Fertilité Environnement, Montpellier, France; CHU Montpellier, Univ Montpellier, Département de Biologie de la Reproduction, Biologie de la Reproduction/DPI et CECOS, Montpellier, France. Electronic address:

Endocrine disruptor chemicals (EDCs) are ubiquitous contaminants in the environment, wildlife, and humans. During the last 20 years, several epidemiological, clinical and experimental studies have demonstrated the role of EDCs on the reduction of male and female fertility. The concept of foetal origins of adult disease is particularly topical in the field of reproduction. Read More

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September 2021

Dose-dependent toxicological effects in rats following a 90-day dietary exposure to PCB-156 include retinoid disruption.

Reprod Toxicol 2021 Sep 21. Epub 2021 Sep 21.

Unit of Integrative Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

The toxicity of PCB-156 (2,3,3',4,4',5-hexachlorobiphenyl) was investigated in rats following subchronic dietary exposure. Groups of 10 male and female Sprague-Dawley rats were administered PCB-156 in the diet at 0, 0.01, 0. Read More

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September 2021

The poorly conducted orchestra of steroid hormones, oxidative stress and inflammation in frailty needs a maestro: Regular physical exercise.

Exp Gerontol 2021 Sep 21:111562. Epub 2021 Sep 21.

Health Sciences Research Unit: Nursing (UICISA: E), Nursing School of Coimbra (ESEnfC), Coimbra, Portugal; Institute Polytechnic of Maia, Porto, Portugal; University of Coimbra, Research Unit for Sport and Physical Activity (CIDAF, UID/PTD/04213/2019) at Faculty of Sport Science and Physical Education, (FCDEF-UC), Portugal. Electronic address:

This review outlines the various factors associated with unhealthy aging which includes becoming frail and dependent. With many people not engaging in recommended exercise, facilitators and barriers to engage with exercise must be investigated to promote exercise uptake and adherence over the lifespan for different demographics, including the old, less affluent, women, and those with different cultural-ethnic backgrounds. Governmental and locally funded public health messages and environmental facilitation (gyms, parks etc. Read More

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September 2021

A Common Endocrine Signature Marks the Convergent Evolution of an Elaborate Dance Display in Frogs.

Am Nat 2021 Oct 31;198(4):522-539. Epub 2021 Aug 31.

AbstractUnrelated species often evolve similar phenotypic solutions to the same environmental problem, a phenomenon known as convergent evolution. But how do these common traits arise? We address this question from a physiological perspective by assessing how convergence of an elaborate gestural display in frogs (foot-flagging) is linked to changes in the androgenic hormone systems that underlie it. We show that the emergence of this rare display in unrelated anuran taxa is marked by a robust increase in the expression of androgen receptor (AR) messenger RNA in the musculature that actuates leg and foot movements, but we find no evidence of changes in the abundance of AR expression in these frogs' central nervous systems. Read More

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October 2021

Degradation of Adsorbed Bisphenol A by Soluble Mn(III).

Environ Sci Technol 2021 Sep 24. Epub 2021 Sep 24.

Department of Civil and Environmental Engineering, University of Tennessee, Knoxville, Tennessee 37996, United States.

Bisphenol A (BPA), a high production volume chemical and potential endocrine disruptor, is found to be associated with sediments and soils due to its hydrophobicity (log of 3.42). We used superfine powdered activated carbon (SPAC) with a particle size of 1. Read More

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September 2021

Obesity and endocrine therapy resistance in breast cancer: Mechanistic insights and perspectives.

Obes Rev 2021 Sep 24:e13358. Epub 2021 Sep 24.

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata di Rende, Cosenza, Italy.

The incidence of obesity, a recognized risk factor for various metabolic and chronic diseases, including numerous types of cancers, has risen dramatically over the recent decades worldwide. To date, convincing research in this area has painted a complex picture about the adverse impact of high body adiposity on breast cancer onset and progression. However, an emerging but overlooked issue of clinical significance is the limited efficacy of the conventional endocrine therapies with selective estrogen receptor modulators (SERMs) or degraders (SERDs) and aromatase inhibitors (AIs) in patients affected by breast cancer and obesity. Read More

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September 2021

Clinical aspects of SARS-CoV-2 infection and vitamin D : COVID-19 and the endocrine system: special issue for reviews in endocrine and metabolic disorders (Felipe Casaneuva, Editor in Chief) A. Giustina and JP Bilezikian, Guest Editors.

Rev Endocr Metab Disord 2021 Sep 24. Epub 2021 Sep 24.

School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.

In December 2019, the first cases of severe acute respiratory syndrome due to a new coronavirus (SARS-Cov-2), later designated as Covid-19, were described in China. With rapid advance of the infection to several continents, in March 2020, WHO declared this to be a pandemic. In April 2020, the first papers suggesting a possible role of Vitamin D deficiency in the severity of this infection began to appear and dozens of articles evaluating a potential relationship of vitamin D with COVID have emerged subsequntly. Read More

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September 2021

Different management of adrenocortical carcinoma in children compared to adults: is it time to share guidelines?

Endocrine 2021 Sep 24. Epub 2021 Sep 24.

Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia at ASST Spedali Civili, Brescia, Italy.

Pediatric and adult adrenocortical carcinomas differ in many respects but treatment is often similar in both age groups. The Journal of Clinical Oncology recently published the results of a risk-stratified single-arm interventional trial conducted by the Children's Oncology Group in which 77 patients were treated in three different interventional cohorts. In this Point of View paper we comment on the treatment strategies adopted within the ARAR0332 trial in terms of surgery approach, duration of adjuvant therapies, and palliative chemotherapy. Read More

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September 2021

High-dose interleukin-2 therapy related adverse events and implications on imaging.

Diagn Interv Radiol 2021 Sep;27(5):684-689

Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, USA;Department of Radiology, Ege University Faculty of Medicine, Izmir, Turkey.

High-dose interleukin-2 (HDIL-2) therapy was initially approved by the U.S. Food and Drug Administration for metastatic renal cell carcinoma (mRCC) and metastatic melanoma. Read More

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September 2021

Systemic Lupus Erythematosus is a Risk Factor for Mortality in Elderly Patients with Early Breast Cancer.

Arthritis Care Res (Hoboken) 2021 Sep 24. Epub 2021 Sep 24.

Department of Health Services Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Objective: Cancer patients with systemic lupus erythematosus (SLE) may have worse outcomes than those without SLE, given their comorbidities. We examined survival in elderly women with breast cancer (BC) and SLE, and hypothesized that it would be decreased compared to women with BC but without SLE.

Methods: We identified BC SLE and BC non-SLE patients in the Texas Cancer Registry, and Surveillance, Epidemiology, and End Results, linked to Medicare claims. Read More

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September 2021

Serum zinc level and its association with multidrug-resistant tuberculosis.

Int J Mycobacteriol 2021 Apr-Jun;10(2):177-181

Department of Public Health and Informatics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.

Background: Zinc deficiency is evident in chronic diseases, but little is known about its association with multi-drug resistant tuberculosis (MDRTB). We aimed to measure serum zinc level in MDRTB patients and explore its association with MDRTB compared to drug-sensitive tuberculosis (DSTB).

Methods: We recruited 107 MDRTB and 87 DSTB patients from a tuberculosis referral hospital in Bangladesh. Read More

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September 2021

Changing paradigms in endoscopic thyroid surgery: A comparison between scarless-in-the-neck axillo-breast approach and totally scarless transoral approach.

J Minim Access Surg 2021 Oct-Dec;17(4):509-512

Department of Endocrine Surgery, SGPGIMS, Lucknow, Uttar Pradesh, India.

Background: To avoid cervical scar in thyroid surgery, various approaches have been proposed. The commonly used approach is combined axillo-breast approach (ABA). However, trans-orovestibular approach (TOVA) is getting popular. Read More

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September 2021

The effect of guar gum consumption on the lipid profile in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.

Crit Rev Food Sci Nutr 2021 Sep 24:1-10. Epub 2021 Sep 24.

Department of Endocrine and Metabolic Diseases, Longhu Hospital, The First Affiliated Hospital of Shantou University Medical College,Shantou City, Guangdong Province.

Dyslipidemia is a common encounter in type 2 diabetes mellitus (T2DM) and the current strategies to manage it are still suboptimal. Subsequently, identifying newer molecules with lipid-lowering effects is necessary. A great deal of attention has been given in recent years to fiber supplements, e. Read More

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September 2021

Vitamin D and upper respiratory tract infections in young active males exposed to cold environments.

Ann Agric Environ Med 2021 Sep 30;28(3):446-451. Epub 2020 Oct 30.

Institute of Sport - National Research Institute, Warsaw, Poland.

Introduction And Objective: Performing indoor and outdoor work in cold environments may result in various adverse effects on human health and may lead to increased risk of respiratory infection. The aim of this study was to determine the relation of vitamin D status to secretory immunoglobulin A concentration, leucocyte counts, cytokine concentrations and incidence of upper respiratory tract infection (URTI) episodes in young active men during an autumn-winter period.

Material And Methods: The effect of work in a cold microclimate was studied among 23 young active male ice hockey players during a 19-week study period. Read More

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September 2021

Axillary management based on American college of surgeons oncology group Z0011 criteria makes it possible to omit intraoperative diagnosis of sentinel lymph nodes in early breast cancer patients.

Breast J 2021 Sep 23. Epub 2021 Sep 23.

Department of Breast and Endocrine Surgery, Osaka International Cancer Institute, Osaka, Japan.

The ACOSOG Z0011 trial has resulted in the omission of axillary lymph node dissection (ALND) in early breast cancer patients with one or two metastatic sentinel lymph nodes (SLNs). There has been increasing interest in the necessity of intraoperative assessment of SLNs in patients treated based on the Z0011 criteria. We evaluated the utility of intraoperative assessment in these eligible patients. Read More

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September 2021

Environmental and occupational exposure of metals and female reproductive health.

Environ Sci Pollut Res Int 2021 Sep 24. Epub 2021 Sep 24.

Department of Physiology, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Jenjarom, Malaysia.

Untainted environment promotes health, but the last few decades experienced steep upsurge in environmental contaminants posing detrimental physiological impact. The responsible factors mainly include the exponential growth of human population, havoc rise in industrialization, poorly planned urbanization, and slapdash environment management. Environmental degradation can increase the likelihood of human exposure to heavy metals, resulting in health consequences such as reproductive problems. Read More

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September 2021

Biography of Professor Edward L. Felix, MD, FACS.

Authors:
Omar M Ghanem

Obes Surg 2021 Sep 23. Epub 2021 Sep 23.

Division of Endocrine and Metabolic Surgery, Department of Surgery, Mayo Clinic, Rochester, MN, 55905, USA.

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September 2021

The LEAF questionnaire is a good screening tool for the identification of the Female Athlete Triad/Relative Energy Deficiency in Sport among young football players.

PeerJ 2021 3;9:e12118. Epub 2021 Sep 3.

Orthopaedic and Rehabilitation Department, Medical University of Warsaw, Warszawa, Poland.

Background: It has been noticed that Female Athlete Triad (Fat) and Relative Energy Deficiency (Red-S) in Sport are characterized by the symptoms of impaired endocrine-metabolic function and bone health in female athletes. In addition, it may be evaluated with a qualitative tool, such as Low Energy Availability in Females questionnaire (LEAF-Q) and quantitative measurements: bone mineral density (BMD), resting energy expenditure (REE), body composition, 24-hour dietary recall.

Methods: The aim of this study was to assess the prevalence of Triad and Red-S using the LEAF-Q in youth female football players. Read More

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September 2021

Common Pitfalls in the Interpretation of Endocrine Tests.

Front Endocrinol (Lausanne) 2021 7;12:727628. Epub 2021 Sep 7.

Endocrinology Section, Internal Medicine Department, Faculty of Medicine, University of Antioquia, Medellin, Colombia.

Endocrine tests are the cornerstone of diagnosing multiple diseases that primary care physicians are frequently faced with. Some of these tests can be affected by situations that affect the proper interpretation, leading to incorrect diagnoses and unnecessary treatment, such as the interference of biotin with thyroid function test, falsely elevated prolactin values in presence of macroprolactinemia or falsely normal due to the "hook effect" in macroprolactinomas. Recognizing these situations is essential for the clinician to make an adequate interpretation of these tests as well as an accurate diagnosis that guarantees the best outcomes for the patient. Read More

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September 2021

Plasma Metabolome Profiling for the Diagnosis of Catecholamine Producing Tumors.

Front Endocrinol (Lausanne) 2021 7;12:722656. Epub 2021 Sep 7.

Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital, University of Würzburg, Würzburg, Germany.

Context: Pheochromocytomas and paragangliomas (PPGL) cause catecholamine excess leading to a characteristic clinical phenotype. Intra-individual changes at metabolome level have been described after surgical PPGL removal. The value of metabolomics for the diagnosis of PPGL has not been studied yet. Read More

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September 2021

Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis.

Cell Death Dis 2021 Sep 23;12(10):867. Epub 2021 Sep 23.

Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Some individuals develop prediabetes and/or diabetes following acute pancreatitis (AP). AP-induced beta-cell injury and the limited regenerative capacity of beta cells might account for pancreatic endocrine insufficiency. Previously, we found that only a few pancreatic cytokeratin 5 positive (Krt5) cells differentiated into beta cells in the murine AP model, which was insufficient to maintain glucose homeostasis. Read More

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September 2021

Breast cancer and pregnancy: Why special considerations prior to treatment are needed in multidisciplinary care.

Biosci Trends 2021 Sep 23. Epub 2021 Sep 23.

Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Breast cancer diagnosed during pregnancy poses ethical and professional challenges. Clinical management of that condition should ensure the safety of both the mother and fetus. Clinical trials on breast cancer exclude pregnant women, so sufficient evidence with which to formulate guidelines for the management of these patients is lacking. Read More

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September 2021

Diagnostic performance of [I]m-iodobenzylguanidine PET/CT in patients with pheochromocytoma.

J Nucl Med 2021 Sep 23. Epub 2021 Sep 23.

University Clinic Essen.

I-MIBG scintigraphy has shown a high specificity for imaging pheochromocytoma and paraganglioma however with low sensitivity due to low spatial resolution. I-MIBG PET may overcome this limitation to improve the staging of patients with (suspected) pheochromocytoma. We analyzed the sensitivity, specificity, positive and negative predictive values (PPV, NPV) of I-MIBG PET in 43 consecutive patients with suspected (recurrence of) pheochromocytoma using histopathological ( = 25) and clinical validation ( = 18) as standard of truth. Read More

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September 2021

Endocrine Therapy With or Without CDK4/6 Inhibitors in Women With Hormone-receptor Positive Breast Cancer: What do we Know About the Effects on Cognition?

Clin Breast Cancer 2021 Aug 14. Epub 2021 Aug 14.

Netherlands Cancer Institute, Amsterdam, Netherlands; University of Amsterdam, Amsterdam, Netherlands. Electronic address:

Adjuvant endocrine therapy (ET) is the cornerstone of treatment for hormone-receptor positive breast cancer. Recently, ET is increasingly combined with "cyclin-dependent kinases 4 and 6'' (CDK4/6) inhibitors. Given the importance of estrogens in neural processes and the role of cyclin D in hippocampal cell proliferation, it is plausible that these therapies affect cognition, but studies on these potential cognitive effects are sparse. Read More

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Nodal metastatic load in papillary thyroid carcinoma. Morphological and molecular analysis with one-step nucleic acid amplification on more than 550 lymph nodes.

Endocrinol Diabetes Nutr (Engl Ed) 2021 May;68(5):346-353

Department of Endocrinology, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, 119-129 Passeig Vall d'Hebron, Barcelona, Spain.

Background And Objective: The risk of recurrence in papillary thyroid carcinoma (PTC) is likely related to the amount of tumour in the metastatic lymph node (LN). Therefore, the current TNM classification (N0/N1) make it necessary to find a method to quantify the LN metastasis (LNM). We propose that the quantitative molecular assay One-Step Nucleic-Acid Amplification (OSNA), which measures the number of cytokeratin-19 (CK-19) mRNA copies as a marker of LNM, could play this role. Read More

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A review of systemic infiltrative diseases and associated endocrine diseases.

Endocrinol Diabetes Nutr (Engl Ed) 2021 May 6;68(5):312-320. Epub 2021 Sep 6.

Servicio de Endocrinología y Nutrición, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Systemic infiltrative diseases are relatively rare conditions consisting of cell infiltration or substance deposition in multiple organs and systems, including endocrine glands. This article reviews endocrine changes in the main four diseases at epidemiological level: sarcoidosis, Langerhans cell histiocytosis, hereditary hemochromatosis, and systemic amyloidosis. Recommendations to endocrinologists for hormone work-up and management of patients with each of these conditions are provided. Read More

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Concomitant familial hypocalciuric hypercalcemia and single parathyroid adenoma: a case report.

J Med Case Rep 2021 Sep 24;15(1):471. Epub 2021 Sep 24.

Department of Endocrinology & Diabetes and Bone-metabolic Research Unit, Rigshospitalet, Copenhagen, Denmark.

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder and the most frequent benign cause of hypercalcemia. PHPT is characterized by autonomous hypersecretion of parathyroid hormone (PTH), regardless of serum calcium levels. Familial hypocalciuric hypercalcemia (FHH) is a rare, benign syndrome only affecting the regulation of calcium metabolism. Read More

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September 2021