65 results match your criteria endeavors suggestions

Challenges in surgical video annotation.

Comput Assist Surg (Abingdon) 2021 Dec;26(1):58-68

Surgical AI & Innovation Laboratory, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.

Annotation of surgical video is important for establishing ground truth in surgical data science endeavors that involve computer vision. With the growth of the field over the last decade, several challenges have been identified in annotating spatial, temporal, and clinical elements of surgical video as well as challenges in selecting annotators. In reviewing current challenges, we provide suggestions on opportunities for improvement and possible next steps to enable translation of surgical data science efforts in surgical video analysis to clinical research and practice. Read More

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December 2021

Lost in Translation: Simple Steps in Experimental Design of Neurorehabilitation-Based Research Interventions to Promote Motor Recovery Post-Stroke.

Front Hum Neurosci 2021 20;15:644335. Epub 2021 Apr 20.

Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, United States.

Stroke continues to be a leading cause of disability. Basic neurorehabilitation research is necessary to inform the neuropathophysiology of impaired motor control, and to develop targeted interventions with potential to remediate disability post-stroke. Despite knowledge gained from basic research studies, the effectiveness of research-based interventions for reducing motor impairment has been no greater than standard of practice interventions. Read More

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Lessons and tips for designing a machine learning study using EHR data.

J Clin Transl Sci 2020 Jul 24;5(1):e21. Epub 2020 Jul 24.

Department of Preventive Medicine and Population Health, University of Texas Medical Branch, Galveston, TX, USA.

Machine learning (ML) provides the ability to examine massive datasets and uncover patterns within data without relying on assumptions such as specific variable associations, linearity in relationships, or prespecified statistical interactions. However, the application of ML to healthcare data has been met with mixed results, especially when using administrative datasets such as the electronic health record. The black box nature of many ML algorithms contributes to an erroneous assumption that these algorithms can overcome major data issues inherent in large administrative healthcare data. Read More

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Are the concerns destroying mental health of college students?: A qualitative analysis portraying experiences amidst COVID-19 ambiguities.

Anal Soc Issues Public Policy 2021 Feb 1. Epub 2021 Feb 1.

Department of Management Studies J.C. Bose University of Science and Technology, YMCA Faridabad Haryana India.

Coronavirus presenting an unforeseeable chain of events has exaggerated misery for students in India as they attracted the most detrimental experiences associated with lockdown restrictions leading to a shutdown of colleges as a preventive measure. The research endeavors to furnish a review of the overall hardships and psychological state of mind of college students and improvement in the implementation of policy decisions. Researchers conceptualize the newly discovered phenomenon by adopting grounded theory. Read More

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February 2021

Racism and Kidney Health: Turning Equity Into a Reality.

Am J Kidney Dis 2021 Jun 24;77(6):951-962. Epub 2021 Feb 24.

Center for Community and Population Health Improvement, Clinical and Translational Science Institute, Duke University School of Medicine, Durham, NC; Division of General Internal Medicine, Department of Medicine, Duke University School of Medicine, Durham, NC.

Kidney disease continues to manifest stark racial inequities in the United States, revealing the entrenchment of racism and bias within multiple facets of society, including in our institutions, practices, norms, and beliefs. In this perspective, we synthesize theory and evidence to describe why an understanding of race and racism is integral to kidney care, providing examples of how kidney health disparities manifest interpersonal and structural racism. We then describe racialized medicine and "colorblind" approaches as well as their pitfalls, offering in their place suggestions to embed antiracism and an "equity lens" into our practice. Read More

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Anatomy in a Post-Covid-19 World: Tracing a New Trajectory.

Anat Sci Educ 2021 Mar;14(2):148-153

Department of Anatomy, Division of Health Sciences, University of Otago, Dunedin, New Zealand.

In responding to Covid-19 anatomists have succeeded in adapting their teaching to online delivery. However, long-term reliance on this mode of teaching raises the prospect that transferring the whole of the learning environment to an impersonal digital world will lead to loss of anatomy's humanistic side. In looking to a future increasingly dependent upon digital input to teaching, a number of roadblocks are identified. Read More

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Governance of a Learning Health Care System for Oncology: Patient Recommendations.

JCO Oncol Pract 2021 Apr 23;17(4):e479-e489. Epub 2020 Oct 23.

University of Michigan, Ann Arbor, MI.

Purpose: The learning health care system (LHS) was designed to enable real-time learning and research by harnessing data generated during patients' clinical encounters. This novel approach begets ethical questions regarding the oversight of users and uses of patient data. Understanding patients' perspectives is vitally important. Read More

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Enhancing junior doctors' working lives.

Surgery (Oxf) 2020 Oct 30;38(10):607-611. Epub 2020 Aug 30.

is a Specialty Trainee in Vascular Surgery on the Scotland Vascular Training Programme., UK. Conflicts of Interest: none.

Junior doctor wellbeing has been a topic of increasing interest in recent years. There is increasing evidence of poor workplace satisfaction, rising levels of burnout and increasing diaspora of UK-trained junior doctors. There is therefore a pressing need to address the wellbeing of our trainees and recent concerted efforts at local, national and international levels are working towards this, with the ultimate goal of also improving patient care. Read More

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October 2020

Association of primary care physician supply with maternal and child health in China: a national panel dataset, 2012-2017.

BMC Public Health 2020 Jul 11;20(1):1093. Epub 2020 Jul 11.

Department of Health Administration, School of Public Health, Sun Yat-sen University, No.74, Zhong Shan Er Road, Guangzhou, 510080, China.

Background: The Chinese government has been strengthening the primary care system since the launch of the New Healthcare System Reform in 2009. Among all endeavors, the most obvious and significant improvement lays in maternal and child health. This study was designed to explore the association of primary care physician supply with maternal and child health outcomes in China, and provide policy suggestions to the law makers. Read More

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Identifying best approaches for engaging patients and family members in health informatics initiatives: a case study of the Group Priority Sort technique.

Res Involv Engagem 2020 18;6:25. Epub 2020 May 18.

1Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, M6J 1H4 ON Canada.

Background: Patient engagement strategies in health service delivery have become more common in recent years. However, many healthcare organizations are challenged in identifying the best methods to engage patients in health information technology (IT) initiatives. Engaging with important stakeholders to identify effective opportunities can inform the development of a resource that addresses this issue and supports organizations in their endeavors. Read More

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Apps for pain self-management of older people's arthritic pain, one size doesn't fit all: A qualitative study.

Arch Gerontol Geriatr 2020 Jul - Aug;89:104062. Epub 2020 May 16.

University of Technology Sydney, Sydney, NSW, Australia.

Introduction Arthritic pain is a major cause of illness and disability among older people. People living with arthritic pain carry out self-management activities to adequately manage their pain. As the trend of smartphone uptake continues to rise among older people, there are opportunities to explore the role of these devices in helping older people better manage their pain. Read More

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November 2020

Goal-Concordant Care in the Era of Advanced Stroke Therapies.

J Palliat Med 2021 02 14;24(2):297-301. Epub 2020 May 14.

Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.

Stroke is a leading cause of disability and mortality worldwide. Recent advances in stroke care now enable patients with severe ischemic stroke owing to large vessel occlusion to safely undergo endovascular thrombectomy (EVT) up to 24 hours since their time of last known well, with the goal of improving functional outcomes by recanalization of the occluded vessel and reperfusion of downstream ischemic brain tissue. The objective of this analysis is to highlight clinical and ethical challenges related to ensuring goal-concordant care in this era of unprecedented advances in acute stroke care. Read More

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February 2021

A qualitative analysis to identify the elements that support department level change in the life sciences: The PULSE Vision & Change Recognition Program.

PLoS One 2019 30;14(5):e0217088. Epub 2019 May 30.

Division of Science, Technology, Engineering and Math, Harford Community College, Bel Air, MD, United States of America.

The 2011 report, Vision and Change in Undergraduate Biology Education: A Call to Action, provided the impetus to mobilize the undergraduate life sciences education community to affect change in order to enhance the educational experiences of life sciences majors. The work of the appointed Partnership for Undergraduate Life Sciences Education (PULSE) Vision and Change (V&C) Leadership Fellows has focused on the development of programs and resources to support departmental change. In this report, we present a qualitative assessment of several documents generated from the PULSE V&C Leadership Fellow Recognition Team. Read More

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January 2020

When 3 Rs meet a forth R: Replacement, reduction and refinement of animals in research on reproduction.

Petra Clara Arck

J Reprod Immunol 2019 04 25;132:54-59. Epub 2019 Mar 25.

Division of Experimental Feto-Maternal Medicine, Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Research endeavors aiming to understand the maternal immune adaptation to pregnancy significantly rely on the use of animal models, such as mice and rats. These models have provided important insights into the pathophysiology of a number of pregnancy disorders in humans. However, the use of animal models in scientific research is a vividly debated and emotive topic. Read More

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A multidisciplinary understanding of polarization.

Am Psychol 2019 04;74(3):301-314

Department of Philosophy.

This article aims to describe the last 10 years of the collaborative scientific endeavors on polarization in particular and collective problem-solving in general by our multidisciplinary research team. We describe the team's disciplinary composition-social psychology, political science, social philosophy/epistemology, and complex systems science-highlighting the shared and unique skill sets of our group members and how each discipline contributes to studying polarization and collective problem-solving. With an eye to the literature on team dynamics, we describe team logistics and processes that we believe make our multidisciplinary team persistent and productive. Read More

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Universal Health Coverage in Bangladesh: Activities, Challenges, and Suggestions.

Psyche (Camb Mass) 2019 3;2019:4954095. Epub 2019 Mar 3.

Bangladesh Country Office, Save the Children, Dhaka 1212, Bangladesh.

Catastrophic health expenditure forces 5.7 million Bangladeshis into poverty. Inequity is present in most of health indicators across social, economic, and demographic parameters. Read More

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Community-academic partnerships in implementation research.

J Community Psychol 2018 09 6;46(7):941-952. Epub 2018 Apr 6.

University of Pennsylvania.

Community-academic partnerships(CAPs) are a critical component of implementing and sustaining evidence-based practices (EBPs) in community settings; however, the approaches used and mechanisms of change within CAPs have not been rigorously studied. The first step to advancing the science of CAP is to operationally define and contextualize the approaches used in CAP as part of the implementation process. Our research group has gleaned valuable lessons about the best ways to develop, support, and nurture community partnerships within the context of implementation. Read More

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September 2018

Possible Role of Chitin-Like Proteins in the Etiology of Alzheimer's Disease.

J Alzheimers Dis 2018 ;66(2):439-444

Department of Basic Biomedical Sciences, Touro College of Osteopathic Medicine, New York, NY, USA.

Chitin is a β-linked straight chain carbohydrate matrix monopolymer prominent in invertebrates, from fungi to arthropods. Surprisingly, chitin is now documented in vertebrates, including humans, a component of vertebrate physiology that has been neglected until now. Chitin levels are elevated in Alzheimer's disease (AD) patients, not only in the central nervous system but also in the cerebrospinal fluid and plasma. Read More

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October 2019

Roles of medical education department: What are expectations of the faculty?

Pak J Med Sci 2018 Jul-Aug;34(4):864-868

Prof. Dr. Rehan Ahmed Khan, FCPS, FRCS, MHPE, Ph.D. (Scholar). Professor of Surgery, Assistant Director Medical Education Department, Riphah International University, Islamabad, Pakistan.

Background & Objective: Pakistan like many Asian countries is investing in medical education to address increased societal needs and to meet the requirement of national and international accrediting bodies. Establishing medical education departments is part of this investment. The research question was "What are the expectations of faculty from medical education department?" The objective of this study was to explore the Faculty's perception about the roles of medical education department and their suggestions for its future endeavors. Read More

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September 2018

HIV Prevention After Discontinuing Pre-Exposure Prophylaxis: Conclusions From a Case Study.

Front Public Health 2018 9;6:137. Epub 2018 May 9.

Work and Social Psychology, Maastricht University, Maastricht, Netherlands.

Pre-exposure prophylaxis (PrEP) with tenofovir disoproxil fumarate in combination with emtricitabine (FTC) is a highly effective form of HIV prevention. Endeavors of health-care providers and activists in many countries over the world are directed at making access to PrEP possible, or increasing PrEP use among men-who-have-sex-with-men (MSM). We argue while this effort is necessary, we also need to consider modes of HIV prevention after a period of PrEP use. Read More

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Syndemics: A theory in search of data or data in search of a theory?

Alexander C Tsai

Soc Sci Med 2018 06 30;206:117-122. Epub 2018 Mar 30.

Harvard Medical School and The Massachusetts General Hospital, United States; Mbarara University of Science and Technology, Uganda. Electronic address:

The concept of a syndemic was proposed more than two decades ago to explain how large-scale social forces might give rise to co-occurring epidemics that synergistically interact to undermine health in vulnerable populations. This conceptual instrument has the potential to help policymakers and program implementers in their endeavors to improve population health. Accordingly, it has become an increasingly popular heuristic for advocacy, most notably in the field of HIV treatment and prevention. Read More

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Principles of dynamic network reconfiguration across diverse brain states.

Neuroimage 2018 10 3;180(Pt B):396-405. Epub 2017 Aug 3.

Department of Psychology, Stanford University, Stanford, CA, USA.

Recent methodological advances have enabled researchers to track the network structure of the human brain over time. Together, these studies provide novel insights into effective brain function, highlighting the importance of the systems-level perspective in understanding the manner in which the human brain organizes its activity to facilitate behavior. Here, we review a range of recent fMRI and electrophysiological studies that have mapped the relationship between inter-regional communication and network structure across a diverse range of brain states. Read More

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October 2018

A Protocol for Collecting Human Cardiac Tissue for Research.

VAD J 2016 3;2(1). Epub 2016 Jun 3.

Department of Physiology, University of Kentucky, Lexington, KY; Division of Cardiovascular Medicine, University of Kentucky, Lexington, KY.

This manuscript describes a protocol at the University of Kentucky that allows a translational research team to collect human myocardium that can be used for biological research. We have gained a great deal of practical experience since we started this protocol in 2008, and we hope that other groups might be able to learn from our endeavors. To date, we have procured ~4000 samples from ~230 patients. Read More

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Deceased Donor Uterine Transplantation: Innovation and Adaptation.

Obstet Gynecol 2016 10;128(4):837-842

Cleveland Clinic, Cleveland, Ohio.

This commentary endeavors to share our practical experience in developing and implementing the first uterine transplant clinical trial in the United States. Uterine transplant is a promising novel treatment for uterine factor infertility. After reported successful live births after uterine transplant in Sweden, research teams around the world are either embarking on or are considering the development of uterine transplant protocols. Read More

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October 2016

Is the Divide a Chasm?: Bridging Affective Science with Clinical Practice.

J Psychopathol Behav Assess 2016 Mar 2;38(1):42-47. Epub 2015 Nov 2.

Department of Psychology, University of South Florida.

This special section endeavors to facilitate the integration of biologically-based assessments of emotion into the clinical setting. This goal is consistent with the Research Domain Criteria (RDoC) initiative, which aims to identify transdiagnostic biobehavioral mechanisms that underlie mental disorders. We focus on four challenges to applying biologically-informed research on emotion and emotion regulation to clinical contexts: (1) How do we assess emotion in an RDoC framework? (2) How do we integrate measures of emotion with other systems in a wider context? (3) What do physiological indices of emotion tell us about clinical phenomena? and (4) How do we integrate physiological assessments into clinical practice? Throughout this comment, we refer to the articles in this special section to make our points, and, when possible, offer suggestions for future work to continue to address these challenges. Read More

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Investigational new drugs for brain cancer.

Expert Opin Investig Drugs 2016 Aug 17;25(8):937-56. Epub 2016 May 17.

a Department of Neurology , Johns Hopkins Medical Institutions , Baltimore , MD , USA.

Introduction: Despite substantial improvements in standards of care, the most common aggressive pediatric and adult high-grade gliomas (HGG) carry uniformly fatal diagnoses due to unique treatment limitations, high recurrence rates and the absence of effective treatments following recurrence. Recent advancements in our understanding of the pathophysiology, genetics and epigenetics as well as mechanisms of immune surveillance during gliomagenesis have created new knowledge to design more effective and target-directed therapies to improve patient outcomes.

Areas Covered: In this review, the authors discuss the critical genetic, epigenetic and immunologic aberrations found in gliomas that appear rational and promising for therapeutic developments in the presence and future. Read More

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Integrating Environmental Management of Asthma into Pediatric Health Care: What Worked and What Still Needs Improvement?

Clin Pediatr (Phila) 2016 12 20;55(14):1271-1278. Epub 2016 Jul 20.

8 University of Washington, Seattle, WA, USA.

The National Environmental Education Foundation (NEEF) launched an initiative in 2005 to integrate environmental management of asthma into pediatric health care. This study, a follow-up to a 2013 study, evaluated the program's impact and assessed training results by 5 new faculty champions. We surveyed attendees at training sessions to measure knowledge and the likelihood of asking about and managing environmental triggers of asthma. Read More

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December 2016

Clinician and Staff Perspectives on Participating in Practice-based Research (PBR): A Report from the Wisconsin Research and Education Network (WREN).

J Am Board Fam Med 2015 Sep-Oct;28(5):639-48

From the Department of Family Medicine and Community Health, University of Wisconsin School of Medicine & Public Health, Madison, WI.

Background: The success of practice-based research (PBR) depends on the willingness of clinicians and staff to incorporate meaningful and useful research protocols into already demanding clinic schedules. The impact of participation on those who implement multiple projects and how to address the issues that arise during this complex process remain incompletely described. This article reports a qualitative evaluation of the experiences of primary care clinicians and clinic staff who participated in multiple PBR projects with the Wisconsin Research and Education Network (WREN). Read More

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PBIS Is (Not) Behavior Analysis: a Response to Horner and Sugai (2015).

Amy K Loukus

Behav Anal Pract 2015 May 16;8(1):95-98. Epub 2015 Apr 16.

grid.261432.00000000404165056Oregon Institute of Technology, Klamath Falls, OR USA.

I comment on Horner's and Sugai's article regarding the lessons learned from implementing Positive Behavioral Interventions and Support (PBIS)-that is, the things to consider when attempting to extend other works in behavior analysis to the likes of mainstream society. In adopting a critical eye toward the PBIS model, I comment first on the need for dissemination of behavioral principles to a public audience, and then outline the suggestions made by the authors for enhancing acceptance across disciplines. I clarify the definition of PBIS presented by the authors, and summarize the benefits and drawbacks associated with the conceptual argument surrounding the contention that PBIS is a behavior analytic approach to system-wide change, and argue instead for the distinction of elements in the PBIS model and their respective empirical effectiveness. Read More

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Civil Liabilities for Unsafe Foods in Bangladesh and Australia: A Comparative Perspective on Consumer Protection.

Compr Rev Food Sci Food Saf 2014 Jul;13(4):656-668

School of Law, Univ. of Wollongong, NSW 2522, Australia.

The statutory laws concerning food safety, which allow the consumers affected by unsafe foods to claim compensation for their loss or damage in Bangladesh, are flawed in several respects. These flaws are argued to have harmful impacts on consumer protection. The ineffective legislation in the absence of application of the common law principles of negligence has left the consumers virtually helpless in securing remedies for their injuries. Read More

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