263 results match your criteria emr generated

Novel semi-automated fluorescence microscope imaging algorithm for monitoring IgG aggregates in serum.

Sci Rep 2021 May 31;11(1):11375. Epub 2021 May 31.

Department of Chemical Engineering, DBT Center of Excellence for Biopharmaceutical Technology, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.

Analysis of therapeutic IgG aggregates in serum is a potential area of investigation as it can give deeper insights about the function, immunogenic issues and protein interaction associated with the aggregates. To overcome various complexities associated with the existing analytical techniques for analyzing aggregates in serum, a novel florescence microscopy-based image processing approach was developed. The monoclonal antibody (mAb) was tagged with a fluorescent dye, fluorescein isothiocyanate (FITC). Read More

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A Method for Detecting Adverse Drug Events through the Chronological Relationship Between the Medication Period and the Presence of Adverse Reactions from Electronic Medical Record Systems: Observational Study.

JMIR Med Inform 2021 Apr 17. Epub 2021 Apr 17.

Department of Medical Informatics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, JP.

Background: Medicines may cause various adverse reactions. An enormous amount of money and effort are spent investigating adverse drug events (ADEs) in clinical trials and post-marketing surveillance. Real-world data from multiple electronic medical records (EMRs) can make it easy to understand the ADEs that occur in actual patients. Read More

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Routine T4 No More? Reducing Excess Thyroid Hormone Testing at a Pediatric Tertiary Care Hospital.

J Pediatr 2021 May 11. Epub 2021 May 11.

Division of Endocrinology, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8; Department of Pediatrics, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8; Department of Physiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada, M5S 1A8.

Objectives: To promote resource stewardship in thyroid hormone testing at a pediatric tertiary care hospital.

Study Design: Quality improvement approaches generated three change ideas that were implemented simultaneously in the hospital electronic medical record (EMR): (1) a reflex free thyroxine (fT4), whereby fT4 is automatically reported if the thyroid stimulating hormone (TSH) is outside the normal range; (2) a forced-function for thyroid hormone ordering, whereby a provider must select an appropriate indication for ordering fT4 or triiodothyronine (T3); and (3) a clinical decision support message displayed at the time of ordering thyroid function tests. Laboratory data were audited to determine the mean number of fT4 and T3 tests performed per week as well as indications for testing. Read More

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Automated NLP Extraction of Clinical Rationale for Treatment Discontinuation in Breast Cancer.

JCO Clin Cancer Inform 2021 May;5:550-560

CSAIL & IMES, Massachusetts Institute of Technology, Cambridge, MA.

Purpose: Key oncology end points are not routinely encoded into electronic medical records (EMRs). We assessed whether natural language processing (NLP) can abstract treatment discontinuation rationale from unstructured EMR notes to estimate toxicity incidence and progression-free survival (PFS).

Methods: We constructed a retrospective cohort of 6,115 patients with early-stage and 701 patients with metastatic breast cancer initiating care at Memorial Sloan Kettering Cancer Center from 2008 to 2019. Read More

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Assessing Use of a Standardized Allergy History Questionnaire for Patients with Reported Allergy to Penicillin.

Can J Hosp Pharm 2021 1;74(2):104-109. Epub 2021 Apr 1.

, BSc, PharmD, ACPR, is with the University Hospital of Northern British Columbia, Northern Health, Prince George, British Columbia.

Background: Inappropriate allergy labelling is associated with significant clinical and pharmacoeconomic implications. Detailed antimicrobial allergy assessments represent a key component of antimicrobial stewardship and aid in identifying true type I (immediate hypersensitivity) reactions. The allergy history form currently used at the University Hospital of Northern British Columbia (UHNBC), in Prince George, relies on the assessor's ability to ask appropriate prompting questions to obtain a thorough history, but it may not be sufficient to accurately identify true allergies. Read More

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Penta band single negative meta-atom absorber designed on square enclosed star-shaped modified split ring resonator for S-, C-, X- and Ku- bands microwave applications.

Sci Rep 2021 Apr 22;11(1):8784. Epub 2021 Apr 22.

Institute of IR4.0, Universiti Kebangsaan Malaysia (UKM), 43600, Bangi, Selangor, Malaysia.

This paper represents a penta band square enclosed star-shaped modified split ring resonator (SRR) based single negative meta-atom absorber (MAA) for multi-band microwave regime applications. FR-4 low-cost material has been used as a substrate to make the MAA unit cell with 0.101λ × 0. Read More

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Evolving treatment patterns and outcomes of neovascular age-related macular degeneration over a decade.

Ophthalmol Retina 2021 Apr 15. Epub 2021 Apr 15.

Moorfields Eye Hospital NHS Foundation Trust, London, UK; Institute of Ophthalmology, University College London, London, UK.

Purpose: Management of neovascular age-related macular degeneration (nAMD) has evolved over the last decade with several treatment regimens and different medications. This study describes the treatment patterns and, importantly, visual outcomes over ten years in a large cohort of patients.

Design: Retrospective analysis of electronic health records from 27 National Health Service (NHS) secondary care healthcare providers in the UK. Read More

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Simultaneous ultrasound- and microwave-assisted one-pot 'click' synthesis of 3-formyl-indole clubbed 1,2,3-triazole derivatives and their biological evaluation.

Mol Divers 2021 Apr 8. Epub 2021 Apr 8.

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India.

An environment friendly, high yielding, promising one-pot protocol for the click reaction of N-propargyl-3-formylindole 2(a-b), chloroacetic acid/ester 3(a-b) and sodium azide, leading to the formation of 3-formyl-indole clubbed 1,4-disubstituted-1,2,3-triazole derivatives 4(a-b), 5(a-b) and 6(a-f) aided by CuI catalyst accomplished under acceleration of simultaneous ultrasound and microwave irradiation in a very short reaction time has been described. Further, acid derivative 4(a-b) is subjected to acid-amine coupling reaction with secondary amine (p-t) in the presence of HATU to afford 6(p-t) and 7(p-t). The perspective of this protocol is to get rid of the hectic preparation and handling of organic azide which are generated in situ. Read More

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Quantifying the Risk Continuum for Cardiovascular Death in Adults with Type 2 Diabetes.

Can J Diabetes 2021 Jan 23. Epub 2021 Jan 23.

Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut, United States.

Objectives: In type 2 diabetes (T2D), the most common causes of death are cardiovascular (CV) related, accounting for >50% of deaths in some reports. As novel diabetes therapies reduce CV death risk, identifying patients with T2D at highest CV death risk allows for cost-effective prioritization of these therapies. Accordingly, the primary goal of this study was to quantify the risk continuum for CV death in a real-world T2D population as a means to identify patients with the greatest expected benefit from cardioprotective antidiabetes therapies. Read More

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January 2021

Neurological complications of COVID19 during March 2020 at LCMC health university medical center: Dataset.

Data Brief 2021 Apr 5;35:106944. Epub 2021 Mar 5.

Department of Neurology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.

We reviewed the electronic medical records (EMR) of patients hospitalized during the peak of the pandemic, March 1st through March 31st, to document the type and frequency of neurological problems seen in patients with COVID-19 at presentation to the emergency room. Secondary aims were to determine: 1) the frequency of neurological complaints during the hospital stay; 2) whether the presence of any neurological complaint at presentation or any of the individual types of neurological complaints at admission predicted three separate outcomes: death, length of hospital stay, or the need for intubation; and 3) if the presence of any neurological complaint or any of the individual types of neurological complaints developed during hospital stay predicted the previous three outcomes.

Setting: The Louisiana Health Sciences Center - New Orleans Institutional Review Board and the University Medical Center Clinical Research Review Committee approved the study protocol. Read More

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Evaluation of the environmental costs of tourism based on an emergy analysis of tourism waste disposal: a case study of Yarlung Zangbo Grand Canyon National Park in Motuo County, Tibet.

Environ Sci Pollut Res Int 2021 Feb 25. Epub 2021 Feb 25.

Cultural Service Center of Dam Lhoba Ethnic Town, Motuo County, Lin Zhi, 860000, China.

Eco-tourism has become increasingly popular in the postmodern era. However, the management of tourism waste remains a major challenge for tourist destinations worldwide. Here, a non-participatory survey was conducted in five famous scenic spots in Yarlung Zangbo Grand Canyon National Park in Motuo County, Tibet, to characterize the waste composition and the amount of average daily production per capita during sightseeing. Read More

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February 2021

Novel Biphenyl Amines Inhibit Oestrogen Receptor (ER)-α in ER-Positive Mammary Carcinoma Cells.

Molecules 2021 Feb 3;26(4). Epub 2021 Feb 3.

Tsinghua Berkeley Shenzhen Institute, Tsinghua Shenzhen International Graduate School, Tsinghua University, Beijing 518055, China.

Herein, the activity of adamantanyl-tethered-biphenyl amines (ATBAs) as oestrogen receptor alpha (ERα) modulating ligands is reported. Using an ERα competitor assay it was demonstrated that ATBA compound 3-(adamantan-1-yl)-4-methoxy-N-(4-(trifluoromethyl) phenyl) aniline (AMTA) exhibited an inhibitory concentration 50% (IC) value of 62.84 nM and demonstrated better binding affinity compared to tamoxifen (IC 79. Read More

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February 2021

A data quality assessment to inform hypertension surveillance using primary care electronic medical record data from Alberta, Canada.

BMC Public Health 2021 02 2;21(1):264. Epub 2021 Feb 2.

Department of Community Health Sciences, University of Calgary, 3280 Hospital Drive NW, Calgary, Alberta, T2N 4Z6, Canada.

Background: Hypertension is a common chronic condition affecting nearly a quarter of Canadians. Hypertension surveillance in Canada typically relies on administrative data and/or national surveys. Routinely-captured data from primary care electronic medical records (EMRs) are a complementary source for chronic disease surveillance, with longitudinal patient-level details such as sociodemographics, blood pressure, weight, prescribed medications, and behavioural risk factors. Read More

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February 2021

Mitoapocynin, a mitochondria targeted derivative of apocynin induces mitochondrial ROS generation and apoptosis in multiple cell types including cardiac myoblasts: a potential constraint to its therapeutic use.

Mol Cell Biochem 2021 May 30;476(5):2047-2059. Epub 2021 Jan 30.

School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.

Mitoapocynin is a triphenylphosphonium conjugated derivative of apocynin that specifically locates to the mitochondria. It has been developed as a mitochondrially targeted therapeutic antioxidant. We attempted to attenuate the mitochondrial ROS induced in H9c2 cardiac myoblast cells treated with norepinephrine. Read More

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Development and Validation of the Stent Tracking Algorithm Registry for Monitoring and Retrieving Forgotten Ureteral Stents.

J Endourol 2021 Mar 2. Epub 2021 Mar 2.

Department of Urology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Forgotten ureteral stents are associated with safety issues, increased cost, and medicolegal disputes. Tracking ureteral stents is cumbersome because of the variety in placement periods. We developed and validated an electronic medical record (EMR) system-based algorithm for monitoring patients with ureteral stent placements. Read More

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Pt Nanoparticles Supported on a Dynamic Boronate Ester-Based G-quadruplex Hydrogel as a Nanoreactor.

Chem Asian J 2021 Feb 30;16(3):215-223. Epub 2020 Dec 30.

Department of Chemistry and Centre for Advanced Electronics (CAE), Indian Institute of Technology Indore, Indore, 453552, India.

Herein, we have reported a dynamic boronic ester mediated guanosine (G) based G-quadruplex hydrogel as an ideal template for in situ and 'green chemical' approach for the synthesis and stabilization of Pt NPs. B NMR and FT-IR spectra reveal the formation of dynamic boronate ester bonds. The TEM images of the G-quadruplex hydrogel reveal entangled three-dimensional (3D) crosslink nanofibrillar networks with average diameter of 20 nm. Read More

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February 2021

Automated Categorization of Systemic Disease and Duration From Electronic Medical Record System Data Using Finite-State Machine Modeling: Prospective Validation Study.

JMIR Form Res 2020 Dec 17;4(12):e24490. Epub 2020 Dec 17.

Department of eyeSmart EMR & AEye, LV Prasad Eye Institute, Hyderabad, Telangana, India.

Background: One of the major challenges in the health care sector is that approximately 80% of generated data remains unstructured and unused. Since it is difficult to handle unstructured data from electronic medical record systems, it tends to be neglected for analyses in most hospitals and medical centers. Therefore, there is a need to analyze unstructured big data in health care systems so that we can optimally utilize and unearth all unexploited information from it. Read More

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December 2020

Modeling clinical activities based on multi-perspective declarative process mining with openEHR's characteristic.

BMC Med Inform Decis Mak 2020 12 15;20(Suppl 14):303. Epub 2020 Dec 15.

Information Center, Academy of Military Medical Sciences, Beijing, China.

Background: It is significant to model clinical activities for process mining, which assists in improving medical service quality. However, current process mining studies in healthcare pay more attention to the control flow of events, while the data properties and the time perspective are generally ignored. Moreover, classifying event attributes from the view of computers usually are difficult for medical experts. Read More

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December 2020

How to Develop a Risk Prediction Smartphone App.

Surg Innov 2020 Dec 8:1553350620974827. Epub 2020 Dec 8.

Division of Plastic Surgery, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.

. Powered by big data, predictive models provide individualized risk stratification to inform clinical decision-making and mitigate long-term morbidity. We describe how to transform a large institutional dataset into a real-time, interactive clinical decision support mobile user interface for risk prediction. Read More

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December 2020

Integrating Patient-Generated Health Data in an Electronic Medical Record: Stakeholders' Perspectives.

Stud Health Technol Inform 2020 Nov;275:12-16

University Hospitals of Geneva, Switzerland.

Patient-generated health data (PGHD), when shared with the provider, provides potential as an approach to improve quality of care. Based on interviews and a focus group with stakeholders involved in PGHD integration in the electronic medical record (EMR), we explore the benefits, barriers and possible risks. We propose solutions to address liability concerns, such as clarifying patient and provider expectations for the analyses of PGHD and emphasize considerations for future steps, which include the need to screen PGHD for patient safety. Read More

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November 2020

Revealing the Similarities of α,β-Unsaturated Iminiums and Acylazoliums in Organocatalysis.

Angew Chem Int Ed Engl 2021 Jun 25;60(25):13712-13724. Epub 2021 Feb 25.

Department of Organic Chemistry, Indian Institute of Science, Bangalore, 560012, India.

The secondary amine-catalyzed reactions proceeding via α,β-unsaturated iminiums and the N-heterocyclic carbene (NHC)-catalyzed transformations taking place via α,β-unsaturated acylazoliums are the two widely used electrophilic intermediates in organocatalysis. Over the last two decades, these two intermediates are extensively utilized for the enantioselective construction of valuable molecules. Both intermediates are generated by the covalent binding of catalysts to the substrates leading to LUMO activation of α,β-unsaturated carbonyls. Read More

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Genotypic diversity in multi-drug-resistant E. coli isolated from animal feces and Yamuna River water, India, using rep-PCR fingerprinting.

Environ Monit Assess 2020 Oct 7;192(11):681. Epub 2020 Oct 7.

Medical Microbiology and Bioprocess Technology Laboratory, Department of Microbiology, Maharshi Dayanand University, Rohtak, Haryana, India.

Genotypic diversity among multi-drug-resistant (MDR) aquatic E. coli isolated from different sites of Yamuna River was analyzed using repetitive element PCR (rep-PCR) methods viz. ERIC-PCR and (GTG)-PCR and compared with the MDR animal fecal isolates. Read More

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October 2020

First DNA sequence reference library for mammals and plants of the Eastern Mediterranean Region.

Genome 2021 Jan 1;64(1):39-49. Epub 2020 Oct 1.

Laboratoire Biodiversité et Génomique Fonctionnelle, Faculté des Sciences, Université Saint-Joseph, Campus Sciences et Technologies, Mar Roukos, Mkalles, BP: 1514 Riad el Solh, Beirut 1107 2050, Lebanon.

The Mediterranean region is identified as one of the world's 36 biodiversity hotspots, with the Earth's most biologically rich yet threatened areas. Lebanon is a hub for Eastern Mediterranean Region (EMR) biodiversity with 9116 characterized plant and animal species (4486 fauna and 4630 flora). Using DNA barcoding as a tool has become crucial in the accurate identification of species in multiple contexts. Read More

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January 2021

A chromosome-level genome assembly of the woolly apple aphid, Eriosoma lanigerum Hausmann (Hemiptera: Aphididae).

Mol Ecol Resour 2021 Jan 19;21(1):316-326. Epub 2020 Oct 19.

Department of Crop Genetics, John Innes Centre, Norwich Research Park, Norwich, UK.

Woolly apple aphid (WAA, Eriosoma lanigerum Hausmann) (Hemiptera: Aphididae) is a major pest of apple trees (Malus domestica, order Rosales) and is critical to the economics of the apple industry in most parts of the world. Here, we generated a chromosome-level genome assembly of WAA-representing the first genome sequence from the aphid subfamily Eriosomatinae-using a combination of 10X Genomics linked-reads and in vivo Hi-C data. The final genome assembly is 327 Mb, with 91% of the assembled sequences anchored into six chromosomes. Read More

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January 2021

Molecular insights of NADPH oxidases and its pathological consequences.

Cell Biochem Funct 2021 Mar 25;39(2):218-234. Epub 2020 Sep 25.

School of Biological Sciences & Biotechnology, Indian Institute of Advanced Research, Gandhinagar, Gujarat, India.

Reactive oxygen species (ROS), formed by the partial reduction of oxygen, were for a long time considered to be a byproduct of cellular metabolism. Since, increase in cellular levels of ROS results in oxidative stress leading to damage of nucleic acids, proteins, and lipids resulting in numerous pathological conditions; ROS was considered a bane for aerobic species. Hence, the discovery of NADPH oxidases (NOX), an enzyme family that specifically generates ROS as its prime product came as a surprise to redox biologists. Read More

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Discovery of anaplastic lymphoma kinase inhibitors from natural product library: A holistic in silico approach.

Biotechnol Appl Biochem 2020 Sep 24. Epub 2020 Sep 24.

Department of Biotechnology, School of Bio Sciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India.

Over the years, phytochemical compounds have shown compelling evidences in exhibiting powerful antitumor properties. Moreover, due to the lack of safety and high cost of cancer therapies, opportunities are being sought out in these compounds as an alternative treatment modality. Therefore, in the present study, 1,574 compounds from NPACT library were examined to excavate potent and nontoxic anaplastic lymphoma kinase (ALK) inhibitors. Read More

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September 2020

Multicentre study of 4626 patients assesses the effectiveness, safety and burden of two categories of treatments for central retinal vein occlusion: intravitreal anti-vascular endothelial growth factor injections and intravitreal Ozurdex injections.

Br J Ophthalmol 2020 Sep 22. Epub 2020 Sep 22.

Institute of Health Informatics, University College London, London, UK.

Background/aims: To assess the effectiveness, burden and safety of two categories of treatment for central retinal vein occlusion (CRVO): intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) and dexamethasone (Ozurdex).

Methods: A retrospective analysis of Medisoft electronic medical record (EMR) data from 27 National Health Service sites in the UK identified 4626 treatment-naive patients with a single mode of treatment for macular oedema secondary to CRVO. Statistics describing the overall CRVO patient cohort and individual patient subpopulations stratified by treatment type were generated. Read More

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September 2020

The evolution of emergency general surgery: its time for a dedicated program manager.

Eur J Trauma Emerg Surg 2020 Sep 3. Epub 2020 Sep 3.

Division of Acute Care Surgery, University of Maryland, R Adams Cowley Shock Trauma Center, 22 South Greene St, Baltimore, MD, 21201, USA.

Background: Emergency general surgery (EGS) is emerging as a distinct sub-specialty of acute care surgery but continues to exist without essential processes that drive modern trauma programs. An EGS-specific quality program was created with service-based Advanced Practice Provider (SB APP) administrative oversight, thus validating the need for a dedicated EGS program manager.

Methods: In 2017, a quality structure was formalized with primary focus on scheduled quality meetings, peer review and outcomes review. Read More

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September 2020

Introduction of patient electronic medical records (EMR) into undergraduate nursing education: An integrated literature review.

Nurse Educ Today 2020 Nov 29;94:104517. Epub 2020 Jun 29.

School of Nursing and Midwifery, University of Newcastle, University Dr, Callaghan, NSW 2308, Australia. Electronic address:

Background: To prepare student nurses for clinical practice where patient electronic medical records (EMR) competence is required, nursing undergraduate curricula must provide simulation access to developing this skill set. At this stage, however, the integration of electronic documentation into the Australian undergraduate nursing curriculum has been piecemeal. Aim The aim of this integrated literature review was to identify benefits and challenges for faculty nursing staff and nursing students in relation to the integration, use and evaluation of EMR in an undergraduate nursing program. Read More

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November 2020