34,014 results match your criteria employed multiple


Unsupervised machine learning can delineate central sulcus by using the spatiotemporal characteristic of somatosensory evoked potentials.

J Neural Eng 2021 Apr 9. Epub 2021 Apr 9.

Biomedical Engineering Department, University of Houston, 4849 Calhoun Rd. HBS-Building 592, Houston, Texas, 77204-5060, UNITED STATES.

Objective: Somatosensory evoked potentials (SSEPs) recorded with electrocorticography (ECoG) for central sulcus (CS) identification is a widely accepted procedure in routine intraoperative neurophysiological monitoring. Clinical practices test the short-latency SSEPs for the phase reversal over strip electrodes. However, assessments based on waveform morphology are susceptible to variations in interpretations due to the hand area's localized nature and usually require multiple electrode placements or electrode relocation. Read More

View Article and Full-Text PDF

Targeted degradation of transcription factors by TRAFTACs: TRAnscription Factor TArgeting Chimeras.

Cell Chem Biol 2021 Apr 1. Epub 2021 Apr 1.

Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT 06511, USA; Department of Chemistry, Yale University, New Haven, CT 06511, USA; Department of Pharmacology, Yale University, New Haven, CT 06511, USA. Electronic address:

Many diseases, including cancer, stem from aberrant activation or overexpression of oncoproteins that are associated with multiple signaling pathways. Although proteins with catalytic activity can be successfully drugged, the majority of other protein families, such as transcription factors, remain intractable due to their lack of ligandable sites. In this study, we report the development of TRAnscription Factor TArgeting Chimeras (TRAFTACs) as a generalizable strategy for targeted transcription factor degradation. Read More

View Article and Full-Text PDF

Multi-Source Contribution Learning for Domain Adaptation.

IEEE Trans Neural Netw Learn Syst 2021 Apr 9;PP. Epub 2021 Apr 9.

Transfer learning becomes an attractive technology to tackle a task from a target domain by leveraging previously acquired knowledge from a similar domain (source domain). Many existing transfer learning methods focus on learning one discriminator with single-source domain. Sometimes, knowledge from single-source domain might not be enough for predicting the target task. Read More

View Article and Full-Text PDF

Multiview Subspace Clustering via Co-Training Robust Data Representation.

IEEE Trans Neural Netw Learn Syst 2021 Apr 9;PP. Epub 2021 Apr 9.

Taking the assumption that data samples are able to be reconstructed with the dictionary formed by themselves, recent multiview subspace clustering (MSC) algorithms aim to find a consensus reconstruction matrix via exploring complementary information across multiple views. Most of them directly operate on the original data observations without preprocessing, while others operate on the corresponding kernel matrices. However, they both ignore that the collected features may be designed arbitrarily and hard guaranteed to be independent and nonoverlapping. Read More

View Article and Full-Text PDF

Are digital technologies fit for clinical purposes? A systematic review and qualitative synthesis of information quality frameworks for digital healthcare.

J Med Internet Res 2021 Apr 3. Epub 2021 Apr 3.

Malawi eHealth Research Centre, University College Cork, Cork, IE.

Background: Digital Health Technologies (DHTs) generate large volume of information used in healthcare for administrative, educational, research and clinical purposes. Clinical use of digital information for diagnostic, therapeutic and prognostic purposes has multiple patient safety problems; some of which result from poor information quality.

Objective: The aim of this systematic review was to synthesize an Information Quality (IQ) framework which could be used to evaluate the extent to which digital health information is fit for clinical purposes. Read More

View Article and Full-Text PDF

A systematic review of security and privacy issues in the internet of medical things; the role of machine learning approaches.

PeerJ Comput Sci 2021 23;7:e414. Epub 2021 Mar 23.

Information Systems Department, College of Computer Sciences and Engineering, Taibah University, Medina, Saudi Arabia.

Background: The Internet of Medical Things (IoMTs) is gradually replacing the traditional healthcare system. However, little attention has been paid to their security requirements in the development of the IoMT devices and systems. One of the main reasons can be the difficulty of tuning conventional security solutions to the IoMT system. Read More

View Article and Full-Text PDF

Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs.

Front Vet Sci 2021 23;8:664718. Epub 2021 Mar 23.

PetDx, La Jolla, CA, United States.

Cancer is the leading cause of death in dogs, in part because many cases are identified at an advanced stage when clinical signs have developed, and prognosis is poor. Increased understanding of cancer as a disease of the genome has led to the introduction of liquid biopsy testing, allowing for detection of genomic alterations in cell-free DNA fragments in blood to facilitate earlier detection, characterization, and management of cancer through non-invasive means. Recent discoveries in the areas of genomics and oncology have provided a deeper understanding of the molecular origins and evolution of cancer, and of the "one health" similarities between humans and dogs that underlie the field of comparative oncology. Read More

View Article and Full-Text PDF

Transcriptomic Profiling Identifies DCBLD2 as a Diagnostic and Prognostic Biomarker in Pancreatic Ductal Adenocarcinoma.

Front Mol Biosci 2021 23;8:659168. Epub 2021 Mar 23.

Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Accumulating evidence shows that the elevated expression of DCBLD2 (discoidin, CUB and LCCL domain-containing protein 2) is associated with unfavorable prognosis of various cancers. However, the correlation of DCBLD2 expression value with the diagnosis and prognosis of pancreatic ductal adenocarcinoma (PDAC) has not yet been elucidated.

Methods: Univariate Cox regression analysis was used to screen robust survival-related genes. Read More

View Article and Full-Text PDF

Automated Online Flow Cytometry Advances Microalgal Ecosystem Management as , High-Temporal Resolution Monitoring Tool.

Front Bioeng Biotechnol 2021 23;9:642671. Epub 2021 Mar 23.

Sustainable Food Processing Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.

Microalgae are emerging as a next-generation biotechnological production system in the pharmaceutical, biofuel, and food domain. The economization of microalgal biorefineries remains a main target, where culture contamination and prokaryotic upsurge are main bottlenecks to impair culture stability, reproducibility, and consequently productivity. Automated online flow cytometry (FCM) is gaining momentum as bioprocess optimization tool, as it allows for spatial and temporal landscaping, real-time investigations of rapid microbial processes, and the assessment of intrinsic cell features. Read More

View Article and Full-Text PDF

Trypanosome KKIP1 Dynamically Links the Inner Kinetochore to a Kinetoplastid Outer Kinetochore Complex.

Front Cell Infect Microbiol 2021 23;11:641174. Epub 2021 Mar 23.

School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.

Kinetochores perform an essential role in eukaryotes, coupling chromosomes to the mitotic spindle. In model organisms they are composed of a centromere-proximal inner kinetochore and an outer kinetochore network that binds to microtubules. In spite of universal function, the composition of kinetochores in extant eukaryotes differs greatly. Read More

View Article and Full-Text PDF

Forensic Microbiome Database: A Tool for Forensic Geolocation Meta-Analysis Using Publicly Available 16S rRNA Microbiome Sequencing.

Front Microbiol 2021 23;12:644861. Epub 2021 Mar 23.

J. Craig Venter Institute, Rockville, MD, United States.

The human microbiome has been proposed as a tool to investigate different forensic questions, including for the identification of multiple personal information. However, the fragmented state of the publicly available data has retarded the development of analysis techniques and, therefore, the implementation of microbiomes as a forensic tool. To address this, we introduce the forensic microbiome database (FMD), which is a collection of 16S rRNA data and associated metadata generated from publicly available data. Read More

View Article and Full-Text PDF

Evaluation of the Development of Tolerance Following Frequent Administration of Propofol in Children Requiring Successive Sedation for Separate Procedures.

J Pediatr Pharmacol Ther 2021 31;26(3):277-283. Epub 2021 Mar 31.

Objective: Propofol is frequently used for outpatient sedation for pediatric patients, some of whom require multiple rounds of sedation for separate procedures within a short period. Anecdotal experience suggests that frequent use of propofol results in escalating doses; however, clinical evidence is unconvincing. This study was designed to evaluate if tolerance develops with frequent administration of propofol for children requiring multiple successive sedations. Read More

View Article and Full-Text PDF

Comprehensive rotational study and astronomical search for cyclopropanecarboxaldehyde.

Astron Astrophys 2021 Jan 15;645. Epub 2021 Jan 15.

Instituto de Física Fundamental (IFF-CSIC). Group of Molecular Astrophysics, C/Serrano 123, 28006 Madrid, Spain.

Context: At least a dozen molecules with a formyl group (HCO) have been observed to date in the interstellar medium (ISM), suggesting that other such species exist and remain to be discovered. However, there is still a lack of high-resolution spectroscopic data for simple molecular species of this type that could provide a basis for their detection.

Aims: Cyclopropanecarboxaldehyde, c-CHCHO, is a small molecule containing a formyl group and is therefore an interesting candidate for astrophysical detection. Read More

View Article and Full-Text PDF
January 2021

Intrapartum Group B Streptococcal Prophylaxis and Childhood Allergic Disorders.

Pediatrics 2021 Apr 8. Epub 2021 Apr 8.

Divisions of Neonatology,

Objectives: To determine if maternal intrapartum group B (GBS) antibiotic prophylaxis is associated with increased risk of childhood asthma, eczema, food allergy, or allergic rhinitis.

Methods: Retrospective cohort study of 14 046 children. GBS prophylaxis was defined as administration of intravenous penicillin, ampicillin, cefazolin, clindamycin, or vancomycin to the mother, ≥4 hours before delivery. Read More

View Article and Full-Text PDF

The Compounded Burden of Poverty on Mental Health for People with Disabilities.

Soc Work Public Health 2021 Apr 8:1-13. Epub 2021 Apr 8.

Joseph J. Zilber School of Public Health, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin, USA.

Using 2008-2017 National Health Interview Survey data (N = 127,973), we investigated the relationship between income and psychological distress, measured by the Kessler 6 (K6) Scale (range 0-24), net of education, employment, and other sociodemographic characteristics. Regression models allowed the association to differ by disability status and number of disabilities. Lower income predicted higher psychological distress for those with and without disabilities. Read More

View Article and Full-Text PDF

An electrostatic energy-based charge model for molecular dynamics simulation.

J Chem Phys 2021 Apr;154(13):134107

Shanghai Engineering Research Center for Molecular Therapeutics and New Drug Development, Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.

The interactions of the polar chemical bonds such as C=O and N-H with an external electric field were investigated, and a linear relationship between the QM/MM interaction energies and the electric field along the chemical bond is established in the range of weak to intermediate electrical fields. The linear relationship indicates that the electrostatic interactions of a polar group with its surroundings can be described by a simple model of a dipole with constant moment under the action of an electric field. This relationship is employed to develop a general approach to generating an electrostatic energy-based charge (EEC) model for molecules containing single or multiple polar chemical bonds. Read More

View Article and Full-Text PDF

Childhood trauma affects autobiographical memory deficits through basal cortisol and prefrontal-extrastriate functional connectivity.

Psychoneuroendocrinology 2021 Feb 10;127:105172. Epub 2021 Feb 10.

Department of Health Science, Kitasato University School of Allied Health Sciences, Japan.

Background: Psychological trauma can damage the brain, especially in areas where glucocorticoid receptors are expressed, via perturbed secretion of cortisol. Childhood trauma is associated with blunted basal cortisol secretion, brain alterations, and autobiographical memory deficits referred to as overgeneral autobiographical memory (OGM). However, it remains unknown whether childhood trauma affects OGM through altered cortisol and brain alterations. Read More

View Article and Full-Text PDF
February 2021

Lipid nanovesicles for biomedical applications: 'What is in a name'?

Prog Lipid Res 2021 Apr 5:101096. Epub 2021 Apr 5.

Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, Brazil. Electronic address:

Vesicles, generally defined as self-assembled structures formed by single or multiple concentric bilayers that surround an aqueous core, have been widely used for biomedical applications. They can either occur naturally (e.g. Read More

View Article and Full-Text PDF

Prevalence and predictors of smoking, quit attempts and total smoking ban at the University of Turku, Finland.

Cent Eur J Public Health 2021 Mar;29(1):45-55

Department of Epidemiology and Biostatistics, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Objectives: The current study employed socio-demographic, health and lifestyle, and academic variables to assess the prevalence and independent predictors of daily smoking, attempts to quit smoking, and agreement with total smoking ban at university.

Methods: Students at the University of Turku (1,177) completed an online questionnaire that assessed socio-demographic, health and lifestyle, and academic characteristics, and three smoking variables (smoking, attempts to quit, agreement with total smoking ban at university). Bivariate relationships and multiple logistic regression assessed relationships between student characteristics and the three smoking variables before and after controlling for all other variables. Read More

View Article and Full-Text PDF

Validation of a Mortality Composite Score in the Real-World Setting: Overcoming Source-Specific Disparities and Biases.

JCO Clin Cancer Inform 2021 Apr;5:401-413

Syapse, San Francisco, CA.

Purpose: This study tested whether a composite mortality score could overcome gaps and potential biases in individual real-world mortality data sources. Complete and accurate mortality data are necessary to calculate important outcomes in oncology, including overall survival. However, in the United States, there is not a single complete and broadly applicable mortality data source. Read More

View Article and Full-Text PDF

Interaction of Alkali Ions with Flavins: Infrared and Optical Spectra of Metal-Riboflavin Complexes.

J Phys Chem A 2021 Apr 8. Epub 2021 Apr 8.

Institut für Optik und Atomare Physik, Technische Universität Berlin, Hardenbergstr. 36, D-10623 Berlin, Germany.

Flavin compounds are of great interest in biochemistry because of their diverse functions in catalytic and photochemical processes. The intrinsic optical properties of flavins depend sensitively on their environment such as complexation with metal ions. Herein, we characterize the interaction of alkali metal ions (M) with riboflavin (RF, vitamin B). Read More

View Article and Full-Text PDF

Physiotherapists' job satisfaction according to employment situation: Findings from an online survey in Austria.

Physiother Res Int 2021 Apr 7. Epub 2021 Apr 7.

Department Health Sciences, FH Campus Vienna-University of Applied Sciences, Vienna, Austria.

Background And Purpose: Physiotherapists are commonly working in self-employed, employed, or in combined employed and self-employed work arrangements. This study aimed at examining aspects of job satisfaction and predictors of physiotherapists' overall job satisfaction across those three types of work arrangements.

Methods: Austrian physiotherapists rated their overall job satisfaction as well as the importance and realisation of aspects of job satisfaction in a cross-sectional online survey. Read More

View Article and Full-Text PDF

Telehealth to train interventionists teaching functional living skills to children with autism spectrum disorder.

J Appl Behav Anal 2021 Apr 8. Epub 2021 Apr 8.

School of Social Sciences, Education & Social Work, Queen's University of Belfast.

The number of Board Certified Behavior Analysts® (BCBA®s) available outside of the United States is significantly lower than the number of individuals with a diagnosis of autism spectrum disorder (ASD) requiring services. Research on alternative delivery platforms, such as telehealth, to disseminate interventions to those in need is of paramount importance. The current study evaluated the effectiveness of training professionals working with individuals with ASD in behavior-analytic procedures through telehealth. Read More

View Article and Full-Text PDF

The Effects of Physically Embodied Multiple Conversation Robots on the Elderly.

Front Robot AI 2021 22;8:633045. Epub 2021 Mar 22.

Department of Systems Innovation, Graduate School of Engineering Science, Osaka University, Osaka, Japan.

In recent years, communication robots aiming to offer mental support to the elderly have attracted increasing attention. Dialogue systems consisting of two robots could provide the elderly with opportunities to hold longer conversations in care homes. In this study, we conducted an experiment to compare two types of scenario-based dialogue systems with different types of bodies-physical and virtual robots-to investigate the effects of embodying such dialogue systems. Read More

View Article and Full-Text PDF

Wireless Powered Encoding and Broadcasting of Frequency Modulated Detection Signals.

IEEE Access 2020 4;8:200450-200460. Epub 2020 Nov 4.

Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA.

Wireless transmission of locally detected RF signals is necessary for long-term operation of batteryless and embedded transducers. To improve signal transmission efficiency over larger distances, multi-stage circuits were employed to down-convert RF signals before encoding them onto the emitted carrier wave. Such multi-stage arrangement had complicated design and high-power consumption. Read More

View Article and Full-Text PDF
November 2020

VisME: Visual Microsaccades Explorer.

J Eye Mov Res 2019 Dec 12;12(6). Epub 2019 Dec 12.

VISUS, University of Stuttgart, Germany.

This work presents a visual analytics approach to explore microsaccade distributions in high-frequency eye tracking data. Research studies often apply filter algorithms and parameter values for microsaccade detection. Even when the same algorithms are employed, different parameter values might be adopted across different studies. Read More

View Article and Full-Text PDF
December 2019

Fluorescence based rapid optical volume screening system (OVSS) for interrogating multicellular organisms.

Sci Rep 2021 Apr 7;11(1):7616. Epub 2021 Apr 7.

Nanobioimaging Lab., Department of Instrumentation and Applied Physics, Indian Institute of Science, Bangalore, 560012, India.

Continuous monitoring of large specimens for long durations requires fast volume imaging. This is essential for understanding the processes occurring during the developmental stages of multicellular organisms. One of the key obstacles of fluorescence based prolonged monitoring and data collection is photobleaching. Read More

View Article and Full-Text PDF

The FRAME-IS: a framework for documenting modifications to implementation strategies in healthcare.

Implement Sci 2021 Apr 7;16(1):36. Epub 2021 Apr 7.

National Center for PTSD Dissemination and Training Division, Palo Alto, CA, USA.

Background: Implementation strategies are necessary to ensure that evidence-based practices are successfully incorporated into routine clinical practice. Such strategies, however, are frequently modified to fit local populations, settings, and contexts. While such modifications can be crucial to implementation success, the literature on documenting and evaluating them is virtually nonexistent. Read More

View Article and Full-Text PDF

Students' perspectives of factors related to delayed completion of online RN-BSN programs.

BMC Nurs 2021 Apr 7;20(1):53. Epub 2021 Apr 7.

School of Rehabilitation and Medical Sciences, the Herbert H. and Grace A. Dow College of Health Professions, Central Michigan University, 1280 E Campus Dr, Mount Pleasant, MI, 48859, USA.

Background: There are multiple educational programs for individuals to become registered nurses (RNs), and the transition from an associate degree or diploma to a Bachelor of Science in Nursing (BSN) degree is vital to healthcare. This study examined the factors contributing to delayed completion or withdrawal from online RN-BSN nursing programs from students' perspectives.

Method: Thematic content analyses were conducted on qualitative data obtained from semi-structured interviews (N = 26). Read More

View Article and Full-Text PDF

Predicting cell invasion in breast tumor microenvironment from radiological imaging phenotypes.

BMC Cancer 2021 Apr 7;21(1):370. Epub 2021 Apr 7.

Department of Radiology, University of Pittsburgh School of Medicine, 4200 Fifth Ave, Pittsburgh, PA, 15260, USA.

Background: The abundance of immune and stromal cells in the tumor microenvironment (TME) is informative of levels of inflammation, angiogenesis, and desmoplasia. Radiomics, an approach of extracting quantitative features from radiological imaging to characterize diseases, have been shown to predict molecular classification, cancer recurrence risk, and many other disease outcomes. However, the ability of radiomics methods to predict the abundance of various cell types in the TME remains unclear. Read More

View Article and Full-Text PDF