Prog Neurobiol 2021 Feb 19:102023. Epub 2021 Feb 19.
School of Psychological and Cognitive Sciences, Peking University, China; PKU-IDG/McGovern Institute for Brain Research, Peking University, China; Beijing Key Laboratory of Behavior and Mental Health, Peking University, China. Electronic address:
Temporarily storing a list of items in working memory (WM), a fundamental ability in cognition, has been posited to rely on the temporal dynamics of multi-item neural representations during retention. However, the causal evidence, particularly in human subjects, is still lacking, let alone WM manipulation. Here, we develop a novel "dynamic perturbation" approach to manipulate the relative memory strength of WM items held in human brain, by presenting temporally correlated luminance sequences during retention to interfere with the multi-item neural dynamics. Read More