Dev Biol 2021 Jul 24;479:1-10. Epub 2021 Jul 24.
BIN RAS, St-Petersburg, Russia; IHES, France; I2BC, CEA, CNRS, Université Paris-Sud, Université Paris Saclay, France. Electronic address:
Along with a strict determinism of early embryogenesis in most living organisms, some of them exhibit variability of cell fates and developmental pathways. Here we discuss the phenomena of determinism and variability of developmental pathways, defining its dependence upon cell potency, cell sensitivity to the external signals and cell signaling. We propose a set of conjectures on the phenomenon of variability of developmental pathways, and denote a difference between a normal (local) variability, leading to an invariant final structure (e. Read More