26,706 results match your criteria embedding social


Quasiparticle Electronic Structure of Two-Dimensional Heterotriangulene-Based Covalent Organic Frameworks Adsorbed on Au(111).

J Phys Condens Matter 2021 Apr 13. Epub 2021 Apr 13.

Chemistry, Wayne State University, 5101 Cass Ave, Detroit, Michigan, 48202, UNITED STATES.

The modular nature and unique electronic properties of two-dimensional (2D) covalent organic frameworks (COFs) make them an attractive option for applications in catalysis, optoelectronics, and spintronics. The fabrications of such devices often involve interfaces formed between COFs and substrates. In this work, we employ the first-principles GW approach to accurately determine the quasiparticle electronic structure of three 2D carbonyl bridged heterotriangulene-based COFs featuring kagome lattice, with their properties ranging from a semi-metal to a wide-gap semiconductor. Read More

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Learning Multi-Modal Nonlinear Embeddings: Performance Bounds and an Algorithm.

IEEE Trans Image Process 2021 Apr 13;PP. Epub 2021 Apr 13.

While many approaches exist in the literature to learn low-dimensional representations for data collections in multiple modalities, the generalizability of multi-modal nonlinear embeddings to previously unseen data is a rather overlooked subject. In this work, we first present a theoretical analysis of learning multi-modal nonlinear embeddings in a supervised setting. Our performance bounds indicate that for successful generalization in multi-modal classification and retrieval problems, the regularity of the interpolation functions extending the embedding to the whole data space is as important as the between-class separation and cross-modal alignment criteria. Read More

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Developing acute care-based mental health nurses' knowledge and skills in providing recovery-orientated care: A mixed methods study.

Int J Ment Health Nurs 2021 Apr 13. Epub 2021 Apr 13.

School of Nursing and Midwifery, Centre for Quality and Patient Safety Research Epworth/Deakin Partnership, Faculty of Health, Deakin University, Geelong, Victoria, Australia.

Recovery-oriented principles have progressively been accepted as a standard of mental health practice in many countries, including Australia. A private mental health Clinic in Melbourne, Australia, is dedicated to embedding the principles of recovery-oriented practice into care by (i) providing recovery education and training for their staff and (ii) co-designing resources with consumers to promote active consumer engagement and participation. The purpose of this study was to evaluate the impact of these initiatives on staff knowledge and provision of recovery-oriented care in acute care. Read More

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Regenerative medicine meets mathematical modelling: developing symbiotic relationships.

NPJ Regen Med 2021 Apr 12;6(1):24. Epub 2021 Apr 12.

Healthcare Technology Institute, Institute of Translational Medicine, School of Chemical Engineering, University of Birmingham, Birmingham, UK.

Successful progression from bench to bedside for regenerative medicine products is challenging and requires a multidisciplinary approach. What has not yet been fully recognised is the potential for quantitative data analysis and mathematical modelling approaches to support this process. In this review, we highlight the wealth of opportunities for embedding mathematical and computational approaches within all stages of the regenerative medicine pipeline. Read More

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Central-to-peripheral corneal edema during wear of embedded-component contact lenses.

Cont Lens Anterior Eye 2021 Apr 9:101443. Epub 2021 Apr 9.

Vision Science Group, University of California, Berkeley, CA, 94720, United States; Chemical and Biomolecular Engineering Department, University of California, Berkeley, CA, 94720, United States. Electronic address:

Purpose: With active investigation underway for embedded-circuit contact lenses, safe oxygen supply of these novel lenses remains a question. Central-to-peripheral corneal edema for healthy eyes during wear of soft contact (SCL) and scleral lenses (SL) with embedding components is assessed.

Methods: Various 2-dimensional (2D) designs of SL and SCL with embedded components are constructed on Comsol Multiphysics 5. Read More

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Preparation and in vitro/vivo evaluation of folate-conjugated pluronic F87-PLGA/TPGS mixed nanoparticles for targeted drug delivery.

Curr Drug Deliv 2021 Apr 12. Epub 2021 Apr 12.

School of Life Science, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi. China.

Aim: Folate-conjugated Pluronic F87-poly(lactic-co-glycolic acid) block copolymer (FA-F87-PLGA) was synthesized to encapsulate anticancer drug Paclitaxel (PTX) for targeted drug delivery. To further improve the curative effect, D-α-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS or Vitamin E TPGS) was added to form FA-F87-PLGA/TPGS mixed NPs.

Methods: FA-F87-PLGA was synthesized by the ring-opening polymerization and the structure was characterized. Read More

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Staining and High-Resolution Imaging of Three-Dimensional Organoid and Spheroid Models.

J Vis Exp 2021 Mar 27(169). Epub 2021 Mar 27.

Childhood Cancer & Cell Death (C3), Université de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de recherche en cancérologie de Lyon (CRCL), Lyon 69373;

In vitro three-dimensional (3D) cell culture models, such as organoids and spheroids, are valuable tools for many applications including development and disease modeling, drug discovery, and regenerative medicine. To fully exploit these models, it is crucial to study them at cellular and subcellular levels. However, characterizing such in vitro 3D cell culture models can be technically challenging and requires specific expertise to perform effective analyses. Read More

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Supporting Discovery and Inquiry: A Canadian Hospital's Approach to Building Research and Innovation Capacity in Point-of-Care Health Professionals.

Qual Manag Health Care 2021 Apr 8. Epub 2021 Apr 8.

Department of Surgery, St Michael's Hospital, Toronto, Ontario, Canada (Ms Ruco); Institute of Health Policy, Management and Evaluation (Ms Ruco), Dalla Lana School of Public Health (Dr Nichol), and Department of Radiation Oncology (Ms Di Prospero), University of Toronto, Toronto, Ontario, Canada; VHA Home HealthCare, Toronto, Ontario, Canada (Dr Nichol); Centre for Research Expertise in Occupational Disease, Toronto, Ontario, Canada (Dr Nichol); Practice-Based Research and Innovation (Ms Morassaei), Odette Cancer Centre (Ms Bola), and Practice-Based Research and Innovation and Education Research Unit (Ms Di Prospero), Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada; School of Rehabilitation Therapy, Queen's University, Kingston, Ontario, Canada (Ms Morassaei); Elekta Reference Site, SBRT Training Institute, Toronto, Ontario, Canada (Ms Bola); and Sunnybrook Research Institute, Toronto, Ontario, Canada (Ms Bola).

Background And Objectives: Building capacity for research and innovation among point-of-care health professionals can translate into positive outcomes from the organization, staff, and patient perspective. However, there is not a widely accepted framework in place across academic hospitals to guide this work and measure impact. This article outlines one Canadian hospital's approach and provides a blueprint with appropriate indicators as a starting point and guide for organizations looking to develop and implement a practice-based research and innovation strategy. Read More

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Knowledge graphs and their applications in drug discovery.

Authors:
Finlay MacLean

Expert Opin Drug Discov 2021 Apr 12:1-13. Epub 2021 Apr 12.

Target Identification., BenevolentAI, United Kingdom of Great Britain and Northern Ireland.

Introduction: Knowledge graphs have proven to be promising systems of information storage and retrieval. Due to the recent explosion of heterogeneous multimodal data sources generated in the biomedical domain, and an industry shift toward a systems biology approach, knowledge graphs have emerged as attractive methods of data storage and hypothesis generation.

Areas Covered: In this review, the author summarizes the applications of knowledge graphs in drug discovery. Read More

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Impact of Porous Matrices and Concentration by Lyophilization on Cell-Free Expression.

ACS Synth Biol 2021 Apr 12. Epub 2021 Apr 12.

United States Army Combat Capabilities Development Command Chemical Biological Center. 8198 Blackhawk Road, APG, Aberdeen, Maryland 21010, United States.

Cell-free expression systems have drawn increasing attention as a tool to achieve complex biological functions outside of the cell. Several applications of the technology involve the delivery of functionality to challenging environments, such as field-forward diagnostics or point-of-need manufacturing of pharmaceuticals. To achieve these goals, cell-free reaction components are preserved using encapsulation or lyophilization methods, both of which often involve an embedding of components in porous matrices like paper or hydrogels. Read More

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Effects of acupoint catgut embedding on the postmenopausal osteoporosis patients and related mechanism.

Am J Transl Res 2021 15;13(3):1789-1798. Epub 2021 Mar 15.

Department of Traditional Medicine, Jiangsu Province Geriatric Hospital Nanjing, Jiangsu Province, China.

Objective: To study the effect and mechanism of acupoint catgut embedding on patients of postmenopausal osteoporosis (PMOP).

Methods: In this prospective study, 90 patients with PMOP who received treatment in our hospital were randomly divided into the drug treatment group (n=45) and drug treatment + catgut embedding group (n=45) according to SPSS random table method. The drug treatment group was given conventional western medicine treatment, and the drug treatment + catgut embedding group was given point embedding therapy. Read More

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