10,606 results match your criteria elimination kidneys

Relationship Between Antithymocyte Globulin Concentrations and Lymphocyte Sub-Populations in Kidney Transplant Patients.

Clin Pharmacokinet 2021 Jul 22. Epub 2021 Jul 22.

University of Tours, EA4245 T2I, Tours, France.

Background: Rabbit antithymocyte globulins (rATGs) are polyclonal antibodies used to prevent acute cellular rejection in kidney transplantation. Their dosing remains largely empirical and the question of an individualized dose is still unresolved.

Methods: Data from a prospective study in 17 kidney transplant patients were used to develop a model describing the dose-concentration-response relationship of rATG with T-lymphocyte subpopulation counts over time. Read More

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Marked and prolonged serotonin toxicity in a tramadol-poisoned patient with a pharmacokinetic study.

Clin Toxicol (Phila) 2021 Jul 21:1-4. Epub 2021 Jul 21.

Biologie du Médicament, AP-HP, Hôpital Cochin, Paris, France.

Background: Tramadol poisoning rarely causes serotonin toxicity, which mechanisms remain poorly understood. We investigated alterations in tramadol pharmacokinetics in a tramadol-poisoned patient who presented with marked and prolonged serotonin toxicity.

Case Report: A 21-year-old male self-ingested 750 mg-tramadol, 200 mg-sotalol, 400 mg-propranolol and 6 mg-lorazepam. Read More

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TMAO reductase, a biomarker for gut permeability defect induced inflammation, in mouse model of chronic kidney disease and dextran sulfate solution-induced mucositis.

Asian Pac J Allergy Immunol 2021 Jul 21. Epub 2021 Jul 21.

Department of Microbiology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.

Background: The excretion of trimethylamine N-oxide (TMAO) (uremic toxin) into the intestine might be enhanced, due to the limited renal elimination in chronic kidney disease (CKD), possibly induced TMAO reductase (a TMAO-neutralizing enzyme) in gut bacteria. Detection of TMAO reductase in serum could be used as a biomarker of gut permeability defect.

Objective: To explore the correlation between serum TMAO reductase, gut leakage, and systemic inflammation in CKD. Read More

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Muricholic Acids Promote Resistance to Hypercholesterolemia in Cholesterol-Fed Mice.

Int J Mol Sci 2021 Jul 2;22(13). Epub 2021 Jul 2.

Center for Translational Medicine, UMR1231 INSERM-uB-AgroSupDijon, Université de Bourgogne Franche-Comté (UBFC), 21000 Dijon, France.

Background And Aims: Hypercholesterolemia is a major risk factor for atherosclerosis and cardiovascular diseases. Although resistant to hypercholesterolemia, the mouse is a prominent model in cardiovascular research. To assess the contribution of bile acids to this protective phenotype, we explored the impact of a 2-week-long dietary cholesterol overload on cholesterol and bile acid metabolism in mice. Read More

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Weight loss reduces the incidence of dipstick proteinuria: a cohort study from the Japanese general population.

Clin Exp Nephrol 2021 Jul 17. Epub 2021 Jul 17.

The Steering Committee for "Japan Specific Health Checkups Study (J-SHC Study) Group", Fukushima, Japan.

Background: Though elimination of obesity is one of main therapeutic goal for lifestyle-related diseases, the impact of appropriate weight loss on reduction of the incidence of proteinuria in the general population is still unclear.

Methods: The study cohort was based on a general population of 9,33,490 from 40 to 74 years of age who had undergone annual specific health checkups. The subjects who were finally included were the 2,74,598 people for whom all the data necessary for this study were available. Read More

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Functionally Essential Tubular Proteins Are Lost to Urine-Excreted, Large Extracellular Vesicles during Chronic Renal Insufficiency.

Kidney360 2020 Oct 29;1(10):1105-1115. Epub 2020 Oct 29.

Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin.

Background: The 5/6 nephrectomy (5/6Nx) rat model recapitulates many elements of human CKD. Within weeks of surgery, 5/6Nx rats spontaneously exhibit proximal tubular damage, including the production of very large extracellular vesicles and brush border shedding. We hypothesized that production and elimination of these structures, termed large renal tubular extracellular vesicles (LRT-EVs), into the urine represents a pathologic mechanism by which essential tubule proteins are lost. Read More

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October 2020

Outcomes of symptomatic coronavirus disease 19 in maintenance hemodialysis patient in India.

Semin Dial 2021 09 14;34(5):360-367. Epub 2021 Jul 14.

George Institute India, University of New South Wales, Sydney, New South Wales, Australia.

Background: Maintenance hemodialysis (MHD) patients face disadvantages with higher risk of acquiring SARS-CoV-2 infection, atypical manifestations, and associated multiple comorbidities. We describe patients' outcomes with symptomatic COVID-19 on MHD in a large cohort of patients from India.

Methods: Data were collected prospectively from hemodialysis units in 11 public and private hospitals between March 15, 2020, and July 31, 2020. Read More

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September 2021

Pharmacokinetics of Polymyxin B in Hospitalized Adults with Cystic Fibrosis.

Antimicrob Agents Chemother 2021 Sep 12;65(10):e0079221. Epub 2021 Jul 12.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.

The optimal polymyxin B dosage needed to achieve an efficacy target of 50 to 100 mg · h/liter when treating multidrug-resistant bacterial infections in adult cystic fibrosis (CF) patients is unclear. The pharmacokinetics of intravenous polymyxin B were evaluated to better inform dosing. This was a prospective, observational pharmacokinetic (PK) study of nine CF adults receiving intravenous polymyxin B as part of usual clinical care. Read More

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September 2021

Brazilian registry for the elimination of hepatitis C in dialysis units: a call to action for Nephrology.

J Bras Nefrol 2021 Jul 7. Epub 2021 Jul 7.

Sociedade Brasileira de Nefrologia, São Paulo, SP, Brasil.

Infection by the hepatitis C virus is more prevalent in patients on dialysis than in the general population in Brazil, and has been associated with worse outcomes. Current therapy for hepatitis C is highly effective, safe, and widely available in Brazil, with coverage provided to dialysis patients with chronic kidney disease, which makes the elimination of hepatitis C a viable target. The Brazilian Society of Nephrology, the Brazilian Society of Hepatology, and the Brazilian Liver Institute developed the "Brazilian Registry for the Elimination of Hepatitis C in Dialysis Units". Read More

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[Reflux nephropathy in children: pathogenesis and prognosis. Part 1].

Urologiia 2021 Jun(3):150-154

Sechenov First Moscow State Medical University, Moscow, Russia, Moscow, Russia.

The purpose of this review is to analyze the modern literature about renal damage caused by vesicoureteral reflux (VUR). VUR is the most common urodynamic pathology in children and reflux nephropathy (RN), as its main complication, ranks first among the causes of chronic kidney disease (CKD). The risk factors for the appearance and progression of RN are presented in the first part of the review. Read More

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Preclinical development and characterisation of Tc-NM-01 for SPECT/CT imaging of human PD-L1.

Am J Nucl Med Mol Imaging 2021 15;11(3):154-166. Epub 2021 Jun 15.

Department of Nuclear Medicine, University Hospital RWTH Aachen Germany.

The level of expression of programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1) is a predictive biomarker for cancer immunotherapy, however, its detection remains challenging due to tumour heterogeneity and the influence from the binding of therapeutic agents. We recently developed [Tc]-NM-01 as a companion diagnostic imaging agent for non-invasive molecular imaging of PD-L1 by single-photon emission computed tomography (SPECT). The aim of the study was to evaluate the [Tc] radiolabelling of GMP graded NM-01 and its pharmacology, pharmacokinetics and toxicology. Read More

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Mixing Matrix-corrected Whole-body Pharmacokinetic Modeling Using Longitudinal Micro-computed Tomography and Fluorescence-mediated Tomography.

Mol Imaging Biol 2021 Jul 6. Epub 2021 Jul 6.

Institute for Experimental Molecular Imaging, Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University Clinic, 52074, Aachen, Germany.

Purpose: Pharmacokinetic modeling can be applied to quantify the kinetics of fluorescently labeled compounds using longitudinal micro-computed tomography and fluorescence-mediated tomography (μCT-FMT). However, fluorescence blurring from neighboring organs or tissues and the vasculature within tissues impede the accuracy in the estimation of kinetic parameters. Contributions of elimination and retention activities of fluorescent probes inside the kidneys and liver can be hard to distinguish by a kinetic model. Read More

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Tagetes erecta L. flowers, a medicinal plant traditionally used to promote diuresis, induced diuretic and natriuretic effects in normotensive and hypertensive rats.

J Ethnopharmacol 2021 Oct 3;279:114393. Epub 2021 Jul 3.

Postgraduate Program in Pharmaceutical Sciences, Nucleus of Chemical-Pharmaceutical Investigations, University of Vale do Itajaí, Itajaí, Brazil. Electronic address:

Ethnopharmacological Relevance: Tagetes erecta L., known as marigold, belongs to the Asteraceae family and is mainly found in South America. Despite reports that T. Read More

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October 2021

Bile Salts Regulate Zinc Uptake and Capsule Synthesis in a Mastitis-Associated Extraintestinal Pathogenic Escherichia coli Strain.

Infect Immun 2021 Sep 6;89(10):e0035721. Epub 2021 Jul 6.

Department of Microbiology and Molecular Biology, Brigham Young Universitygrid.253294.b, Provo, Utah, USA.

Extraintestinal pathogenic Escherichia coli (ExPEC) strains are major causes of urinary and bloodstream infections. ExPEC reservoirs are not completely understood. Some mastitis-associated E. Read More

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September 2021

The biological effects of radiation-induced liver damage and its natural protective medicine.

Prog Biophys Mol Biol 2021 Jul 1. Epub 2021 Jul 1.

Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.

The biological damage caused by the environmental factors such as radiation and its control methods are one of the frontiers of life science research that has received widespread attention. Ionizing radiation can directly interact with target molecules (such as DNA, proteins and lipids) or decomposed by radiation from water, leading to changes in oxidative events and biological activities in cells. Liver is a radiation-sensitive organ, and its radiosensitivity is second only to bone marrow, lymph, gastrointestinal tissue, gonads, embryos and kidneys. Read More

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Diagnosis of Chronic Kidney Disease Using Effective Classification Algorithms and Recursive Feature Elimination Techniques.

J Healthc Eng 2021 9;2021:1004767. Epub 2021 Jun 9.

Department of Computer Sciences and Information Technology, Albaha University, Al Bahah, Saudi Arabia.

Chronic kidney disease (CKD) is among the top 20 causes of death worldwide and affects approximately 10% of the world adult population. CKD is a disorder that disrupts normal kidney function. Due to the increasing number of people with CKD, effective prediction measures for the early diagnosis of CKD are required. Read More

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Serum Liberation of Fetal Fibronectin Variants in Patients with Pulmonary Hypertension: ED-A Fn as Promising Novel Biomarker of Pulmonary Vascular and Right Ventricular Myocardial Remodeling.

J Clin Med 2021 Jun 9;10(12). Epub 2021 Jun 9.

Department of Internal Medicine I, Jena University Hospital, 07740 Jena, Germany.

Background And Aims: Pulmonary Hypertension (PH) represents an aetiologically and clinically heterogeneous disorder accompanied by a severely impaired prognosis. Key steps of PH pathogenesis are vascular and right ventricular myocardial remodelling entailing the re-occurrence of fetal variants of the cell adhesion modulating protein fibronectin (Fn) being virtually absent in healthy adult tissues. These variants are liberated into circulation and are therefore qualified as excellent novel serum biomarkers. Read More

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The Role of ABCG2 in the Pathogenesis of Primary Hyperuricemia and Gout-An Update.

Int J Mol Sci 2021 Jun 22;22(13). Epub 2021 Jun 22.

Institute of Pharmacy, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.

Urate homeostasis in humans is a complex and highly heritable process that involves i.e., metabolic urate biosynthesis, renal urate reabsorption, as well as renal and extrarenal urate excretion. Read More

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Management and Treatment of Hepatitis C: Are There Still Unsolved Problems and Unique Populations?

Viruses 2021 Jun 1;13(6). Epub 2021 Jun 1.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20082 Milan, Italy.

Direct-acting antivirals (DAA) have revolutionized the treatment of patients with chronic hepatitis C virus (HCV) infection, possibly leading to HCV elimination by 2030 as endorsed by the World Health Organization (WHO). However, some patients belonging to the so-called unique or special populations are referred to as difficult-to-treat due to unreached sustained virological response, potential drug side effects or interactions or co-morbidities. Several years after the DAA introduction and on the basis of excellent findings in terms of efficacy and safety, some doubts arise around the exact meaning of the special population designation and whether this group of patients actually exists. Read More

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Transit and Metabolic Pathways of Quercetin in Tubular Cells: Involvement of Its Antioxidant Properties in the Kidney.

Antioxidants (Basel) 2021 Jun 3;10(6). Epub 2021 Jun 3.

Toxicology Unit, University of Salamanca, 37007 Salamanca, Spain.

Quercetin is a flavonoid with antioxidant, antiviral, antimicrobial, and anti-inflammatory properties. Therefore, it has been postulated as a molecule with great therapeutic potential. The renoprotective capacity of quercetin against various toxins that produce oxidative stress, in both in vivo and in vitro models, has been shown. Read More

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Dolutegravir in Mexico for special populations: A cost analysis perspective.

AIDS Rev 2021 Jul 1. Epub 2021 Jul 1.

ViiV Healthcare, Uruguay.

Integrase strand-transfer inhibitors (INSTI) are the latest class of antiretrovirals registered in Mexico. They include raltegravir (RAL), elvitegravir/cobicistat (EVG/c), dolutegravir (DTG) and bictegravir (BIC). Along with international guidelines, Mexico adopted the use of INSTI about two years ago as initial antiretroviral therapy (ART). Read More

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Traditional Chinese Medicine Intervenes in Vascular Dementia: Traditional Medicine Brings New Expectations.

Xue Bai Meng Zhang

Front Pharmacol 2021 14;12:689625. Epub 2021 Jun 14.

Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, China.

Vascular dementia (VD) is one of the most common forms of dementia, referring to a group of symptoms that mainly manifest as advanced neurocognitive dysfunction induced by cerebrovascular disease (CVD). A significant number of studies have shown that traditional Chinese medicine (TCM) has a clinical impact on VD and thus has promising prospects. There have been many discussions regarding the pharmacological mechanisms involved in treatment of the kidney, elimination of turbidity, and promotion of blood circulation. Read More

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ACE2 interaction with cytoplasmic PDZ protein enhances SARS-CoV-2 invasion.

iScience 2021 Jul 24;24(7):102770. Epub 2021 Jun 24.

Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh PA15261, USA.

SARS-CoV-2 is responsible for the global COVID-19 pandemic. Angiotensin converting enzyme 2 (ACE2) is the membrane-delimited receptor for SARS-CoV-2. Lung, intestine, and kidney, major sites of viral infection, express ACE2 that harbors an intracellular, carboxy-terminal PDZ-recognition motif. Read More

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Temperature-Dependent Residue Depletion Regularities of Tiamulin in Nile Tilapia () Following Multiple Oral Administrations.

Front Vet Sci 2021 11;8:679657. Epub 2021 Jun 11.

Yangtze River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Wuhan, China.

The aim of this study was to investigate the effect of different water temperatures (19, 25, and 30°C) on tissue residue depletion of tiamulin in Nile tilapia () after five consecutive days of oral administration at the dose of 20 mg/kg body weight and to calculate the corresponding elimination half-life ( ) and withdrawal times (WTs). After oral administration at scheduled 11 time points (1, 2, 3, 5, 7, 9, 12, 15, 20, 25, and 30 days), samples of plasma and tissues (muscle plus skin, liver, kidney, and gill) were collected. Tiamulin concentration in samples were determined by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS). Read More

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The effects of intrinsic apoptosis on cystogenesis in PKD1-deficient ADPKD pig model.

Gene 2021 Sep 25;798:145792. Epub 2021 Jun 25.

College of Biological Sciences, State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing, PR China. Electronic address:

Background: Apoptosis is a form of cell death that plays a critical role in the maintenance of tissue homeostasis involving the development and elimination of unwanted cells. Dysregulation of apoptosis appears to be associated in the pathogenesis of many human diseases. Autosomal dominant polycystic kidney disease (ADPKD) is a common monogenetic disease and is mainly caused by mutations in PKD1. Read More

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September 2021

Edaravone attenuates cadmium-induced toxicity by inhibiting oxidative stress and inflammation in ICR mice.

Neurotoxicology 2021 Sep 24;86:1-9. Epub 2021 Jun 24.

Key Laboratory of Ecology and Environment in Minority Areas National Ethnic Affairs Commission, Center on Translational Neuroscience, College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China. Electronic address:

The neurotoxicity caused by cadmium (Cd) is well known in humans and experimental animals. However, there is no effective treatment for its toxicity. In this study, we established Cd toxicity models in cultured cells or mice to investigate the detoxification effect of edaravone (Eda). Read More

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September 2021

Serum markers of fibrosis, cardiovascular and all-cause mortality in hemodialysis patients: the AURORA trial.

Clin Res Cardiol 2021 Jun 25. Epub 2021 Jun 25.

Université de Lorraine, Inserm, Centre d'Investigations Cliniques-1433, and Inserm U1116, CHRU Nancy; F-CRIN INI-CRCT, Nancy, France.

Background: Biomarkers of fibrosis are associated with outcome in several cardiovascular diseases. However, their relevance to chronic kidney disease and dialysis is uncertain, as it remains unclear how the kidneys and the dialysis procedure itself affect their elimination and degradation. We aimed to investigate the relationship of the blood levels of two markers associated with fibrosis: procollagen type I C-terminal pro-peptide (PICP) and galectin-3 (Gal-3) with mortality in dialysis patients. Read More

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Virtual Unenhanced Images: Qualitative and Quantitative Comparison Between Different Dual-Energy CT Scanners in a Patient and Phantom Study.

Invest Radiol 2021 Jun 22. Epub 2021 Jun 22.

From the Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA Institute for Diagnostic and Interventional Radiology, University Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany Department of Radiology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Department of Radiology, University of Washington, Seattle, WA.

The aim of this study was to compare qualitative and quantitative metrics of virtual unenhanced (VUE) images among dual-source dual-energy computed tomography (dsDECT), rapid kV-switching DECT (rsDECT), and dual-layer detector DECT (dlDECT) using patient and phantom data.

Materials And Methods: Forty-four patients with clinical contrast-enhanced abdominal examinations on each of the 3 DECT scanner types and a phantom scanned with the same protocols were included in this retrospective study. Qualitative and quantitative assessment was performed on VUE images. Read More

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Is elimination of HCV realistic by 2030: France.

Liver Int 2021 06;41 Suppl 1:45-49

Université Paris Centre, Département d'Hépatologie, Hôpital Cochin, APHP; INSERM U1223, Institut Pasteur, Paris, France.

The World Health Organization (WHO) has proposed a plan for the elimination of viral hepatitis with a goal of reducing new hepatitis infections by 30% and 90% in 2020 and 2030, and associated mortality by 10% and 65% respectively. Actions and targets to reach these goals include improving hepatitis B virus (HBV) vaccination programs, the prevention of mother-to-child transmission of HBV, improving the safety of blood products and injections, risk reduction policies and optimizing the diagnosis and treatment of hepatitis. The goal of eliminating hepatitis C virus (HCV) by 2030 is based on three main actions: increased screening, strengthening access to care and the prevention of infections and re-infections. Read More

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