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Infliximab use in the Netherlands: Uptake and characteristics of originator and biosimilars over time.

Br J Clin Pharmacol 2021 Sep 27. Epub 2021 Sep 27.

PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands.

Aims: The objective of this retrospective cohort study was to provide an overview of the utilization of originator and biosimilar infliximab in the Netherlands.

Methods: All infliximab dispensings were selected from the PHARMO In-patient Pharmacy Database from 2002-2018. Descriptive analyses were performed in order to characterise initiators and to describe switching patterns over time. Read More

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September 2021

Community Resource Connection for Pediatric Caregivers with Unmet Social Needs: A Qualitative Study.

Acad Pediatr 2021 Sep 24. Epub 2021 Sep 24.

PolicyLab and Center for Pediatric Clinical Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA; Leonard Davis Institute of Health Economics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Objective: Pediatric health systems are increasingly screening caregivers for unmet social needs. However, it remains unclear how best to connect families with unmet needs to available and appropriate community resources. We aimed to explore caregivers' perceived barriers to and facilitators of community resource connection. Read More

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September 2021

An Educational Video's Impact on the Induction of Labor Experience: A Randomized Controlled Trial: Educational Video's Impact on IOL, RCT.

Am J Obstet Gynecol MFM 2021 Sep 24:100495. Epub 2021 Sep 24.

OB GYN Department, George Washington University Hospital, Washington, D.C.; Present address for this author: Main Line HealthCare Gynecology at Lankenau Medical Center, Wynnewood, Pennsylvania.

Background: Induction of labor is a common obstetrical intervention; much research focuses on medical indications, clinical outcomes, and induction agents. Little research has been conducted evaluating patients' understanding of and satisfaction with induction of labor. Video-based educational tools have been validated as both a practical and efficient counseling method by previous studies. Read More

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September 2021

Uptake of genetic counseling and multi-gene panel testing among women in the Intermountain West with previous negative BRCA1 and BRCA2 results contacted for updated testing.

J Genet Couns 2021 Sep 27. Epub 2021 Sep 27.

Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.

Women with a personal history of breast or ovarian cancer who previously had BRCA1/2 testing now have the opportunity for additional genetic risk information through multi-gene panel testing. However, little is known about women's receptivity to further contact and uptake of genetic counseling and updated genetic testing. Utilizing a clinic database to identify potential participants, we prospectively contacted women in the United States with a personal and/or family history of breast or ovarian cancer who had negative BRCA1/2 testing, which was performed primarily between 2011 and 2018. Read More

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September 2021

A systematic review on SARS-CoV-2 Associated Fungal Co-Infections.

J Med Virol 2021 Sep 27. Epub 2021 Sep 27.

Amity Institute of Nanotechnology (AINT), Amity University Uttar Pradesh (AUUP), Noida, 201313, India.

Sever pandemic of Coronavirus disease (COVID-19) has been sweeping around the globe since 2019, and this time, it did not stop at frequent mutations to transform into virulent strains for instance B.1.1. Read More

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September 2021

Autologous Transplant versus Chimeric Antigen Receptor T-cell Therapy for Relapsed DLBCL in Partial Remission.

Blood 2021 Sep 27. Epub 2021 Sep 27.

CIBMTR, Medical College of WI, Milwaukee, Wisconsin, United States.

The relative efficacy of autologous hematopoietic cell transplant (auto-HCT) versus chimeric antigen receptor T-cell (CAR-T) therapy in diffuse large B-cell lymphoma (DLBCL) patients who achieve a partial remission (PR) after salvage chemotherapy is not known. Using the Center for International Blood & Marrow Transplant Research registry database, we identified adult DLBCL patients who received either an auto-HCT (2013-2019) or CAR-T treatment with axicabtagene ciloleucel (2018-2019) while in a PR by CT or PET scan. We compared the clinical outcomes between the two cohorts using univariable and multivariable regression models after adjustment for relevant baseline and clinical factors. Read More

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September 2021

The association between pre-colectomy thiopurine use and risk of neoplasia after ileal pouch anal anastomosis in patients with ulcerative colitis or indeterminate colitis: a propensity score analysis.

Int J Colorectal Dis 2021 Sep 27. Epub 2021 Sep 27.

Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: The risk of neoplasia of the pouch or residual rectum in patients with ulcerative colitis (UC) who undergo total proctocolectomy (TPC) with ileal pouch anal anastomosis (IPAA) is incompletely investigated. Thiopurine use is associated with a reduced risk of colorectal neoplasia in patients with UC. We tested the hypothesis that thiopurine use prior to TPC may be associated with a reduced risk of primary neoplasia after IPAA. Read More

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September 2021

Effect of Methylphenidate on Apathy in Patients With Alzheimer Disease: The ADMET 2 Randomized Clinical Trial.

JAMA Neurol 2021 Sep 27. Epub 2021 Sep 27.

Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland.

Importance: Apathy, characterized by diminished will or initiative and one of the most prevalent neuropsychiatric symptoms in individuals with Alzheimer disease, is associated with significant caregiver burden, excess disability, increased medical costs, and mortality.

Objective: To measure whether methylphenidate compared with placebo decreases the severity of apathy in individuals with Alzheimer disease.

Design, Setting, And Participants: This multicenter randomized placebo-controlled clinical trial was conducted from August 2016 to July 2020 in 9 US clinics and 1 Canadian clinic specializing in dementia care. Read More

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September 2021

Low-Value Care at the Actionable Level of Individual Health Systems.

JAMA Intern Med 2021 Sep 27. Epub 2021 Sep 27.

The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, New Hampshire.

Importance: Low-value health care remains prevalent in the US despite decades of work to measure and reduce such care. Efforts have been only modestly effective in part because the measurement of low-value care has largely been restricted to the national or regional level, limiting actionability.

Objectives: To measure and report low-value care use across and within individual health systems and identify system characteristics associated with higher use using Medicare administrative data. Read More

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September 2021

Sling Exercise in the Management of Chronic Low Back Pain: A Systematic Review and Meta-Analysis.

J Strength Cond Res 2021 Sep 23. Epub 2021 Sep 23.

Department of Physical Therapy, Long Island University, Brooklyn, New York.

Abstract: Drummond, C, Lebedeva, V, Kirker, K, and Masaracchio, M. Sling exercise in the management of chronic low back pain: A systematic review and meta-analysis. J Strength Cond Res XX(X): 000-000, 2021-The purpose of this systematic review is to assess the effectiveness of sling exercise therapy (SET) in individuals with chronic low back pain (LBP). Read More

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September 2021

Changes in Product Use and Quality of Life After Patch Testing in Children With Allergic Contact Dermatitis: A Follow-up Survey.

Dermatitis 2021 Sep 23. Epub 2021 Sep 23.

From the Medical Education Program Medical Scientist Training Program Division of Dermatology, Department of Medicine Department of Pediatrics, Washington University School of Medicine, St Louis, MO.

Background: Patch testing is the criterion standard to diagnose allergic contact dermatitis (ACD).

Objective: This study assessed the value of patch testing for product changes and quality of life in children with ACD.

Methods: In this cross-sectional survey, we used a questionnaire to follow up with families of ACD patients about changes since patch testing and counseling preferences. Read More

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September 2021

EXPRESS: Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis.

Int J Stroke 2021 Sep 27:17474930211045836. Epub 2021 Sep 27.

The University of Edinburgh, Geriatric Medicine, Usher Institute, Edinburgh, Edinburgh, United Kingdom of Great Britain and Northern Ireland.

Background: Identifying whether acute stroke patients are at risk of cognitive decline could improve prognostic discussions and management. Structural computed tomography (CT) neuroimaging is routine in acute stroke, and may, identify those at risk of post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI).

Aim: To systematically review the literature to identify which stroke or pre-stroke features on brain CT scans, performed at the time of stroke, are associated with PSD or PSCI. Read More

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September 2021

Survey of Patients Employing Cannabigerol-Predominant Cannabis Preparations: Perceived Medical Effects, Adverse Events, and Withdrawal Symptoms.

Cannabis Cannabinoid Res 2021 Sep 27. Epub 2021 Sep 27.

University of California, San Diego, San Diego, California, USA.

Cannabigerol (CBG), and its precursor before decarboxylation, cannabigerolic acid is sometimes labeled the "mother of all cannabinoids." The purpose of the present study was to investigate reasons for use and self-reported therapeutic effects in CBG-predominant cannabis users. Usage patterns and adverse effects, including withdrawal symptoms were also explored. Read More

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September 2021

Development and validation of a predictive model for bleeding after peripheral vascular intervention: A report from the National Cardiovascular Data Registry Peripheral Vascular Interventions Registry.

Catheter Cardiovasc Interv 2021 Sep 27. Epub 2021 Sep 27.

University of Missouri-Kansas City, Kansas City, Missouri, USA.

Objectives: To develop a model to predict risk of in-hospital bleeding following endovascular peripheral vascular intervention.

Background: Peri-procedural bleeding is a common, potentially preventable complication of catheter-based peripheral vascular procedures and is associated with increased mortality. We used the National Cardiovascular Data Registry (NCDR) Peripheral Vascular Interventions (PVI) Registry to develop a novel risk-prediction model to identify patients who may derive the greatest benefit from application of strategies to prevent bleeding. Read More

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September 2021

Biomarkers in the Prediction of Hemorrhagic Transformation in Acute Stroke: A Systematic Review and Meta-Analysis.

Cerebrovasc Dis 2021 Sep 22:1-13. Epub 2021 Sep 22.

Comprehensive Stroke Care Program, Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.

Background: Hemorrhagic transformation (HT) is a complication that occurs spontaneously or after thrombolysis in acute ischemic stroke (AIS) and can increase morbidity and mortality. The association of biomarkers with the risk of HT has been variably reported. We conducted a systematic review of the literature and meta-analysis and sought to compare blood biomarkers associated with HT and its subtypes by evaluating its predictability and correlation with outcome in AIS. Read More

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September 2021

Effect of Blood Flow Rate on the Accuracy of Central Venous Pressure Measurement during Continuous Renal Replacement Therapy.

Blood Purif 2021 Sep 21:1-8. Epub 2021 Sep 21.

Department of Critical Care Medicine, Dalian Municipal Central Hospital Affiliated of Dalian Medical University, Dalian, China.

Background: The objective of this study was to study the influence of extracorporeal blood flow rate (BFR) on the accuracy of central venous pressure (CVP) measurement during continuous renal replacement therapy (CRRT).

Methods: Eligible patients were randomly divided into 3 groups based on the location of catheters used for their CRRT and CVP measurement. CVP levels measured at increased extracorporeal BFR (from 0 to 300 mL/min) in the normal and reverse positions of inlet and outlet lines connected to the CV catheter (CVC) in the course of the CRRT session were collected. Read More

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September 2021

The implementation of risk minimization measures to prevent teratogenic pregnancy outcomes related to oral retinoid and valproate use in Belgium.

Acta Clin Belg 2021 Sep 26:1-8. Epub 2021 Sep 26.

Pharmaceutical Care Unit, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.

Introduction: Both oral retinoid and valproate containing medicines are highly teratogenic. Their use by women of childbearing age is controlled by risk minimization measures (RMMs) introduced by the European Medicine Agency, including the pregnancy prevention programme (PPP). In 2018, the RMMs were revised as previous measures were insufficient to prevent the use of these medicines during pregnancies. Read More

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September 2021

Systematic Review on the Mid-Term Outcomes of Elective Endovascular Aneurysm Sealing in Comparison to Endovascular Aneurysm Repair.

J Endovasc Ther 2021 Sep 27:15266028211047941. Epub 2021 Sep 27.

Department of Surgery, Division of Vascular Surgery, Universitair Medisch Centrum Groningen, Groningen, The Netherlands.

Introduction: The Nellix endovascular aneurysm sealing (EVAS) system has been a topic of discussion. Early results were promising but did not deliver on the long-term and the device has been recalled from the market. This study compares literature for EVAS and conventional endovascular aneurysm repair (EVAR). Read More

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September 2021

Combined Use of Tranexamic Acid and Rivaroxaban in Posterior/Transforaminal Lumbar Interbody Fusion Surgeries Safely Reduces Blood Loss and Incidence of Thrombosis: Evidence From a Prospective, Randomized, Double-Blind, Placebo-Controlled Study.

Global Spine J 2021 Sep 26:21925682211024556. Epub 2021 Sep 26.

Department of Orthopedics, Qilu Hospital of Shandong University, Lixia District, Ji'nan, Shandong, China.

Study Design: A prospective, randomized, double-blind, placebo-controlled study.

Objectives: There are few studies examining the balance between preventing venous thrombus embolism (VTE) and reducing blood loss in posterior/transforaminal lumbar interbody fusion (PLIF/TLIF) surgeries. This study aimed to evaluate the efficacy and safety of the combine application of TXA and rivaroxaban in patients undergoing PLIF/TLIF and explore relevant factors related to blood loss and VTE. Read More

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September 2021

The effectiveness of interventions to increase patient involvement in decision-making in orthodontics: A systematic review.

J Orthod 2021 Sep 27:14653125211048202. Epub 2021 Sep 27.

University of Leeds, Leeds, UK.

Objectives: To examine the effectiveness of interventions that aim to increase patient involvement in treatment decisions in orthodontic, orthognathic and cleft treatment, based on patient-reported outcomes and patient knowledge.

Design: Systematic review.

Data Sources: OVID databases (MEDLINE, EMBASE and EBM reviews), CENTRAL, WHO's International Clinical Trials Registry Platform and reference lists of included studies. Read More

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September 2021

Headache in progressive facial hemiatrophy (Parry-Romberg syndrome): A paradigmatic case and systematic review of the literature.

Cephalalgia 2021 Sep 26:3331024211043452. Epub 2021 Sep 26.

Pediatric Clinic, Maggiore Hospital, ASST Crema, Crema, Italy.

Background: Parry-Romberg syndrome is a neuro-cutaneous disease characterized by progressive hemifacial atrophy. Although common, headache in this population is scarcely reported in the literature.

Objective: To evaluate the clinical features of headache in pediatric and adult patients with Parry-Romberg syndrome, and to discuss diagnostic and treatment approaches of headache in Parry-Romberg syndrome. Read More

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September 2021

Psychometric validation of the Chinese version of the PROMIS Social Relationships Short Forms.

Nurs Open 2021 Sep 26. Epub 2021 Sep 26.

School of Nursing, Fudan University, Shanghai, China.

Aim: This study aimed to culturally adapt and psychometrically validate the PROMIS Social Relationships Short Forms (PROMIS-SR) among Chinese patients with breast cancer.

Design: A cross-sectional study.

Method: The PROMIS-SR was translated into simplified Chinese by strictly adhering to the Functional Assessment of Chronic Illness Therapy translation method and was subsequently tested among patients with breast cancer (N = 965). Read More

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September 2021

Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: a cross-sectional study.

J Gastroenterol Hepatol 2021 Sep 27. Epub 2021 Sep 27.

Department of Gastroenterology and Hepatology, Tokai University School of Medicine, Isehara, Japan.

Background: Two methods are used to evaluate gastritis: the updated Sydney system (USS) with pathology and Kyoto classification, a new endoscopy-based diagnostic criterion for which evidence is accumulating. However, the consistency of their results is unclear. This study investigated the consistency of their results. Read More

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September 2021

What is the threshold of mature oocytes to obtain at least one healthy transferable cleavage-stage embryo after preimplantation genetic testing for fragile X syndrome?

Hum Reprod 2021 Sep 26. Epub 2021 Sep 26.

Assistance Publique Hopitaux de Paris, Hopital Béclère, Service de Médecine de la Reproduction et Préservation de la Fertilité, Université Paris-Saclay, Clamart, France.

Study Question: What are the chances of obtaining a healthy transferable cleavage-stage embryo according to the number of mature oocytes in fragile X mental retardation 1 (FMR1)-mutated or premutated females undergoing preimplantation genetic testing (PGT)?

Summary Answer: In our population, a cycle with seven or more mature oocytes has an 83% chance of obtaining one or more healthy embryos.

What Is Known Already: PGT may be an option to achieve a pregnancy with a healthy baby for FMR1 mutation carriers. In addition, FMR1 premutation is associated with a higher risk of diminished ovarian reserve and premature ovarian failure. Read More

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September 2021

Family history recording in UK general practice: the lIFeLONG study.

Fam Pract 2021 Sep 27. Epub 2021 Sep 27.

College of Medicine and Health, University of Exeter, Exeter, Devon, United Kingdom.

Background: In order to integrate genomic medicine into routine patient care and stratify personal risk, it is increasingly important to record family history (FH) information in general/family practice records. This is true for classic genetic disease as well as multifactorial conditions. Research suggests that FH recording is currently inadequate. Read More

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September 2021

A Human Trafficking Educational Program and Point-of-Care Reference Tool for Pediatric Residents.

MedEdPORTAL 2021 13;17:11179. Epub 2021 Sep 13.

Associate Professor, Department of Pediatrics, Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine.

Introduction: Trafficked youth experience complex health issues such as substance abuse, severe physical trauma, and sexual health problems, with many entering trafficking between 15 and 17 years old. There is increasing awareness of the need to educate pediatric health care providers on identifying and aiding trafficked children; however, critical gaps in the literature exist regarding educational sessions specific to the human trafficking of pediatric patients. Our objective was to implement and evaluate a survivor-informed educational session for pediatric resident physicians to improve identification of and assistance to trafficked youth in the clinical setting. Read More

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September 2021

Laparoscopic vs. Open Pancreaticoduodenectomy After Learning Curve: A Systematic Review and Meta-Analysis of Single-Center Studies.

Front Surg 2021 10;8:715083. Epub 2021 Sep 10.

Department of Ultrasound Diagnosis, Air Force Medical Centre, Beijing, China.

Although laparoscopic pancreaticoduodenectomy (LPD) is a safe and feasible treatment compared with open pancreaticoduodenectomy (OPD), surgeons need a relatively long training time to become technically proficient in this complex procedure. In addition, the incidence of complications and mortality of LPD will be significantly higher than that of OPD in the initial stage. This meta-analysis aimed to compare the safety and overall effect of LPD to OPD after learning curve based on eligible large-scale retrospective cohorts and randomized controlled trials (RCTs), especially the difference in the perioperative and short-term oncological outcomes. Read More

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September 2021

The Impact of Nucleos(t)ide Analogs Off-Therapy Among Chronic Hepatitis B Patients: A Systematic Review and Meta-Analysis.

Front Public Health 2021 10;9:709220. Epub 2021 Sep 10.

Emergency Medical Center, Ningbo Yinzhou No. 2 Hospital, Ningbo, China.

Although most chronic hepatitis B (CHB) patients achieve effective virological suppression after receiving long-term nucleos(t)ide analogs (Nucs) therapy, the safety of off-therapy is controversial under the monitor. We identified studies through searching PubMed, Embase, Cochrane Library, and Web of Science from January 1990 to February 2021. The eligible studies compare the long outcomes between discontinued and continued Nucs treatments groups among CHB patients. Read More

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September 2021

Study of Treatment Outcome in Adults with TFE-Related RCC.

South Asian J Cancer 2021 Apr 4;10(2):92-96. Epub 2021 Sep 4.

Department of Medical Oncology, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.

TFE Translocation renal cell carcinoma (TRCC) represents 1 to 5% of all cases of renal cell carcinoma, with the highest frequency among children and young adults. Management of these tumors is not very well defined in literature. Although in pediatric age group it has favorable prognosis, in adults it has an aggressive nature, with poor outcome. Read More

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Real-World Experience of Immunotherapy from India in Recurrent Squamous Cell Carcinoma of Head and Neck Cancer.

South Asian J Cancer 2021 Apr 20;10(2):72-75. Epub 2021 Aug 20.

Department of Oncology, Max Super Speciality Hospital, Delhi, India.

Recurrent metastatic head and neck squamous cell carcinoma (HNSCC) patients carry a poor prognosis and have limited therapeutic options. In the randomized phase-3 trial CheckMate 141, nivolumab showed benefit in overall survival (OS) with manageable toxicity. Nivolumab is available for clinical practice since 2017 in India. Read More

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