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Clin Orthop Relat Res 2021 Apr 8. Epub 2021 Apr 8.

D. G. Weekes, R. E. Campbell, E. D. Wicks, C. J. Hadley, Z. S. Chaudhry, A. H. Carter, M. D. Pepe, B. S. Tucker, K. B. Freedman, F. P. Tjoumakaris, The Rothman Orthopaedic Institute, Thomas Jefferson University, Philadelphia, PA, USA.

Background: Pain after rotator cuff repair is commonly managed with opioid medications; however, these medications are associated with serious adverse effects. Relaxation exercises represent a potential nonpharmacologic method of pain management that can be easily implemented without substantial adverse effects; however, the effects of relaxation exercises have not been studied in a practical, reproducible protocol after arthroscopic rotator cuff repair.

Questions/purposes: (1) Does performing relaxation exercises after arthroscopic rotator cuff repair (ARCR) decrease pain compared with standard pain management medication? (2) Does performing relaxation exercises after ARCR decrease opioid consumption? (3) What proportion of patients who used the relaxation techniques believed they decreased their pain level, and what proportion continued using these techniques at 2 weeks? (4) Does performing relaxation exercises after ARCR affect shoulder function?

Methods: During the study period, 563 patients were eligible for inclusion; however, only 146 were enrolled, randomized, and postoperatively followed (relaxation group: 74, control group: 72); 68% (384 of 563) of patients were not contacted due to patient and research staff availability. Read More

Support Care Cancer 2021 Apr 8. Epub 2021 Apr 8.

The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, No.17 Lujiang Road, Hefei, People's Republic of China.

Objective: The aim of this study is to evaluate the effectiveness of web-based decision aids (WDAs) on cancer-related clinical care in terms of different decision categories and by different cancer types.

Methods: Literature retrieval utilized highly inclusive algorithms searching randomized controlled trials (RCTs) in MEDLINE, EMBASE, and Cochrane Library and manual searching of eligible studies from reference lists of relevant articles. Two researchers examined the articles selected separately and extracted the information about the studies (e. Read More

Knee Surg Sports Traumatol Arthrosc 2021 Apr 8. Epub 2021 Apr 8.

Orthopedic Department, Reinier Haga Orthopedisch Centrum, Toneellaan 2, 2725 NA, Zoetermeer, The Netherlands.

Purpose: Postoperative mortality is commonly reported as outcome measurement after total knee arthroplasty (TKA). Mortality might be influenced by multiple factors including cementation of the prosthesis. Until now, the influence of cementation on early and late mortality after TKA is unknown. Read More

Medicine (Baltimore) 2021 Apr;100(14):e25240

Department of Orthopedic Surgery, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China.

Background: Bilateral unicompartmental knee arthroplasty (UKA) can be divided into one or two stages clinically. Compared with staged bilateral UKA, whether simultaneous bilateral UKA has better clinical efficacy remains to be verified.

Methods: PubMed, EBSCO, and Web of Science were searched by us for meta-analysis. Read More

Dan Med J 2021 Mar 24;68(4). Epub 2021 Mar 24.

Introduction: This was a surgical pilot study to systematically introduce the technique of sentinel lymph node (SLN) mapping in women with early-stage stage cervical cancer (CC) and endometrial cancer (EC) in Denmark. The study aimed to facilitate structured surgical training to ensure surgeon proficiency in SLN mapping. The study precedes two national prospective studies on the oncological safety and correct patient selection for SLN mapping in CC and EC. Read More

J Rehabil Med 2021 Apr 8. Epub 2021 Apr 8.

Sensation and Perception Research Group, GIGA Consciousness and Cognitive Ergonomy and Work Intervention Department, University of Liège, Liège, Belgium.

Objective: To identify profiles of patients who are at risk of dropping out from biopsychosocial approaches to chronic pain management.

Patients: A total of 575 patients were included in the study. Of these, 203 were randomized into 4 treatment groups: self-hypnosis/self-care; music/self-care; self-care; and psychoeducation/cognitive behavioural therapy. Read More

Front Pediatr 2021 22;9:656806. Epub 2021 Mar 22.

Department of Anaesthesiology, Erasmus MC University Medical Centre, Rotterdam, Netherlands.

Newborns needing major surgical intervention are at risk of brain injury and impaired neurodevelopment later in life. Disturbance of cerebral perfusion might be an underlying factor. This study investigates the feasibility of serial transfontanellar ultrasound measurements of the pial arteries during neonatal surgery, and whether perioperative changes in cerebral perfusion can be observed and related to changes in the perioperative management. Read More

J Glob Health 2021 Apr 3;11:04023. Epub 2021 Apr 3.

Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Background: In resource-constrained settings, mobile health (mHealth) has varied applications. While there is strong evidence for its use in chronic disease management, the applications of mHealth for management of acute illness in low- and middle-income countries (LMICs) are not as well described. This review systematically explores current available evidence on the effectiveness of mHealth interventions at improving health outcomes in emergency care settings in LMICs. Read More

World J Gastroenterol 2021 Mar;27(12):1240-1254

Department of Medicine, Mayo Clinic, Rochester, MN 55905, United States.

Background: Hepatitis E virus (HEV) infection is underdiagnosed due to the use of serological assays with low sensitivity. Although most patients with HEV recover completely, HEV infection among patients with pre-existing chronic liver disease and organ-transplant recipients on immunosuppressive therapy can result in decompensated liver disease and death.

Aim: To demonstrate the prevalence of HEV infection in solid organ transplant (SOT) recipients. Read More

Int J Food Sci Nutr 2021 Apr 7:1-16. Epub 2021 Apr 7.

Faculty of Health Sciences, Institute of Public Health, Department of Nutrition and Drug Research, Jagiellonian University Medical College, Krakow, Poland.

The aim of this study was to identify the health risk factors associated with flavonoid intake in cohort studies investigating the association between dietary polyphenols and the risk of cardiovascular disease (CVD). A systematic search of the PubMed and EMBASE databases was performed. Prospective studies with the background characteristics given for categories of flavonoid intake were eligible to inclusion. Read More

Cleft Palate Craniofac J 2021 Apr 8:10556656211007680. Epub 2021 Apr 8.

Department of Orthodontics, School and Hospital of Stomatology, Wuhan University, Hubei, People's Republic of China.

Objective: The objective of this systematic review was to evaluate the evidence regarding skeletal maturation in patients with cleft lip and/or palate (CL/P) and to investigate whether the skeletal maturation is delayed in these patients.

Design: Systematic review.

Methods: Electronic and manual searches of scientific literature were conducted in 4 databases (MEDLINE, Embase, Cochrane Library, and Web of Science). Read More

Am J Clin Nutr 2021 Apr 7. Epub 2021 Apr 7.

Priority Research Centre Grow Up Well, University of Newcastle, Newcastle, NSW, Australia.

Background: The risk of wheezing is high in infancy and is heightened in infants with a family history of asthma/atopy. The role of breastfeeding in influencing respiratory health for these high-risk infants is unclear.

Objectives: To systematically appraise evidence for the association between breastfeeding and wheeze incidences and severity in high-risk infants. Read More

PLoS One 2021 7;16(4):e0249628. Epub 2021 Apr 7.

Experimental Parasitology Unit, Department of Medical Microbiology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

Cutaneous and mucocutaneous leishmaniasis affect a million people yearly, leading to skin lesions and potentially disfiguring mucosal disease. Current treatments can have severe side effects. Allylamine drugs, like terbinafine, are safe, including during pregnancy. Read More

Qual Life Res 2021 Apr 7. Epub 2021 Apr 7.

Department of Cardiothoracic Surgery, Maastricht University Medical Center+, P. Debyelaan 25, PO Box 5800, 6202 AZ, Maastricht, the Netherlands.

Background: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) has been used successfully for the past decade in adult patients with acute respiratory distress syndrome (ARDS) refractory to conventional ventilatory support. However, knowledge of the health-related quality of life (HRQoL) in VV-ECMO patients is still limited. Thus, this study aimed to provide a comprehensive overview of the HRQoL following VV-ECMO support in ARDS patients. Read More

JMIR Mhealth Uhealth 2021 Apr 7;9(4):e23649. Epub 2021 Apr 7.

School of Health, Medical and Applied Sciences, CQUniversity, Rockhampton, Australia.

Background: Physical activity during pregnancy is associated with several health benefits for the mother and child. However, very few women participate in regular physical activity during pregnancy. eHealth platforms (internet and mobile apps) have become an important information source for pregnant women. Read More

Langenbecks Arch Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Hepatobiliary and Pancreatic Surgery, Manchester Royal Infirmary Hospital, Manchester, UK.

Objectives: This study aims to evaluate the risk of postoperative mortality in octogenarians undergoing emergency laparotomy.

Methods: In compliance with STROCSS guideline for observational studies, we conducted a multicentre retrospective cohort study. All consecutive patients aged over 80 with acute abdominal pathology requiring emergency laparotomy between April 2014 and August 2019 were considered eligible for inclusion. Read More

J Interv Cardiol 2021 24;2021:6672400. Epub 2021 Mar 24.

Department of Cardiology, Rangueil University Hospital, Toulouse, France.

Introduction: The prevalence of coronary artery disease (CAD) detected in preoperative work-up for transcatheter aortic valve implantation (TAVI) is high. Instead, the management of a concomitant CAD remains unclear. We evaluate the impact of CAD and percutaneous coronary intervention (PCI) on TAVI procedures. Read More

Neuropsychiatr Dis Treat 2021 29;17:971-990. Epub 2021 Mar 29.

Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.

Background: Transcranial direct current stimulation (tDCS) has been proposed as a possible method for remediating age-associated cognitive decline in the older adult population. While tDCS has shown potential for improving cognitive functions in healthy older adults, stimulation outcomes on various cognitive domains have been mixed.

Methods: A systematic search was performed in four databases: PubMed, EMBASE, Web of Science, and PsychInfo. Read More

J Orthop Surg Res 2021 Apr 6;16(1):239. Epub 2021 Apr 6.

Department of Medicine, Surgery and Dentistry, University of Salerno, Via S. Allende, 84081, Baronissi, SA, Italy.

Background: The medial patellofemoral ligament (MPFL) is always damaged after patellar dislocation. In selected patients, MPFL reconstruction is necessary to restore a correct patellar tracking. Despite the large number of different techniques reported to reconstruct the MPFL, there is no consensus concerning the optimal procedure, and debates is still ongoing. Read More

J Neurotrauma 2021 Apr 6. Epub 2021 Apr 6.

The Royal Melbourne Hospital, 90134, Intensive Care Unit , Melbourne, Victoria, Australia.

Paroxysmal sympathetic hyperactivity (PSH) occurs in ~10% of patients following acute severe brain injury. Whilst PSH is associated with worse outcomes there are no clinical practice guidelines to inform treatment. We aimed to systematically review the literature on the pharmacological management of PSH. Read More

Int J Adolesc Med Health 2021 Apr 6. Epub 2021 Apr 6.

Laboratory of Striated Muscle Study (LEME/INISA), Federal University of Mato Grosso do Sul (UFMS), Campo Grande, MS, Brazil.

This review analyzed the studies that evaluated cardiovascular health indicators (blood pressure, waist circumference, heart rate, glucose index and lipid blood) in recreational soccer players during adolescence, and identify possible associated factors. The search was performed in the electronic databases (PubMED, SciELO, LILACS, Scopus, SPORTDiscus and Web of Science). Inclusion criteria were: population composed of children and/or adolescents (10-19 years or average age up to 19 years); studies adolescents engaged in recreational soccer regularly and observational studies with cross-sectional or longitudinal design. Read More

J Crohns Colitis 2021 Apr 5. Epub 2021 Apr 5.

Department of Gastroenterology and Inserm NGERE U1256, University Hospital of Nancy, University of Lorraine,Vandoeuvre-lès-Nancy, France.

Background And Aims: Histological healing might be the ultimate therapeutic goal in ulcerative colitis (UC). Our aim was to investigate the association between histological disease activity as measured by a validated index and long-term outcomes in patients with UC.

Methods: An observational retrospective cohort study was conducted at the Nancy University Hospital between January 2014 and March 2020. Read More

PLoS One 2021 6;16(4):e0249527. Epub 2021 Apr 6.

Department of Life Science, Hulunbuir University, Hulunbuir, Inner Mongolia Autonomous Region, China.

Objective: A meta-analysis was conducted to assess the effects of dietary chromium picolinate (CrPic) supplementation on broiler growth performance and to determine whether such effects are regulated by broiler strains, sex, environmental stress, or contextual factors including study area and years.

Methods: Eligible studies were identified by searching the Web of Science, Springer, Elsevier, ScienceDirect, Taylor & Francis Online databases. Weighted average differences with corresponding 95% confidence intervals were computed with a random-effects model. Read More

PLoS One 2021 6;16(4):e0247556. Epub 2021 Apr 6.

State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China.

Background: Few microRNAs were found consistently dysregulated in type 2 diabetes (T2D) that would gain confidence from Big Pharma to develop diagnostic or therapeutic biomarkers. This study aimed to corroborate evidence from eligible microRNAs-T2D association studies according to stringent quality criteria covering both biological and statistical significance in T2D for biomarker development.

Methods And Analyses: Controlled microRNA expression profiling studies on human with T2D will be retrieved from PubMed, ScienceDirect, and Embase for selecting the statistically significant microRNAs according to pre-specified search strategies and inclusion criteria. Read More

Semin Ophthalmol 2021 Apr 6:1-7. Epub 2021 Apr 6.

2 Department of Ophthalmology, University of Athens, Athens, Greece.

: The purpose of this review was to evaluate the association between glaucoma and depression and to identify possible risk factors for depressive symptoms in glaucoma patients.: A total of 587 abstracts were screened and 32 studies were deemed eligible for inclusion in this review.: An association of glaucoma and depression was found, while advanced disease stage, older age, female sex and faster visual loss progression were recognized as potential risk factors for depression in patients with glaucoma. Read More

Nutr Rev 2021 Apr 2. Epub 2021 Apr 2.

S.B. Jilcott Pitts, N.S. Johnson, and A.P. Kaur are with the Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA. Q. Wu is with the Department of Biostatistics, East Carolina University, East Carolina Heart Institute, Greenville, North Carolina, USA. G. Cahoon Firnhaber is with the Nurse Anesthesia Program, East Carolina University College of Nursing, Greenville, North Carolina, USA. J. Obasohan is with the National Human Genome Research Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland, USA.

Context: No meta-analyses appeared to have been conducted to examine overall correlations between resonance Raman spectroscopy (RRS)-assessed skin carotenoids and plasma/serum carotenoids.

Objective: To review the available literature and quantify the association between RRS-assessed skin carotenoids and plasma/serum carotenoids via a meta-analysis of observational studies.

Data Sources: To identify relevant publications, we searched the PubMed, Embase, CINAHL, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, ProQuest, and Scopus databases in April 2020 for items combining 3 concepts: Raman spectroscopy, skin, and plasma or serum. Read More

Prostate Cancer Prostatic Dis 2021 Apr 5. Epub 2021 Apr 5.

Radiation Medicine Program, The Ottawa Hospital Cancer Centre, Ottawa, ON, Canada.

Background: In patients presenting with metastatic prostate cancer, the role of local therapy is evolving. Two recently reported large-scale randomized trials suggest that radiotherapy (RT) directed at the prostate improves overall survival (OS) in patients with low metastatic burden. We reviewed the experience of prostate RT in this setting at our center. Read More

BMJ Open 2021 Apr 5;11(4):e044456. Epub 2021 Apr 5.

Institute of Public Health, United Arab Emirates University, College of Medicine and Health Sciences, Al Ain, UAE.

Introduction: Quad bikes are four-wheeled vehicles, driven off-road on uneven terrains by farmers for work or young adults for leisure. Quad bike accidental crashes result mostly due to the unique ecosystem of uneven terrain, where these unstable vehicles are commonly driven, in addition to numerous distinctive sociodemographic characteristics related to drivers. This is a protocol for a systematic review of observational studies from all geographical regions and demographic groups in the world to summarise the common risk factors relating to quad bike crashes. Read More

Curr Diabetes Rev 2021 Apr 4. Epub 2021 Apr 4.

Department of Physiology & Biochemistry, Govt. Yoga & Naturopathy Medical College & Hospital, Chennai- 600106. India.

Background: Diabetes mellitus has a significant impact on public health. Oxidative stress plays a major role in the pathophysiology of type 2 diabetes mellitus (T2DM), leading to various complications of T2DM. Yoga is being widely used in the management of T2DM. Read More

Brain Lang 2021 Apr 2;217:104940. Epub 2021 Apr 2.

Department of Psychology, Trent University, Peterborough, ON, Canada.

The psychosocial well-being of children and adolescents with epilepsy is affected by comorbid language deficits. Little is known about the focus of current research in language and epilepsy. A systematic review of research was conducted to identify gaps in knowledge regarding language and epilepsy. Read More