Environ Health Perspect 2004 May;112(7):799-804
Laboratory of Molecular Gerontology, Gerontology Research Center, National Institute on Aging, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224-6825, USA.
Many environmental metals are co-carcinogens, eliciting their effects via inhibition of DNA repair. Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is the major mammalian abasic endonuclease and initiates repair of this cytotoxic/mutagenic lesion by incising the DNA backbone via a Mg(2+)-dependent reaction. In this study we examined the effects of arsenite [As(III)], cadmium [Cd(II)], cobalt [Co(II)], iron [Fe(II)], nickel [Ni(II)], and lead [Pb(II)] at concentrations ranging from 0. Read More