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Tocilizumab for the Management of Thyroid-Associated Orbitopathy.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

The Pacific Center for Oculofacial and Aesthetic Plastic Surgery, San Francisco, California, U.S.A. California Pacific Medical Center, San Francisco, California, U.S.A. University of California San Francisco, San Francisco, California, U.S.A.

Purpose: To describe the efficacy of tocilizumab in the treatment of a cohort of patients with active thyroid-associated orbitopathy.

Methods: Patients were identified with active thyroid-associated orbitopathy who were intolerant of or had progression of disease despite systemic corticosteroids and subsequently were treated with tocilizumab between January 2015 and December 2020. Clinical Activity Score, Thyroid-Associated Ophthalmopathy Scale score, and thyroid-stimulating immunoglobulin levels were assessed prior to initiation of tocilizumab, following the first dose, and after the completion of treatment. Read More

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Ecotoxicity of chlorpyrifos on earthworm Eisenia fetida (Savigny, 1826): Modifications in oxidative biomarkers.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jul 19:109145. Epub 2021 Jul 19.

Department of Basic Sciences, Faculty of Veterinary, Shahrekord University, Iran.

Chlorpyrifos (CPF; O, O'-diethyl-3, 5, 6-trichloro-2-pyridyl phosphorothionate) as an organophosphate compound with moderate toxicity that entered the soil in 1965, is widely used as an active substance of many insecticides. CPF may affect some biochemical mechanisms, particularly through disrupting pro- and anti-oxidant balance and inducing free radical-induced oxidative stress. Expired pesticides, if present in ecosystem, may pose new issues of toxicological concern. Read More

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Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-signaling.

Am J Respir Cell Mol Biol 2021 Jul 22. Epub 2021 Jul 22.

Thomas Jefferson University, 6559, Center for Translational Medicine, Philadelphia, Pennsylvania, United States;

Exaggerated airway smooth muscle (ASM) contraction regulated by the Gq family of G protein-coupled receptors (GPCRs) causes airway hyperresponsiveness (AHR) in asthma. Activation of Gq-coupled GPCRs leads to phospholipase C (PLC)-mediated generation of inositol triphosphate (IP3) and diacylglycerol (DAG). DAG signaling is terminated by the action of DAG kinase (DGK) that converts DAG into phosphatidic acid (PA). Read More

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Measuring the difference in natural head position between the standing and sitting positions using an inertial measurement unit.

J Oral Rehabil 2021 Jul 22. Epub 2021 Jul 22.

Division of Orthodontics, University Clinics of Dental Medicine, University of Geneva, Switzerland.

The purpose of this study was to compare the natural head position (NHP) in the sitting position to the NHP in a standing position using inertial measurement unit (IMU) and lateral photographs. Twenty healthy young adult volunteers were asked to look at a mirror located at 1 meter in front of their eyes while being recorded with the IMU system. Lateral photographs were also taken. Read More

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Effects of Upper Extremity Elevation on Intra-Cast Pressure and Digital Perfusion in a Fiberglass Short-Arm Cast Model.

Orthopedics 2021 Jul-Aug;44(4):e487-e492. Epub 2021 Jul 1.

The goal of this study was to determine the relationship of digital artery pressure to arm position and forearm skin surface pressure using a short-arm cast experimental setup, to ascertain the safest position for the injured casted upper extremity. A total of 27 volunteers were placed in bilateral short-arm fiber-glass casts with an empty 50-mL bladder bag under the cast and attached to a pressure transducer. Digital systolic pressure (P), and skin surface pressure under the cast (P) were assessed in 4 positions. Read More

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Clinical and Radiological Outcomes in Reverse Total Shoulder Arthroplasty by Inclination Angle With a Modular Prosthesis.

Orthopedics 2021 Jul-Aug;44(4):e527-e533. Epub 2021 Jul 1.

The influence of the humeral inclination in reverse total shoulder arthroplasty (RTSA) is not well understood. The purpose of this study was to determine outcomes and complications after RTSA with an inclination of 135° or 155° in a modular prosthesis. American Shoulder and Elbow Surgeons (ASES), visual analog scale (VAS), Single Assessment Numeric Evaluation (SANE), and Simple Shoulder Test (SST) scores, as well as forward elevation (FE), abduction (ABD), and external rotation (ER), were assessed after a minimum 2-year follow-up. Read More

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Comparison of Hepatotoxicity Associated With New BCR-ABL Tyrosine Kinase Inhibitors vs Imatinib Among Patients With Chronic Myeloid Leukemia: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 Jul 1;4(7):e2120165. Epub 2021 Jul 1.

School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin, China.

Importance: Although BCR-ABL fusion oncoprotein tyrosine kinase inhibitors (BCR-ABL TKIs) can substantially improve the survival rate of chronic myeloid leukemia (CML), they are clinically accompanied by severe hepatotoxicity.

Objective: To compare the relative risk (RR) of hepatotoxicity of new-generation BCR-ABL TKIs with that of imatinib, and to provide an overall assessment of the clinical benefit.

Data Sources: PubMed, Embase, Cochrane library databases, and ClinicalTrials. Read More

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Pericardial SCUBE1 levels may help predict postoperative results in patients operated on for coronary artery bypass graft surgery.

Cardiovasc J Afr 2021 Jul 5;32:1-5. Epub 2021 Jul 5.

Cardiovascular Surgery Department, Trakya University, Edirne, Turkey.

Introduction: Signal peptide-CUB epidermal growth factorlike domain-containing protein (SCUBE1) is a newly described, secretable and measurable cellular surface protein associated with atherosclerotic lesions in humans, which may be involved in hypertension and cardiovascular pathologies. We aimed to detect normal SCUBE1 levels in pericardial fluid and investigate the effects of SCUBE1 values on postoperative outcomes after coronary artery bypass surgery.

Methods: Between February 2016 and March 2017, 184 consecutive patients were included in the study. Read More

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Long-Term Fertilization Alters Nitrous Oxide Cycling Dynamics in Salt Marsh Sediments.

Environ Sci Technol 2021 Jul 22. Epub 2021 Jul 22.

Department of Geosciences, Princeton University, Princeton 08544, New Jersey, United States.

Salt marsh sediments are known hotspots for nitrogen cycling, including the production and consumption of nitrous oxide (NO), a potent greenhouse gas and ozone-depleting agent. Coastal eutrophication, particularly elevated nitrogen loading from the application of fertilizers, is accelerating nitrogen cycling processes in salt marsh sediments. Here, we examine the impact of long-term fertilization on nitrogen cycling processes with a focus on NO dynamics in a New England salt marsh. Read More

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Early triggers of moderately high-fat diet-induced kidney damage.

Physiol Rep 2021 Jul;9(14):e14937

Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Most of the obesity murine models inducing renal injury use calorie-enriched foods, where fat represents 60% of the total caloric supply, however, this strategy doubles the standard proportion of fat ingestion in obese patients. Therefore, it is crucial to study the impact of a high-fat intake on kidney physiology that resembles common obesity in humans to understand the trigger mechanisms of the long-term consequences of overweight and obesity. In this study, we analyzed whether chronic feeding with a moderately high fat diet (MHFD) representing 45% of total calories, may induce kidney function and structural injury compared to C57BL/6 mice fed a control diet. Read More

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Identification and expression analysis of lncRNA in seven organs of Rhinopithecus roxellana.

Funct Integr Genomics 2021 Jul 21. Epub 2021 Jul 21.

Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, 610065, Sichuan, China.

Long non-coding RNA (lncRNA) represents a new direction to identify expression profiles and regulatory mechanisms in various organisms. Here, we report the first dataset of lncRNAs of the golden snub-nosed monkey (GSM), including 12,557 putative lncRNAs identified from seven organs. Compared with mRNA, GSM lncRNA had fewer exons and isoforms, and longer length. Read More

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Does Chronic Obstructive Pulmonary Disease Affect Workers' Health?

Authors:
Li-Peng Yao Ran Tao

Front Public Health 2021 5;9:711629. Epub 2021 Jul 5.

Qingdao Municipal Center for Disease Control and Preventation, Qingdao, China.

During recent decades, the elevation of workers' health has become the utmost point of concern since it is considered among the primary indicators of economies. The economies, especially the emerging ones, are primarily focusing on every indicator to uplift their businesses. Along with the other aspects, it is also required to assess the impact of Chronic Obstructive Pulmonary Disease (COPD) on workers' health conditions in small- and medium-scale enterprises (SMEs). Read More

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New mechanistic insights into hepatoprotective activity of milk thistle and chicory quantified extract: The role of hepatic Farnesoid-X activated receptors.

Avicenna J Phytomed 2021 Jul-Aug;11(4):367-379

Department of Physiology-Pharmacology-Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

Objective: Farnesoid-X-activated receptors (FXR) are key modulators of liver regeneration. Milk thistle and Chicory are known as potent protective remedies in several liver disorders. The objective of this work was to examine the role of in the hepato-healing properties of milk thistle (MTE) and chicory extracts (CE) in a rat model of acetaminophen-induced hepatotoxicity. Read More

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January 2020

Use of tape for the management of hypertrophic scar development: A comprehensive review.

Scars Burn Heal 2021 Jan-Dec;7:20595131211029206. Epub 2021 Jul 12.

The University of Queensland, School of Health and Rehabilitation Sciences, Brisbane, QLD, Australia.

Introduction: Tapes have been used to aid fresh wound closure. For hypertrophic scars, the use of tapes as a therapy to reduce the mechanical forces that stimulate excessive and long-term scarring is yet to be evaluated. The aim of this comprehensive review was to explore the current clinical application of tapes, as a minimally invasive option, as purposed specifically for the management of hypertrophic scarring, regardless of scar causation. Read More

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Reduction of Lipid-Core Burden Index in Nonculprit Lesions at Follow-Up after ST-Elevation Myocardial Infarction: A Randomized Study of Bioresorbable Vascular Scaffold versus Optimal Medical Therapy.

J Interv Cardiol 2021 1;2021:5590093. Epub 2021 Jul 1.

Division of Cardiology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain (UCLouvain), Brussels, Belgium.

Background: Non-flow-limiting nonculprit lesions (NCL) that contain a large lipid-rich necrotic core (nonculprit lipid-rich plaques (NC-LRP)) are most likely to cause recurrent acute coronary syndrome after ST-elevation myocardial infarction (STEMI). Near-infrared spectroscopy (NIRS) detects LRPs using the maximum 4 mm lipid-core burden index (maxLCBI). Few data are available regarding NIRS-guided therapy of these NC-LRPs, which are a potential target for preventive stenting. Read More

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Anterior segment dysmorphogenesis of the eye and glaucoma in MG-W gerbils.

J Toxicol Pathol 2021 Jul 18;34(3):245-249. Epub 2021 Apr 18.

Gotemba Research Institute, BoZo Research Center Inc., 1284 Kamado, Gotemba Shizuoka, 412-0039, Japan.

Unilaterally swollen eyes were histopathologically characterized in four MG-W gerbils. The primary lesions resided in the anterior segment of the eye where neural crest cells play a critical role in embryonic development. They included indistinct filtration angle, unformed canal of Schlemm, hypoplastic iris, and ciliary body. Read More

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Deubiquitinating enzyme USP30 negatively regulates mitophagy and accelerates myocardial cell senescence through antagonism of Parkin.

Cell Death Discov 2021 Jul 21;7(1):187. Epub 2021 Jul 21.

Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, 563000, Zunyi, P. R. China.

Cell senescence is associated with age-related pathological changes. Increasing evidence has revealed that mitophagy can selectively remove dysfunctional mitochondria. Overexpression of ubiquitin-specific protease 30 (USP30) has been documented to influence mitophagy and deubiquitination of mitochondrial Parkin substrates. Read More

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Presynaptic short-term plasticity persists in the absence of PKC phosphorylation of Munc18-1.

J Neurosci 2021 Jul 21. Epub 2021 Jul 21.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115

Post tetanic potentiation (PTP) is a form of short-term plasticity that lasts for tens of seconds following a burst of presynaptic activity. It has been proposed that PTP arises from protein kinase C (PKC) phosphorylation of Munc18-1, an SM (Sec1/Munc-18 like) family protein that is essential for release. To test this model, we made a knockin mouse in which all Munc18-1 PKC phosphorylation sites were eliminated through serine-to-alanine point mutations (Munc18-1SA mice) and we studied mice of either sex. Read More

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Exposure-safety analyses of nintedanib in patients with chronic fibrosing interstitial lung disease.

BMC Pulm Med 2021 Jul 21;21(1):244. Epub 2021 Jul 21.

Translational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, Birkendorfer Strasse 65, 88397, Biberach an der Riss, Germany.

Background: Nintedanib reduces the rate of decline in forced vital capacity in patients with idiopathic pulmonary fibrosis (IPF), other chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype and systemic sclerosis-associated ILD (SSc-ILD). The recommended dose of nintedanib is 150 mg twice daily (BID).

Methods: Data from Phase II and III trials in IPF and Phase III trials in SSc-ILD and progressive fibrosing ILDs other than IPF were analyzed to investigate the relationship between nintedanib plasma concentrations (exposure) and safety (liver enzyme elevations [defined as transaminase elevations equal or greater than 3 times the upper limit of normal] and diarrhea). Read More

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Chrysin alleviates alteration of bone-remodeling markers in ovariectomized rats and exhibits estrogen-like activity .

Hum Exp Toxicol 2021 Jul 21:9603271211033777. Epub 2021 Jul 21.

Department of Biochemistry, 58989Ahmadu Bello University, Zaria, Nigeria.

Background: Evidences are beginning to accrue that flavonoids, particularly phytoestrogens, could have beneficial effects against several age-related diseases linked to estrogen deficiency including postmenopausal osteoporosis.

Methods: In this study, the effect of chrysin on selected bone-remodeling markers in ovariectomized rats and its estrogen-like activity were investigated.

Results: The data indicated that administration of chrysin at 50 mg/kg and 100 mg/kg for 6 weeks to OVX rats significantly ( < 0. Read More

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[Risk factors of peritoneal metastasis in primary appendiceal tumor].

Zhonghua Zhong Liu Za Zhi 2021 Jul;43(7):806-809

Department of Coloretcal Surgery, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.

To investigate the risk factors of peritoneal metastasis in primary appendiceal tumor. The clinic data of 71 patients with primary appendiceal tumor admitted in the Sixth Affiliated Hospital of Sun Yat-sen University between Dec 2012 and Jan 2019 were enrolled retrospectively. Multivariate logistic regression analysis were carried out to evaluate the risk factors of appendiceal tumor with peritoneal metastasis. Read More

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[Clinical features and treatment outcome of extranodal nasal-type NK/T-cell lymphoma of the extra-upper aerodigestive tract].

Zhonghua Zhong Liu Za Zhi 2021 Jul;43(7):787-794

Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To investigate the clinical features and prognosis of extranodal nasal-type NK/T-cell lymphoma of the extra-upper aerodigestive tract (extra-UADT NKTCL). The clinical data of 159 patients with extra-UADT NKTCL from the China Lymphoma Collaborative Group (CLCG) database between November 2001 and December 2015 were retrospectively analyzed. Kaplan-Meier survival analysis and Log-rank test were used to evaluate the prognosis. Read More

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Coronary Artery Bypass Grafting Following Acute Coronary Syndrome: Impact of Gender.

Semin Thorac Cardiovasc Surg 2021 Jul 18. Epub 2021 Jul 18.

Department of Cardiac Surgery and Cardiology, Tel Aviv University, Israel; Leviev Cardiothoracic and Vascular Center, Sheba Medical Center, affiliated to the Sackler School of Medicine, Tel Aviv University, Israel.

The impact of gender on clinical outcomes after coronary artery bypass grafting (CABG) has generated conflicting results. We investigated the impact of gender, on 30-day mortality, complications and late survival in patients with acute coronary syndrome (ACS) undergoing CABG. The study included 1308 patients enrolled from the biennial Acute Coronary Syndrome Israeli Survey between 2000 and 2016, who were hospitalized for ACS and underwent CABG. Read More

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Characteristic manifestation of ocular and cervical vestibular evoked myogenic potentials findings in severe obstructive sleep apnea patients.

Acta Otolaryngol 2021 Jul 21:1-8. Epub 2021 Jul 21.

ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.

Background: Studies of saccular and utricular function in patients with obstructive sleep apnea (OSA) are rare. We noticed that some OSA patients also had positive results in vestibular function tests, and this inspired our interest in exploring the vestibular function patterns of OSA patients.

Objectives: To investigate otolithic organ function in severe OSA patients who lack vestibular symptoms and systemic disease. Read More

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Patterns of thyroid dysfunctions in adolescent patients suffering from severe acne during isotretinoin treatment.

Clin Exp Pharmacol Physiol 2021 Jul 21. Epub 2021 Jul 21.

Department of Dermatology and Andrology, Al-Azhar University (Assuit), Egypt.

Although oral isotretinoin has been widely used as a basic treatment of acne in adolescents, several studies have noted some alterations in thyroid functions during oral isotretinoin therapy. Therefore, the present study aims at evaluating the possible changes in thyroid-stimulating hormone (TSH), free thyroxin (fT4) and free triiodothyronine (fT3) levels during isotretinoin treatment and analyzing the possible factors which may contribute to such changes. In the present study, forty-seven patients received (0. Read More

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A Comparative Spatial and Climate Analysis of Human Granulocytic Anaplasmosis and Human Babesiosis in New York State (2013-2018).

J Med Entomol 2021 Jul 21. Epub 2021 Jul 21.

New York State Department of Health, Bureau of Communicable Disease Control, Albany, NY, USA.

Human granulocytic anaplasmosis (HGA) and human babesiosis are tick-borne diseases spread by the blacklegged tick (Ixodes scapularis Say, Acari: Ixodidae) and are the result of infection with Anaplasma phagocytophilum and Babesia microti, respectively. In New York State (NYS), incidence rates of these diseases increased concordantly until around 2013, when rates of HGA began to increase more rapidly than human babesiosis, and the spatial extent of the diseases diverged. Surveillance data of tick-borne pathogens (2007 to 2018) and reported human cases of HGA (n = 4,297) and human babesiosis (n = 2,986) (2013-2018) from the New York State Department of Health (NYSDOH) showed a positive association between the presence/temporal emergence of each pathogen and rates of disease in surrounding areas. Read More

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Early intrahepatic duct defects in a cystic fibrosis porcine model.

Physiol Rep 2021 Jul;9(14):e14978

Department of Internal Medicine, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Hepatobiliary disease causes significant morbidity and mortality in people with cystic fibrosis (CF), yet this problem remains understudied. Previous studies in the newborn CF pig demonstrated decreased bile flow into the small intestine and a microgallbladder with increased luminal mucus and fluid secretion defects. In this study, we examined the intrahepatic bile ducts of the newborn CF pig. Read More

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Letter to the Editor regarding article "J point elevation in high precordial leads associated with risk of ventricular fibrillation".

Ann Noninvasive Electrocardiol 2021 Jul;26(4):e12867

Department of Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.

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Scanning electron microscopy of the palatine mucosa with connective tissue papillae of the Egyptian red fox (Vulpes vulpes aegyptiaca, Linnaeus, 1758).

Microsc Res Tech 2021 Jul 20. Epub 2021 Jul 20.

Department of Histology and Cytology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt.

The present study investigated the morphological, as well as the histological features of the Egyptian red fox's palate, in addition to the three-dimensional characteristics of the connective tissue papillae (CTP) of the palate by scanning electron microscopy (SEM). The hard palate was narrow rostrally and its width increased caudally. The maximum width was located at the caudal border of the upper fourth premolar tooth. Read More

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