7,305 results match your criteria elevation lead


Sharing and Teaching Electrocardiograms to Minimize Infarction (STEMI): reducing diagnostic time for acute coronary occlusion in the emergency department.

Am J Emerg Med 2021 Mar 25;48:18-32. Epub 2021 Mar 25.

Emergency Department, University Health Network, Toronto, ON, Canada; Division of Emergency Medicine, Department of Medicine, University of Toronto, Toronto, ON, Canada. Electronic address:

Background: Limits to ST-Elevation Myocardial Infarction (STEMI) criteria may lead to prolonged diagnostic time for acute coronary occlusion. We aimed to reduce ECG-to-Activation (ETA) time through audit and feedback on STEMI-equivalents and subtle occlusions, without increasing Code STEMIs without culprit lesions.

Methods: This multi-centre, quality improvement initiative reviewed all Code STEMI patients from the emergency department (ED) over a one-year baseline and one-year intervention period. Read More

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Saccharated ferric oxide attenuates haematopoietic response induced by epoetin beta pegol in patients undergoing haemodialysis.

BMC Nephrol 2021 Apr 8;22(1):124. Epub 2021 Apr 8.

Internal Medicine (Nephrology and Dialysis), Hyogo College of Medicine, Mukogawa-cho, Nishinomiya City, Hyogo, 663-8501, Japan.

Background: Decreased erythropoietin levels and impaired iron metabolism due to excessive hepcidin levels are responsible for renal anaemia in patients undergoing haemodialysis. Recently, erythroferrone (ERFE) has been identified as a factor that regulates hepcidin. In addition, fibroblast growth factor 23 (FGF23), which has been recognized as a phosphorus-regulating hormone, appears to be involved in haematopoietic regulation. Read More

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Lead aVR predicts early revascularization but not long-term events in patients referred for stress electrocardiography.

PLoS One 2021 8;16(4):e0249779. Epub 2021 Apr 8.

Division of Cardiovascular Medicine, Department of Medicine, The Cardiovascular Imaging Center, University of Virginia Health System, Charlottesville, VA, United States of America.

Background: Exercise stress electrocardiography (ExECG) is recommended as a first-line tool to assess ischemia, but standard ST-analysis has limited diagnostic accuracy. ST elevation in lead aVR has been associated with left main and LAD disease in the population undergoing coronary angiography but has not been studied in the general population undergoing stress testing for the initial evaluation of CAD without coronary angiography. We sought to determine the predictive value of lead aVR elevation for ischemia, early revascularization, and subsequent cardiac events in consecutive patients undergoing ExECG. Read More

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A Rare Cause of ST-Segment Elevation Myocardial Infarction in COVID-19: MINOCA Syndrome.

Medeni Med J 2021 26;36(1):63-68. Epub 2021 Mar 26.

Health Sciences University, Umraniye Research and Training Hospital, Department of Emergency Medicine, Istanbul, Turkey.

Myocardial infarction with nonobstructive coronary arteries (MINOCA) is defined as having a stenosis of less than 50% or no stenosis in coronary angiography in a patient diagnosed with myocardial infarction. Because of its thrombogenic predisposition in COVID-19, the diagnosis of MINOCA syndrome is rarely thought in the patients with ST-segment elevation myocardial Infarction on electrocardiogram. In this case report, we discuss a 47-year-old male patient diagnosed with MINOCA who was followed up with respiratory failure due to COVID-19 viral pneumonia in intensive care unit. Read More

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Rapid deforestation of a coastal landscape driven by sea level rise and extreme events.

Ecol Appl 2021 Apr 4:e2339. Epub 2021 Apr 4.

Department of Biology, Duke University, Box 90338, Durham, North Carolina, 27708, USA.

Climate change is driving ecological shifts in coastal regions of the world, where low topographic relief makes ecosystems particularly vulnerable to sea level rise, salinization, storm surge, and other effects of global climate change. The consequences of rising water tables and salinity can penetrate well inland, and lead to particularly dramatic changes in freshwater forested wetlands dominated by tree species with low salt tolerance. The resulting loss of coastal forests could have significant implications to the coastal carbon cycle. Read More

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Visual Side Effects Linked to Sildenafil Consumption: An Update.

Biomedicines 2021 Mar 12;9(3). Epub 2021 Mar 12.

Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain.

Phosphodiesterase type 5 (PDE5) inhibitors such as Viagra (sildenafil citrate) have demonstrated efficacy in the treatment of erectile dysfunction (ED) by inducing cyclic guanosine monophosphate (cGMP) elevation followed by vasodilation and increased blood flow. It also exerts minor inhibitory action against PDE6, which is present exclusively in rod and cone photoreceptors. The effects of sildenafil on the visual system have been investigated in a wide variety of clinical and preclinical studies due to the fact that a high dose of sildenafil may cause mild and transient visual symptoms in some patients. Read More

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Cardiac Rupture-The Most Serious Complication of Takotsubo Syndrome: A Series of Five Cases and a Systematic Review.

J Clin Med 2021 Mar 4;10(5). Epub 2021 Mar 4.

Department of Invasive Cardiology, Medical University of Bialystok, 15-276 Bialystok, Poland.

Background: The most serious complication of the acute Takotsubo phase is a myocardial perforation, which is rare, but it usually results in the death of the patient.

Methods: In the years 2008-2020, 265 patients were added to the Podlasie Takotsubo Registry. Cardiac rupture was observed in five patients (1. Read More

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Sleeve Gastrectomy Is Associated with a Greater Reduction in Plasma Liver Enzymes Than Bypass Surgeries-A Registry-Based Two-Year Follow-Up Analysis.

J Clin Med 2021 Mar 9;10(5). Epub 2021 Mar 9.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem-Hadassah Medical School, Jerusalem 91120, Israel.

Bariatric surgeries may lead to an improvement in metabolic fatty liver disease, and a reduction in the levels of the hepatic enzyme Alanine Aminotransferase (ALT). We compared the effects of Sleeve Gastrectomy (SG), Roux en Y Gastric Bypass (RYGB) and One Anastomosis Gastric Bypass (OAGB) on the levels of ALT by analysis of two-year follow-up data from 4980 patients in the Israeli Bariatric Registry that included laboratory tests and demographic information. Pre-operative characteristics of patients, and particularly levels of liver enzymes, were similar across surgery types. Read More

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Role of Provocable Brugada ECG Pattern in The Correct Risk Stratification for Major Arrhythmic Events.

J Clin Med 2021 Mar 2;10(5). Epub 2021 Mar 2.

Cardiac Unit, Alto Vicentino Hospital, 36014 Santorso, Italy.

The so-called Brugada syndrome (BS), first called precordial early repolarization syndrome (PERS), is characterized by the association of a fascinating electrocardiographic pattern, namely an aspect resembling right bundle branch block with a coved and sometime upsloping ST segment elevation in the precordial leads, and major ventricular arrhythmic events that could rarely lead to sudden death. Its electrogenesis has been related to a conduction delay mostly, but not only, located on the right ventricular outflow tract (RVOT), probably due to a progressive fibrosis of the conduction system. Many tests have been proposed to identify people at risk of sudden death and, among all, ajmaline challenge, thanks to its ability to enhance latent conduction defects, became so popular, even if its role is still controversial as it is neither specific nor sensitive enough to guide further invasive investigations and managements. Read More

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Feasibility of Using Low-Cost Dual-Frequency GNSS Receivers for Land Surveying.

Sensors (Basel) 2021 Mar 11;21(6). Epub 2021 Mar 11.

Institute of Geodesy and Geoinformatics, Wrocław University of Environmental and Life Sciences, 50-375 Wrocław, Poland.

Global Navigation Satellite Systems (GNSS) have revolutionized land surveying, by determining position coordinates with centimeter-level accuracy in real-time or up to sub-millimeter accuracy in post-processing solutions. Although low-cost single-frequency receivers do not meet the accuracy requirements of many surveying applications, multi-frequency hardware is expected to overcome the major issues. Therefore, this paper is aimed at investigating the performance of a u-blox ZED-F9P receiver, connected to a u-blox ANN-MB-00-00 antenna, during multiple field experiments. Read More

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Mastering Electrocardiogram Interpretation Skills Through a Perceptual and Adaptive Learning Module.

AEM Educ Train 2021 Apr 5;5(2):e10454. Epub 2020 May 5.

Department of Emergency Medicine Harbor-UCLA Medical Center Torrance CA.

Although accurate interpretation of the standard 12-lead electrocardiogram (ECG) is fundamental to diagnosing heart disease, several prior studies report low accuracy rates among medical students, residents, and practicing physicians. The objective of this study was to determine if an online ECG Perceptual and Adaptive Learning Module (ECG PALM) is an efficient instrument to teach ECG interpretation. The ECG PALM consists of 415 unique ECG tracings with associated pretest, posttest, and delayed tests, each using 30 additional ECGs to gauge the effectiveness and durability of training. Read More

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Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival.

Front Pharmacol 2021 16;12:653035. Epub 2021 Mar 16.

Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.

Random-pattern skin flap replantation is generally used in the reconstruction of surgical tissues and covering a series of skin flap defects. However, ischemia often occurs at the flap distal parts, which lead to flap necrosis. Previous studies have shown that andrographolide (Andro) protects against ischemic cardiovascular diseases, but little is known about the effect of Andro on flap viability. Read More

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Twelve-Lead Electrocardiogram Acquisition With a Patchy-Type Wireless Device in Ambulance Transport: Simulation-Based Randomized Controlled Trial.

JMIR Mhealth Uhealth 2021 Apr 1;9(4):e24142. Epub 2021 Apr 1.

Department of Digital Health, Samsung Advanced Institute for Health Science & Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea.

Background: Cardiovascular disease is the leading cause of death worldwide. Early recognition, diagnosis, and reperfusion are the key elements of treatment for ST-segment elevation myocardial infarction. The absence of a prehospital 12-lead electrocardiogram (P12ECG) can cause definitive treatment delay and repeated transfer. Read More

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Primary Aldosteronism with Parathyroid Hormone Elevation: A Single-center Retrospective Study.

Intern Med 2021 1;60(7):993-998. Epub 2021 Apr 1.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Japan.

Objective Primary aldosteronism (PA) is a major cause of secondary hypertension. The association between PA and other hormone disorders is unclear. The present study aimed to evaluate whether the parathyroid hormone (PTH) value is associated with PA subtypes or specific treatments. Read More

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Association of the combined effects of air pollution and changes in physical activity with cardiovascular disease in young adults.

Eur Heart J 2021 Mar 29. Epub 2021 Mar 29.

Department of Biomedical Sciences, Seoul National University Graduate School, 101, Daehak-ro, Jongno-gu, Seoul 03080, South Korea.

Aims: Little is known about the trade-off between the health benefits of physical activity (PA) and the potential harmful effects of increased exposure to air pollution during outdoor PA. We examined the association of the combined effects of air pollution and changes in PA with cardiovascular disease (CVD) in young adults.

Methods And Results: This nationwide cohort study included 1 469 972 young adults aged 20-39 years. Read More

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[What are the main surgical and non-surgical techniques of the acceleration of orthodontic tooth movement?]

Orthod Fr 2021 Mar 26. Epub 2021 Mar 26.

Unité Fonctionnelle d'ODF, Hôpital de la Timone, 264 rue Saint-Pierre, 13005 Marseille, France.

Different surgical and non-surgical techniques have been developed in order to reduce the duration of orthodontic treatment. Regarding surgical techniques, corticotomies are widely used. The micro-osteoperforation technique (MOP), in addition to the piezocision technique, have been developed to provide minimally invasive surgery as an alternative to conventional corticotomies, without the elevation of a mucoperiosteal flap. Read More

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Fluid-structure interaction in a fully coupled three-dimensional mitral-atrium-pulmonary model.

Biomech Model Mechanobiol 2021 Mar 26. Epub 2021 Mar 26.

School of Mathematics and Statistics, University of Glasgow, Glasgow, G12 8SQ, UK.

This paper aims to investigate detailed mechanical interactions between the pulmonary haemodynamics and left heart function in pathophysiological situations (e.g. atrial fibrillation and acute mitral regurgitation). Read More

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Percutaneous management of reperfusion arrhythmias during primary percutaneous coronary intervention: a case report.

Egypt Heart J 2021 Mar 25;73(1):30. Epub 2021 Mar 25.

Department of Cardiology, Faculty of Medicine, Cairo University, 27 Nafezet Sheem El Shafae St Kasr Al Ainy, Cairo, 11562, Egypt.

Background: Myocardial reperfusion may cause profound electrophysiological alterations and can lead to serious reperfusion arrhythmias (RA). Management of RA and the accompanying electrical storm that may occur remains a problem. To our knowledge, the role of balloon re-inflation of the infarct-related artery (IRA) has never been addressed as a treatment modality for RA presenting as ventricular tachycardia (VT) with pulse or supraventricular tachycardia (SVT). Read More

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Immune modulating activity of the CHK1 inhibitor prexasertib and anti-PD-L1 antibody LY3300054 in patients with high-grade serous ovarian cancer and other solid tumors.

Cancer Immunol Immunother 2021 Mar 20. Epub 2021 Mar 20.

Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, USA.

Background: Checkpoint kinase 1 (CHK1) has dual roles in both the DNA damage response and in the innate immune response to genotoxic stress. The combination of CHK1 inhibition and immune checkpoint blockade has the potential to enhance anti-tumoral T-cell activation.

Methods: This was an open-label phase 1 study evaluating the CHK1 inhibitor prexasertib and the anti-PD-L1 antibody LY3300054. Read More

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Elevated Prosthetic Valve Gradients: What to Consider When Determining an Etiology.

J Cardiothorac Vasc Anesth 2021 Feb 12. Epub 2021 Feb 12.

Mayo Clinic Rochester, Rochester, MN.

DOPPLER echocardiography is a useful noninvasive tool for the assessment of cardiac hemodynamics. However, it is subject to limitations that can have important clinical implications, especially in the setting of valve prosthesis. Elevation in mean transvalvular gradient is a finding that has a variety of etiologies. Read More

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February 2021

A 66-Year-Old Woman with Intermittent Chest Pain and Dyspnea Who Underwent Continued ST-Segment Monitoring to Identify Occult ST-Segment Elevation that Expedited Coronary Angiography and Revascularization.

Am J Case Rep 2021 Mar 20;22:e929736. Epub 2021 Mar 20.

Department of Cardiology, Regional Hospital West Jutland, Herning, Denmark.

BACKGROUND In patients admitted to the hospital owing to suspected acute coronary syndrome and where the first electrocardiogram (ECG) is non-diagnostic of ST-elevated myocardial infarction (STEMI), international guidelines recommend that sequential ECGs are performed to identify new or intermittent ST-deviations. Continued monitoring for ST-segment alterations is rarely performed, in contrast to the continued monitoring for arrhythmias. Continued monitoring for ST-segment alteration may detect intermittent ST-segment elevations not captured by routine 12-lead ECGs. Read More

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Ghrelin attenuate cerebral microvascular leakage by regulating inflammation and apoptosis potentially via a p38 MAPK-JNK dependent pathway.

Biochem Biophys Res Commun 2021 May 17;552:37-43. Epub 2021 Mar 17.

Department of General Practice, The Second Affiliated Hospital of Chongqing Medical University, No. 76 Linjiang Road, Chongqing, 400010, China.

Ghrelin is a peptide hormone with strong anti-inflammatory properties. In fact, Ghrelin was reported to improve endothelial dysfunction caused by excessive fat. However, its role in preserving the integrity of brain microvascular, under conditions of lipid dysregulation and inflammation, is not known. Read More

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Optimum diameter threshold for lung nodules at baseline lung cancer screening with low-dose chest CT: exploration of results from the Korean Lung Cancer Screening Project.

Eur Radiol 2021 Mar 18. Epub 2021 Mar 18.

National Cancer Control Institute, National Cancer Center, Goyang, South Korea.

Objectives: To explore the optimum diameter threshold for solid nodules to define positive results at baseline screening low-dose CT (LDCT) and to compare two-dimensional and volumetric measurement of lung nodules for the diagnosis of lung cancers.

Methods: We included consecutive participants from the Korean Lung Cancer Screening project between 2017 and 2018. The average transverse diameter and effective diameter (diameter of a sphere with the same volume) of lung nodules were measured by semi-automated segmentation. Read More

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Immunoregulatory therapy strategies that target cytokine storms in patients with COVID-19 (Review).

Exp Ther Med 2021 Apr 3;21(4):319. Epub 2021 Feb 3.

Center for Tissue Engineering and Stem Cell Research, Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China.

A cytokine storm is an uncontrolled, excessive immune response that contributes to the pathogenesis of coronavirus disease 2019 (COVID-19). Viral infections lead to the loss of negative feedback in immune regulation and an abnormal elevation of the levels of multiple cytokines. In COVID-19, this causes diffuse damage to alveolar functions and may culminate in multiple organ dysfunction. Read More

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Needle in the heart: a rare case of cardiac tamponade caused by a migrated foreign body and mimicking ST segment elevation myocardial infarction.

BMC Cardiovasc Disord 2021 Mar 17;21(1):143. Epub 2021 Mar 17.

Heart and Vascular Center, Semmelweis University, Varosmajor Str. 68, 1122, Budapest, Hungary.

Background: Pericardial tamponade is a serious condition which may eventually lead to severe haemodynamic disturbances and cardiac arrest. It is most often caused by the accumulation of fluid inside the pericardium, as a result of different aetiological factors such as pericarditis, neoplastic diseases, lymphatic dysfunctions, or idiopathic pericardial disease. Pericardial tamponade can develop after cardiac surgical procedures or as a complication of myocardial infarction. Read More

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SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells.

Cell Rep 2021 Mar;34(11):108821

Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA. Electronic address:

Loss of integrin-mediated attachment to extracellular matrix (ECM) proteins can trigger a variety of cellular changes that affect cell viability. Foremost among these is the activation of anoikis, caspase-mediated cell death induced by ECM detachment. In addition, loss of ECM attachment causes profound alterations in cellular metabolism, which can lead to anoikis-independent cell death. Read More

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Brugada syndrome clinical update.

Hosp Pract (1995) 2021 Mar 30:1-7. Epub 2021 Mar 30.

New York Medical College School of Medicine, Valhalla, NY, USA.

Brugada syndrome (BrS) was initially described in southeast Asians with a structurally normal heart presenting with polymorphic ventricular tachycardia and fibrillation. This condition is marked by J-point elevation ≥ 2 mm with coved-type ST segment elevation followed by negative T wave inversions in at least one precordial lead (V1 or V2) when other etiologies have been excluded. These changes on electrocardiogram (EKG) can either be spontaneous or manifest after sodium channel blockade. Read More

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ECG Changes in a Case of Posterior Myocardial Infarction in the Presence of Right Bundle Branch Block.

Cureus 2021 Feb 11;13(2):e13281. Epub 2021 Feb 11.

Emergency Medicine, McMaster University, Hamilton, CAN.

A 70-year-old male with hypertension and diabetes presented to the emergency department with a 1-hour history of chest pain. Initial 12-lead ECG revealed a right bundle branch block (RBBB) and ST depression (STD) in V2-V4. The anterior STD prompted a 15-lead ECG in which there was no evidence of ST elevation (STE). Read More

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February 2021

Precisely Fabricated Sulpiride-Loaded Nanolipospheres with Ameliorated Oral Bioavailability and Antidepressant Activity.

Int J Nanomedicine 2021 9;16:2013-2044. Epub 2021 Mar 9.

Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Background: Sulpiride (SUL), is a selective antidopaminergic drug that had extensive biological activities. However, its sparingly aqueous solubility and limited gastrointestinal permeability lead to scanty oral bioavailability which hinders its clinical efficacy.

Objective: SUL-loaded lipospheres (SUL-LPS) were designed to serve as an oral biocompatible nanovector for improving SUL permeability as well as conquering its low oral absorption and then in turn enhancing its antidepressant action. Read More

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