20,349 results match your criteria elevated subsequent

Tumor-induced osteomalacia - a mystery illness beyond aches, pains, and depression.

Endocr Regul 2021 Sep 13;55(3):163-168. Epub 2021 Sep 13.

Endocrinology Department, Sutherland Hospital, Sydney, NSW, Australia.

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome characterized by chronic hypophosphatemia and osteomalacia. We present case of a patient with a protracted clinical course of TIO. TIO profoundly affected every aspect of his life with subsequent profound physical and psychosocial disabilities. Read More

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September 2021

Using genetics to detangle the relationships between red cell distribution width and cardiovascular diseases: a unique role for body mass index.

Open Heart 2021 Sep;8(2)

Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Objective: Red cell distribution width (RDW) is an enigmatic biomarker associated with the presence and severity of multiple cardiovascular diseases (CVDs). It is unclear whether elevated RDW contributes to, results from, or is pleiotropically related to CVDs. We used contemporary genetic techniques to probe for evidence of aetiological associations between RDW, CVDs, and CVD risk factors. Read More

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September 2021

Evaluating Serum Thymidine Kinase 1 in Hormone Receptor Positive Metastatic Breast Cancer Patients Receiving First Line Endocrine Therapy in the SWOG S0226 Trial.

Clin Cancer Res 2021 Sep 14. Epub 2021 Sep 14.

Internal Medicine, Division of Hematology/Oncology, Department of Pharmacology, University of Michigan Medical School

Purpose: Serum Thymidine Kinase 1 (sTK1) activity is associated with poor prognosis in metastatic breast cancer (MBC). We assessed the prognostic effect of sTK1 in patients with hormone receptor-positive MBC treated on a prospective randomized trial of anastrozole (A) vs. A plus fulvestrant (A+F). Read More

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September 2021

Multiple Grafting with Single Left Internal Mammary Artery as T-Graft with Itself.

Thorac Cardiovasc Surg 2021 Sep 14. Epub 2021 Sep 14.

Department of Cardiothoracic Surgery, Heart Center, University of Cologne, Cologne, Germany.

Background:  Revascularization strategies might be limited in patients with lack of sufficient bypass graft material and increased risk of wound healing disturbances. In this regard, we present first results of patients treated with left internal mammary artery (LIMA) as T-graft with itself due to left-sided double-vessel disease, elevated risk of wound healing infection, and lack of graft material.

Methods:  Eighteen patients were retrospectively analyzed in this study. Read More

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September 2021

Larger pupil dilation to nonsocial sounds in infants with subsequent autism diagnosis.

J Child Psychol Psychiatry 2021 Sep 13. Epub 2021 Sep 13.

Development and Neurodiversity Lab, Department of Psychology, Uppsala University, Uppsala, Sweden.

Background: Studies of infants with an elevated likelihood of autism spectrum disorder can identify basic developmental processes that are associated with subsequently emerging clinical symptoms. Atypical responsiveness to sounds in infancy is such a potential early marker of autism. Here, we used pupillometry to quantify reactivity to social and nonsocial sounds in infants with a subsequent diagnosis. Read More

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September 2021

Late-Onset Systemic Lupus Erythematosus Associated with Autoimmune Hemolytic Anemia and Sixth Cranial Nerve Palsy.

Am J Case Rep 2021 Sep 14;22:e932959. Epub 2021 Sep 14.

Department of Rheumatology, Okinawa Chubu Hospital, Uruma, Okinawa, Japan.

BACKGROUND Patients with late-onset systemic lupus erythematosus (SLE) do not present with typical SLE symptoms or serology, and this can lead to a major delay in diagnosis. We report a complex case of an older woman who developed autoimmune hemolytic anemia and sixth cranial nerve palsy that posed considerable challenges in diagnosing late-onset SLE. CASE REPORT A 78-year-old Japanese woman presented with polyarthritis associated with generalized fatigue for 2 months, who later developed diplopia. Read More

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September 2021

Primary Ciliary Dyskinesia: Ancestral Haplotypes Analysis of the RSPH4A Founder Mutation in Puerto Rico.

Cureus 2021 Sep 3;13(9):e17673. Epub 2021 Sep 3.

Department of Biology, University of Puerto Rico in Mayagüez, Mayagüez, PRI.

Genetic mutations in >50 genes, including can lead to primary ciliary dyskinesia (PCD). mutations affect radial spokes, which alter the configuration of the ciliary ultrastructure and lead to chronic oto-sinopulmonary disease. The  [c. Read More

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September 2021

Electrophysiological Characterization of Regular and Burst Firing Pyramidal Neurons of the Dorsal Subiculum in an Angelman Syndrome Mouse Model.

Front Cell Neurosci 2021 26;15:670998. Epub 2021 Aug 26.

Sagol Department of Neurobiology, The Integrated Brain and Behavior Research Center, University of Haifa, Haifa, Israel.

Angelman syndrome (AS) is a debilitating neurogenetic disorder characterized by severe developmental delay, speech impairment, gait ataxia, sleep disturbances, epilepsy, and a unique behavioral phenotype. AS is caused by a microdeletion or mutation in the maternal 15q11-q13 chromosome region containing gene. The hippocampus is one of the important brain regions affected in AS mice leading to substantial hippocampal-dependent cognitive and behavioral deficits. Read More

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If Hoofbeats are not From Horses, It Could be Zebras!! Isolated Hyper-alkaline Phosphatasemia.

J Clin Exp Hepatol 2021 Sep-Oct;11(5):619-622. Epub 2020 Dec 17.

Institute of Digestive Health and Liver Diseases, Mercy Medical Center, Baltimore, MD, USA.

Alkaline phosphatase (AP) is a membrane bound enzyme and when it is elevated in blood, it is mostly due to either hepatobiliary or bone diseases. We report isolated intestinal hyperphosphatasemia (IAP) in two sisters. Both sisters presented with identical trends of isolated AP elevation. Read More

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December 2020

Associations of Serum Insulin-Like Growth Factor 1 with New Cardiovascular Events and Subsequent Death in Hemodialysis Patients: The DREAM Cohort.

J Atheroscler Thromb 2021 Sep 11. Epub 2021 Sep 11.

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine.

Aim: Patients with chronic kidney disease (CKD) have elevated risk of death from cardiovascular disease (CVD). A low serum insulin-like growth factor 1 (IGF-1) level is known to predict higher risk for all-cause mortality in incident dialysis patients, although it is unknown whether IGF-1 predicts cardiovascular outcomes.

Methods: This was a prospective cohort study of maintenance hemodialysis patients followed up for 5 years. Read More

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September 2021

Use of disease-modifying antirheumatic drugs and the subsequent risk of herpes zoster in older adults.

Rheumatology (Oxford) 2021 Sep 11. Epub 2021 Sep 11.

School of Population Health, University of New South Wales, Sydney, NSW, Australia.

Objectives: To examine the association between DMARD use and subsequent risk of herpes zoster in a large, heterogeneous, and prospective population-based cohort.

Methods: Using data from a cohort of adults (45 and Up Study) recruited between 2006 and 2009 and linked to pharmaceutical, hospital and death data (2004-2015), the effect of DMARD use on zoster risk was analysed using Cox proportional hazards models, adjusting for sociodemographic characteristics, comorbidities and corticosteroid use.

Results: Among 254 065 eligible participants, over 1,826 311 person-years follow-up, there were 6295 new DMARD users and 17 024 incident herpes zoster events. Read More

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September 2021

Coinfection with dengue and hepatitis A complicated with infective endocarditis in a Yemeni patient: a case report.

J Med Case Rep 2021 Sep 11;15(1):450. Epub 2021 Sep 11.

University of Science and Technology Hospital, Sana'a, Yemen.

Introduction: Coinfection with dengue and hepatitis A is rare and challenging for physicians since their clinical features can be overlapping. These infections are self-limiting but can become complicated by subsequent infective endocarditis. We report a case of infective endocarditis following a coinfection with dengue and hepatitis A. Read More

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September 2021

Auxin Metabolome Profiling in the Arabidopsis Endoplasmic Reticulum Using an Optimised Organelle Isolation Protocol.

Int J Mol Sci 2021 Aug 29;22(17). Epub 2021 Aug 29.

Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences, and Faculty of Science, Palacký University, Šlechtitelů 27, CZ-78371 Olomouc, Czech Republic.

The endoplasmic reticulum (ER) is an extensive network of intracellular membranes. Its major functions include proteosynthesis, protein folding, post-transcriptional modification and sorting of proteins within the cell, and lipid anabolism. Moreover, several studies have suggested that it may be involved in regulating intracellular auxin homeostasis in plants by modulating its metabolism. Read More

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Incidence of Chronic Immune-Mediated Inflammatory Diseases After Diagnosis with Kawasaki Disease: A Population-Based Cohort Study.

Rheumatology (Oxford) 2021 Sep 8. Epub 2021 Sep 8.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.

Objectives: Kawasaki disease (kDa) is an immune-mediated vasculitis of childhood with multi-organ inflammation. We determined the risk of subsequent immune-mediated inflammatory disease (IMID), including arthritis, type 1 diabetes, inflammatory bowel disease (IBD), autoimmune liver disease (ALD), primary sclerosing cholangitis (PSC) and multiple sclerosis (MS).

Methods: We conducted a matched population-based cohort study using health administrative data from Ontario, Canada. Read More

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September 2021

Risk Factors of Mortality for Patients Receiving Venovenous Extracorporeal Membrane Oxygenation for COVID-19 Acute Respiratory Distress Syndrome.

Surg Infect (Larchmt) 2021 Sep 6. Epub 2021 Sep 6.

Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.

Venovenous extracorporeal membrane oxygenation (VV-ECMO) for select adults with severe acute respiratory distress syndrome (ARDS) cause by coronavirus disease 2019 (COVID-19) infection is a guideline-supported therapy with associated hospital survival of 62%-74%, similar to expected survival with VV-ECMO for other indications. However, ECMO is a resource-heavy intervention, and these patients often require long ECMO runs and prolonged intensive care unit (ICU) care. Identifying factors associated with mortality in VV-ECMO patients with COVID-19 infection can inform the evaluation of ECMO candidates as well as prognostication for those patients on prolonged VV-ECMO. Read More

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September 2021

Whooping cough complicating pulmonary hypertension in pregnancy.

BMJ Case Rep 2021 Sep 7;14(9). Epub 2021 Sep 7.

Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore.

We report a case of a previously fit woman who presented at 26 weeks into her fourth pregnancy with a dry cough. Following a nasopharyngeal swab, she was diagnosed with a infection, and treated with antibiotics. A chest X-ray showed right atrial dilatation and an echocardiogram was scheduled outpatient. Read More

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September 2021

Pericyte Contractile Responses to Endothelin-1 and Aβ Peptides: Assessment by Electrical Impedance Assay.

Front Cell Neurosci 2021 20;15:723953. Epub 2021 Aug 20.

Dementia Research Group, Clinical Neurosciences, University of Bristol, Bristol, United Kingdom.

Pericytes are vascular mural cells that contract and relax in response to vasoactive stimuli to regulate neurovascular coupling and cerebral blood flow. Pericytes are damaged and degenerate in Alzheimer's disease (AD). We previously showed that the level of the regulatory vasoconstrictor, endothelin-1 (EDN1), is elevated in AD cerebral cortex and upregulated by amyloid-beta (Aβ). Read More

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Iron-sulphur cluster biogenesis factor LYRM4 is a novel prognostic biomarker associated with immune infiltrates in hepatocellular carcinoma.

Cancer Cell Int 2021 Sep 6;21(1):463. Epub 2021 Sep 6.

College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, 410128, Hunan, China.

Background: LYRM4 is necessary to maintain the stability and activity of the human cysteine desulfurase complex NFS1-LYRM4-ACP. The existing experimental results indicate that cancer cells rely on the high expression of NFS1. However, the role of LYRM4 in liver hepatocellular carcinoma (LIHC) remains unclear. Read More

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September 2021

Concussion history in rugby union players is associated with depressed cerebrovascular reactivity and cognition.

Scand J Med Sci Sports 2021 Sep 6. Epub 2021 Sep 6.

Neurovascular Research Laboratory, Faculty of Life Sciences and Education, University of South Wales, Pontypridd, UK.

Recurrent contact and concussion in rugby union remains a significant public health concern given the potential increased risk of neurodegeneration in later life. This study determined to what extent prior-recurrent contact impacts molecular-hemodynamic biomarkers underpinning cognition in current professional rugby union players with a history of concussion. Measurements were performed in 20 professional rugby union players with an average of 16 (interquartile range [IQR] 13-19) years playing history reporting 3 (IQR 1-4) concussions. Read More

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September 2021

Clinical utility of methionine restriction in adenosine kinase deficiency.

JIMD Rep 2021 Sep 27;61(1):52-59. Epub 2021 Jul 27.

Division of Genetics, Department of Specialized Medicine McGill University Health Center Montréal Quebec Canada.

Adenosine kinase (ADK) deficiency is a rare autosomal recessive inborn error of metabolism involving the methionine and purine metabolic pathways. Prior reports show that most patients present in infancy with jaundice, hypotonia, developmental delay, and mild dysmorphic features. Characteristic biochemical findings included hypoglycemic hyperinsulinism, cholestasis, elevated liver functions, methionine, S-adenosylhomocysteine, and S-adenosylmethionine, with normal or mildly elevated homocysteine level. Read More

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September 2021

Diskogenic Dural Defect Is the Reason for the Ventral Location of the Epidural Spinal Fluid Collection Seen in Superficial Siderosis.

Neeraj Kumar

Neurol Clin Pract 2021 Aug;11(4):e508-e515

Department of Neurology, Mayo Clinic, Rochester, MN.

Purpose Of Review: Superficial siderosis (SS) of the nervous system is often due to a dural pathology. This review focuses on recent developments related to the management of this subgroup of patients with SS.

Recent Findings: The presence of an epidural ventral spinal fluid collection in patients with SS is a clue to the presence of a diskogenic dural defect. Read More

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Maternal Angiotensin II-Induced Hypertension Sensitizes Postweaning High-Fat Diet-Elicited Hypertensive Response Through Increased Brain Reactivity in Rat Offspring.

J Am Heart Assoc 2021 Sep 6:e022170. Epub 2021 Sep 6.

Departments of Psychological and Brain Sciences University of Iowa Iowa City IA.

Background Prenatal and postnatal insults can induce a physiological state that leaves offspring later in life vulnerable to subsequent challenges (stressors) eliciting cardiometabolic diseases including hypertension. In this study, we investigated whether maternal angiotensin II-induced hypertension in rats sensitizes postweaning high-fat diet (HFD)-elicited hypertensive response and whether this is associated with autonomic dysfunction and altered central mechanisms controlling sympathetic tone in offspring. Methods and Results When eating a low-lard-fat diet, basal mean arterial pressure of male offspring of normotensive or hypertensive dams were comparable. Read More

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September 2021

Prenatal Tobacco Exposure and the Risk of Tobacco Smoking and Dependence in Offspring: a Systematic Review and Meta-Analysis.

Drug Alcohol Depend 2021 Aug 27;227:108993. Epub 2021 Aug 27.

Curtin School of Population Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia; Institute for Social Sciences Research, The University of Queensland, 80 Meier's Rd, Indooroopilly, QLD, 4068, Australia.

Background: There is some compelling, though not comprehensive, epidemiological evidence which suggests an association between prenatal tobacco exposure and tobacco smoking/dependence in offspring. We conducted a systematic review and meta-analysis to identify the magnitude and consistency of associations reported between prenatal tobacco exposure and subsequent tobacco smoking/dependence in offspring.

Methods: Using the PRISMA guideline, we systematically searched PubMed, SCOPUS, EMBASE and Psych-INFO to identify relevant studies. Read More

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Trajectories of glycemic control with clinical pharmacy specialist management of veterans with type 2 diabetes.

Res Social Adm Pharm 2021 Aug 26. Epub 2021 Aug 26.

University of Kansas School of Pharmacy, Department of Pharmacy Practice, Lawrence, KS, United States.

Background: Improved control of glycemic control likely lowers the risk of diabetes complications and clinical pharmacy specialist (CPS) services can improve glycemic control. Though the pattern of control may also matter in terms of outcomes.

Objectives: The objective of this study was to examine the longitudinal trajectories of HbA1c among a large population of Veterans with type 2 diabetes who received CPS-led diabetes management. Read More

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Relation of the Metabolic Syndrome to Incident Colorectal Cancer in Young Adults Aged 20 to 49 Years.

Am J Cardiol 2021 Sep 1. Epub 2021 Sep 1.

The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.

Onco-cardiology is the emerging field, and the concept of shared risk factor holds an important position in this field. The increasing prevalence of colorectal cancer (CRC) in young adults is a critical epidemiological issue. Although metabolic syndrome, which is a major risk factor for cardiovascular disease, is known to be associated with CRC incidence in middle-aged and elderly individuals, it is unclear whether this association is present in young adults. Read More

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September 2021

Diabetes complication burden and patterns and risk of mortality in people with schizophrenia and diabetes: A population-based cohort study with 16-year follow-up.

Eur Neuropsychopharmacol 2021 Sep 1;53:79-88. Epub 2021 Sep 1.

Department of Psychiatry, Queen Mary Hospital, The University of Hong Kong, Pokfulam, Hong Kong; State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong. Electronic address:

Schizophrenia is associated with increased prevalence of diabetes. However, risk of diabetes complications as well as the impact of complication burden and patterns on subsequent mortality risk in schizophrenia patients with co-existing diabetes is understudied. This population-based, propensity-score matched (1:10) cohort study identified 6991 patients with incident diabetes and pre-existing schizophrenia and 68,682 patients with incident diabetes only (comparison group) between 2001 and 2016 in Hong Kong, using territory-wide medical-record database of public healthcare services. Read More

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September 2021

COVID-19, cardiovascular diseases and cardiac troponins.

Future Cardiol 2021 Sep 3. Epub 2021 Sep 3.

Cardiology Department, & The Department of Medicine, Westchester Medical Center & New York Medical College, Valhalla, NY 10595, USA.

There has been strong evidence of myocardial injury in coronavirus disease 2019 (COVID-19) patients with significantly elevated serum cardiac troponin (cTn). While the exact mechanism of injury is unclear, possible suggested pathological mechanisms of injury are discussed. These include increased susceptibility of the myocardium and endothelium to viral invasion, underlying hyperinflammatory state and subsequent cytokine storm, a hypercoagulable and prothrombotic state, and indirect myocardial injury due to hypoxemia. Read More

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September 2021

Sleeping Beauty transposon mutagenesis identifies genes driving the initiation and metastasis of uterine leiomyosarcoma.

Cancer Res 2021 Sep 2. Epub 2021 Sep 2.

The University of Texas MD Anderson Cancer Center

Uterine leiomyosarcoma (ULMS) is a malignancy that arises from the uterine smooth muscle. Due to its rarity, aggressive nature, and extremely poor prognosis, the molecular mechanisms driving ULMS remain elusive. To identify candidate cancer genes (CCG) driving ULMS, we conducted an in vivo Sleeping Beauty (SB) transposon mutagenesis screen in uterine myometrium-specific, Pten knockout, Kras mutant (PtenKO/Kras) mice. Read More

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September 2021

Inhibition of ceramide de novo synthesis ameliorates meibomian gland dysfunction induced by SCD1 deficiency.

Ocul Surf 2021 Aug 30;22:230-241. Epub 2021 Aug 30.

Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of Medicine, Xiamen University, Xiamen, China. Electronic address:

High expression of stearoyl-CoA desaturase-1 (SCD1) in meibomian glands produces monounsaturated fatty acids that allow the biosynthesis of glycerolipids and other wax-esters but only the low production of sphingolipids. Here, we found that SCD1 deficiency in mice induces the spill of free fatty acids into a parallel pathway for ceramide biosynthesis, resulting in severe meibomian gland dysfunction associated with meibum accumulation in duct lumen and orifices and subsequent atrophy and loss of acinar cells. Genetic and pharmacological inhibition of SCD1 in mice resulted in meibomian gland pathological phenotypes, including local lipid microenvironment alterations, reduced normal cellular differentiation, increased keratinization, inflammatory cell infiltration, cell apoptosis, and mitochondrial dysfunction. Read More

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