115,235 results match your criteria elevated risks

Potential Cost-Effectiveness of Risk-Based Pancreatic Cancer Screening in Patients With New-Onset Diabetes.

J Natl Compr Canc Netw 2021 Jun 21:1-9. Epub 2021 Jun 21.

1CHOICE Institute, Department of Pharmacy, University of Washington, Seattle, Washington.

Background: There are no established methods for pancreatic cancer (PAC) screening, but the NCI and the Pancreatic Cancer Action Network (PanCAN) are investigating risk-based screening strategies in patients with new-onset diabetes (NOD), a group with elevated PAC risk. Preliminary estimates of the cost-effectiveness of these strategies can provide insights about potential value and inform supplemental data collection. Using data from the Enriching New-Onset Diabetes for Pancreatic Cancer (END-PAC) risk model validation study, we assessed the potential value of CT screening for PAC in those determined to be at elevated risk, as is being done in a planned PanCAN Early Detection Initiative trial. Read More

View Article and Full-Text PDF

Cardiac manifestation is evident in chorea-acanthocytosis but different from McLeod syndrome.

Parkinsonism Relat Disord 2021 May 24;88:90-95. Epub 2021 May 24.

Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Translational Neurodegeneration Section "Albrecht-Kossel", Department of Neurology, University Medical Center, University of Rostock, Rostock, Germany. Electronic address:

Introduction: We aimed to study the various cardiac manifestations of the two core neuroacanthocytosis (NA) syndromes, namely chorea-acanthocytosis (ChAc) and McLeod syndrome (MLS). So far, cardiac involvement has been described as specific feature only for MLS.

Methods: We studied six patients with ChAc (mean age 44. Read More

View Article and Full-Text PDF

Trends and age-period-cohort analysis of upper aerodigestive tract and stomach cancer mortality in Lithuania, 1987-2016.

Public Health 2021 Jun 18;196:62-68. Epub 2021 Jun 18.

Laboratory of Cancer Epidemiology, National Cancer Institute, P. Baublio 3B, LT-08406, Vilnius, Lithuania. Electronic address:

Objectives: Lithuania has among the highest mortality rates for upper aerodigestive tract (UADT) and stomach cancer in Europe. The aim of this study was to analyze trends during the period 1987-2016 in Lithuania, evaluating the effect of birth-cohort, period, and age.

Study Design: Observational time trends study. Read More

View Article and Full-Text PDF

Cardiovascular and cortisol responses to experimentally-induced minority stress.

Health Psychol 2021 May;40(5):316-325

Department of Psychology.

Objective: Lesbian, gay, and bisexual (LGB) individuals who report greater minority stress (e.g., discrimination) are at an elevated risk for multiple health problems. Read More

View Article and Full-Text PDF

Neutrophil Counts Help Predict Free Wall Rupture Following St-elevation Myocardial Infarction.

Clin Invest Med 2021 Jun 15;44(2):E62-70. Epub 2021 Jun 15.

Emergency and Critical Care Center, Beijing Anzhen Hospital, Capital Medical University and Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing, China.

Purpose: Free wall rupture (FWR) is a lethal complication after acute myocardial infarction; however, the un-derlying mechanisms of FWR are unclear. This study analyzes the relationship between neutrophil counts and FWR following ST-elevation myocardial infarction (STEMI).

Methods: The case group was STEMI patients with FWR and the control group was STEMI patients without FWR (case-control ratio was 1:4). Read More

View Article and Full-Text PDF

Characterizing Decisional Conflict in Patients Presenting to Sleep Surgery Clinic and an Exploration of Resource Limitations.

Laryngoscope 2021 Jun 21. Epub 2021 Jun 21.

Department of Otolaryngology-Head and Neck Surgery, University of California San Francisco School of Medicine, San Francisco, California, U.S.A.

Objectives: Numerous therapies exist for adult obstructive sleep apnea (OSA), creating potential for patient decisional conflict (DC) that impacts treatment adherence and post-treatment regret. We evaluated the prevalence of elevated DC in OSA patients presenting for positive airway pressure (PAP) alternative therapies and identified gaps in available resources about OSA therapies.

Study Design: Cross-sectional study. Read More

View Article and Full-Text PDF

Mirabegron Ameliorated Atherosclerosis of ApoE Mice in Chronic Intermittent Hypoxia but Not in Normoxia.

Cardiovasc Drugs Ther 2021 Jun 21. Epub 2021 Jun 21.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China.

Purpose: It has been established that obstructive sleep apnea (OSA) is an independent risk factor for atherosclerosis. Chronic intermittent hypoxia (CIH) activates sympathoadrenal system and upregulates β3 adrenergic receptor (β3 AR). However, the effect of selective β3 AR agonist mirabegron in CIH-induced atherosclerosis remains unknown. Read More

View Article and Full-Text PDF

Ambient air monitoring around the dioxin remediation site in Da Nang, Vietnam, using passive air samplers.

Environ Monit Assess 2021 Jun 21;193(7):434. Epub 2021 Jun 21.

Institute of Bio-Medicine, Vietnam-Russia Tropical Centre, 63 Nguyen Van Huyen, Hanoi, Vietnam.

The concentrations and temporal variations of polychlorodibenzo-p-dioxins and polychlorodibenzofurans (PCDDs/PCDFs) in ambient air between March 2013 and February 2017 were investigated by passive air samplers containing polyurethane foam (PUF) disks in the dioxin remediation area using in-pile thermal desorption (IPTD) technology at Da Nang airport, Vietnam. The PCDD/PCDF concentrations in ambient air at each site depended on the location of the emission sources and the wind direction, the dioxin contamination level of excavated materials, the periods of excavation and transport, and the operation of the IPTD treatment system. The PCDD/PCDF concentrations were the highest in the former Agent Orange mixing and loading area (AOMLA), which was the closest to the IPTD system, with total toxic equivalent (TEQ) values ranging from 0. Read More

View Article and Full-Text PDF

Uptake and outcomes of a novel community-based HIV post-exposure prophylaxis (PEP) programme in rural Kenya and Uganda.

J Int AIDS Soc 2021 Jun;24(6):e25670

Department of Medicine, University of California, San Francisco, CA, USA.

Introduction: Antiretroviral-based HIV prevention, including pre-exposure prophylaxis (PrEP), is expanding in generalized epidemic settings, but additional prevention options are needed for individuals with periodic, high-risk sexual exposures. Non-occupational post-exposure prophylaxis (PEP) is recommended in global guidelines. However, in Africa, awareness of and access to PEP for sexual exposures are limited. Read More

View Article and Full-Text PDF

Characteristics of persistent postural perceptual dizziness patients in a multidisciplinary dizziness clinic.

J Vestib Res 2021 Jun 11. Epub 2021 Jun 11.

Division of Neurology, Department of Internal Medicine, University of Ottawa, Ontario, Canada.

Background: Persistent Postural Perceptual Dizziness (PPPD) is a newly defined condition which was added to the International Classification of Vestibular Disorders in 2017. Little is known about its impact on patients.

Objective: The goal of this study was to analyze the symptomology, epidemiology and impact of PPPD on patients. Read More

View Article and Full-Text PDF

Elevated Plasma Free Fatty Acid Susceptible to Early Cognitive Impairment in Type 2 Diabetes Mellitus.

J Alzheimers Dis 2021 Jun 17. Epub 2021 Jun 17.

Department of Endocrinology, Affiliated Zhongda Hospital of Southeast University, Nanjing, China.

Background: Elevated free fatty acid (FFA) induces lipotoxicity, attributed to diabetes and cognitive decline. Sterol regulatory element-binding protein-1c (SREBP-1c) regulates lipid metabolism.

Objective: We investigated the roles of FFA in mild cognitive impairment (MCI) of type 2 diabetes mellitus (T2DM) patients and determine its association with rs11868035 polymorphism. Read More

View Article and Full-Text PDF

Current and new imaging techniques in risk stratification of asymptomatic severe aortic stenosis.

Acta Cardiol 2021 Jun 21:1-9. Epub 2021 Jun 21.

Cardiology Department, Abderrahmane Mami's Hospital, Ariana, Tunisia.

Aortic stenosis (AS) is one of the most common valvular diseases in clinical practice. The prevalence of calcified AS with moderate or severe stenosis exceeds 2% after 75 years. The optimal timing of intervention for asymptomatic severe AS is uncertain and controversial. Read More

View Article and Full-Text PDF

Cardiac troponin T is elevated and increases longitudinally in ALS patients.

Amyotroph Lateral Scler Frontotemporal Degener 2021 Jun 21:1-8. Epub 2021 Jun 21.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

To test whether high-sensitivity cardiac troponin T (hs-cTnT) could act as a diagnostic or prognostic biomarker in ALS, comparing hs-cTnT to neurofilament light (NfL). We performed a case-control study, including 150 ALS patients, 28 ALS mimics, and 108 healthy controls, and a follow-up study of the ALS patients, during 2014-2020 in Stockholm, Sweden. We compared concentrations of hs-cTnT in plasma and NfL in the cerebrospinal fluid between cases and controls. Read More

View Article and Full-Text PDF

Outcomes of Barotrauma in Critically Ill COVID-19 Patients With Severe Pneumonia.

J Intensive Care Med 2021 Jun 21:8850666211023360. Epub 2021 Jun 21.

Department of Surgery, 2042Maimonides Medical Center, Brooklyn, NY, USA.

Background: Pneumomediastinum and pneumothorax are complications which may be associated with barotrauma in mechanically ventilated patients. The current literature demonstrates unclear outcomes regarding barotrauma in critically ill patients with severe COVID-19. The purpose of this study was to examine the incidence of barotrauma in patients with severe COVID-19 pneumonia and its influence on survival. Read More

View Article and Full-Text PDF

Reducing glutamic acid decarboxylase in the dorsal dentate gyrus attenuates juvenile stress induced emotional and cognitive deficits.

Neurobiol Stress 2021 Nov 2;15:100350. Epub 2021 Jun 2.

Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke-University, Magdeburg, Germany.

A high degree of regional, temporal and molecular specificity is evident in the regulation of GABAergic signaling in stress-responsive circuitry, hampering the use of systemic GABAergic modulators for the treatment of stress-related psychopathology. Here we investigated the effectiveness of local intervention with the GABA synthetic enzymes GAD65 and GAD67 in the dorsal dentate gyrus (dDG) ventral DG (vDG) to alleviate anxiety-like behavior and stress-induced symptoms in the rat. We induced shRNA-mediated knock down of either GAD65 or GAD67 with lentiviral vectors microinjected into the dDG or vDG of young adult male rats and examined anxiety behavior, learning and memory performance. Read More

View Article and Full-Text PDF
November 2021

Growth Differentiation Factor 15 Predicts Cancer Death in Patients With Cardiovascular Risk Factors: The J-HOP Study.

Front Cardiovasc Med 2021 4;8:660317. Epub 2021 Jun 4.

Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University, Tochigi, Japan.

Disease-related anorexia-cachexia is associated with poor prognosis of patients with cardiovascular disease (CVD) or cancer. Growth differentiation factor-15 (GDF-15) has emerged as a central regulator of appetite and body weight. However, the exact role of GDF-15 in lean patients has not been elucidated. Read More

View Article and Full-Text PDF

The Role of Self-Efficacy and Injunctive Norms in Helping Older Adults Decide to Stay Home During the COVID-19 Pandemic.

Front Public Health 2021 4;9:660813. Epub 2021 Jun 4.

Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, United States.

Because older adults are at elevated risk of COVID-19-related adverse health outcomes, and staying at home is an effective strategy to avoid unnecessary exposures, the current formative study used the Reasoned Action Approach (RAA) to identify the beliefs underlying older adults' decision to stay home for the next month. The participants (weighted = 206, age 65-94) for the current study were selected from a nationally representative online survey of US adults from April 10-20, 2020. We used multiple linear regression to estimate the relative contribution of the four RAA global constructs (instrumental attitude, injunctive norms, descriptive norms, and self-efficacy) in explaining intention to stay home after controlling for demographic covariates. Read More

View Article and Full-Text PDF

Petroleum and Chlorinated Solvents in Meconium and the Risk of Hypospadias: A Pilot Study.

Front Pediatr 2021 2;9:640064. Epub 2021 Jun 2.

CHU Rennes, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail)-UMR_S 1085, Rennes, France.

Hypospadias is a male congenital malformation that occurs in ~2 of 1,000 births. The association between hypospadias and fetal exposure to environmental chemicals has been studied, but the results are inconsistent. Although several petroleum and chlorinated solvents are suspected to have teratogenic effects, their role in the occurrence of hypospadias has been little studied and never using biomarkers of exposure. Read More

View Article and Full-Text PDF

Diabetes as a Risk Factor for Orthopedic Implant Surface Performance: A Retrieval and Study.

J Bio Tribocorros 2021 Jun 22;7(2). Epub 2021 Feb 22.

Department of Biomedical Engineering, University of Texas at Dallas, Richardson, TX, USA.

Orthopedic devices are often associated with increased risk for diabetic patients due to impaired wound healing capabilities. Adverse biological responses for immunocompromised patients at the implant-tissue interface can lead to significant bone resorption that may increase failure rates. The goal of this study was to characterize the surface of implants removed from diabetic patients to determine underlying mechanisms of diabetes-induced impaired osseointegration. Read More

View Article and Full-Text PDF

Retrospective study of factors associated with progression and remission/regression of diabetic kidney disease-hypomagnesemia was associated with progression and elevated serum alanine aminotransferase levels were associated with remission or regression.

Diabetol Int 2021 Jul 2;12(3):268-276. Epub 2021 Jan 2.

Department of Medicine, Nerima General Hospital, 1-24-1 Asahigaoka, Nerima-ku, Tokyo, 176-8530 Japan.

Aim: This study was aimed at retrospectively investigating some common clinical factors, including the serum level of magnesium (Mg), associated with progression and remission/regression of diabetic kidney disease (DKD).

Methods: The subjects were 690 Japanese patients with type 2 diabetes mellitus who were receiving treatment with oral antidiabetic drugs other than SGLT2 inhibitors. Routine clinical data were collected on the first and last day of the observation period. Read More

View Article and Full-Text PDF

Y-shaped Muscular Wrapping Technique Avoiding Re-infection of a Replaced Aortic Graft: A Cadaveric Study.

Plast Reconstr Surg Glob Open 2021 Jun 16;9(6):e3626. Epub 2021 Jun 16.

Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Replacing an infected prosthetic thoracic aorta graft carries a high re-infection risk. We previously reported two clinical cases successfully treated with a new muscular wrapping technique: latissimus dorsi (LD) muscle flap with a distally based serratus anterior (SA) extension; however, a cadaveric study to prove the regular existence of the distal attachment area was lacking. We tried to establish an appropriate way of elevating the combined muscle flap safely. Read More

View Article and Full-Text PDF

An analysis of implementation of evidence-based nursing model in health education for early fracture patients and its therapeutic influences.

Am J Transl Res 2021 15;13(5):4868-4875. Epub 2021 May 15.

Department of Pain Clinic, The First People's Hospital of Chuzhou Chuzhou 239000, Anhui, China.

Objective: To investigate the implementation of evidence-based nursing model (EBNM) in health education and its influences on the therapeutic effects, degrees of pain, adverse emotions, postoperative complications and degrees of cognition of health knowledge of elderly fracture patients.

Methods: A total of 75 elderly patients with hip fractures receiving surgery in the First People's Hospital of Chuzhou from January 2019 to June 2020 were selected as the study subjects, and were divided into control group (n = 37) and experimental group (n = 38) in accordance with random number table method. The control group received conventional health education, while the experimental group received health education intervention based on EBNM. Read More

View Article and Full-Text PDF

Serum Anti-Müllerian Hormone Levels Were Negatively Associated With Body Fat Percentage in PCOS Patients.

Front Endocrinol (Lausanne) 2021 4;12:659717. Epub 2021 Jun 4.

Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, China.

Background: Obesity is a state of excess body fat accumulation, and appears to be closely associated with polycystic ovary syndrome (PCOS). Notably, plausible biological pathways through which obesity can regulate anti-Müllerian hormone (AMH) production have been proposed, and women with PCOS characteristically have an increased AMH level. Body fat accumulation can be described by body fat percentage (BFP). Read More

View Article and Full-Text PDF

Challenges for Diagnostic Clarity for Post-stroke Cognitive Impairment and Behavioural Issues in Middle-Income Countries: Case Studies From Malaysia.

Front Neurol 2021 2;12:628876. Epub 2021 Jun 2.

Health Systems and Population Studies Division, icddr, b, Dhaka, Bangladesh.

Following stroke, individuals require ongoing screening, diagnosis and monitoring for cognitive impairment. Services and policies around these vary widely between settings, and reports from many countries highlight persistent under-diagnosis of cognitive impairment in the months and years after stroke. Missed and delayed diagnosis of post-stroke cognitive impairment, including dementia, are important factors in shaping the experiences of people so affected and their family members, especially in low- and middle-income countries. Read More

View Article and Full-Text PDF

Unrealistic Optimism and Risk for COVID-19 Disease.

Front Psychol 2021 4;12:647461. Epub 2021 Jun 4.

Department of Anthropology, Baylor University, Waco, TX, United States.

Risk perception and consequently engagement in behaviors to avoid illness often do not match actual risk of infection, morbidity, and mortality. Unrealistic optimism occurs when individuals falsely believe that their personal outcomes will be more favorable than others' in the same risk category. Natural selection could favor overconfidence if its benefits, such as psychological resilience, outweigh its costs. Read More

View Article and Full-Text PDF

Blood Pressure Level Is Associated With Changes in Plasma Aβ and Aβ Levels: A Cross-sectional Study Conducted in the Suburbs of Xi'an, China.

Front Aging Neurosci 2021 4;13:650679. Epub 2021 Jun 4.

Department of Neurology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

: Amyloid-β (Aβ) deposition in the brain is the hallmark of Alzheimer's disease (AD) pathology. Hypertension is a risk factor for AD, but the effects of hypertension on Aβ deposition are not fully determined. Considering peripheral Aβ closely relates to Aβ deposition in the brain, we investigated the relationships between blood pressure (BP) level and plasma Aβ concentrations. Read More

View Article and Full-Text PDF

Muscle Flap Closures in Spine Surgery: Predictors of Usage Patterns and Factors Associated With Postoperative Complications From the NSQIP Database.

Clin Spine Surg 2021 Jun 21. Epub 2021 Jun 21.

Department of Neurosurgery, Division of Spine Department of Surgery, Division of Plastic, Maxillofacial, and Oral Surgery Department of Biostatistics and Bioinformatics, Duke Cancer Institute, Duke University Medical Center, Durham, NC.

Study Design: Retrospective cohort study using the National Surgical Quality Improvement Program.

Objective: The objective of this study was to identify preoperative factors that impact the decision to perform prophylactic muscle flap closure and assess risk factors for wound healing complications in patients undergoing spinal procedures with and without muscle flap closure.

Summary Of Background Data: Prior studies suggest that muscle flap closure following complex spine surgery results in a lower risk of wound healing complications. Read More

View Article and Full-Text PDF

Radiotherapy-induced tumor lysis syndrome in a dog with thymoma.

J Vet Med Sci 2021 Jun 21. Epub 2021 Jun 21.

Veterinary Medical Center, College of Life, Environmental and Advanced Sciences, Osaka Prefecture University.

A 13-year-old, female, mixed-breed dog with a huge cranial mediastinal mass underwent radiotherapy (RT). On the following day, the dog presented with lethargy and anorexia. Hematological examination revealed elevated levels of blood urea nitrogen, creatinine, inorganic phosphorus, potassium, lactate dehydrogenase, creatine phosphokinase and aspartate aminotransferase, decreased calcium level, and metabolic acidosis. Read More

View Article and Full-Text PDF

Type 1 Kounis Syndrome Induced by Inactivated SARS-COV-2 Vaccine.

J Emerg Med 2021 May 7. Epub 2021 May 7.

Department of Cardiology, Manisa Celal Bayar University, Faculty of Medicine, Manisa, Turkey.

Background Vaccination is the most important way out of the novel coronavirus disease 2019 (COVID-19) pandemic. Vaccination practices have started in different countries for community immunity. In this process, health authorities in different countries have preferred different type of COVID-19 vaccines. Read More

View Article and Full-Text PDF