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Muscle Activation in the Shoulder Girdle and Lumbopelvic-Hip Complex During Common Therapeutic Exercises.

J Sport Rehabil 2021 Sep 15:1-7. Epub 2021 Sep 15.

Context: Lumbopelvic-hip complex (LPHC) exercises are used to increase stabilization within the human body. Torso-elevated side support (TESS), foot-elevated side support (FESS), prone bridge plank (PBP), and V-sit are common LPHC exercises.

Objective: To evaluate muscle activation in the shoulder girdle and LPHC during 4 LPHC exercises and evaluate the reasoning for termination. Read More

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September 2021

Sonographic and ophthalmic assessment of optic nerve in patients with idiopathic intracranial hypertension: A longitudinal study.

J Neurol Sci 2021 Sep 4;430:118069. Epub 2021 Sep 4.

Department of Neurology, Saarland University Medical Center, Homburg, Germany.

Background: To assess the validity of neurosonological parameters (transorbital sonography (TOS)) for detection and monitoring of patients with idiopathic intracranial hypertension (IIH).

Methods: Prospective, single-center, case-controlled study in 25 patients with IIH and 19 controls. Visual parameters of papilledema, visual acuity, computerized static threshold perimetry, fundus examination, and neurosonological parameters of papilledema/optic disc elevation (ODE), optic nerve sheath diameter (ONSD) and optic nerve diameter (OND) were recorded at baseline and only for patients with IIH again within 6 months. Read More

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September 2021

Climate change and drinking water from Scottish peatlands: Where increasing DOC is an issue?

J Environ Manage 2021 Sep 11;300:113688. Epub 2021 Sep 11.

School of Biological Sciences, University of Aberdeen, 23 St Machar Drive, AB24 3UU, UK.

Increasing levels of dissolved organic carbon (DOC) have been detected in the last decades in water bodies of the Northern hemisphere, and climate change might fuel this rise. For drinking water reservoirs located in peatland catchments, already subjected to elevated amounts of DOC that needs to be removed, this might pose a further problem. Scotland is predicted to face warmer temperatures and a change in rainfall patterns, which will result in more frequent and severe summer droughts and in heavier winter precipitation. Read More

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September 2021

Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer.

Cell Chem Biol 2021 Sep 8. Epub 2021 Sep 8.

Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611, USA. Electronic address:

Triple-negative breast cancer (TNBC) is the breast cancer subtype with the poorest clinical outcome. The PIM family of kinases has emerged as a factor that is both overexpressed in TNBC and associated with poor outcomes. Preclinical data suggest that TNBC with an elevated MYC expression is sensitive to PIM inhibition. Read More

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September 2021

Personality in Children With Vocal Fold Nodules: A Multitrait Analysis.

J Speech Lang Hear Res 2021 Sep 15:1-17. Epub 2021 Sep 15.

Pediatric Otolaryngology Clinic, Primary Children's Medical Center, Salt Lake City, UT.

Purpose Vocal fold nodules (VNs) are bilateral, symmetrical, callous-like lesions secondary to phonotrauma and possibly related to specific personality traits. This case-control study examined the relation between personality and VNs in children within the context of the Trait Theory of VNs. Method Parents of children with VNs ( = 39, = 7. Read More

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September 2021

Age-Related Functional Reserve Decline Is Not Seen in Pharyngeal Swallowing Pressures.

J Speech Lang Hear Res 2021 Sep 15:1-8. Epub 2021 Sep 15.

Department of Neurology, Dell Medical School, The University of Texas at Austin.

Purpose Functional reserve represents the difference between an individual's ability to produce a maximum output function and the ability to perform a functional task. Several studies have documented an age-related decrease in functional reserve with oral tongue pressure generation. Whether this pattern is seen in pharyngeal swallowing pressures is unknown. Read More

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September 2021

Reprocessing of Covalent Adaptable Polyamide Networks through Internal Catalysis and Ring-Size Effects.

J Am Chem Soc 2021 Sep 15. Epub 2021 Sep 15.

Polymer Chemistry Research Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Faculty of Sciences, Ghent University, Krijgslaan 281-S4, Ghent 9000, Belgium.

Here, we report the introduction of internally catalyzed amide bonds to obtain covalent adaptable polyamide networks that rely on the dissociation equilibrium between dicarboxamides and imides. While amide bonds are usually considered to be robust and thermally stable, the present study shows that their dynamic character can be activated by a smart choice of available building blocks without the addition of any external catalyst or other additives. Hence, a range of polyamide-based dynamic networks with variable mechanical and viscoelastic properties have been obtained in a systematic study, using a straightforward curing process of dibasic ester and amine compounds. Read More

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September 2021

Characterization of HLH-Like Manifestations as a CRS Variant in Patients Receiving CD22 CAR T-Cells.

Blood 2021 Sep 15. Epub 2021 Sep 15.

National Institute of Health, Bethesda, Maryland, United States.

CAR T-cell toxicities resembling hemophagocytic lymphohistiocytosis (HLH) occur in a subset of patients with cytokine release syndrome (CRS). As a variant of conventional CRS, a comprehensive characterization of CAR T-cell associated HLH (carHLH) and investigations into associated risk factors are lacking. In the context of 59 patients infused with CD22 CAR T-cells where a substantial proportion developed carHLH, we comprehensively describe the manifestations and timing of carHLH as a CRS variant and explore factors associated with this clinical profile. Read More

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September 2021

Essential but Ill-Prepared: How the COVID-19 Pandemic Affects the Mental Health of the Grocery Store Workforce.

Public Health Rep 2021 Sep 15:333549211045817. Epub 2021 Sep 15.

242715 Norton School of Family and Consumer Sciences, College of Agriculture and Life Sciences, University of Arizona, Tucson, AZ, USA.

Objectives: Frontline essential workers face elevated risks of exposure to COVID-19 because of the interactive nature of their jobs, which require high levels of interaction with the general public and coworkers. The impact of these elevated risks on the mental health of essential workers, especially outside the health care sector, is not well studied. To address this knowledge gap, we examined correlations between perceptions of workplace risks and mental health distress among grocery store workers in Arizona. Read More

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September 2021

Cross-Seeded Fibrillation Induced by Pyroglutamate-3 and Truncated Aβ Variants Leads to Aβ Structural Polymorphism Modulation and Elevated Toxicity.

ACS Chem Neurosci 2021 Sep 15. Epub 2021 Sep 15.

Department of Chemistry, Binghamton University, State University of New York, Binghamton, New York 13902, United States.

The pathological amyloid plaques in Alzheimer's disease (AD) patients contain not only the wild-type β-amyloid (wt-Aβ) peptide sequences but also a variety of post-translationally modified variants. The pyroglutamate-3 Aβ (pyroE3-Aβ), which is generated from its truncated precursors ΔE3-Aβ, shows the highest abundance among all modified Aβ variants. Previous works have shown that pyroE3-Aβ and/or ΔE3-Aβ, compared with the wild-type sequences, led to a more rapid fibrillation process and final fibrils with higher neuronal cytotoxicity levels. Read More

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September 2021

Role of cellular prion protein in splenic CD4 T cell differentiation in cerebral ischaemic/reperfusion.

Ann Clin Transl Neurol 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurology, Neuroscience Center, The First Hospital of Jilin University, Jilin University, Changchun, China.

Objective: Cellular prion protein (PrP ), the primary form of prion diseases pathogen, has received increasing attention for its protective effect against ischaemic stroke. Little is known about its role in peripheral immune responses after cerebral ischaemia/reperfusion (I/R) injury. This study is to detect the variation of splenic CD4 T lymphocytes differentiation and the concentration of inflammatory cytokines after murine cerebral I/R injury in the context of PRNP expression as well as its influence on the ischaemic neuronal apoptosis. Read More

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September 2021

Locus-of-care disparities in end-of-life care intensity among adolescents and young adults with cancer: A population-based study using the IMPACT cohort.

Cancer 2021 Sep 15. Epub 2021 Sep 15.

Division of Haematology/Oncology, Hospital for Sick Children, Toronto, Ontario, Canada.

Background: Adolescents and young adults (AYAs) with cancer may experience elevated rates of high-intensity end-of-life (HI-EOL) care. Locus-of-care (LOC) disparities (pediatric vs adult) in AYA end-of-life (EOL) care are unstudied.

Methods: A decedent population-based cohort of Ontario AYAs diagnosed between 1992 and 2012 at the ages of 15 to 21 years was linked to administrative data. Read More

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September 2021

Elevated seasonal temperature disrupts prooxidant-antioxidant homeostasis and promotes cellular apoptosis in the American oyster, Crassostrea virginica, in the Gulf of Mexico: a field study.

Cell Stress Chaperones 2021 Sep 15. Epub 2021 Sep 15.

School of Earth, Environmental, and Marine Sciences, University of Texas Rio Grande Valley, Brownsville, TX, USA.

One of the major impacts of climate change has been the marked rise in global temperature. Recently, we demonstrated that high temperatures (1-week exposure) disrupt prooxidant-antioxidant homeostasis and promote cellular apoptosis in the American oyster. In this study, we evaluated the effects of seasonal sea surface temperature (SST) on tissue morphology, extrapallial fluid (EPF) conditions, heat shock protein-70 (HSP70), dinitrophenyl protein (DNP, an indicator of reactive oxygen species, ROS), 3-nitrotyrosine protein (NTP, an indicator of RNS), catalase (CAT), superoxide dismutase (SOD) protein expressions, and cellular apoptosis in gills and digestive glands of oysters collected on the southern Texas coast during the winter (15 °C), spring (24 °C), summer (30 °C), and fall (27 °C). Read More

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September 2021

Components of metabolic syndrome associated with lower neurocognitive performance in youth with perinatally acquired HIV and youth who are HIV-exposed uninfected.

J Neurovirol 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

We investigated the association of metabolic syndrome (MetS) and its components [abdominal obesity, elevated triglycerides (TG), low HDL cholesterol, elevated blood pressure (BP), and impaired fasting glycemia (IFG)] with neurocognitive impairment in youth with perinatally acquired HIV (YPHIV) or who are perinatally HIV-exposed uninfected (YPHEU). This was an observational study with a comparison group of 350 YPHIV and 68 YPHEU ages 10-19 years. Youth with MetS components measured between 1 year before and 3 months after a baseline neurocognitive assessment (Wechsler Intelligence Scale) were selected from the Pediatric HIV/AIDS Cohort Study (PHACS). Read More

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September 2021

Comparison between cystic biliary atresia and choledochal cyst: a clinical controlled study.

Pediatr Surg Int 2021 Sep 15. Epub 2021 Sep 15.

Department of General Surgery, Capital Institute of Pediatrics, Beijing, China.

Purpose: It is difficult to distinguish cystic biliary atresia (CBA) from choledochal cyst (CC) before intraoperative cholangiography in neonates or young infants because of the similar ultrasonographic patterns and clinical manifestations. This study is to investigate the difference of clinical parameters between CBA and CC.

Methods: 96 patients with cyst at hepatic hilum whose ages were less than 120 days during the period from Jan'2013 to Nov'2015 were retrospectively studied, they were divided into CBA group and CC group by intraoperative cholangiography, there were 29 cases of CBA and 67 cases of CC. Read More

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September 2021

Uterine kisspeptin receptor critically regulates epithelial estrogen receptor Α transcriptional activity at the time of embryo implantation in a mouse model.

Mol Hum Reprod 2021 Sep 15. Epub 2021 Sep 15.

Laboratory of Human Growth and Reproductive Development, Department of Pediatrics, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ, USA.

Embryo implantation failure is a major cause of infertility in women of reproductive age and a better understanding of uterine factors that regulate implantation is required for developing effective treatments for female infertility. This study investigated the role of the uterine kisspeptin receptor (KISS1R) in the molecular regulation of implantation in a mouse model. To conduct this study, a conditional uterine knockout (KO) of Kiss1r was created using the Pgr-Cre (progesterone receptor-CRE recombinase) driver. Read More

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September 2021

Repeated stimulation of the HPA axis alters white blood cell counts without increasing oxidative stress or inflammatory cytokines in fasting elephant seal pups.

J Exp Biol 2021 Sep 15. Epub 2021 Sep 15.

Department of Integrative Biology, University of California, Berkeley, USA.

The hypothalamic-pituitary-adrenal (HPA) axis controls the release of glucocorticoids, which regulate immune and inflammatory function by modulating cytokines, white blood cells (WBCs), and oxidative stress via glucocorticoid receptor (GR) signaling. Although the response to HPA activation is well characterized in many species, little is known about the impacts of HPA activation during extreme physiological conditions. Hence, we challenged 18 simultaneously fasting and developing elephant seal pups with daily intramuscular injections of adrenocorticotropin (ACTH), a GR antagonist (RU486), or a combination (ACTH+RU486) for four days (4d). Read More

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September 2021

Association of Timing and Duration of Prenatal Analgesic Opioid Exposure With Attention-Deficit/Hyperactivity Disorder in Children.

JAMA Netw Open 2021 Sep 1;4(9):e2124324. Epub 2021 Sep 1.

PharmacoEpidemiology and Drug Safety Research Group, Department of Pharmacy, PharmaTox Strategic Research Initiative, Faculty of Mathematics and Natural Sciences, University of Oslo, Oslo, Norway.

Importance: Prior studies have reported that the use of illicit opioids during pregnancy is associated with increased risk of attention-deficit/hyperactivity disorder (ADHD) in offspring; however, evidence regarding the association of analgesic opioids is limited.

Objective: To examine the association of timing and duration of prenatal analgesic opioid exposure with ADHD in children.

Design, Setting, And Participants: This cohort study uses data from the Norwegian Mother, Father and Child Cohort study (1999-2008), a nationwide birth cohort study linked to national health registries, with a mean (SD) follow-up of 10. Read More

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September 2021

Enzyme-responsive micellar JQ1 induces enhanced BET protein inhibition and immunotherapy of malignant tumors.

Biomater Sci 2021 Sep 15. Epub 2021 Sep 15.

Biomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, and State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China.

Bromodomain and extra-terminal (BET) proteins are attractive targets for treating various malignancies including melanoma. The inhibition of BET bromodomains, with JQ1, is found to downregulate the expression of both c-MYC oncoprotein and programmed cell death ligand 1 (PD-L1), which play a crucial role in tumor growth and the immunosuppressive tumor microenvironment, respectively. The BET bromodomain inhibitors like JQ1 though exhibiting high selectivity and affinity show usually low bioavailability and efficacy due to fast clearance and inferior uptake by tumor cells. Read More

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September 2021

Consensus statement and recommendations on the treatment of COVID-19: 2021 update.

J Chin Med Assoc 2021 Sep 3. Epub 2021 Sep 3.

Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Department and Institute of Physiology, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Institute of Emergency and Critical Care Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC Division of Infectious Disease, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC.

Many treatments including antiviral and non-antiviral drugs, and critical care are considered for the management of coronavirus disease 2019 (COVID-19). Practice recommendations need to be updated and graded according to critical evaluation of rapidly emerging literature. In June 2020, Research Center for Epidemic Prevention - National Yang Ming Chiao Tung University formed a task group comprising infectious disease clinicians, pulmonologists, and intensivists with varied areas of expertise. Read More

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September 2021

Lower melanoma pulmonary metastatic burden in obese mice: role of FGF-21.

Melanoma Res 2021 Sep 13. Epub 2021 Sep 13.

Department of Biomedicine, Faculty of Medicine, University of Porto Metabesity Research Group, I3S, Institute for Investigation and Innovation in Health, University of Porto Chemical Sciences and Biomolecules, School of Health, Polytechnic Institute of Porto, Porto, Portugal.

Obesity is a risk factor for malignant melanoma. The lungs are main target organs for metastization and their immune response is a key modulator of this mechanism. The concept that the metastatic potential of some types of cancer is reduced or inhibited by obesity, known as the obesity paradox, drives major concerns on the prognosis of metastasized patients. Read More

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September 2021

Low-Energy Availability and the Electronic Preparticipation Examination in College Athletes: Is There a Better Way to Screen?

Curr Sports Med Rep 2021 Sep;20(9):489-493

Division of Physical Medicine and Rehabilitation, Department of Orthopaedic Surgery, Stanford University, Stanford, Stanford University, Palo Alto, CA.

Abstract: The electronic preparticipation physical examination (ePPE) is commonly used to identify health conditions that would affect participation in sports for athletes, including disordered eating and/or low energy availability (EA). A secondary analysis was performed using a cohort study of female college athletes attending a Division 1 university between 2008 and 2014. Descriptive statistics and logistic regression analyses were used to explore the association between responses to questions on the ePPE related to eating behaviors and Female Athlete Triad (Triad). Read More

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September 2021

The Programmed Cell Death Ligand-1/Programmed Cell Death-1 Pathway Mediates Pregnancy-Induced Analgesia via Regulating Spinal Inflammatory Cytokines.

Anesth Analg 2021 Sep 14. Epub 2021 Sep 14.

Department of Obstetrics, Xiangya Hospital, Central South University, Changsha, China.

Background: The maternal pain threshold gradually increases during pregnancy, especially in late pregnancy. A series of mechanisms underlying pregnancy-induced analgesia have been reported. However, these mechanisms are still not completely clear, and the underlying molecular mechanisms need further investigation. Read More

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September 2021

Idiopathic spontaneous liver hemorrhage A report of two cases and a review of the literature.

Ann Ital Chir 2021 ;92:361-364

Spontaneous liver hemorrhage (SLH) is a serious, extremely rare, and life-threatening occurrence requiring a multidisciplinary approach. Since diagnosis might be difficult, a high mortality rate is reported. Survival depends on a prompt diagnosis followed by an appropriate management. Read More

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January 2021

A Social Media Group Cognitive Behavioral Therapy Intervention to Prevent Depression in Perinatal Youth: Stakeholder Interviews and Intervention Design.

JMIR Ment Health 2021 Sep 15;8(9):e26188. Epub 2021 Sep 15.

Department of Global Health, University of Washington, Seattle, WA, United States.

Background: Adolescents and young adults aged <25 years (youth) are at a higher risk of perinatal depression than older adults, and they experience elevated barriers to in-person care. Digital platforms such as social media offer an accessible avenue to deliver group cognitive behavioral therapy (CBT) to perinatal youth.

Objective: We aim to develop the Interactive Maternal Group for Information and Emotional Support (IMAGINE) intervention, a facilitated social media group CBT intervention to prevent perinatal depression in youth in the United States, by adapting the Mothers and Babies (MB) course, an evidence-based in-person group CBT intervention. Read More

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September 2021

South African university women's perspectives on intimate partner violence: a qualitative study of reactions to a tailored vignette.

Cult Health Sex 2021 Sep 15:1-17. Epub 2021 Sep 15.

Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA, USA.

Intimate partner violence is an ongoing issue in South Africa, which has the highest rates of violence against women and girls in the world. Intimate partner violence is common in Limpopo, where women, including university students, experience elevated rates of violent crime. This qualitative study was conducted to examine university students' perspectives regarding intimate partner violence among their peers. Read More

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September 2021

Monocyte to high density lipoprotein ratio in patients with acute kidney injury after cardiac surgery.

Perfusion 2021 Sep 15:2676591211041945. Epub 2021 Sep 15.

Division of Nephrology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, PR China.

Background: The Monocyte to high density lipoprotein ratio (MHR) has been postulated as a novel parameter associated with adverse renal and cardiovascular outcomes. In this study we investigated the association of MHR with cardiac surgery-associated acute kidney injury (CSA-AKI).

Methods: In this retrospective study, we analyzed the data pertaining to 1505 patients undergoing cardiopulmonary bypass (CPB) surgery. Read More

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September 2021

The association of left ventricular histologically verified myocardial fibrosis with pulmonary hypertension in severe aortic stenosis.

Perfusion 2021 Sep 15:2676591211042733. Epub 2021 Sep 15.

Department of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Objectives: To evaluate the association between histologically verified left ventricular (LV) myocardial fibrosis (MF) and its bio- and functional markers with pulmonary hypertension (PH) in severe aortic stenosis (AS).

Methods: About 34 patients with isolated severe AS underwent 2D echocardiography, cardiac magnetic resonance (CMR) imaging, and plasma NT-proBNP evaluation before aortic valve replacement (AVR). LV measurements were analyzed by CMR and LV strain using feature tracking software (Medis Suite QStrain 2. Read More

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September 2021

Ethyl Acetate Fraction of (L.) Medic Flowers Exerts Inhibitory Effects Against Oxidative Stress in HO-Induced HepG2 Cells and D-Galactose-Induced Aging Mice.

J Med Food 2021 Sep;24(9):997-1009

College of Food Science and Biology, Hebei University of Science and Technology, Shijiazhuang, China.

Oxidative stress has been demonstrated to be associated with numerous aging-related diseases. Ethyl acetate fraction of (L.) Medic (EA) had been reported to possess strong radical-scavenging activity due to its rich content of flavonoids. Read More

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September 2021

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison.

Am Fam Physician 2021 Sep;104(3):244-252

Wake Forest School of Medicine, Winston-Salem, NC, USA.

Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) are inflammatory conditions that present diagnostic and therapeutic challenges to the physician. Although many of their features overlap, they are two distinct conditions. KD is a febrile illness most commonly affecting children younger than five years. Read More

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September 2021