4,497 results match your criteria electrospinning technology


Formononetin/methyl-β-cyclodextrin inclusion complex incorporated into electrospun polyvinyl-alcohol nanofibers: Enhanced water solubility and oral fast-dissolving property.

Int J Pharm 2021 May 10:120696. Epub 2021 May 10.

College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address:

Improving solubility and administration route of isoflavone formononetin (FMN) are critical factors to improve its bioavailability in the oral cavity. This study fabricated fast-dissolving nanofibers containing FMN/methyl-β-cyclodextrin (FMN/Me-β-CD) inclusion complex. The solubility of FMN could be increased by approximately 50 times at 20 mM aqueous Me-β-CD. Read More

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Physicomechanical performance and encapsulation efficiency of β-cyclodextrin loaded functional electrospun mats based on aliphatic polyesters and their blends.

J Biomater Sci Polym Ed 2021 May 12:1-14. Epub 2021 May 12.

Department of Materials Science and Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi, 110016, India.

Designing complex-forming biodegradable and biocompatible electrospun mats (EMs) by incorporating β- cyclodextrin (β-CD) into polylactic acid PLA)/poly(ε-caprolactone) (PCL) (70:30 w/w) blend based polyester matrix. The influence of β-CD loading on the morphological, thermal, and microstructural properties was investigated using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). The studies revealed the presence of characteristic interactions between the polymer matrix and β-CD moieties. Read More

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Integrating the Essence of a Metal-Organic Framework with Electrospinning: A New Approach for Making a Metal Nanoparticle Confined N-Doped Carbon Nanotubes/Porous Carbon Nanofibrous Membrane for Energy Storage and Conversion.

ACS Appl Mater Interfaces 2021 May 12. Epub 2021 May 12.

Department of Nano Convergence Engineering, Jeonbuk National University, Jeonju 561-756, Republic of Korea.

The fabrication of an economic and efficient multifunctional advanced nanomaterial with a rational composition and configuration by a facile methodology is a crucial challenge. Herein, we are the first to report the growth of Co nanoparticle-integrated nitrogen-doped carbon nanotubes (N-CNTs) on porous carbon nanofibers by simply heating in the situ-developed metal-organic framework (MOF)-based electrospun nanofibrous membrane with no need for an external supply of any additional precursors and reducing gases. The long and entangled N-CNTs originating from highly porous and graphitic carbon nanofibers offer good flexibility, large surface area, high porosity, high conductivity, the homogeneous incorporation of heteroatoms and metallic constituents, and an abundant exposure of active nanocatalytic sites. Read More

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Stimuli-Responsive Electrospun Piezoelectric Mats of Ethylene--vinyl Acetate-Millable Polyurethane-Nanohydroxyapatite Composites.

ACS Appl Mater Interfaces 2021 May 11. Epub 2021 May 11.

Polymer Science and Technology Research Laboratory, Department of Chemistry, National Institute of Technology Calicut, Calicut, Kerala 673601, India.

Piezoelectric materials have gained interest among materials scientists as body motion sensors and energy harvesters on account of their fast responsiveness and substantial output signals. In this work, piezoelectric polymer mats have been fabricated from ethylene--vinyl acetate-millable polyurethane/nanohydroxyapatite (EVA-MPU/nHA) composite systems by employing the electrospinning technique. The ferro-piezoelectric features of the samples were confirmed from the butterfly loops of electrostatic force microscopy (EFM) amplitude signals as well as through the hysteresis curves of the EFM phase recorded with the assistance of dynamic-contact EFM. Read More

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Fabrication and characterization of dextran/zein hybrid electrospun fibers with tailored properties for controlled release of curcumin.

J Sci Food Agric 2021 May 10. Epub 2021 May 10.

College of Biological Science and Technology, Hubei Key Laboratory of Biological Resources Protection and Utilization, Key Laboratory of Green Manufacturing of Super-light Elastomer Materials of State Ethnic Affairs Commission, Hubei Minzu University, Enshi, 445000, China.

Background: In recent years, there has been considerable interest in the use of biopolymer electrospun nanofibers for various food applications due to the biocompatibility, biodegradability, and high loading capacity. Herein, we fabricated and characterized novel hybrid electrospun fibers from dextran (50%, w/v) and zein (0%-30%, w/v) solutions, and the effects of various zein concentrations on the properties of the hybrid electrospun fibers were investigated.

Results: When zein was added at low concentrations (5% and 10%), dextran and zein showed poor miscibility, as reflected by significantly decreased viscosity of the solutions, and the poor mechanical properties of the derived fiber membranes. Read More

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The kinetics and release behaviour of curcumin loaded pH-responsive PLGA/chitosan fibers with antitumor activity against HT-29 cells.

Carbohydr Polym 2021 Aug 15;265:118077. Epub 2021 Apr 15.

School of Chemistry and Chemical Engineering, Hefei University of Technology, 230009, Hefei, Anhui, PR China; Anhui Institute of Agro-Products Intensive Processing Technology, 230009, Hefei, Anhui, PR China. Electronic address:

The bioavailability and clinical effect of curcumin (Cur) are greatly restricted due to its physicochemical instability and high hydrophobicity. To overcome the disadvantages, the nanofibers of poly(lactide-glycolide)/chitosan loaded with Cur (PLGA/CS/Cur) was developed here by electrospinning technique for controlled Cur delivery. The incorporated Cur was well-dispersed and maintained crystalline form in PLGA/CS fiber matrix by hydrogen bonding. Read More

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Polysaccharides as wall material for the encapsulation of essential oils by electrospun technique.

Carbohydr Polym 2021 Aug 12;265:118068. Epub 2021 Apr 12.

Department of Agroindustrial Science and Technology, Federal University of Pelotas, Pelotas, RS, 96010-900, Brazil. Electronic address:

Electrospinning is a versatile, inexpensive and reliable technique for the synthesis of nanometric fibers or particles from polymeric solutions, under a high voltage electric field. The use of natural polysaccharides such as starch, chitosan, pectin, alginate, pullulan, cellulose and dextran as polymeric materials allows the formation of biodegradable fibers and capsules. Bioactive compounds extracted from natural sources, such as essential oils, have been widely studied due to their antioxidant, antimicrobial and antifungal properties. Read More

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Electrospun fibrous sponge via short fiber for mimicking 3D ECM.

J Nanobiotechnology 2021 May 8;19(1):131. Epub 2021 May 8.

Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People's Republic of China.

Background: Most of the natural extracellular matrix (ECM) is a three-dimensional (3D) network structure of micro/nanofibers for cell adhesion and growth of 3D. Electrospun fibers distinctive mimicked 2D ECM, however, it is impossible to simulate 3D ECM because of longitudinal collapse of continuous micro/nanofibers. Herein, 3D electrospun micro/nano-fibrous sponge was fabricated via electrospinning, homogenization, shaping and thermal crosslinking for 3D tissue regeneration of cells and vascular. Read More

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Ultrahigh-response hydrogen sensor based on PdO/NiO co-doped InO nanotubes.

J Colloid Interface Sci 2021 Apr 28;599:533-542. Epub 2021 Apr 28.

School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China. Electronic address:

Hydrogen can be regarded as an ideal type of secondary energy considering its potential for achieving renewable and sustainable development due to water being its sole combustion product and its possible production by solar energy-based water electrolysis. Monitoring the presence and concentration of hydrogen during production, transportation, and application requires a hydrogen gas sensor with high response, high selectivity, and fast response and recovery times. In an attempt to meet these requirements, NiO and PdO are used in the co-doping of InO nanotubes by subsequent electrospinning and impregnation under UV irradiation. Read More

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A microphysiological system combining electrospun fibers and electrical stimulation for the maturation of highly anisotropic cardiac tissue.

Biofabrication 2021 May 7. Epub 2021 May 7.

Biomaterials for Regenerative Therapies, Institute for Bioengineering in Catalonia, C/ Baldiri i Reixac, 15-21, 2nd Floor, Barcelona, Catalunya, 08028, SPAIN.

In the present work, we present a microfluidic platform that aims to provide a range of signaling cues to immature cardiac cells to drive them towards an adult phenotype. The device combines topographical electrospun nanofibers with electrical stimulation in a microfabricated system. We validated our platform using a co-culture of neonatal mouse cardiomyocytes and cardiac fibroblasts, showing that it allows us to control the degree of anisotropy of the cardiac tissue inside the microdevice in a cost-effective way. Read More

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Early time-point cell morphology classifiers successfully predict human bone marrow stromal cell differentiation modulated by fiber density in nanofiber scaffolds.

Biomaterials 2021 Apr 26;274:120812. Epub 2021 Apr 26.

National Institute of Standards & Technology, Biosystems & Biomaterials Division, 100 Bureau Dr. Stop 8543, Gaithersburg, MD, 20899, USA. Electronic address:

Nanofiber scaffolds can induce osteogenic differentiation and cell morphology alterations of human bone marrow stromal cells (hBMSCs) without introduction of chemical cues. In this study, we investigate the predictive power of day 1 cell morphology, quantified by a machine learning based method, as an indicator of osteogenic differentiation modulated by nanofiber density. Nanofiber scaffolds are fabricated via electrospinning. Read More

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Titanium carbide/zeolite imidazole framework-8/polylactic acid electrospun membrane for near-infrared regulated photothermal/photodynamic therapy of drug-resistant bacterial infections.

J Colloid Interface Sci 2021 Apr 24;599:390-403. Epub 2021 Apr 24.

State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian, Liaoning 116024, PR China. Electronic address:

Bacteria induced wound infection has become fatal healthcare issues needed to be resolved urgently. It is of vital importance to develop multifunctional therapeutic platforms to fight against increased bacterial antibiotic resistance. Herein, a titanium carbide (MXene)/zeolite imidazole framework-8 (ZIF-8)/polylactic acid (PLA) composite membrane (MZ-8/PLA) was fabricated through in-situ growth of ZIF-8 on MXene and the subsequent electrospinning process. Read More

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Robust Electrospun Nanofibers from Chemosynthetic Poly(4-hydroxybutyrate) as Artificial Dural Substitute.

Macromol Biosci 2021 May 5:e2100134. Epub 2021 May 5.

Key Lab of Biobased Polymer Materials of Shandong Provincial Education Department, College of Polymer Science and Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao, 266042, P. R. China.

Bioresorbable poly(4-hydroxybutyrate) (P4HB) may fulfill the specific requirements that are necessary for a dural substitute, including its high elasticity, long-term strength retention properties, and the biocompatibility without significant accumulation of acidic degradation products. However, commercial P4HB can only be produced by the bacterial fermentation, which limits its applications in the cerebrospinal system due to higher endotoxin restriction. Meanwhile, P4HB can be prepared via the ring-opening polymerization of γ-butyrolactone. Read More

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An organic-inorganic hybrid scaffold with honeycomb-like structures enabled by one-step self-assembly-driven electrospinning.

Mater Sci Eng C Mater Biol Appl 2021 May 27;124:112079. Epub 2021 Mar 27.

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, FI-00014 Helsinki, Finland. Electronic address:

Electrospun organic/inorganic hybrid scaffolds have been appealing in tissue regeneration owing to the integrated physicochemical and biological performances. However, the conventional electrospun scaffolds with non-woven structures usually failed to enable deep cell infiltration due to the densely stacked layers among the fibers. Herein, through self-assembly-driven electrospinning, a polyhydroxybutyrate/poly(ε-caprolactone)/58S sol-gel bioactive glass (PHB/PCL/58S) hybrid scaffold with honeycomb-like structures was prepared by manipulating the solution composition and concentration during a one-step electrospinning process. Read More

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Enzymatic Time-Temperature Indicator Prototype Developed by Immobilizing Laccase on Electrospun Fibers to Predict Lactic Acid Bacterial Growth in Milk during Storage.

Nanomaterials (Basel) 2021 Apr 29;11(5). Epub 2021 Apr 29.

Department of Food Science, National Ilan University, 1, Sec. 1, Shennong Rd., Yilan County, Yilan City 26047, Taiwan.

Laccase was immobilized on a chitosan/polyvinyl alcohol/tetraethylorthosilicate electrospun film (ceCPTL) and colored with guaiacol to obtain a laccase time-temperature indicator (TTI) prototype. The activation energy () of coloration of the prototype was 50.89-33. Read More

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Multi-scale structuring of cell-instructive cellulose nanocrystal composite hydrogel sheets via sequential electrospinning and thermal wrinkling.

Acta Biomater 2021 May 1. Epub 2021 May 1.

Department of Chemical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada; School of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada. Electronic address:

Structured hydrogel sheets offer the potential to mimic the mechanics and morphology of native cell environments in vitro; however, controlling the morphology of such sheets across multiple length scales to give cells consistent multi-dimensional cues remains challenging. Here, we demonstrate a simple two-step process based on sequential electrospinning and thermal wrinkling to create nanocomposite poly(oligoethylene glycol methacrylate)/cellulose nanocrystal hydrogel sheets with a highly tunable multi-scale wrinkled (micro) and fibrous (nano) morphology. By varying the time of electrospinning, rotation speed of the collector, and geometry of the thermal wrinkling process, the hydrogel nanofiber density, fiber alignment, and wrinkle geometry (biaxial or uniaxial) can be independently controlled. Read More

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Mimicking the Human Tympanic Membrane: The Significance of Scaffold Geometry.

Adv Healthc Mater 2021 May 4:e2002082. Epub 2021 May 4.

Department of Complex Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, 6229 ER, The Netherlands.

The human tympanic membrane (TM) captures sound waves from the environment and transforms them into mechanical motion. The successful transmission of these acoustic vibrations is attributed to the unique architecture of the TM. However, a limited knowledge is available on the contribution of its discrete anatomical features, which is important for fabricating functional TM replacements. Read More

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Studies on the electrostatic effects of stretched PVDF films and nanofibers.

Nanoscale Res Lett 2021 May 3;16(1):79. Epub 2021 May 3.

Sino-Danish Center for Education and Research (SDC), Interdisciplinary Nanoscience Center (iNANO), Aarhus University, DK-8000, Aarhus C, Denmark.

The electroactive β-phase in Poly (vinylidene fluoride, PVDF) is the most desirable conformation due to its highest pyro- and piezoelectric properties, which make it feasible to be used as flexible sensors, wearable electronics, and energy harvesters etc. In this study, we successfully developed a method to obtain high-content β-phase PVDF films and nanofiber meshes by mechanical stretching and electric spinning. The phase transition process and pyro- and piezoelectric effects of stretched films and nanofiber meshes were characterized by monitoring the polarized light microscopy (PLM) images, outputting currents and open-circuit voltages respectively, which were proved to be closely related to stretching ratio (λ) and concentrations. Read More

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Free-Standing N-Doped Porous Carbon Fiber Membrane Derived From Zn-MOF-74: Synthesis and Application as Anode for Sodium-Ion Battery With an Excellent Performance.

Front Chem 2021 16;9:647545. Epub 2021 Apr 16.

Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, China.

It is important to develop new energy storage and conversion technology to mitigate the energy crisis for the sustainable development of human society. In this study, free-standing porous nitrogen-doped carbon fiber (PN-CF) membranes were obtained from the pyrolysis of Zn-MOF-74/polyacrylonitrile (PAN) composite fibers, which were fabricated by an electrospinning technology. The resulting free-standing fibers can be cut into membrane disks and directly used as an anode electrode without the addition of any binder or additive. Read More

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Rigid anchoring of highly crystallized and uniformly dispersed Pd nanocrystals on carbon fibers for ambient electrocatalytic reduction of nitrogen to ammonia.

Dalton Trans 2021 Apr 30. Epub 2021 Apr 30.

Laboratory of Advanced Materials and Energy Electrochemistry, Institute of New Carbon Materials, College of Materials Science & Engineering, Taiyuan University of Technology, Taiyuan, 030024, China. and Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization, Taiyuan, 030024, China.

Developing efficient and stable electrocatalysts for ammonia synthesis via the nitrogen reduction reaction (NRR) is essential for the Earth's nitrogen cycle. Herein, a palladium nanocrystals anchored carbon fibers (PdNCs@CNFs) composite was prepared via electrospinning and carbonization processes. X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) characterization studies show that the as-prepared Pd grains are homogeneously anchored on the outer/inner section of the carbon nanofibers. Read More

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Improved chondrogenic performance with protective tracheal design of Chitosan membrane surrounding 3D-printed trachea.

Sci Rep 2021 Apr 29;11(1):9258. Epub 2021 Apr 29.

Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), 37673, Pohang, Gyeongbuk, South Korea.

In recent tracheal tissue engineering, limitations in cartilage reconstruction, caused by immature delivery of chondrocyte-laden components, have been reported beyond the complete epithelialization and integration of the tracheal substitutes with the host tissue. In an attempt to overcome such limitations, this article introduces a protective design of tissue-engineered trachea (TraCHIM) composed of a chitosan-based nanofiber membrane (CHIM) and a 3D-printed biotracheal construct. The CHIM was created from chitosan and polycaprolactone (PCL) using an electrospinning process. Read More

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A heparin-rosuvastatin-loaded P(LLA-CL) nanofiber-covered stent inhibits inflammatory smooth-muscle cell viability to reduce in-stent stenosis and thrombosis.

J Nanobiotechnology 2021 Apr 29;19(1):123. Epub 2021 Apr 29.

Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Background: An endovascular covered-stent has unique advantages in treating complex intracranial aneurysms; however, in-stent stenosis and late thrombosis have become the main factors affecting the efficacy of covered-stent treatment. Smooth-muscle-cell phenotypic modulation plays an important role in late in-stent stenosis and thrombosis. Here, we determined the efficacy of using covered stents loaded with drugs to inhibit smooth-muscle-cell phenotypic modulation and potentially lower the incidence of long-term complications. Read More

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Green Synthesis and Incorporation of Sericin Silver Nanoclusters into Electrospun Ultrafine Cellulose Acetate Fibers for Anti-Bacterial Applications.

Polymers (Basel) 2021 Apr 27;13(9). Epub 2021 Apr 27.

Center of Excellence in Nanotechnology and Materials, Mehran University of Engineering and Technology, Jamshoro 76060, Pakistan.

Fiber based antibacterial materials have gained an enormous attraction for the researchers in these days. In this study, a novel Sericin Encapsulated Silver Nanoclusters (sericin-AgNCs) were synthesized through single pot and green synthesis route. Subsequently these sericin-AgNCs were incorporated into ultrafine electrospun cellulose acetate (CA) fibers for assessing the antibacterial performance. Read More

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Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications.

Pharmaceutics 2021 Apr 27;13(5). Epub 2021 Apr 27.

Group of Polymeric Materials and Composites, Department of Chemistry, State University of Maringá (UEM), Maringá 87020-900, PR, Brazil.

Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Read More

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Propolis-Based Nanofiber Patches to Repair Corneal Microbial Keratitis.

Molecules 2021 Apr 28;26(9). Epub 2021 Apr 28.

Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, 34722 Istanbul, Turkey.

In this research, polyvinyl-alcohol (PVA)/gelatin (GEL)/propolis (Ps) biocompatible nanofiber patches were fabricated via electrospinning technique. The controlled release of Propolis, surface wettability behaviors, antimicrobial activities against the and , and biocompatibility properties with the mesenchymal stem cells (MSCs) were investigated in detail. By adding 0. Read More

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Tunable Mechanical and Electrical Properties of Coaxial Electrospun Composite Nanofibers of P(VDF-TrFE) and P(VDF-TrFE-CTFE).

Int J Mol Sci 2021 Apr 28;22(9). Epub 2021 Apr 28.

Department of Materials Science and Engineering, National Yang Ming Chiao Tung University, Hsinchu 30013, Taiwan.

The coaxial core/shell composite electrospun nanofibers consisting of relaxor ferroelectric P(VDF-TrFE-CTFE) and ferroelectric P(VDF-TrFE) polymers are successfully tailored towards superior structural, mechanical, and electrical properties over the individual polymers. The core/shell-TrFE/CTFE membrane discloses a more prominent mechanical anisotropy between the revolving direction (RD) and cross direction (CD) associated with a higher tensile modulus of 26.9 MPa and good strength-ductility balance, beneficial from a better degree of nanofiber alignment, the increased density, and C-F bonding. Read More

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Development and Characterization of Cellulose/Iron Acetate Nanofibers for Bone Tissue Engineering Applications.

Polymers (Basel) 2021 Apr 20;13(8). Epub 2021 Apr 20.

Stem Cell Institute, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Gangwon, Korea.

In tissue engineering, design of biomaterial with a micro/nano structure is an essential step to mimic extracellular matrix (ECM) and to enhance biomineralization as well as cell biocompatibility. Composite polymeric nanofiber with iron particles/ions has an important role in biomineralization and collagen synthesis for bone tissue engineering. Herein, we report development of polymeric cellulose acetate (CA) nanofibers (17 wt. Read More

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Advances in Fabricating the Electrospun Biopolymer-Based Biomaterials.

J Funct Biomater 2021 Apr 16;12(2). Epub 2021 Apr 16.

Faculty of Materials Science and Ceramics, AGH University of Science and Technology, A. Mickiewicz 30 Avenue, 30-059 Krakow, Poland.

Biopolymers formed into a fibrous morphology through electrospinning are of increasing interest in the field of biomedicine due to their intrinsic biocompatibility and biodegradability and their ability to be biomimetic to various fibrous structures present in animal tissues. However, their mechanical properties are often unsatisfactory and their processing may be troublesome. Thus, extensive research interest is focused on improving these qualities. Read More

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Epithelial Growth Factor-Anchored on Polycaprolactone/6-deoxy-6-amino--cyclodextrin Nanofibers: In Vitro and In Vivo Evaluation.

Polymers (Basel) 2021 Apr 16;13(8). Epub 2021 Apr 16.

Institute of Engineering and Technology, Autonomous University of the City of Juárez, UACJ ve. Del Charro 450 Norte, Ciudad Juárez 32310, Mexico.

Polycaprolactone (PCL) is a well-known FDA approved biomaterial for tissue engineering. However, its hydrophobic properties limit its use for skin wound healing which makes its functionalization necessary. In this work, we present the fabrication and evaluation of PCL nanofibers by the electrospinning technique, as well as PCL functionalized with 6-deoxy-6-amino-β-cyclodextrin (aminated nanofibers). Read More

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Electrospun Janus Beads-On-A-String Structures for Different Types of Controlled Release Profiles of Double Drugs.

Biomolecules 2021 Apr 25;11(5). Epub 2021 Apr 25.

School of Health Sciences, Caritas Institute of Higher Education, Hong Kong 999077, China.

A side-by-side electrospinning process characterized by a home-made eccentric spinneret was established to produce the Janus beads-on-a-string products. In this study, ketoprofen (KET) and methylene blue (MB) were used as model drugs, which loaded in Janus beads-on-a-string products, in which polyvinylpyrrolidone K90 (PVP K90) and ethyl cellulose (EC) were exploited as the polymer matrices. From SEM images, distinct nanofibers and microparticles in the Janus beads-on-a-string structures could be observed clearly. Read More

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