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Optimizing Clinical Monitoring Tools to Enhance Patient Review by Pharmacists.

Appl Clin Inform 2021 May 23;12(3):621-628. Epub 2021 Jun 23.

Department of Pharmacy, Mayo Clinic, Rochester, Minnesota, United States.

Background:  The Clinical Monitoring List (CML) is a real-time scoring system and intervention tool used by Mayo Clinic pharmacists caring for hospitalized patients.

Objective:  The study aimed to describe the iterative development and implementation of pharmacist clinical monitoring tools within the electronic health record at a multicampus health system enterprise.

Methods:  Between October 2018 and January 2019, pharmacists across the enterprise were surveyed to determine opportunities and gaps in CML functionality. Read More

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Nursing Attitudes and Practices in Code Documentation Employing a New Electronic Health Record.

Appl Clin Inform 2021 May 23;12(3):589-596. Epub 2021 Jun 23.

Division of Pediatric Critical Care Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States.

Objective:  Based on feedback from nurses regarding the challenges of code documentation following the implementation of a new electronic health record (EHR), we sought to better understand inpatient nurse attitudes and practices in code documentation and to identify opportunities for improvement.

Methods:  An anonymous electronic survey was distributed to all inpatient nurses working at a single, 999-bed, university-based, and quaternary care hospital. Participation in the study was voluntary and consent was implied by survey completion. Read More

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[Assessing Electronic Prescription: A Cross-sectional Study of Pharmacists in Germany].

Gesundheitswesen 2021 Jun 23. Epub 2021 Jun 23.

Institute of Family Medicine, Universitätsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck, Deutschland.

Background: The GERDA ("Protected e-prescription service for pharmacies") project of the Chamber of Pharmacists (LAK) and Pharmacists Association (LAV) of the federal state of Baden-Wuerttemberg provided the opportunity to prescribe medications within the telemedical portal "docdirekt" that is operated by the Association of Statutory Health Insurance Physicians of Baden-Wuerttemberg. Against this background, the aim of the study was to explore and prioritize barriers and enablers among pharmacists to participate in a medical supply system that includes electronic prescriptions (e-prescriptions). Based on these determinants, recommendations for optimizing the successful implementation of similar care offers were derived. Read More

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Women's experiences and satisfaction with maternal referral service in Northern Ghana: A qualitative inquiry.

Midwifery 2021 Jun 9;101:103065. Epub 2021 Jun 9.

School of Public Health, Faculty of Health, University of Technology Sydney, Australia. Electronic address:

Objective: To gain insights and improve existing referral structures with maternity care in Northern region of Ghana, this study explored the referral experiences and satisfaction of women.

Research Design: Twenty women referred to the Tamale Teaching Hospital for maternal health conditions were interviewed along with three husdands of these women between January and April 2020. An interview guide was used in individual face-to-face semi-structured interviews. Read More

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Breastfeeding intention and trait mindfulness during pregnancy.

Midwifery 2021 Jun 10;101:103064. Epub 2021 Jun 10.

Center of Research in Psychological and Somatic disorders (CoRPS), Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.

Objective: Breastfeeding has been associated with many health benefits for both infant and mother. Trait mindfulness during pregnancy may have a beneficial impact on breastfeeding intention. The current study aimed to examine whether trait mindfulness during pregnancy was associated with antenatal breastfeeding intention. Read More

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Corrigendum to "Use of kinetic data to model potential antioxidant activity: Radical scavenging capacity of Australian Eucalyptus honeys" [Food Chem. 342 (2021) 128332].

Food Chem 2021 Jun 20;364:130359. Epub 2021 Jun 20.

GeneCology Research Centre, University of the Sunshine Coast, Qld, Australia; School of Health and Sport Sciences, University of the Sunshine Coast, Qld, Australia; CRC for Honey Bee Products Ltd., 128 Yanchep Beach Road, Yanchep, WA, Australia. Electronic address:

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Effect of protein-fatty acid interactions on the formation of starch-lipid-protein complexes.

Food Chem 2021 Jun 17;364:130390. Epub 2021 Jun 17.

State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin 300457, China; School of Food Science and Engineering, Tianjin University of Science & Technology, 300457, China; College of Biological and Chemical Engineering, Guangxi University of Science and Technology, 545006, China. Electronic address:

The effect of interactions between beta-lactoglobulin (βLG) and lauric acid (LA) on the formation of ternary maize starch-LA-protein complexes was investigated. Analysis of the secondary structure of βLG by FTIR and changes in fluorescence λmax and intensity indicated that βLG and LA interacted during heating and cooling in a Rapid Visco Analyser (RVA). Results from RVA, DSC and Raman spectroscopy analyses showed that increasing the concentration of βLG from 25 to 200 mg increased the amount of ternary starch-LA-βLG complexes formed. Read More

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Analysis of efficacy of intervention strategies for COVID-19 transmission: A case study of Hong Kong.

Environ Int 2021 Jun 18;156:106723. Epub 2021 Jun 18.

Department of Mechanical Engineering, The University of Hong Kong, Hong Kong SAR, China. Electronic address:

By the end of February 2021, COVID-19 had spread to over 230 countries, with more than 100 million confirmed cases and 2.5 million deaths. To control infection spread with the least disruption to economic and societal activities, it is crucial to implement the various interventions effectively. Read More

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Polystyrene microplastics induce microbial dysbiosis and dysfunction in surrounding seawater.

Environ Int 2021 Jun 20;156:106724. Epub 2021 Jun 20.

Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China; Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, 1799 Jimei Road, Xiamen 361021, China. Electronic address:

Microplastics are ubiquitously present in the environment, accumulate in aquaculture water, and cause toxicological effects on aquatic organisms. Besides, microplastics provide ecological niches for microorganisms in aquatic environments. However, the effects of microplastics on microbial balance and function in surrounding water are still unclear, especially for aquaculture water. Read More

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Firefighters' occupational exposure: Contribution from biomarkers of effect to assess health risks.

Environ Int 2021 Jun 20;156:106704. Epub 2021 Jun 20.

REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto. Electronic address:

Firefighting is physically and physiologically exhausting besides encompassing exposure to toxic fire emissions. Biomonitoring studies from the past five years have been significantly contributing to characterize the occupational-related health effects in this group of professionals and to improve risk assessment. Therefore, this study gathers and critically discusses the most characterized biomarkers of effect (oxidative stress, DNA and protein damage, stress hormones, inflammation, and vascular, lung, and liver injury), including those potentially more promising to be explored in future studies, and their relation with health outcomes. Read More

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The exposures and health effects of benzene, toluene and naphthalene for Chinese chefs in multiple cooking styles of kitchens.

Environ Int 2021 Jun 20;156:106721. Epub 2021 Jun 20.

Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China. Electronic address:

Commercial cooking has higher intensity and more severe instantaneous cooking pollution from volatile organic chemicals compared to home cooking, making health risk assessment of occupational exposure for chefs a priority. In this study, chefs from three cooking styles of kitchens, including steaming, frying, and grilling, were selected to investigate the external and internal exposures, health risks and effects of several typical aromatic hydrocarbons (benzene, toluene and naphthalene). Naphthalene was found to be the most concentrated contaminant in air samples among the different kitchens, while benzene had the lowest concentration. Read More

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Prevalence, healthcare resource utilization and mortality of Lennox-Gastaut syndrome: retrospective linkage cohort study.

Seizure 2021 Jun 9;91:159-166. Epub 2021 Jun 9.

Evidence Synthesis, Modeling, Communications, Evidera, The Ark, 201 Talgarth Road, London W6 8BJ, UK. Electronic address:

Purpose: To retrospectively investigate the prevalence, demography, antiseizure medication (ASM) usage, healthcare resource utilization (HCRU), and mortality of patients with Lennox-Gastaut syndrome (LGS) in primary and secondary care in the UK.

Methods: Patients with confirmed LGS were anonymously identified from the UK Clinical Practice Research Datalink (CPRD) GOLD database (01/01/1987-31/10/2018) using the LGS Read Code (F250500). Probable LGS was identified using the International Classification of Diseases-10/Read Code for epilepsy (Hospital Episode Statistics [HES]/CPRD) plus rufinamide prescription. Read More

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How do machine learning algorithms perform in predicting hospital choices? evidence from changing environments.

J Health Econ 2021 Jun 4;78:102481. Epub 2021 Jun 4.

Federal Trade Commission. Electronic address:

Researchers have found that machine learning methods are typically better at prediction than econometric models when the choice environment is stable. We study hospital demand models, and evaluate the relative performance of machine learning algorithms when the choice environment changes substantially due to natural disasters that closed previously available hospitals. While machine learning algorithms outperform traditional econometric models in prediction, the gain they provide shrinks when patients' choice sets are more profoundly affected. Read More

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When particulate matter strikes cities: Social disparities and health costs of air pollution.

J Health Econ 2021 Jun 5;78:102478. Epub 2021 Jun 5.

CEIS, University of Rome "Tor Vergata", Via Columbia 2, 00133 Rome, Italy; Gran Sasso Science Institute (GSSI), Viale Francesco Crispi 7, 67100, L'Aquila, Italy. Electronic address:

We investigate the heterogeneous effects of particle pollution on Italian daily hospitalizations and their costs by exploiting public transportation strikes as plausibly-exogenous shocks in pollution exposure. We find that a one standard deviation increase in PM causes additional 0.79 hospitalizations per 100,000 residents, and the effect is stronger for the elderly, low educated individuals and migrants. Read More

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Evidence for association of vasopressin receptor 1A promoter region repeat with childhood onset aggression.

J Psychiatr Res 2021 May 27;140:522-528. Epub 2021 May 27.

Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Institute of Medical Science & Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

Objective: Childhood onset aggression can cause major suffering to affected families and is associated with many negative outcomes in the child's later life, including poor academic performance, adolescent delinquency, drug abuse, depression and antisocial personality disorder. Currently available prevention and intervention strategies have limited efficacy, but a better understanding of underlying genetic and neurobiological factors can lead to more effective prevention and treatment strategies, through genetic screening programs and novel therapies.

Method: This study examined the RS1 (n = 299 aggression, n = 192 controls) and RS3 (n = 291 aggression, n = 189 controls) microsatellite repeats within the promoter region of the vasopressin receptor 1A gene (AVPR1A) and their association with extreme childhood aggression, as assessed by the Child Behavior Checklist (CBCL), as well as the Teacher Report Form (TRF) and Youth Self Report (YSR). Read More

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Preoperative high intensity interval training for oncological resections: A systematic review and meta-analysis.

Surg Oncol 2021 Jun 12;38:101620. Epub 2021 Jun 12.

School of Medicine, Trinity College Dublin, Dublin, Ireland. Electronic address:

Exercise prehabilitation prior to major surgery targets a reduction in postoperative complications through improved conditioning and respiratory function. However its effectiveness in cancer surgery is unclear. The objective of this review was to determine if preoperative high-intensity interval training (HIIT) improves preoperative fitness in patients scheduled for oncologic resection, and whether postoperative complications are impacted. Read More

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Male depression syndrome is characterized by pronounced Cluster B personality traits.

J Affect Disord 2021 Jun 4;292:725-732. Epub 2021 Jun 4.

Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Germany; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health (CIMH), Medical Faculty Mannheim, Heidelberg University, Germany. Electronic address:

Background: Male depression syndrome (Male-DS) refers to alternative depression symptoms related to the male sex, such as externalizing behaviors, emotional suppression, substance misuse, and risk-seeking. Although these symptoms contribute to gender bias in the diagnosis of depression, Male-DS can be found in both sexes. In this cross-sectional study, we analyzed associations between Male-DS and clinical personality accentuations. Read More

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Predicting postpartum depression by evaluating temperament during pregnancy.

J Affect Disord 2021 Jun 4;292:720-724. Epub 2021 Jun 4.

Department of Obstetrics and Gynecology, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.

Aim: The purpose of this study was to investigate premorbid temperaments to predict postpartum depression in pregnant women with no previous psychiatric history and to clarify the correlation between postpartum depression and the factors included in the Postpartum Depression Predictors Inventory-Revised (PDPI-R) and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto questionnaire (TEMPS-A)/Munich Personality Test (MPT).

Methods: A total of 170 eligible pregnant women filled out both questionnaires, the first between the 8th and 23rd week of gestation, and the latter between the 34th and 38th week of gestation. Participants filled out The Edinburgh Postnatal Depression Scale (EPDS) one month postpartum to measure for postpartum depression symptoms. Read More

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Does pre-treatment functioning influence response to intravenous ketamine in adults with treatment-resistant depression?

J Affect Disord 2021 Jun 20;292:714-719. Epub 2021 Jun 20.

Mood Disorder Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Canadian Rapid Treatment Center of Excellence, Mississauga, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

Background: The efficacy of monoamine-based antidepressants in adults with major depressive disorder (MDD) is attenuated in persons with greater pre-treatment functional impairment. Herein, we investigated whether pre-treatment functioning in outpatients with treatment-resistant depression (TRD) moderates response to intravenous (IV) ketamine.

Methods: Adults (N= 326; M = 45) with DSM-5-defined MDD or bipolar disorder and TRD received repeat-dose IV ketamine at a community-based clinic. Read More

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Multiplatform metabolomics for an integrative exploration of metabolic syndrome in older men.

EBioMedicine 2021 Jun 19;69:103440. Epub 2021 Jun 19.

Université Clermont Auvergne, INRAE, UNH, Plateforme d'Exploration du Métabolisme, MetaboHUB Clermont, Clermont-Ferrand, France. Electronic address:

Background: Metabolic syndrome (MetS), a cluster of factors associated with risks of developing cardiovascular diseases, is a public health concern because of its growing prevalence. Considering the combination of concomitant components, their development and severity, MetS phenotypes are largely heterogeneous, inducing disparity in diagnosis.

Methods: A case/control study was designed within the NuAge longitudinal cohort on aging. Read More

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Intrinsic functional connectivity in families genetically enriched for social anxiety disorder - an endophenotype study.

EBioMedicine 2021 Jun 19;69:103445. Epub 2021 Jun 19.

Department of Psychiatry, Leiden University Medical Center, Albinusdreef 2, 2333, ZA, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands. Electronic address:

Background: Social anxiety disorder (SAD) is a serious psychiatric condition with a high prevalence, and a typical onset during childhood/adolescence. The condition runs in families, but it is largely unknown which neurobiological characteristics transfer this genetic vulnerability ('endophenotypes'). Using data from the Leiden Family Lab study on SAD, including two generations of families genetically enriched for SAD, we investigated whether social anxiety (SA) co-segregated with changes in intrinsic functional connectivity (iFC), and examined heritability. Read More

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Oestrogen receptor activity in hormone-dependent breast cancer during chemotherapy: ER activity in pre-menopausal HR+ breast cancer during CT.

EBioMedicine 2021 Jun 20;69:103451. Epub 2021 Jun 20.

Translational Genomics and Targeted Therapies in Solid Tumors, August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Barcelona, Spain; Department of Medical Oncology, Hospital Clinic of Barcelona, Spain; SOLTI cooperative group, Barcelona, Spain; Institute of Oncology (IOB)-Hospital Quirónsalud, Barcelona, Spain; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, USA; Department of Medicine, University of Barcelona, Barcelona, Spain. Electronic address:

Background: Chemotherapy efficacy in early-stage hormone receptor-positive (HR+) breast cancer (BC) according to menopausal status needs a biological explanation.

Methods: We compared early-stage HR+ BC biological features before and after (neo)adjuvant chemotherapy or endocrine therapy (ET), and assessed oestrogen receptor (ER) pathway activity in both pre- and post-menopausal patients. The nCounter platform was used to detect gene expression levels. Read More

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Test, trace, isolate: evidence for declining SARS-CoV-2 PCR sensitivity in a clinical cohort.

Diagn Microbiol Infect Dis 2021 Apr 21;101(2):115392. Epub 2021 Apr 21.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. Electronic address:

Real-time reverse transcription-polymerase chain reaction (RT-PCR) on upper respiratory tract (URT) samples is the primary method to diagnose SARS-CoV-2 infections and guide public health measures, with a supportive role for serology. We reinforce previous findings on limited sensitivity of PCR testing, and solidify this fact by statistically utilizing a firm basis of multiple tests per individual. We integrate stratifications with respect to several patient characteristics such as severity of disease and time since onset of symptoms. Read More

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Host association of Borrelia burgdorferi sensu lato: A review.

Ticks Tick Borne Dis 2021 Jun 10;12(5):101766. Epub 2021 Jun 10.

Division of Evolutionary Biology, Faculty of Biology, LMU Munich, Grosshaderner Strasse 2, 82152 Planegg-Martinsried, Germany. Electronic address:

Borrelia burgdorferi sensu lato (Bbsl) is a bacterial species complex that includes the etiological agents of the most frequently reported vector-borne disease in the Northern hemisphere, Lyme borreliosis. It currently comprises > 20 named and proposed genospecies that use vertebrate hosts and tick vectors for transmission in the Americas and Eurasia. Host (and vector) associations influence geographic distribution and speciation in Bbsl, which is of particular relevance to human health. Read More

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Anaplasmosis in Poland - analysis of 120 patients.

Ticks Tick Borne Dis 2021 Jun 2;12(5):101763. Epub 2021 Jun 2.

Department of Infectious Diseases and Neuroinfections Medical University of Bialystok, Zurawia, 14 15-540 Bialystok, Poland.

The aim of our study was to clarify the clinical picture of anaplasmosis through analysis of the symptoms and clinical signs presented by infected patients in a cohort of tick-bitten individuals. The study included 1375 patients with suspicion of tick-borne disease. Finally, 120 patients (8. Read More

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Facial analysis technology for the detection of down syndrome in the Democratic Republic of the Congo.

Eur J Med Genet 2021 Jun 20:104267. Epub 2021 Jun 20.

Center for Genetic Medicine Research, Children's Research Institute, Children's National Hospital, Washington, DC, USA; International Research Laboratory of Epigenetics, Data, Politics, Centre National de la Recherche Scientifique, Washington, DC, USA; Department of Genomics and Precision Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, USA; International Research Laboratory of Epigenetics, Data, Politics, Centre National de la Recherche Scientifique, Paris, France. Electronic address:

Down syndrome is one of the most common chromosomal anomalies affecting the world's population, with an estimated frequency of 1 in 700 live births. Despite its relatively high prevalence, diagnostic rates based on clinical features have remained under 70% for most of the developed world and even lower in countries with limited resources. While genetic and cytogenetic confirmation greatly increases the diagnostic rate, such resources are often non-existent in many low- and middle-income countries, particularly in Sub-Saharan Africa. Read More

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Racial/ethnic differences in health-related quality of life among female breast cancer survivors: cross-sectional findings from the Medical Expenditure Panel Survey.

Public Health 2021 Jun 20;196:74-81. Epub 2021 Jun 20.

University of Texas School of Public Health, Center for Health Promotion and Prevention Research, Division of Health Promotion and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.

Objectives: Breast cancer survivors have reported worse health-related quality of life (HRQoL) outcomes on some subscales when compared with members of the general population. However, the increased attention to breast cancer survivorship should have improved the HRQoL of these survivors. Our aim was to examine whether physical and mental component scores (PCS-12 and MCS-12) using the Short Form (SF-12) questionnaire were different for racial/ethnic minorities, specifically for Black and Hispanic women relative to White women. Read More

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CELLULAR AND METABOLIC CHANGES AFTER PHOTODYNAMIC THERAPY IN LEISHMANIA PROMASTIGOTES.

Photodiagnosis Photodyn Ther 2021 Jun 20:102403. Epub 2021 Jun 20.

Photobiology Applied to Health - Universidade do Vale do Paraíba. Av. Shishima Hifumi, 2911, Urbanova, São José dos Campos, S.P, Brazil. Electronic address:

Leishmaniasis is a zoonotic disease, regarded by WHO as a public health problem that has presented a significant increase in the recent years. Conventional treatment is toxic and leads to serious side effects. Photodynamic therapy has been studied as an alternative treatment to cutaneous leishmaniasis. Read More

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Comparison of three scales (BIS, SUMD and BCIS) for measuring insight dimensions and their evolution after one-year of follow-up: Findings from the FACE-SZ Cohort.

Psychiatry Res 2021 Jun 20;303:114044. Epub 2021 Jun 20.

Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHU Montpellier, Montpellier, France; Univ Paul Valéry Montpellier 3, Univ. Montpellier, EPSYLON EA, Montpellier, France.

The aim of our study was to compare the performance of three different instruments measuring clinical and cognitive dimensions of insight. Data on 182 outpatients with schizophrenia and one-year follow-up assessments was drawn from the FACE-SZ cohort. Awareness of clinical state (« clinical insight ») was measured using both a clinician-rated measure (the Scale to assess Unawareness of Mental Disorder (SUMD)), and a self-report measure (the Birchwood Insight Scale (BIS). Read More

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