3,060,041 results match your criteria elderly patients

SARS-CoV-2 omicron: Light at the end of the long pandemic tunnel or another false dawn for immunodeficient patients?

J Allergy Clin Immunol Pract 2022 Jun 22. Epub 2022 Jun 22.

Department of Clinical immunology, Auckland Hospital, Park Rd, Grafton 1010, Auckland New Zealand; Department of Medicine, School of Medicine, Faculty of Medical and Health Sciences, University of Auckland.

COVID-19 has had a disastrous impact on the world. Apart from at least 6 million deaths, countless COVID-19 survivors are suffering long-term physical and psychiatric morbidity. Hundreds of millions have been plunged into poverty caused by economic misery, particularly in developing nations. Read More

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Identification of multidimensional phenotypes using cluster analysis in sarcoid uveitis patients.

Am J Ophthalmol 2022 Jun 22. Epub 2022 Jun 22.

Department of Internal Medicine, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, 69004 Lyon, France; University Claude Bernard Lyon 1, Research on Healthcare Performance (RESHAPE), INSERM U1290, Lyon, France.

Purpose: To identify multidimensional phenotypes of sarcoid uveitis patients Design: Retrospective cohort.

Methods: Study Population: Consecutive patients with biopsy-proven, presumed or probable sarcoid uveitis between December 2003 and December 2020 in Lyon.

Observation Procedure: Data were collected from the clinical notes, and consisted in laboratory and imaging findings, systemic treatments and outcome. Read More

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Acute ischemic stroke and vaccine-induced immune thrombotic thrombocytopenia post COVID-19 vaccination; a systematic review.

J Neurol Sci 2022 Jun 20;439:120327. Epub 2022 Jun 20.

Division of Stroke and Endovascular Neurosurgery, Department of Neurological Surgery, Keck School of Medicine, University of Southern California, CA, USA. Electronic address:

Introduction: One of the rare but potentially serious side effects of COVID-19 vaccination is arterial and venous thrombosis. Acute ischemic stroke (AIS) cases have been reported post COVID-19 vaccination. Herein, we systematically reviewed the reported cases of AIS after COVID-19 vaccination. Read More

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Cardiovascular Risk Stratification and Appropriate Use of Statins in Patients with Chronic Kidney Disease According to Different Strategies.

High Blood Press Cardiovasc Prev 2022 Jun 25. Epub 2022 Jun 25.

Nefrology Department, Hospital Italiano de Buenos Aires, Tte. Gral. Juan Domingo Perón 4190, C1199ABB, Buenos Aires, Argentina.

Introduction: Different strategies were proposed to stratify cardiovascular risk and assess the appropriate use of statins in patients with chronic kidney disease (CKD).

Aim: (1) To apply two strategies on the management of lipids in patients with CKD, analyzing what proportion of patients received lipid-lowering treatment and how many patients without statin therapy would be candidates for receiving them; (2) to identify how many patients achieve the lipid goals.

Methods: A cross-sectional study was performed. Read More

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Ovarian torsion in the pediatric population: predictive factors for ovarian-sparing surgery-an international retrospective multicenter study and a systematic review.

Arch Gynecol Obstet 2022 Jun 25. Epub 2022 Jun 25.

Department of Pediatric Surgery "Spirito Santo", Hospital of Pescara "G.D'annunzio", University Chieti-Pescara, Pescara, Italy.

Study Objective: Ovarian torsion (OT) in pediatric age is a challenging condition to diagnose and treat. To date, there is still no clear consensus about its management. Our aim was to assess some possible associated factors that can help surgeons in decision-making. Read More

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Early prediction of prostate cancer risk in younger men using polygenic risk scores and electronic health records.

Cancer Med 2022 Jun 25. Epub 2022 Jun 25.

Dascena Inc., Houston, Texas, USA.

Background: Prostate cancer (PCa) screening is not routinely conducted in men aged 55 and younger, although this age group accounts for more than 10% of cases. Polygenic risk scores (PRSs) and patient data applied toward early prediction of PCa may lead to earlier interventions and increased survival. We have developed machine learning (ML) models to predict PCa risk in men 55 and under using PRSs combined with patient data. Read More

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Prognostic values of muscle mass assessed by dual-energy X-ray absorptiometry and bioelectrical impedance analysis in older patients with heart failure.

Geriatr Gerontol Int 2022 Jun 25. Epub 2022 Jun 25.

Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Aim: This study aimed to compare bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA) in measuring skeletal muscle mass (MM), and its prognostic implications in old patients with heart failure.

Methods: We prospectively evaluated MM measured by both BIA and DEXA in 226 hospitalized elderly (≥65 years) patients with heart failure. The cut-off values proposed by the Asian Working Group in Sarcopenia were used to define low MM. Read More

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Prognostic value of PaO/FiO, SOFA and D-dimer in elderly patients with sepsis.

J Int Med Res 2022 Jun;50(6):3000605221100755

Department of Nursing, Hunan Provincial People's Hospital, Changsha, Hunan Province, China.

Objective: To investigate the prognostic value for predicting mortality of partial pressure of oxygen/fraction of inspired oxygen (PaO/FiO), the Sequential Organ Failure Assessment (SOFA) score and D-dimer in elderly patients with sepsis.

Methods: This retrospective cohort study enrolled elderly patients with sepsis admitted to the intensive care unit (ICU) between January 2019 and October 2020. Patients were divided into a survival group and a non-survival group. Read More

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Development and Validation of the Intravenous Infiltration and Extravasation Risk Assessment Tool (IIERAT) for Pediatric Patients.

Indian Pediatr 2022 Jun 11. Epub 2022 Jun 11.

Department of Child Health Nursing, Maharishi Markandeshwar College of Nursing, Maharishi Markandeshwar (Deemed to be) University, Mullana, Haryana.

Objective: To develop and validate a new tool viz., Intravenous Infiltration and Extravasation Risk Assessment Tool (IIEART) for assessing risk of fluid extravasation in children.

Participants: 120 children (aged 2-18 year) undergoing peripheral intravenous cannulation were recruited from four hospitals of Haryana to determine the IIEART scale's psychometric properties. Read More

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Necrotizing Fasciitis In A Patient with Metastatic Clear Cell Ovarian Carcinoma Treated with Bevacizumab.

Am J Case Rep 2022 Jun 25;23:e935584. Epub 2022 Jun 25.

Department of Internal Medicine, BronxCare Hospital, Affiliated with Icahn School of Medicine at Mount Sinai, Bronx, NY, USA.

BACKGROUND Necrotizing fasciitis is a life-threatening infection of the deep soft tissues that leads to progressive destruction of the fascia and subcutaneous fat. It typically spreads along the muscle fascia planes because of the relatively poor blood supply. Muscle tissue is usually spared because of its better blood supply. Read More

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Effects of aerobic exercise and progressive muscle relaxation on migraine.

J Pak Med Assoc 2022 Jun;72(6):1153-1157

Department of Neurosurgery, Combined Military Hospital, Muzaffarabad, Pakistan.

Objective: To determine the effect of aerobic exercises and progressive muscle relaxation in migraine patients.

Methods: The quasi-experimental study was conducted at the Sheikh Khalifa Bin Zayed Al Nayhan Hospital / Combined Military Hospital, Muzaffarabad, Azad Jammu and Kashmir, from February to July 2017, and comprised migraine patients of either gender aged 20-50 years. They were divided into experimental and control group. Read More

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Perception of massage application among clinicians and parents in spastic cerebral palsy: Qualitative study.

J Pak Med Assoc 2022 Jun;72(6):1086-1091

Department of Rehabilitation and Allied Health Sciences, Riphah International University, Lahore Campus, Pakistan.

Objective: To explore the perceptions about traditional massage and its modified techniques among clinicians and families of the patients with spastic cerebral palsy.

Methods: The qualitative, cross-sectional study was conducted from November 2019 to August 2020 in Sialkot, Pakistan, after approval from the ethics review committee of Riphah College of Rehabilitation Sciences, Islamabad, and comprised neuro paediatricians and paediatricians in Group A, parents of children with spastic cerebral palsy aged 8-15 years in Group B, and musculoskeletal physiotherapists and orthopaedic manual physical therapists in Group C. The professionals in groups A and C had a minimum of 5-year paediatric experience in government and teaching hospitals. Read More

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Vitamin D deficiency: A risk factor for myopia in children - a cross sectional study in a tertiary care centre.

J Pak Med Assoc 2022 Jun;72(6):1075-1079

Department of Pediatrics, Shifa College of Medicine, Shifa international Hospital, Islamabad, Pakistan.

Objective: To study the role of vitamin D deficiency as a risk factor for myopia in children aged 5-15 years.

Methods: The cross-sectional observational study was conducted from January to September 2019 at the Ophthalmology and Paediatric departments of Shifa Foundation Community Health Centre, Islamabad, Pakista. It comprised patients with suspected / symptomatic vitamin D deficiency who were enrolled from the paediatric outpatient department and referred to the ophthalmology clinics for eye exam. Read More

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Nutritional vitamin D is efficacious for reducing intact parathyroid hormone in chronic kidney disease, a prospective interventional study.

J Pak Med Assoc 2022 Jun;72(6):1068-1074

Department of Nephrology, The Indus Hospital, Karachi, Pakistan.

Objective: To see the efficacy of oral cholecalciferol administered to chronic kidney disease patients with vitamin D deficiency.

Methods: The prospective interventional study was conducted at the Indus Hospital, Karachi, from January 11, 2017, to January 10, 2018, and comprised diagnosed pre-dialysis chronic kidney disease patients of either gender aged >14 years having vitamin D deficiency. Oral vitamin D 50,000IU was given weekly to those who had severe deficiency <10ng/ml, and every other week to those with less severe 10-25ng/ml deficiency for 3 months. Read More

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Role of lidocaine and its effect on postoperative outcomes in abdominal cholecystectomy.

J Pak Med Assoc 2022 Jun;72(6):1048-1052

Department of Pharmacology, Wah Medical College, Wah Cantt, Pakistan.

Objective: To investigate the role of pre- and intra-operative lidocaine infusion on post-operative pain management.

Methods: The interventional, prospective study was conducted from September 2019 to June 2020 at the Pakistan Ordnance Factories Hospital, Wah Cantt, Pakistan, and comprised patients aged 18-60 years undergoing elective cholecystectomy who were randomised into intervention group A and control group B. Group A was given a bolus dose of lidocaine hydrochloride 2 mg/kg in addition to the standard anaesthesia protocol, while group B was given continuous intravenous infusion of 0. Read More

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Evaluation of serum indirect haemagglutination test results of suspected cystic echinococcosis cases from 2009-2017.

J Pak Med Assoc 2022 Jun;72(6):1035-1038

Department of Medical Microbiology, Uludag University, Bursa, Turkey.

Objective: This study aims to evaluate the serological, radiological and epidemiological analysis of suspected cystic echinococcosis patients, and to assess the positivity rate in the region.

Methods: The retrospective study was conducted at Bursa Uludag University Hospital, Turkey and comprised data from January 2009 to December 2017 related to patients of either gender with suspected cystic echinococcosis who underwent indirect haemagglutination testing. Demographic and clinical data of patients who tested positive were analysed. Read More

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Community pharmacists' measurement of health-related quality of life in outpatients taking high-risk drugs.

Pharmazie 2022 Jun;77(6):202-206

Study group for Comprehensive Cost-Effectiveness Analysis of Pharmacotherapy, Koto-ku, Tokyo; Department of Pharmacy, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, Koto-ku, Tokyo; Department of Nursing, School of Nursing and Rehabilitation Sciences, Showa University, Shinagawa-ku, Tokyo, Japan;, Email:

Patients experiencing severe side effects when taking high-risk drugs may have a significantly reduced health-related quality of life (QOL); therefore, it is important to identify changes in the health-related QOL in these patients. This study aimed to determine the health-related QOL in community pharmacy outpatients taking high-risk drugs. This prospective observational study was conducted in 29 community pharmacies with 71 pharmacists in 12 regions and cities in Japan from October to December 2020 and 760 patients were enrolled. Read More

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Minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis: predictive model based on machine learning.

Arthritis Res Ther 2022 Jun 24;24(1):153. Epub 2022 Jun 24.

Knowledge Engineering Institute, Universidad Autónoma de Madrid, Madrid, Spain.

Background: Very few data are available on predictors of minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis (PsA). Such data are crucial, since the therapeutic measures used to change the adverse course of PsA are more likely to succeed if we intervene early. In the present study, we used predictive models based on machine learning to detect variables associated with achieving MDA in patients with recent-onset PsA. Read More

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Assessing multidimensional complexity in home care: congruencies and discrepancies between patients and nurses.

BMC Nurs 2022 Jun 24;21(1):166. Epub 2022 Jun 24.

Geneva School of Health Sciences, HES-SO, University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland.

Background: Person-centered care allows for the inclusion of the totality of a person's needs and preferences, beyond just the clinical or medical aspect. This approach requires the development of tools to allow for the integration of the patient in his/her healthcare. Based on a 30-item tool developed for nurses to evaluate the complexity of home care situations (COMID), this study proposed a version for the patients (i. Read More

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Development of mealtime difficulty scale for older adults with dementia in long-term care facilities.

BMC Geriatr 2022 Jun 24;22(1):518. Epub 2022 Jun 24.

Department of Nursing, Semyung University, 65, Semyeong-ro, Jecheon-si, Chungbuk, 27136, Republic of Korea.

Background: In older patients with dementia, functional dependence on individuals affects their eating behavior, leading to difficulties with meals. In addition to individual factors, several social, cultural, and environmental factors influence mealtime difficulties in older individuals with dementia. Therefore, a measure is required to evaluate the difficulty of eating, considering the different interacting phenomena. Read More

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Remifentanil requirement for i-gel insertion is reduced in male patients with Parkinson's disease undergoing deep brain stimulator implantation: an up-and-down sequential allocation trial.

BMC Anesthesiol 2022 Jun 24;22(1):197. Epub 2022 Jun 24.

Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.

Background: Laryngeal mask airways have been widely used in clinical practice. The aim of this study was to investigate whether the remifentanil requirement for facilitation of i-gel insertion in Parkinson's disease (PD) patients undergoing deep brain stimulation (DBS) surgery was different from that in non-PD (NPD) patients undergoing intracranial surgery.

Study Design: An up-and-down sequential allocation trial. Read More

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Severe infections and renal dysfunction during immunosuppressive therapy with cyclosporine A for aplastic anemia.

Int J Hematol 2022 Jun 24. Epub 2022 Jun 24.

Department of Hematology and Oncology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-Ku, Tokyo, 113-8655, Japan.

Although immunosuppressive therapy (IST) with cyclosporine A (CyA) has been widely used in patients with aplastic anemia (AA), little attention has been given to its safety. This study aimed to clarify the adverse events of IST in patients with AA. We retrospectively identified 42 patients with AA treated with IST. Read More

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The effectiveness and safety of bevacizumab versus cetuximab in the treatment of colorectal cancer: a systematic review and meta-analysis.

Int J Clin Pharm 2022 Jun 24. Epub 2022 Jun 24.

College of Pharmacy, Jiamusi University, Jiamusi, 154007, Heilongjiang, China.

Background: Despite available meta-analyses, comparative efficacy and safety between bevacizumab and cetuximab-containing therapies in treating advanced colorectal cancer (CRC) still need to be elucidated.

Aim: This meta-analysis aimed to investigate the efficacy and grade 3-5 treatment-related adverse events (TARE3-5) of bevacizumab versus cetuximab in treating advanced CRC.

Method: A random sample of 400 patients aged 65 years or older from a clinical trial in four Swedish hospitals was selected. Read More

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Association of underlying comorbidities and progression of COVID-19 infection amongst 2586 patients hospitalised in the National Capital Region of India: a retrospective cohort study.

Mol Cell Biochem 2022 Jun 25. Epub 2022 Jun 25.

Department of Research, Sir Ganga Ram Hospital, New Delhi, 110060, India.

This study is conducted to observe the association of diabetes (DM), hypertension (HTN) and chronic kidney disease (CKD) on the prognosis and mortality of COVID-19 infection in hospital admitted patients with above mentioned comorbidities. This is a single centre, observational, retrospective study carried out at Sir Ganga Ram Hospital, Delhi, India. The burden of comorbidities on the prognosis and clinical outcome of COVID-19 patients admitted patients from April 8, 2020, to October 4, 2020. Read More

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Dynamic changes in heparin-binding protein as a prognostic biomarker for 30-day mortality in sepsis patients in the intensive care unit.

Sci Rep 2022 Jun 24;12(1):10751. Epub 2022 Jun 24.

Health Data Science Research Group, Department of Emergency Medicine, The Centre for Intelligent Healthcare, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan.

Heparin-binding protein (HBP) has been shown to be a robust predictor of the progression to organ dysfunction from sepsis, and we hypothesized that dynamic changes in HBP may reflect the severity of sepsis. We therefore aim to investigate the predictive value of baseline HBP, 24-h, and 48-h HBP change for prediction of 30-day mortality in adult patients with sepsis. This is a prospective observational study in an intensive care unit of a tertiary center. Read More

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Clinical performance of a smartphone-based low vision aid.

Sci Rep 2022 Jun 24;12(1):10752. Epub 2022 Jun 24.

Department of Ophthalmology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Republic of Korea.

Real-time digital image processing to optimally enhance low vision is now realizable with recent advances in personal computers. This study aimed to evaluate the efficacy of a wearable smartphone-based low vision aid (LVA) with customizable vision enhancement in patients with visual impairment. We recruited 35 subjects with visual impairment and who were literate and cognitively capable. Read More

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What is the best method to ensure informed consent is valid for orthodontic treatment? A trial to assess long-term recall and comprehension.

Evid Based Dent 2022 Jun 24;23(2):52-53. Epub 2022 Jun 24.

Leeds Dental Institute, Leeds, UK.

Design Single-blind randomised controlled trial.Intervention Patient and parent pairs were randomly assigned via a random number generator to Group A or B. Both groups were given ten minutes to read a modified consent document. Read More

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Caregiver burden in older Indian patients with cancer- Experience from a tertiary care center.

J Geriatr Oncol 2022 Jun 22. Epub 2022 Jun 22.

Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India. Electronic address:

Introduction: Most of the long-term care for older adults with chronic or debilitating illnesses is provided by unpaid family members or informal caregivers. There is limited information on caregiver burden among caregivers of older patients with cancer in India. Hence, we assessed the prevalence and severity of caregiver burden among caregivers of older Indian patients with cancer. Read More

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Examining patterns of traditional Chinese medicine use in pediatric oncology: A systematic review, meta-analysis and data-mining study.

J Integr Med 2022 Jun 10. Epub 2022 Jun 10.

School of Pharmacy, Faculty of Medicine, the Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Background: Traditional Chinese medicine (TCM) is becoming a popular complementary approach in pediatric oncology. However, few or no meta-analyses have focused on clinical studies of the use of TCM in pediatric oncology.

Objective: We explored the patterns of TCM use and its efficacy in children with cancer, using a systematic review, meta-analysis and data mining study. Read More

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Impact of empathic physician contact on patient anxiety and distress during the waiting period after embryo transfer: a randomized controlled trial.

Reprod Biomed Online 2022 May 5. Epub 2022 May 5.

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston MA, USA; Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston MA, USA; Boston IVF/Eugin Group, Waltham MA, USA; Domar Center for Mind/Body Health, Boston IVF, Waltham MA, USA.

Research Question: Can an empathic physician phone call in the interval between embryo transfer and first serum human chorionic gonadotrophin measurement decrease anxiety and distress amongst patients undergoing IVF?

Design: This was a randomized controlled trial at a single academically-affiliated fertility centre including patients aged 18-43 undergoing their first embryo transfer with autologous fresh or euploid cryopreserved embryos following preimplantation genetic testing for aneuploidies (frozen embryo transfer, FET/PGT-A). After embryo transfer, participants were randomized to a 5-minute scripted phone call (intervention) from a single physician 3-4 days after embryo transfer or to routine care. The primary and secondary outcomes included were change in State-Trait Anxiety Inventory (STAI) and Hospital Anxiety and Depression Scale (HADS) scores from the start of IVF stimulation to 8-9 days after embryo transfer, respectively. Read More

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