5,384,810 results match your criteria elderly adults


A Comparison of Physical Activity Levels, Sleep Disrupting Behavior, and Stress/Affective Distress as Predictors of Sleep as Indexed by Actigraphy.

J Phys Act Health 2021 Jun 13:1-12. Epub 2021 Jun 13.

Background: Several behaviors have been reported to interfere with sleep in otherwise healthy adults, including low physical activity (PA) levels. However, few studies have compared low PA with the other behavioral risk factors of objective sleep impairment, despite the behavior tending to cooccur in highly stressed and affectively distressed individuals. Thus, the authors compared objective and subjective measures of PA and other potential sleep disrupting behaviors as predictors of objective sleep (sleep onset latency, actual sleep time, total sleep duration, awake time, and sleep efficacy) at baseline (T1) and 3 months later (T2). Read More

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The relationship between urine polycyclic aromatic hydrocarbons and depressive symptoms in American adults.

J Affect Disord 2021 Jun 5;292:227-233. Epub 2021 Jun 5.

Department of Epidemiology and Health Statistics, The School of Public Health of Qingdao University, No.308 Ningxia Road, Qingdao 266021, China. Electronic address:

Background: Studies have shown that Polycyclic aromatic hydrocarbons (PAHs) were neurotoxic, and PAHs exposure may be related to depressive symptoms. Thus, we conducted this study for further explorations.

Methods: Data from the National Health and Nutrition Examination Survey (NHANES) database of the 2005-2014 cycles were used. Read More

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Frequency and factors associated with post-stroke seizures in a large multicenter study in West Africa.

J Neurol Sci 2021 Jun 9;427:117535. Epub 2021 Jun 9.

Federal Medical Centre, Abeokuta, Nigeria; Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan, Nigeria.

Background: Post-stroke seizures (PSS) are associated with significant morbidity and mortality across the globe. There is a paucity of data on PSS in Africa.

Purpose: To assess the frequency and factors associated with PSS by stroke types across 15 hospitals in Nigeria and Ghana. Read More

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Characteristics of driving self-assessments and factors related to inaccurate self-assessment in Japanese older adults.

Accid Anal Prev 2021 Jun 12;159:106235. Epub 2021 Jun 12.

National Research Institute of Police Science, 6-3-1, Kashiwanoha, Kashiwa-shi, Chiba 277-0882, Japan.

Older adults are considered to decide their driving behaviors based their own assessment of their driving performance, and thus it is important that these self-assessments be accurate. Therefore, this study aimed to clarify how older drivers assess their driving performance and examine factors related to the level of inaccuracy in their self-assessments. Japanese drivers aged 70 years or older (N = 181) were asked to assess their own driving performance by questionnaire and then to drive on a public road while wearing an electronic device that measured their actual driving behaviors. Read More

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The effect of vascular health factors on white matter microstructure mediates age-related differences in executive function performance.

Cortex 2021 May 25;141:403-420. Epub 2021 May 25.

The University of Texas at Dallas, School of Behavioral and Brain Sciences, Center for Vital Longevity, Dallas, TX, USA. Electronic address:

Even within healthy aging, vascular risk factors can detrimentally influence cognition, with executive functions (EF) particularly vulnerable. Fronto-parietal white matter (WM) connectivity in part, supports EF and may be particularly sensitive to vascular risk. Here, we utilized structural equation modeling in 184 healthy adults (aged 20-94 years of age) to test the hypotheses that: 1) fronto-parietal WM microstructure mediates age effects on EF; 2) higher blood pressure (BP) and white matter hyperintensity (WMH) burden influences this association. Read More

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Effects of Mediterranean Diet on plasma metabolites and their relationship with insulin resistance and gut microbiota composition in a crossover randomized clinical trial.

Clin Nutr 2021 Apr 27;40(6):3798-3806. Epub 2021 Apr 27.

Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili (URV), Reus, Spain; Institute of Health Pere Virgili, IISPV, University Hospital Sant Joan, Reus, Spain; Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background & Aims: The Mediterranean Diet (MedDiet) may decrease the cardiometabolic risk through modulation of metabolic pathways. Furthermore, the interplay between MedDiet, metabolites and microbial metabolism may improve our understanding on the metabolic effects of this diet. We aimed to evaluate the effect of the MedDiet compared to nuts supplementation on circulating metabolites and their relationship with cardiometabolic health. Read More

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The role of systemic inflammation in the association between serum 25-hydroxyvitamin D and type 2 diabetes mellitus.

Clin Nutr 2021 Apr 27;40(6):3661-3667. Epub 2021 Apr 27.

Department of Blood Transfusion, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Background & Aims: The association between serum 25-hydroxyvitamin D [25(OH)D] and type 2 diabetes mellitus (T2DM) remains inconclusive. Moreover, whether inflammatory biomarkers are involved in this association has not been explored. This study aims to investigate serum 25(OH)D in relation to T2DM in a Chinese population and provide clues for the inflammatory mechanism whereby serum 25(OH)D deficiency increases T2DM risk. Read More

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Children are safe in schools: a review of the Irish experience of reopening schools during the COVID-19 pandemic.

Public Health 2021 Jun 12;195:158-160. Epub 2021 Jun 12.

Office of the Clinical Director for Health Protection, HSE, Ireland; Department of Public Health, HSE Midlands, Tullamore, Ireland.

Objectives: Schools in the Republic of Ireland reopened to students and staff in late August 2020. We sought to determine the test positivity rate of close contacts of cases of coronavirus disease 2019 (COVID-19) in schools during the first half-term of the 2020/2021 academic year.

Methods: National-level data from the schools' testing pathway were interrogated to determine the positivity rate of close contacts of cases of COVID-19 in Irish primary, postprimary and special schools during the first half-term of 2020/2021 academic year. Read More

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Development and Validation of a Nomogram to Predict Frailty Progression in Nonfrail Chinese Community-Living Older Adults.

J Am Med Dir Assoc 2021 Jun 12. Epub 2021 Jun 12.

Department of General Practice, Zhongshan Hospital of Fudan University, Shanghai, China.

Objective: Frailty state progression is common among older adults, so it is necessary to identify predictors to implement individualized interventions. We aimed to develop and validate a nomogram to predict frailty progression in community-living older adults.

Design: Prospective cohort study. Read More

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The use of cleaning products and its relationship with the increasing health risks during the Covid-19 pandemic.

Int J Clin Pract 2021 Jun 15:e14534. Epub 2021 Jun 15.

Mersin University, Nursing Faculty, Department of Public Helath Nursing.

Objective: The present study aimed to determine the factors affecting the use of cleaning products at the home environment and the frequency of problems during the COVID-19 pandemic.

Materials And Methods: This cross-sectional research was performed online between 30.08. Read More

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Thiazolidinediones and Glucagon-like Peptide-1 Receptor Agonists and the Risk of Nonalcoholic Fatty Liver Disease: A Cohort Study.

Hepatology 2021 Jun 15. Epub 2021 Jun 15.

CARIM School for Cardiovascular Disease, Maastricht University, Maastricht, the Netherlands.

Thiazolidinediones (TZDs) and glucagon-like peptide-1 (GLP-1) receptor agonists are potential pharmacological treatment options for patients at risk of nonalcoholic fatty liver disease (NAFLD). Therefore, we examined the association between the risk of NAFLD and the use of thiazolidinediones and GLP-1 receptor agonists compared with the use of sulfonylureas (SUs) and insulins. Additionally, we calculated the incidence of hepatocellular carcinoma (HCC) in users of TZDs and GLP-1 receptor agonists. Read More

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Population-based incidence and mortality of community-acquired pneumonia in Germany.

PLoS One 2021 15;16(6):e0253118. Epub 2021 Jun 15.

Pfizer Deutschland GmbH, Berlin, Germany.

Background: Little information on the current burden of community-acquired pneumonia (CAP) in adults in Germany is available.

Methods: We conducted a retrospective cohort study using a representative healthcare claims database of approx. 4 million adults to estimate the incidence rates (IR) and associated mortality of CAP in 2015. Read More

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The association between neurohormonal therapy and mortality in older adults with heart failure with reduced ejection fraction.

J Am Geriatr Soc 2021 Jun 15. Epub 2021 Jun 15.

The Dartmouth Institute, Geisel School of Medicine, Hanover, New Hampshire, USA.

Background/objectives: Neurohormonal therapy, which includes beta-blockers and angiotensin-converting enzyme inhibitor/angiotensin receptor blockers (ACEi/ARBs), is the cornerstone of heart failure with reduced ejection fraction (HFrEF) treatment. While neurohormonal therapies have demonstrated efficacy in randomized clinical trials, older patients, which now comprise the majority of HFrEF patients, were underrepresented in those original trials. This study aimed to determine the association between short- (30 day) and long-term (1 year) mortality and the use of neurohormonal therapy in HFrEF patients, across the age spectrum. Read More

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C-reactive protein-to-albumin ratio and 8-year incidence of type 2 diabetes: the Korean genome and epidemiology study.

Acta Diabetol 2021 Jun 15. Epub 2021 Jun 15.

Department of Family Medicine, Yong-in Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin Si, Gyeonggi-do, 16995, Republic of Korea.

Aims: The C-reactive protein-to-albumin ratio (CAR) has been reported as a novel prognostic marker in serious illness and various inflammatory diseases. The aim of this study is to investigate the association of CAR with incidence risk of type 2 diabetes in adults without chronic disease.

Methods: A total of 5904 participants aged 40 to 69 years were selected from the Korean Genome and Epidemiology Study who were observed over 12 years. Read More

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Effects of Intravenous Eptinezumab vs Placebo on Headache Pain and Most Bothersome Symptom When Initiated During a Migraine Attack: A Randomized Clinical Trial.

JAMA 2021 Jun;325(23):2348-2356

Lundbeck La Jolla Research Center, San Diego, California.

Importance: Intravenous eptinezumab, an anti-calcitonin gene-related peptide antibody, is approved for migraine prevention in adults. It has established onset of preventive efficacy on day 1 after infusion.

Objective: To evaluate the efficacy of and adverse events related to eptinezumab when initiated during a migraine attack. Read More

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Treatment Patterns and Survival in Older Adults with Diffuse Large B-cell Lymphoma: A Population-Based Study.

J Registry Manag 2020 ;47(3):135-145

Background And Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, with a median age of diagnosis of 66 years. Anthracycline-containing regimens are the most common treatments, but toxicity concerns can limit their use in patients older than 80 years. Understanding treatment patterns and associated survival in adults older than 80 years (vs adults aged 65-80 years) can help determine effective management strategies in this population. Read More

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Comprehensive Cancer Survival by Neighborhood-Level Income in Ontario, Canada, 2006-2011.

J Registry Manag 2020 ;47(3):102-112

Background: Cancer survival statistics can provide a means to assess the effectiveness of the cancer care system, including early detection strategies, the quality of clinical care, and disease management. Disparities in cancer survival (for instance, by neighborhood-level income) persist in Ontario, Canada despite the existence of a universal health care system. Lower income has been associated with an increased incidence of cancer and worsened survival. Read More

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Hyperglycemia and Hypo-HDL-cholesterolemia Are Primary Risk Factors for Age-related Cataract, and a Korean-style Balanced Diet has a Negative Association, based on the Korean Genome and Epidemiology Study.

J Korean Med Sci 2021 Jun 14;36(23):e155. Epub 2021 Jun 14.

Food and Nutrition, Obesity/Diabetes Research Center, Hoseo University, Asan, Korea.

Background: The prevalence of cataracts is steadily increasing among the middle-aged and elderly worldwide. We hypothesized that adults aged > 50 years with age-related cataracts (ARCs) have an association with metabolic syndrome (MS) and its components, and MS has interactions with different dietary patterns and lifestyles that affect ARC risk. We examined the hypothesis using the Korean Genome and Epidemiology Study (KoGES; a large-scale hospital-based cohort study), which collected data between 2004-2013. Read More

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Association Between Problem Gambling and Functional Disability: A Nationally Representative Study Conducted in the United Kingdom.

J Addict Med 2021 Jun 14. Epub 2021 Jun 14.

Research and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Dr. Antoni Pujadas, 42, Sant Boi de Llobregat, Barcelona 08830, Spain (LJ, AK, JMH); Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain (LJ); Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, Montigny-le-Bretonneux 78180, France (LJ); Vision and Eye Research Institute, School of Medicine, Faculty of Health, Education, Medicine and Social Care, Anglia Ruskin University-Cambridge Campus, Cambridge, United Kingdom (GFL-S, SP); University of Southern California, Suzanne Dworak Peck School of Social Work, 1149 South Hill Street Suite 1422, Los Angeles, CA, 90015 (HO); Philipps University of Marburg, Marburg, Germany (KK); ICREA, Pg. Lluis Companys 23, Barcelona, Spain (AK); Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea (JIS); The Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, Cambridge, United Kingdom (LS).

Objectives: Problem gambling is associated with multiple detrimental health outcomes. However, to date, no study has investigated the association between problem gambling and functional disability. Therefore, the aim of this study was to investigate the association between problem gambling and functional disability in a UK nationally representative sample. Read More

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Invariance of the Household Food Insecurity Access Scale Across Different Groups of Adolescents and Young Adults.

Food Nutr Bull 2021 Jun 15:3795721211019634. Epub 2021 Jun 15.

2331The University of North Carolina at Chapel Hill, NC, USA.

Background: Cross-group comparisons of household food insecurity and its associations using multiple-item scales assume that scale scores can be interpreted as identical across groups. However, scores should not be interpreted as identical across groups without evidence of measurement invariance. Noninvariant measures indicate that the underlying construct may be different across groups. Read More

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Impact of the model of long-term follow-up care on adherence to guideline-recommended surveillance among survivors of adolescent and young adult cancers.

Cancer Med 2021 Jun 15. Epub 2021 Jun 15.

University of Toronto, Institute of Medical Science, Toronto, Canada.

Purpose: Adolescent and young adult cancer survivors require lifelong healthcare to address the late effects of therapy. We examined the impact of different provider models of long-term follow-up (LTFU) care on adherence to recommended surveillance.

Methods: We conducted a retrospective cohort study using administrative health databases in Ontario, Canada. Read More

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Long-term mortality due to infection associated with elevated liver enzymes: a population-based cohort study.

Sci Rep 2021 Jun 14;11(1):12490. Epub 2021 Jun 14.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, 166 Gumi-ro, Bundang-gu, Seongnam, 463-707, South Korea.

We aimed to investigate whether elevated liver enzymes in the adult population were associated with mortality due to infection. As a population-based cohort study, data from the National Health Insurance Service Health Screening Cohort were used. Adult individuals (aged ≥ 40 years) who underwent standardized medical examination between 2002 and 2003 were included, and infectious mortality was defined as mortality due to infection between 2004 and 2015. Read More

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Differences in U.S. Rural-Urban Trends in Diabetes ABCS, 1999-2018.

Diabetes Care 2021 Jun 14. Epub 2021 Jun 14.

Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA.

Objective: To examine changes in and the relationships between diabetes management and rural and urban residence.

Research Design And Methods: Using National Health and Nutrition Examination Survey (1999-2018) data from 6,372 adults aged ≥18 years with self-reported diagnosed diabetes, we examined poor ABCS: A1C >9% (>75 mmol/mol), Blood pressure (BP) ≥140/90 mmHg, Cholesterol (non-HDL) ≥160 mg/dL (≥4.1 mmol/L), and current Smoking. Read More

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Effect of multimorbidity patterns on the decline in health-related quality of life: a nationwide prospective cohort study in Japan.

BMJ Open 2021 06 14;11(6):e047812. Epub 2021 Jun 14.

Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan

Objectives: Longitudinal studies, which consider multimorbidity patterns, are useful for better clarifying the effect of multimorbidity on health-related quality of life (HRQoL) and for identifying the target population with poorer clinical outcomes among patients with multimorbidity. This study aimed to examine the effects of different multimorbidity patterns on the decline in HRQoL.

Design: Nationwide prospective cohort study. Read More

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Hospital initiation of benzodiazepines and Z-drugs in older adults and discontinuation in primary care.

Res Social Adm Pharm 2021 Jun 5. Epub 2021 Jun 5.

HRB Centre for Primary Care Research, Department of General Practice, Royal College of Surgeons in Ireland, Dublin, Ireland; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland. Electronic address:

Objective: To examine factors associated with continuation of hospital-initiated benzodiazepine receptor agonists (BZRAs) among adults aged ≥65 years, specifically instructions on hospital discharge summaries.

Methods: This retrospective cohort study involved anonymised electronic record data on prescribing and hospitalisations for 38,229 patients aged ≥65 from forty-four GP practices in Ireland 2011-2016. BZRA initiations were identified among patients with no BZRA prescription in the previous 12 months. Read More

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CT as a first-line modality in elderly patients with stable blunt chest trauma.

Chin J Traumatol 2021 Apr 1. Epub 2021 Apr 1.

Department of Surgery A, Emek Medical Center, Afula, 18101, Israel; Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, 31096, Israel.

Purpose: Blunt thoracic injuries are common among elderly patients and may be a common cause of morbidity and death from blunt trauma injuries. We aimed to examine the impact of chest CT on the diagnosis and change of management plan in elderly patients with stable blunt chest trauma. We hypothesized that chest CT may play an important role in providing optimal management to this subgroup of trauma patients. Read More

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Psychosocial factors affecting quality of life in patients with anorectal malformation and Hirschsprung disease-a qualitative systematic review.

J Pediatr Surg 2021 May 21. Epub 2021 May 21.

Comprehensive Colorectal Center, Children's Mercy-Kansas City, Kansas City, MO, United States; Department of Surgery, Children's Mercy Hospital Kansas City, MO, United States; University of Missouri-Kansas City School of Medicine, United States. Electronic address:

Introduction: Little is known about psychosocial and behavioral factors that impact the quality of life of patient's with anorectal malformations (ARM) and Hirschsprung disease (HSCR). We aimed to highlight the psychosocial, emotional, and behavioral themes that affect these patients.

Methods: A qualitative literature review of articles published between 1980 and 2019 was performed. Read More

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Effect of physical frailty on elder mistreatment in a national survey: examining psychological vulnerability, housework involvement, and financial independence as mediators.

Int Psychogeriatr 2021 Jun 15:1-11. Epub 2021 Jun 15.

School of Social Development and Public Policy, Fudan University, Shanghai, China.

Objectives: To explore the prevalence of EM in an older Chinese population and examine the mediating role of three psychosocial variables - psychological vulnerability, housework involvement, and financial independence - in the relationship between physical frailty and EM.

Design: Cross-sectional analysis.

Setting: The data source was the Third Survey on Chinese Women's Social Status (SCSSW), which is a nationwide decennial survey conducted in 2010. Read More

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Aripiprazole Lauroxil 2-Month Formulation With 1-Day Initiation for Acute Schizophrenia: ALPINE Exploratory Efficacy and Patient-Reported Outcomes.

CNS Spectr 2021 Apr;26(2):171-172

Alkermes, Inc., Waltham, MA, USA.

Objective: The randomized, controlled, phase 3b ALPINE study evaluated efficacy and safety of a 2-month formulation of aripiprazole lauroxil (AL) initiated with a 1-day regimen during hospitalization for an acute exacerbation of schizophrenia; paliperidone palmitate (PP) was included as an active control. The primary efficacy outcome, within-group change from baseline in PANSS total score at 4 weeks, was previously reported. Here we report additional exploratory PANSS subscale endpoints and patient-reported outcomes (PROs). Read More

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The Brain in Motion II Study: study protocol for a randomized controlled trial of an aerobic exercise intervention for older adults at increased risk of dementia.

Trials 2021 Jun 14;22(1):394. Epub 2021 Jun 14.

Department of Physiology & Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, T2N 4N1, Canada.

Background: There remains no effective intervention capable of reversing most cases of dementia. Current research is focused on prevention by addressing risk factors that are shared between cardiovascular disease and dementia (e.g. Read More

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