12,264 results match your criteria eicosapentaenoic acid

The Use of Defatted Larvae Meal as a Main Protein Source Is Supported in European Sea Bass () by Data on Growth Performance, Lipid Metabolism, and Flesh Quality.

Front Physiol 2021 15;12:659567. Epub 2021 Apr 15.

ICBAS, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.

Objective: This study aims to determine the maximal inclusion level of defatted (-) larvae meal (TM) able to replace dietary fishmeal (FM) without compromising growth performance, general metabolism, and flesh quality traits in European sea bass, and to evaluate the major underlying physiological mechanisms.

Materials And Methods: Fish (55 ± 2 g) were fed with diets containing increasing levels of TM: 0, 40, 80 and 100% (CTRL, TM40, TM80, and TM100, respectively) to replace FM. After 10 weeks of feeding, the growth performance, nutrient and energy balance, intestinal integrity, plasma metabolites and the expression of genes related to growth and nutrient metabolism, in liver and muscle were determined. Read More

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Body surface area-based omega-3 fatty acids supplementation strongly correlates to blood concentrations in children.

Prostaglandins Leukot Essent Fatty Acids 2021 Apr 24;169:102285. Epub 2021 Apr 24.

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden; Pediatric Oncology, Astrid Lindgrens Childrens Hospital, Karolinska University Hospital, Stockholm, Sweden. Electronic address:

Omega-3 fatty acids have been suggested as a complement in cancer treatment, but doses are not established. We performed a dose-finding study in 33 children in remission from cancer. Participants were allocated to a body surface area (BSA) adjusted dose (mg/m) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (40:60), ranging 233-3448 mg/m daily for 90 days. Read More

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Aspirin and omega-3 fatty acid status interact in the prevention of cardiovascular diseases in Framingham Heart Study.

Prostaglandins Leukot Essent Fatty Acids 2021 Apr 24;169:102283. Epub 2021 Apr 24.

Department of Mathematics and Statistics, Dordt University, Sioux Center, Iowa, United States.

Background: The roles of omega-3 (n3) fatty acids [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] and low-dose aspirin in the primary prevention of ischemic cardiovascular disease (CVD) are controversial. Since omega-3 (n3) fatty acids and aspirin affect cyclooxygenase activity in platelets, there could be a clinically-relevant effect of aspirin combined with a particular n3 fatty acid level present in each individual.

Methods: RBC EPA+DHA, arachidonic acid (AA) and docosapentaenoic acid (DPA) were measured in 2500 participants without known CVD in the Framingham Heart Study. Read More

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Time-of-day effects of consumption of fish oil-enriched sausages on serum lipid parameters and fatty acid composition in normolipidemic adults: A randomized, double-blind, placebo-controlled, and parallel-group pilot study.

Nutrition 2021 Mar 24;90:111247. Epub 2021 Mar 24.

Healthy Food Science Research Group, Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan; Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Chiba, Japan; Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Chiba, Japan; School of Integrative and Global Majors, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address:

Objectives: The body clock controls diurnal rhythms of nutrient digestion, absorption, and metabolism. Fish oil (FO) contains abundant ω-3 polyunsaturated fatty acids (PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), that are thought to lower triglyceride (TG) levels. This randomized, placebo-controlled, double-blind, parallel-group trial aimed to confirm the effects of the time of FO intake on TG in healthy Japanese adults. Read More

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Lipidomics Approach in High-Fat-Diet-Induced Atherosclerosis Dyslipidemia Hamsters: Alleviation Using Ether-Phospholipids in Sea Urchin.

J Agric Food Chem 2021 May 7. Epub 2021 May 7.

College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, Qingdao, Shandong 266003, People's Republic of China.

Ether-phospholipids (ether-PLs) in sea urchins, especially eicosapentaenoic-acid-enriched plasmenyl phosphatidylethanolamine (PE-P) and plasmanyl phosphatidylcholine (PC-O), exhibit potential lipid-regulating effects. However, their underlying regulatory mechanisms have not yet been elucidated. Herein, we integrated an untargeted lipidomics strategy and biochemical analysis to investigate these mechanisms in high-fat-induced atherosclerotic hamsters. Read More

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Specialized nutrition improves muscle function and physical activity without affecting chemotherapy efficacy in C26 tumour-bearing mice.

J Cachexia Sarcopenia Muscle 2021 May 6. Epub 2021 May 6.

Laboratory of Translational Oncology, Division of Imaging and Cancer, University Medical Centre Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Skeletal muscle wasting and fatigue are commonly observed in cancer patients receiving chemotherapy and associated with reduced treatment outcome and quality of life. Nutritional support may mitigate these side effects, but potential interference with chemotherapy efficacy could be of concern. Here, we investigated the effects of an ω-3 polyunsaturated fatty acid (eicosapentaenoic acid and docosahexaenoic acid), leucine-enriched, high-protein (100% whey), additional vitamin D, and prebiotic fibres 'specific nutritional composition' (SNC) and chemotherapy on state-of-the-art tumour organoids and muscle cells and studied muscle function, physical activity, systemic inflammation, and chemotherapy efficacy in a mouse model of aggressive colorectal cancer (CRC). Read More

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Analysis of Omega-3 Fatty Acid Content in Fish Oil Products.

J Pharm Pract 2021 May 6:8830738211015051. Epub 2021 May 6.

219251Presbyterian College School of Pharmacy, Clinton, SC, USA.

Background: Omega-3 fatty acids eicosapentaenoic acid (EPA) and docosehexaenoic acid (DHA), often found in fish oil supplements, have been linked to cardiovascular benefits in proper doses.

Objectives: Quantify serving sizes and EPA and DHA content of fish oil products and determine which products contain appropriate amounts of EPA and DHA per serving to lower cholesterol.

Methods: Products were identified through the National Institutes of Health's Dietary Supplement Label Database using the search term "fish oil. Read More

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Integrated 16S rRNA Gene Sequencing and LC-MS Analysis Revealed the Interplay Between Gut Microbiota and Plasma Metabolites in Rats With Ischemic Stroke.

J Mol Neurosci 2021 May 6. Epub 2021 May 6.

Hunan Key Laboratory of Prevention and Treatment in Cardiovascular Disease, Hunan University of Chinese Medicine, Changsha, 410208, Hunan, China.

Gut microbiome and plasma metabolome serve a role in the pathogenesis of ischemic stroke (IS). However, the relationship between the microbiota and metabolites remains unclear. This study aimed to reveal the specific asso-ciation between the microbiota and the metabolites in IS using integrated 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) analysis. Read More

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Interdependent Oxidation of Eicosapentaenoic Acid and Docosahexaenoic Acid in Isada Krill Oil Encapsulated with Maltodextrin by Spray-drying.

J Oleo Sci 2021 ;70(5):633-635

Faculty of Bioenvironmental Science, Kyoto University of Advanced Science.

The major polyunsaturated fatty acids in krill oil extracted from Euphausia pacifica, known as Isada on the Sanriku coast, are eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) acid. A kinetic model was proposed to explain the relationship between the fractions of unoxidized EPA (Y ) and unoxidized DHA (Y ) in the oil spray-dried with maltodextrin and stored at 25, 50, and 70℃. The relationship between Y and Y during storage was independent of the temperature and could be expressed using the proposed model. Read More

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January 2021

Influence of Dietary Lipids and Environmental Salinity on the n-3 Long-Chain Polyunsaturated Fatty Acids Biosynthesis Capacity of the Marine Teleost .

Mar Drugs 2021 Apr 29;19(5). Epub 2021 Apr 29.

Departamento de Biología Animal, Edafología y Geología, Universidad de La Laguna, 38200 San Cristóbal de La Laguna, Spain.

Fish vary in their ability to biosynthesise long-chain polyunsaturated fatty acids (LC-PUFA) depending upon the complement and function of key enzymes commonly known as fatty acyl desaturases and elongases. It has been reported in the existence of a Δ4 desaturase, enabling the biosynthesis of docosahexaenoic acid (DHA) from eicosapentaenoic acid (EPA), which can be modulated by the diet. The present study aims to evaluate the combined effects of the partial replacement of fish oil (FO) with vegetable oils and reduced environmental salinity in the fatty acid composition of relevant body compartments (muscle, hepatocytes and enterocytes), the enzymatic activity over α-linolenic acid (ALA) to form n-3 LC-PUFA through the incubation of isolated hepatocytes and enterocytes with [1-C] 18:3 n-3, and the regulation of the and in the liver and intestine. Read More

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Lipid Peroxidation With Implication of Organic Pollution in Autistic Behaviors.

Cureus 2021 Mar 30;13(3):e14188. Epub 2021 Mar 30.

Department of Anatomy, Graduate School of Science and Technology for Innovation, Yamaguchi University, Ube, 755-8611, JPN.

Background Lipid metabolism has been associated with the development of autism. The omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) readily undergo lipid peroxidation and conversion to malondialdehyde (MDA). MDA-modified low-density lipoprotein (MDA-LDL) is a marker of lipid peroxidation. Read More

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Post-mortem storage conditions and cooking methods affect long-chain omega-3 fatty acid content in Atlantic mackerel (Scomber scombrus).

Food Chem 2021 Apr 20;359:129828. Epub 2021 Apr 20.

Univ Brest, CNRS, IRD, Ifremer, LEMAR, F-29280 Plouzané, France.

Long-chain omega-3 fatty acids such as eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are health beneficial lipids found in high concentration in pelagic fishes, including Atlantic mackerel. While EPA and DHA are sensitive to oxidation during fish storage and processing, post-mortem degradation in the first hours following fish death is poorly documented. Here, we stored fish at two temperatures (2-4 °C and 18-20 °C) and monitored EPA + DHA content in dorsal fillet 6, 12 and 24 h after fish death and after cooking (grill or steam). Read More

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Changes in lipoprotein particle subclasses, standard lipids, and apolipoproteins after supplementation with n-3 or n-6 PUFAs in abdominal obesity: A randomized double-blind crossover study.

Clin Nutr 2021 Apr 3;40(5):2556-2575. Epub 2021 Apr 3.

Department of Heart Disease, Haukeland University Hospital, 5021 Bergen, Norway; Mohn Nutrition Research Laboratory, Department of Clinical Science, University of Bergen, 5020 Bergen, Norway. Electronic address:

Background & Aims: Marine-derived omega-3 (n-3) polyunsaturated fatty acids (PUFAs), mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), lower circulating levels of triacylglycerols (TAGs), and the plant-derived omega-6 (n-6) PUFA linoleic acid (LA) may reduce cholesterol levels. Clinical studies on effects of these dietary or supplemental PUFAs on other blood fat fractions are few and have shown conflicting results. This study aimed to determine effects of high-dose supplemental n-3 (EPA + DHA) and n-6 (LA) PUFAs from high-quality oils on circulating lipoprotein subfractions and standard lipids (primary outcomes), as well as apolipoproteins, fatty acids, and glycemic control (secondary outcomes), in females and males with abdominal obesity. Read More

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Enteral and supplemental parenteral nutrition enriched with omega-3 polyunsaturated fatty acids in intensive care patients - A randomized, controlled, double-blind clinical trial.

Clin Nutr 2021 Apr 1;40(5):2544-2554. Epub 2021 Apr 1.

Department of General Intensive Care and Institute for Nutrition Research, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.

Background & Aims: Enteral nutrition (EN) and parenteral nutrition (PN) enriched with omega-3 polyunsaturated fatty acids (PUFA) have beneficial effects in critical illness. This study aimed to assess the combined effect of EN and supplemental PN enriched with omega-3 PUFA on blood oxygenation in intensive care unit (ICU) patients.

Methods: Single-center, prospective, randomized, controlled, double-blind, phase III trial conducted from 10/2013 to 11/2017. Read More

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The role of icosapent ethyl in cardiovascular risk reduction.

Curr Opin Cardiol 2021 Apr 28. Epub 2021 Apr 28.

LMC Diabetes & Endocrinology, Concord, Ontario Division of Endocrinology and Metabolism, St Michael's Hospital of Unity Health Toronto, Toronto, Ontario Division of Endocrinology, Trillium Health Partners, Mississauga, Ontario Department of Medicine, University of Toronto, Toronto, Ontario Division of Endocrinology and Metabolism, Sunnybrook Health Sciences Centre, Toronto, Ontario Division of Cardiology, Hamilton Health Sciences, Hamilton, Ontario Department of Medicine and The Population Health Research Institute, McMaster University, Hamilton, Ontario C-endo Diabetes and Endocrinology Clinic, Calgary, Alberta Division of Cardiac Surgery, St Michael's Hospital of Unity Health Toronto, Ontario Departments of Surgery, and Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada.

Purpose Of Review: Elevated levels of triglycerides, independent of low-density lipoprotein cholesterol (LDL-C) levels and statin therapy, are associated with heightened cardiovascular risk.

Recent Findings: Mixed omega-3 fatty acid formulations, which contain varying amounts of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), lower triglycerides levels but trial results with omega-3 fatty acids combinations have generally been neutral for cardiovascular outcomes. In contrast, the REDUCE-IT trial with icosapent ethyl (IPE), a highly purified ethyl ester of EPA, demonstrated reduced cardiovascular risk in individuals with established atherosclerotic cardiovascular disease or diabetes with at least one additional risk factor, despite having relatively well controlled LDL-C levels but triglycerides at least 135 mg/dl while on statin therapy. Read More

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Causal Effects of Serum Levels of n-3 or n-6 Polyunsaturated Fatty Acids on Coronary Artery Disease: Mendelian Randomization Study.

Nutrients 2021 Apr 28;13(5). Epub 2021 Apr 28.

Department of Internal Medicine, Seoul National University Hospital, Seoul 03080, Korea.

We aimed to investigate the causal effects of n-3 and n-6 polyunsaturated fatty acids (PUFAs) on the risk of coronary artery disease (CAD) through Mendelian randomization (MR) analysis. This MR study utilized a genetic instrument developed from previous genome-wide association studies for various serum n-3 and n-6 PUFA levels. First, we calculated the allele scores for genetic predisposition of PUFAs in individuals of European ancestry in the UK Biobank data ( = 337,129). Read More

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sp. (T18) Oil as a Fish Oil Replacement in Diets for Juvenile Rainbow Trout (): Effects on Growth Performance, Tissue Fatty Acid Content, and Lipid-Related Transcript Expression.

Animals (Basel) 2021 Apr 20;11(4). Epub 2021 Apr 20.

Department of Animal Science and Aquaculture, Dalhousie University, Truro, NS B2N 5E3, Canada.

In this study, we evaluated whether oil extracted from the marine microbe, sp. (strain T18), with high levels of docosahexaenoic acid (DHA), could replace fish oil (FO) in diets for rainbow trout (). Three experimental diets were tested: (1) a control diet with fish oil (FO diet), (2) a microbial oil (MO) diet with a blend of camelina oil (CO) referred to as MO/CO diet, and (3) a MO diet (at a higher inclusion level). Read More

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Brown Adipose Tissue: New Challenges for Prevention of Childhood Obesity. A Narrative Review.

Nutrients 2021 Apr 24;13(5). Epub 2021 Apr 24.

Department of Pediatrics, Vittore Buzzi Children's Hospital, University of Milan, 20154 Milan, Italy.

Pediatric obesity remains a challenge in modern society. Recently, research has focused on the role of the brown adipose tissue (BAT) as a potential target of intervention. In this review, we revised preclinical and clinical works on factors that may promote BAT or browning of white adipose tissue (WAT) from fetal age to adolescence. Read More

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Disentangling the Molecular Mechanisms of the Antidepressant Activity of Omega-3 Polyunsaturated Fatty Acid: A Comprehensive Review of the Literature.

Int J Mol Sci 2021 Apr 22;22(9). Epub 2021 Apr 22.

Child and Adolescent Psychiatry Research Centre, Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric University Hospital, University of Zurich, CH-8032 Zurich, Switzerland.

Major depressive disorders (MDDs) are often associated with a deficiency in long-chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), as well as signs of low-grade inflammation. Epidemiological and dietary studies suggest that a high intake of fish, the major source of ω-3 PUFAs, is associated with lower rates of MDDs. Meta-analyses of randomized placebo-controlled ω-3 PUFAs intervention-trials suggest that primarily eicosapentaenoic acid (EPA), but not docosahexaenoic acid (DHA), is responsible for the proposed antidepressant effect. Read More

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Polyphenols and Fish Oils for Improving Metabolic Health: A Revision of the Recent Evidence for Their Combined Nutraceutical Effects.

Molecules 2021 Apr 22;26(9). Epub 2021 Apr 22.

Instituto de Investigaciones Marinas-Consejo Superior de Investigaciones Científicas (IIM-CSIC), Eduardo Cabello 6, E-36208 Vigo, Spain.

Polyphenols and omega-3 polyunsaturated fatty acids from fish oils, i.e., eicosapentaenoic and docosahexaenoic acids, are well-recognized nutraceuticals, and their single antioxidant and anti-inflammatory properties have been demonstrated in several studies found in the literature. Read More

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Micronutrients and respiratory infections: the biological rationale and current state of clinical evaluation.

Br J Hosp Med (Lond) 2021 Apr 27;82(4):1-8. Epub 2021 Apr 27.

Nutrition in Medicine Research Group, University of Otago, Christchurch, New Zealand.

A range of nutrients has been studied or proposed for use in preventing respiratory tract infections and reducing their severity. This article gives a narrative review of the existing literature, biological rationales and current state of clinical evaluation for micronutrient therapies. The importance of vitamin A, the B vitamins, vitamin C, vitamin D, eicosapentaenoic acid, vitamin E, selenium, zinc and a range of combination therapies are discussed, looking at their effects on reducing rates of infection, reducing severity of infection and improved recovery from infection. Read More

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Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review.

In Vivo 2021 May-Jun;35(3):1419-1436. Epub 2021 Apr 28.

Department of Veterinary Sciences, University of Trás-os-Montes and Alto Douro, Vila Real, Portugal;

Background/aim: The aim of this study is to identify and describe randomized controlled studies evaluating the therapeutic effect of EPA and DHA supplementation in companion animal diseases.

Materials And Methods: A systematic search was conducted in PubMed database and the information collected was summarized and evaluated according to the risk of bias, using the revised Cochrane tool (RoB2).

Results: Twenty-three studies were eligible for inclusion: twenty performed in dogs and three in cats. Read More

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Omega-3 Fatty Acid Supplementation in the Primary and Secondary Prevention of Cardiovascular Events: NEW INSIGHTS.

J Cardiopulm Rehabil Prev 2021 May;41(3):137-140

Department of Cardiovascular Medicine, Beaumont Health System, Royal Oak, Michigan (Drs O'Connell, Trivax, and Franklin); and Oakland University William Beaumont School of Medicine, Rochester, Michigan (Drs Trivax and Franklin).

Omega-3 fatty acid (O-3FA) supplementation has garnered interest since cardioprotective properties of dietary fish consumption were observed. In the general population, O-3FA supplementation has not improved cardiovascular outcomes. However, icosapent ethyl, a high-dose, purified form of eicosapentaenoic acid, has demonstrated additive cardioprotection to statins in high-risk patients with elevated triglycerides. Read More

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A complete enzymatic capacity for biosynthesis of docosahexaenoic acid (DHA, 22 : 6n-3) exists in the marine Harpacticoida copepod .

Open Biol 2021 Apr 28;11(4):200402. Epub 2021 Apr 28.

Instituto de Acuicultura Torre de la Sal (IATS-CSIC), Ribera de Cabanes 12595, Castellón, Spain.

The long-standing paradigm establishing that global production of Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) derived almost exclusively from marine single-cell organisms, was recently challenged by the discovery that multiple invertebrates possess methyl-end (or x) desaturases, critical enzymes enabling the biosynthesis of n-3 LC-PUFA. However, the question of whether animals with x desaturases have complete n-3 LC-PUFA biosynthetic pathways and hence can contribute to the production of these compounds in marine ecosystems remained unanswered. In the present study, we investigated the complete enzymatic complement involved in the n-3 LC-PUFA biosynthesis in , an intertidal harpacticoid copepod. Read More

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Similar distribution of orally administered eicosapentaenoic acid and M2 macrophage marker in the hypoperfusion-induced abdominal aortic aneurysm wall.

Food Funct 2021 Apr 29;12(8):3469-3475. Epub 2021 Mar 29.

Department of Applied Biological Chemistry, Kindai University, 204-3327 Nakamachi, Nara City, Nara 631-8505, Japan.

Abdominal aortic aneurysm (AAA) is an aortic disease in which the aortic diameter is ≥3.0 cm; if left untreated, the aortic wall continues to weaken, resulting in progressive dilatation. Effective therapeutic drugs for AAA patients have not been discovered. Read More

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EPA's pleiotropic mechanisms of action: a narrative review.

Postgrad Med 2021 Apr 26. Epub 2021 Apr 26.

University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Treatment with icosapent ethyl 4 g/day, a highly purified and stable ethyl ester of eicosapentaenoic acid (EPA), demonstrated a significant reduction in atherosclerotic cardiovascular disease (ASCVD) events and death in REDUCE-IT. However, analyses of REDUCE-IT and meta-analyses have suggested that this clinical benefit is greater than can be achieved by triglyceride reduction alone. EPA therefore may have additional pleiotropic effects, including anti-inflammatory and anti-aggregatory mechanisms. Read More

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ABCA7 Regulates Brain Fatty Acid Metabolism During LPS-Induced Acute Inflammation.

Front Neurosci 2021 7;15:647974. Epub 2021 Apr 7.

Department of Neuroscience, Mayo Clinic, Jacksonville, FL, United States.

The ATP binding cassette subfamily A member 7 () gene is one of the significant susceptibility loci for Alzheimer's disease (AD). Furthermore, ABCA7 loss of function variants resulting from premature termination codon in the gene are associated with increased risk for AD. ABCA7 belongs to the ABC transporter family, which mediates the transport of diverse metabolites across the cell membrane. Read More

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The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY).

Diabetologia 2021 Apr 24. Epub 2021 Apr 24.

University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Aims/hypothesis: Oxylipins are lipid mediators derived from polyunsaturated fatty acids. Some oxylipins are proinflammatory (e.g. Read More

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Effect of salted-drying on bioactive compounds and microbiological changes during the processing of karasumi-like Chinook salmon (Oncorhynchus tshawytscha) roe product.

Food Chem 2021 Apr 20;357:129780. Epub 2021 Apr 20.

Department of Food Sciences, University of Otago, New Zealand. Electronic address:

The physicochemical, biochemical and microbiological changes of karasumi-like Chinook salmon (Oncorrhynchus tshawytscha) roe were determined during 20 days of salted-drying processing. Colour parameters (L*, a*, and b*), water activity (a) and the pH value decreased at the end of the processing. Total bacterial and LAB counts (log CFU/g) varied over the processing period. Read More

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