60,894 results match your criteria effusion

Deep metric learning for otitis media classification.

Med Image Anal 2021 Mar 14;71:102034. Epub 2021 Mar 14.

Department of Applied Mathematics and Computer Science, Technical University of Denmark, Lyngby, Denmark.

In this study, we propose an automatic diagnostic algorithm for detecting otitis media based on otoscopy images of the tympanic membrane. A total of 1336 images were assessed by a medical specialist into three diagnostic groups: acute otitis media, otitis media with effusion, and no effusion. To provide proper treatment and care and limit the use of unnecessary antibiotics, it is crucial to correctly detect tympanic membrane abnormalities, and to distinguish between acute otitis media and otitis media with effusion. Read More

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Prednisone reduction for metastatic castration-resistant prostate cancer with recurrent pulmonary tuberculosis: Case report.

Medicine (Baltimore) 2021 Apr;100(15):e25584

Department of Radiation Oncology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.

Introduction: Prednisone (10 mg/d) is often used in combination with docetaxel or abiraterone in the treatment of advanced prostate cancer. LATITUDE studies have confirmed that the combination of abiraterone and prednisone (5 mg/d) can be used for the treatment of newly diagnosed high-risk metastatic castration-sensitive prostate cancer, and have achieved satisfactory results. However, it has not been reported that abiraterone combined with prednisone (5 mg/d) in the treatment of metastatic castration-resistant prostate cancer (mCRPC). Read More

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IL-26 promotes the pathogenesis of malignant pleural effusion by enhancing CD4 IL-22 T-cell differentiation and inhibiting CD8 T-cell cytotoxicity.

J Leukoc Biol 2021 Apr 13. Epub 2021 Apr 13.

Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

IL-26 is a newly discovered IL-10 cytokine family member mainly secreted by Th17 cells. However, the relationship between IL-26 and lung cancer remains unclear. The present study reported that IL-26 is involved in the production and promotion of malignant pleural effusion (MPE) for the first time. Read More

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Capillary-leak syndrome: an unrecognized early immune adverse effect of checkpoint-inhibitors treatment.

Immunotherapy 2021 Apr 13. Epub 2021 Apr 13.

Faculty of Health Sciences, Ben-Gurion University of The Negev, Beer-Sheva, Israel.

Capillary-leak syndrome is strongly associated with cytokine activity states. It is an ill-recognized adverse effect of checkpoint inhibitors treatment, which are typically associated with cellular immune response. We describe two patients with capillary leak syndrome following immune checkpoint inhibitors treatment. Read More

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Dual retrotympanic aural mass.

BMJ Case Rep 2021 Apr 12;14(4). Epub 2021 Apr 12.

Otorhinolaryngology, University of Malaya, Kuala Lumpur, Malaysia.

High-riding jugular bulb (HRJB), although rare, may pose a challenge as it may be mistaken for other non-alarming condition, such as middle ear effusion. Patients with HRJB classically present with pulsatile tinnitus. We report a unique case of a 26-year-old patient with underlying beta thalassaemia who presented with a 2-month history of intermittent epistaxis and rhinorrhoea. Read More

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Diagnostic yield of semi rigid thoracoscopy in unexplained exudative pleural effusion- Experience from tertiary care hospital of east India.

Indian J Tuberc 2021 Apr 7;68(2):205-209. Epub 2020 Aug 7.

Consultant, Pulmonary Medicine, Asian Hospital, Patna, India.

Introduction: In most of the pleural effusion, fluid analysis generally gives the etiological diagnosis but in almost 20% it remains unclear. This study was designed to determine the diagnostic yield of a pleural biopsy using semi rigid thoracoscope and its complication rates.

Materials And Methods: This was a retrospective observational study conducted in the Department of Pulmonary Medicine, AIIMS Patna. Read More

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Comparison of diagnostic accuracy of digital chest X-ray images between PACS and WhatsApp Messenger in resource poor setting.

Indian J Tuberc 2021 Apr 6;68(2):186-194. Epub 2020 Aug 6.

Department of Respiratory & Sleep Medicine, Medanta the Medicity, Gurgaon, India.

Purpose: Many underserved remote locations without specialists would benefit from the ability to quickly and easily share images of radiographs with trained radiologists using WhatsApp messenger. However, there is limited evidence on the role of WhatsApp messenger for sharing chest x-ray (CXR) images to aid diagnosis and management. The objective of the study was to determine the diagnostic accuracy and inter-observer agreement of WhatsApp messenger images of digital CXR compared to viewing on Picture Archiving and Communication System (PACS) monitor. Read More

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Vitamin D status in children with community acquired pneumonia and its association with severity: a hospital-based study.

Minerva Pediatr (Torino) 2021 Apr 12. Epub 2021 Apr 12.

Department of Microbiology, Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, India.

Background: International and observational epidemiological studies provide evidence that vitamin D deficiency may confer increased risk of influenza and respiratory tract infection. This study was undertaken in an effort to evaluate the prevalence of vitamin D deficiency in pneumonia in children and assess its relationship with the severity.

Methods: Study group included children aged between 2 months to 5 years of age admitted as inpatients who presented with clinical features of pneumonia as per WHO classification. Read More

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Xpert MTB/RIF Ultra enhances tuberculous pleurisy diagnosis for patients with unexplained exudative pleural effusion who underwent a pleural biopsy via thoracoscopy: a prospective cohort study.

Int J Infect Dis 2021 Apr 9. Epub 2021 Apr 9.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Introduction: To evaluate the performance of Xpert MTB/RIF Ultra (Xpert-Ultra) in testing pleural tissue and fluid collected by medical thoracoscopy among patients with unexplained exudative pleural effusion.

Methods: Patients with an undiagnosed exudative pleural effusion were recruited prospectively and consecutively. Pleural tissue and fluid was collected by medical thoracoscopy and subjected to culture, Xpert MTB/RIF (Xpert) and Xpert-Ultra assays. Read More

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RNA Sequencing and Pathways Analyses of Middle Ear Epithelia From Patients With Otitis Media.

Laryngoscope 2021 Apr 12. Epub 2021 Apr 12.

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, U.S.A.

Objectives: Otitis media (OM) is the most common pediatric diagnosis in the United States. However, our understanding of the molecular pathogenesis of OM remains relatively poor. Investigation of molecular pathways involved in OM may improve the understanding of this disease process and elucidate novel therapeutic targets. Read More

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Radiographic case report of a heart transplanted patient suffering from COVID-19.

Heliyon 2021 Apr 3;7(4):e06688. Epub 2021 Apr 3.

Department of Diagnostic and Interventional Radiology, University Hospital, Frankfurt, Germany.

In context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), patients with certain comorbidities and high age, as well as male sex are considered to represent the risk group for severe course of disease. Corona-virus disease 2019 (COVID-19) typical CT-patterns include bilateral, peripheral ground glass opacity (GGO), septal thickening, bronchiectasis, consolidation as well as associated pleural effusion. We report a 77-year-old heart transplanted patient with confirmed COVID-19 infection and coronary heart disease, diabetes type II and other risk factors. Read More

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An 83-year-old-male with bronchopleural fistula and empyema successfully treated with multidisciplinary management of thoracostomy, endoscopic, and surgical treatment: a case report.

Ann Transl Med 2021 Mar;9(5):427

Division of Endocrinology and Metabolism, Department of Medicine, Zhejiang University Medical School Second Affiliated Hospital, Hangzhou, China.

Bronchopleural fistula (BPF) with empyema is a severe complication in patients undergoing lobectomy or pneumonectomy and is associated with high morbidity and mortality rates. Although a wide variety of treatment options exist, refractory cases with larger fistulas are still difficult to cure, especially in elderly patients. Here, we report a case of an 83-year-old man with stage I squamous cell lung carcinoma who underwent minimally invasive right lower lobectomy. Read More

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Novel Patient Metastatic Pleural Effusion-Derived Xenograft Model of Renal Medullary Carcinoma Demonstrates Therapeutic Efficacy of Sunitinib.

Front Oncol 2021 26;11:648097. Epub 2021 Mar 26.

Department of Pediatrics, UC Davis School of Medicine, Sacramento, CA, United States.

Background: Renal medullary carcinoma (RMC) is a rare but aggressive tumor often complicated by early lung metastasis with few treatment options and very poor outcomes. There are currently no verified RMC patient-derived xenograft (PDX) mouse models established from metastatic pleural effusion (PE) available to study RMC and evaluate new therapeutic options.

Methods: Renal tumor tissue and malignant PE cells from an RMC patient were successfully engrafted into 20 NOD. Read More

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Tuberculosis Septic Arthritis of the Elbow: A Case Report and Literature Review.

Cureus 2021 Mar 8;13(3):e13765. Epub 2021 Mar 8.

Department of Orthopedics, Prince of Songkhla University, Songkhla, THA.

Tuberculosis (TB) infections of the musculoskeletal system are rare. A 77-year-old female with chronic left elbow pain for five months was treated by irrigation and debridement of the elbow for a presumed diagnosis of septic arthritis. Her pain and wound condition did not improve, and she was referred to our institution. Read More

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Lung Adenocarcinoma Presenting as Malignant Pericardial Effusion/Tamponade.

Cureus 2021 Mar 8;13(3):e13762. Epub 2021 Mar 8.

Internal Medicine, Chicago Medical School Internal Medicine Residency Program at Northwestern McHenry Hospital, McHenry, USA.

Lung cancers are the most common primary tumors that involve the pericardium with a prevalence of up to 50%. Usually, pericardial involvement goes undetected with almost 10%-12% found among all cancer related autopsies. Rarely pericardial effusions can be the initial site of metastasis and initial manifestation of a primary tumor. Read More

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Type 1 Acute Aortic Dissection in the Early Period After COVID-19 Infection.

Cureus 2021 Mar 7;13(3):e13751. Epub 2021 Mar 7.

Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, TUR.

The coronavirus disease 2019 (COVID-19) pandemic has resulted in over 105 million confirmed cases and over 2.3 million deaths globally as of February 3, 2021. Cardiovascular problems due to COVID-19 infection include acute coronary syndrome (due to coronary occlusion, thrombosis), myocardial damage without coronary artery disease, arrhythmias, heart failure, pericardial effusion, and thromboembolic events. Read More

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Limited Scleroderma-Induced Pulmonary Arterial Hypertension Resulting in Impaired Postoperative Respiratory Function.

Cureus 2021 Mar 6;13(3):e13742. Epub 2021 Mar 6.

Pulmonary and Critical Care, Lewis Gale Medical Center, Salem, USA.

Limited scleroderma falls under the umbrella of systemic sclerosis, an autoimmune disease that presents with multiorgan dysfunction that includes pulmonary arterial hypertension. We examine a case of pulmonary arterial hypertension in an elderly nonsmoker with a history of limited scleroderma.  The patient presented with abdominal tenderness and was diagnosed with a sigmoid colonic stricture. Read More

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Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis.

Chemosphere 2021 Mar 29;278:130349. Epub 2021 Mar 29.

Institute of Reproductive Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, 430030, PR China. Electronic address:

Triclocarban (TCC), considered an endocrine-disrupting, persistent, and bioaccumulating organic matter, has attracted a great deal of attention for its pollution and health risks. However, studies on its toxicological mechanism, especially for embryo development are limited. This article explores the cardiac developmental toxicity induced in zebrafish embryos after exposure to different TCC concentrations. Read More

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A liquid culture cancer spheroid model reveals low PI3K/Akt pathway activity and low adhesiveness to the extracellular matrix.

FEBS J 2021 Apr 9. Epub 2021 Apr 9.

Faculty of Health Sciences, University of Bristol, Bristol, UK.

Three-dimensional (3D) cultures of cancer cells in liquid without extracellular matrix (ECM) offers in vitro models for metastasising conditions such as those in vessels and effusion. However, liquid culturing is often hindered by cell adhesiveness, which causes large cell clumps. We previously described a liquid culture material, LA717, which prevents non-clonal cell adhesion and subsequent clumping, thus allowing clonal growth of spheroids in an anchorage-independent manner. Read More

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Human bite wounds as a portal of entry for infective endocarditis and purulent pericarditis: a very rare association.

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Internal Medicine, University of Chile, Santiago, Chile.

Human bites are an infrequent cause of emergency department visits and hospital admissions. There are rarely published cases of complicated infection, such as infective endocarditis. We present a rare case of a patient with acute infective endocarditis in a healthy native valve and purulent pericarditis from a human bite. Read More

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Computed tomographic features of coronavirus disease-2019 (COVID-19) pneumonia in three groups of Iranian patients: A single center study.

Radiologia 2021 Mar 14. Epub 2021 Mar 14.

Centro de Investigación de Gastroenterología y Enfermedades Hepáticas, Instituto de Investigación de Gastroenterología y Enfermedades Hepáticas, Universidad de Ciencias Médicas Shahid Beheshti, Teherán, Irán.

Introduction And Objectives: The pivotal role of chest computed tomographic (CT) to diagnosis and prognosis coronavirus disease-2019 (COVID-19) is still an open field to be explored. This study was conducted to assess the CT features in confirmed cases with COVID-19.

Materials And Methods: Retrospectively, initial chest CT data of 363 confirmed cases with COVID-19 were reviewed. Read More

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Concurrent manifestations of Horner's syndrome and esophageal metastasis of breast cancer: case report of a young woman after a period of non-adherence to treatment: a case report.

J Med Case Rep 2021 Apr 9;15(1):194. Epub 2021 Apr 9.

Division of Surgical Oncology-Department of Surgery, Dr. Sardjito Hospital/Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Jl Kesehatan No. 1, Yogyakarta, 55281, Indonesia.

Background: Esophageal involvement and Horner's syndrome are rare manifestations of breast cancer distant metastases that can pose a significant challenge in diagnosis and treatment. In addition to the more aggressive behavior of breast cancer diagnosed in young women, non-adherence to treatment is associated with increased risk of distant metastasis.

Case Presentation: A 36-year-old Javanese woman presented to our institution with dysphagia, hoarseness, and frequent hiccups. Read More

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Pericardiocentesis induced right ventricular changes in patients with and without pulmonary hypertension.

Echocardiography 2021 Apr 9. Epub 2021 Apr 9.

MedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC, USA.

Background: Pericardial effusion drainage in patients with significant pulmonary hypertension (PH) has been questioned because of hemodynamic collapse concern, mainly because of right ventricular (RV) function challenging assessment. We aimed to assess RV function changes related to pericardiocentesis in patients with and without PH.

Methods: Consecutive patients with symptomatic moderate-to-large pericardial effusion who had either echocardiographic or clinical signs of cardiac tamponade and who underwent pericardiocentesis from 2013 to 2018 were included. Read More

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A Case of Dapsone-induced Mild Methemoglobinemia with Dyspnea and Cyanosis.

Acta Dermatovenerol Croat 2020 Dec;28(4):249-250

Hisayoshi Imanishi, MD, PhD, Division of Dermatology, Daito Central Hospital, 2-1-11 Ono, Daito, Osaka 574-0042, Japan;

Dear Editor, Dapsone is a dual-function drug with antimicrobial and antiprotozoal effects and anti-inflammatory features (1). In dermatology, it is a first choice for conditions such as leprosy, IgA pemphigus, dermatitis herpetiformis, and linear IgA bullous dermatosis, or an adjunctive treatment for, e.g. Read More

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December 2020

A fatal invasive pulmonary infection in an adult patient with malignant lung adenocarcinoma.

Curr Med Mycol 2020 Sep;6(3):61-64

Department of Infectious Diseases and Clinical Microbiology, Kayseri City Hospital, Kayseri, Turkey.

Background And Purpose: complex as a ubiquitous environmental mold is increasingly reported to cause an invasive fungal infection in immunosuppressive hosts. Herein, we present the case of an immunosuppressive 54 - year-old man who developed complex lung infection and pulmonary adenocarcinoma.

Case Report: The patient had some complaints of dyspnea and cough during a neutropenic episode. Read More

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September 2020

Clinical Misdiagnosis of COVID-19 Infection with Confusing Clinical Course.

Case Rep Infect Dis 2021 31;2021:6629966. Epub 2021 Mar 31.

Pediatric Department, Pediatric Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.

Background: Similarities in the febrile course and other manifestations of some diseases may lead to clinical misdiagnosis of COVID-19 infection. Here, we report a case in a young child with a potentially confusing clinical course. . Read More

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Corrigendum: Previous Radiotherapy Increases the Efficacy of IL-2 in Malignant Pleural Effusion: Potential Evidence of a Radio-Memory Effect?

Front Immunol 2021 23;12:649620. Epub 2021 Mar 23.

Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Jinan, China.

[This corrects the article DOI: 10.3389/fimmu.2018. Read More

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Differential characteristics and management of pseudoseptic arthritis following hyaluronic acid injection is a rare complication: a systematic review.

J ISAKOS 2021 Mar 3;6(2):94-101. Epub 2020 Nov 3.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University Medical Centre, Hamilton, Ontario, Canada

Importance: Acute pseudoseptic arthritis is a rare complication of hyaluronic acid (HA) injections that is not well documented in the literature. Practitioners initially suspect the symptoms of this complication to represent septic arthritis, cautiously prescribing antibiotics. This review identifies that time to presentation of symptoms postinjection, negative cell cultures and lack of crystallisation could be used as differentials to suspect pseudoseptic arthritis and to prescribe anti-inflammatory drugs while closely monitoring change of symptoms. Read More

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Spontaneous cerebrospinal fluid leaks of the temporal bone - clinical features and management outcomes.

Auris Nasus Larynx 2021 Apr 5. Epub 2021 Apr 5.

Department of Ear, Nose and Throat Surgery, Fiona Stanley Hospital, 11 Robin Warren Drive, Murdoch, WA 6150, Australia; Department of Ear, Nose and Throat Surgery, Royal Perth Hospital, Perth, WA 6000, Australia; Department of Otolaryngology and Head and Neck Surgery, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Western ENT, South Perth Hospital, Como, WA 6151, Australia.

Objective: METHODS: A retrospective cohort study over seven-years from 2013 to 2020 was conducted at five tertiary referral centres. Patients identified with biochemically confirmed spontaneous cerebrospinal fluid leaks of the temporal bone manifesting as middle ear fluid with no other obvious cause were included. Demographics (age, gender, body-mass-index), symptomatology, past medical history, examination, investigation (biochemical and radiological), management and outcomes were recorded. Read More

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Clinical Features and Prognosis of Nontuberculous Mycobacterial Pleuritis: A Multicenter Retrospective Study.

Ann Am Thorac Soc 2021 Apr 8. Epub 2021 Apr 8.

Keio University School of Medicine, Department of Infectious Diseases, Shinjuku-ku, Tokyo, Japan;

Rationale: The clinical features and prognosis of nontuberculous mycobacterial (NTM) pleuritis and pleural effusion combined with NTM lung disease (NTM-LD) remain unclear.

Objectives: To investigate the clinical features and prognosis of NTM pleuritis.

Methods: This retrospective observational study included patients with NTM pleuritis from January 2001 to June 2018 across eight hospitals in Japan. Read More

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