125,506 results match your criteria efficacy observed

Psychosocial remediation in depressive disorders: A systematic review.

J Affect Disord 2021 May 1;290:40-51. Epub 2021 May 1.

Mental Health Service, Complejo Hospitalario Universitario de Albacete (CHUA), Albacete, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain; Mental Health Service, Hospital Virgen de la Luz, Cuenca, Spain. Electronic address:

Background: Social functioning impairment has been described in several psychiatric illness, including depressive disorders. It is associated with a deterioration in global functioning and quality of life, thus there is a growing interest in psychosocial functioning remediation interventions. This systematic review aims to review all psychotherapeutic, pharmacological and biological social functioning interventions in depressive disorders. Read More

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What is my child telling me? Reducing stress, increasing competence and improving psychological well-being in parents of children with a developmental disability.

Res Dev Disabil 2021 May 12;114:103984. Epub 2021 May 12.

Central Queensland University, Australia. Electronic address:

High levels of stress in parents of children with a developmental disability have been extensively documented. These heightened stress levels seem independent of diagnosis and are better explained by the level of challenging behavior of the children. Furthermore, the relationship between stress level and difficult behavior appears reciprocal. Read More

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Coblation Discoplasty Alleviates Cervical Chest Pain after Positive Ultrasound-Guided Nerve Root Block: A Retrospective Study.

World Neurosurg 2021 May 12. Epub 2021 May 12.

Department of Pain Management, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.

Objective: The cervical chest pain (CCP), as one atypical symptom associated with cervical spondylosis, often overlaps with other chest-related diseases. If CCP obviously relieved after ultrasound-guided cervical nerve root block nearby herniated disc, which should be considered as a potential pathological source. The purpose of this study is to investigate whether coblation discoplasty can alleviate CCP after positive ultrasound-guided nerve root block. Read More

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Determining the effect of pretreatments on freeze resistance and survival of cryopreserved temperate fruit tree dormant buds.

Cryobiology 2021 May 12. Epub 2021 May 12.

Colorado State University,Department of Horticulture & Landscape Architecture,Fort Collins,CO 80523. Electronic address:

Freeze resistance is critical to successful dormant bud (DB) cryopreservation, and is affected by genotype, environmental conditions, dormancy phase and processing techniques. Pretreatment induced freeze resistance may contribute to more successful and efficient protocols for cryopreserving DB. Differential thermal analysis (DTA) was used to quantify the effects of cryopreservation pretreatments on freeze resistance of dormant budwood. Read More

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In vivo method to evaluate antioxidative activity using UVA-induced carbonylated protein on human skin.

J Cosmet Dermatol 2021 May 15. Epub 2021 May 15.

Department of Genetic Engineering, College of Life Sciences, Graduate School of Biotechnology, Kyung Hee University, Yongin, 17104, Republic of Korea.

Background: Skin is continuously exposed to oxidative stress caused by reactive oxygen species (ROS) produced by the ultraviolet (UV) light, and it is important to evaluate the antioxidant activity. Carbonylated proteins (CPs) are candidate markers of oxidative modification as a result from the ROS. We aimed to develop the CPs based method to assess the efficacy of antioxidants in human skin. Read More

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Comparative efficacy and safety of systemic therapies used in moderate-to-severe atopic dermatitis: a systematic literature review and network meta-analysis.

J Eur Acad Dermatol Venereol 2021 May 15. Epub 2021 May 15.

Pfizer Inc, New York, NY, USA.

Given the lack of head-to-head studies of systemic therapies in moderate-to-severe atopic dermatitis (AD), network meta-analyses (NMAs) can provide comparative efficacy and safety data to inform clinical decision making. In this NMA, eligible randomized controlled trials (RCTs) published before October 24, 2019 were identified by a systematic literature review. Short-term (12-16 weeks) efficacy (Investigator's Global Assessment [IGA] and Eczema Area and Severity Index [EASI] responses), patient-reported outcomes (PROs), and safety data from each trial were abstracted and analyzed separately for monotherapy and combination-therapy (systemic plus topical anti-inflammatory therapy). Read More

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Population Pharmacokinetic Analysis of Bedaquiline-Clarithromycin for Dose Selection Against Pulmonary Nontuberculous Mycobacteria Based on a Phase 1, Randomized, Pharmacokinetic Study.

J Clin Pharmacol 2021 May 15. Epub 2021 May 15.

Johnson and Johnson Services, Inc, New Brunswick, NJ, USA.

Based on in vitro profile of bedaquiline against mycobacterial species, it is being investigated for clinical efficacy against pulmonary nontuberculous mycobacteria (PNTM). Being a cytochrome P450 (CYP) 3A substrate, pharmacokinetic interactions of bedaquiline are anticipated with clarithromycin (a CYP3A inhibitor), which is routinely used in PNTM treatment. This Phase 1, randomized, crossover study assessed the impact of steady-state clarithromycin (500 mg every 12 hours; 14 days) on the pharmacokinetics of bedaquiline and its metabolite (M2) after single-dose bedaquiline (100 mg; n  =  16). Read More

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Direct Comparison of Risankizumab and Fumaric Acid Esters in Systemic-Therapy-Naive Patients With Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial.

Br J Dermatol 2021 May 15. Epub 2021 May 15.

Dermatologikum, Hamburg, Germany.

Background: Fumaric acid esters (FAEs; Fumaderm ) are the most frequently prescribed first-line systemic treatment for moderate-to-severe plaque psoriasis in Germany. Risankizumab (Skyrizi ) is a humanized IgG1 monoclonal antibody that specifically binds to the p19 subunit of interleukin-23.

Objective: This study compared risankizumab treatment with FAEs in psoriasis patients. Read More

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Endoscopic third ventriculostomy and choroid plexus cauterization (ETV/CPC) for hydrocephalus of infancy: a technical review.

Childs Nerv Syst 2021 May 15. Epub 2021 May 15.

Division of Neurosurgery, Hospital for Sick Children (SickKids), Rooms 1504 & 1503, Hill Wing, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.

In the twenty-first century, choroid plexus cauterization (CPC) in combination with endoscopic third ventriculostomy (ETV) has emerged as an effective treatment for some infants with hydrocephalus, leading to the favourable condition of 'shunt independence'. Herein we provide a narrative technical review considering the indications, procedural aspects, morbidity and its avoidance, postoperative care and follow-up. The CP has been the target of hydrocephalus treatment for more than a century. Read More

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Long-term cardiovascular outcomes after orlistat therapy in patients with obesity: a nationwide, propensity-score matched cohort study.

Eur Heart J Cardiovasc Pharmacother 2021 May 15. Epub 2021 May 15.

Department of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.

Aims: The rising prevalence of obesity and its associated comorbidities represent a growing public health issue; in particular, obesity is known to be a major risk factor for cardiovascular disease. Despite the evidence behind the efficacy of orlistat in achieving weight loss in patients with obesity, no study thus far has quantified its long-term effect on cardiovascular outcomes. The purpose of this study is to explore long-term cardiovascular outcomes after orlistat therapy. Read More

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Long-term efficacy and safety of intravenous injection of clonal mesenchymal stem cells derived from bone marrow in five adults with moderate to severe atopic dermatitis.

J Dermatol 2021 May 14. Epub 2021 May 14.

Department of Dermatology, Inha University School of Medicine, Incheon, Republic of Korea.

Atopic dermatitis is a chronic and relapsing inflammatory skin disease that is treated with immunosuppressants. However, long-term use of immunosuppressants may cause toxicity and severe side-effects. To confirm the long-term efficacy and safety of clonal mesenchymal stem cell therapy, we performed investigator-initiated clinical trials and long-term observation in five adult patients with moderate to severe atopic dermatitis that was refractory to conventional treatments. Read More

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Feasibility, efficacy, and safety of ethanol infusion into the vein of Marshall for atrial fibrillation: a meta-analysis.

Pacing Clin Electrophysiol 2021 May 14. Epub 2021 May 14.

Heart Center, the First Hospital of Lanzhou University, Lanzhou, China.

Background: Contemporary radiofrequency catheter ablation (RFCA) approaches for atrial fibrillation (AF) have reached an efficacy "ceiling". Ethanol infusion into the vein of Marshall (EI-VOM) has shown potential in preliminary studies. Data on EI-VOM are largely limited to small single-center reports, and clinical benefits and risks have not been systematically examined. Read More

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Efficacy and safety of jakinibs in rheumatoid arthritis: a systematic review and meta-analysis.

Clin Rheumatol 2021 May 14. Epub 2021 May 14.

Department of Rheumatology, The First Affiliated Hospital of Soochow University, No. 188 Shizi St, Suzhou, 215006, Jiangsu, China.

Objectives: To assess the efficacy and safety of jakinibs for the treatment of active rheumatoid arthritis (RA) in patients with an inadequate response or intolerance to conventional synthetic or biologic disease-modifying antirheumatic drugs (DMARDs).

Methods: A systematic search was conducted in PubMed, Embase, and the Cochrane Library. Randomized placebo-controlled trials (RCTs) of jakinibs in RA patients were eligible. Read More

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A randomized clinical trial evaluating the short-term results of ureteral stent encrustation in urolithiasis patients undergoing ureteroscopy: micro-computed tomography evaluation.

Sci Rep 2021 May 14;11(1):10337. Epub 2021 May 14.

Department of Urology and Andrology, Kansai Medical University, 2-5-1, Shin-machi, Hirakata, 573-1152, Japan.

Although many ureteral stents are commercially available, the actuality of encrustation is yet to be elucidated in humans. This study compared the Tria Ureteral Stent with PercuShield and the Polaris Ultra Ureteral Stent with HydroPlus Coating for short-term encrustation formation. Eighty-four patients, who required ureteral stent placement after ureteroscopy, were randomized into two stent groups. Read More

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Endoscopic Treatment of Enterocutaneous Fistulas in Crohn's Disease.

Dis Colon Rectum 2021 May 13. Epub 2021 May 13.

Department of gastroenterology, Amiens University hospital, Picardie University, Amiens, France Department of digestive surgery, Amiens University hospital, Picardie University, Amiens, France.

Background: Management of enterocutaneous fistulas in Crohn's disease is challenging. The majority of patients still need intestinal resection in the biologic era.

Objective: The aim of this study was to evaluate the efficacy of endoscopic treatment for enterocutaneous fistulas. Read More

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Does Adding the Dialectical Behavior Therapy Prolonged Exposure (DBT PE) Protocol for PTSD to DBT Improve Outcomes in Public Mental Health Settings? A Pilot Nonrandomized Effectiveness Trial With Benchmarking.

Behav Ther 2021 May 1;52(3):639-655. Epub 2020 Sep 1.

West Chester University.

The Dialectical Behavior Therapy Prolonged Exposure (DBT PE) protocol improves DBT's effects on PTSD in research settings, but its effectiveness in community settings is largely unknown. This pilot nonrandomized controlled trial examined DBT with and without DBT PE in four public mental health agencies. Patients (N = 35, 12-56 years old, 80. Read More

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Newly designed solid coupling medium for reducing trapped air pockets during extracorporeal shock wave lithotripsy_ a phantom study.

BMC Urol 2021 May 14;21(1):79. Epub 2021 May 14.

Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University Hospital, No.100, Shiquan 1st Rd., Sanmin Dist., Kaohsiung City 807, Taiwan.

Introduction: Air pockets between the lithotripter head and body surface are almost inevitably generated when applying a handful of gel onto the contact portion of the treatment head and that on the patient's skin during coupling procedure. These air pockets can compromise the transmission of acoustic energy of shock wave and may significantly affect efficacy of stone disintegration. Comparing to conventional gel, this study aims to investigate efficacy of stone disintegration by using a proprietary isolation-coupling pad ("icPad") as the coupling medium to reduce trapped air pockets during ESWL procedure. Read More

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Upregulated Talin1 synergistically boosts β-estradiol-induced proliferation and pro-angiogenesis of eutopic and ectopic endometrial stromal cells in adenomyosis.

Reprod Biol Endocrinol 2021 May 14;19(1):70. Epub 2021 May 14.

Department of Minimally Invasive Gynecologic Center, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, No.17 Qi Helou Road, Dong Cheng District, Beijing, 100006, China.

Adenomyosis (ADS) is an estrogen-dependent gynecological disease with unspecified etiopathogenesis. Local hyperestrogenism may serve a key role in contributing to the origin of ADS. Talin1 is mostly identified to be overexpressed and involved in the progression of numerous human carcinomas through mediating cell proliferation, adhesion and motility. Read More

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Fremanezumab for the Preventive Treatment of Migraine: Subgroup Analysis by Number of Prior Preventive Treatments with Inadequate Response.

Cephalalgia 2021 May 14:3331024211008401. Epub 2021 May 14.

Headache Unit, Neurology Department, Vall d'Hebron University Hospital, Barcelona, Spain.

Objective: To evaluate the efficacy of monthly or quarterly fremanezumab in patients with chronic migraine or episodic migraine and documented inadequate response to 2, 3, or 4 classes of prior migraine preventive medications.

Methods: This is an exploratory analysis of a randomized, double-blind, placebo-controlled, phase 3b trial for patients with chronic migraine or episodic migraine and inadequate response to 2 to 4 prior migraine preventive medication classes randomized (1:1:1) to fremanezumab (quarterly or monthly) or placebo. In this exploratory analysis, changes from baseline in the monthly average number of migraine days during 12 weeks of double-blind treatment and adverse events were evaluated for predefined subgroups of patients by number of prior preventive medication classes with inadequate response. Read More

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New developments in myotonic dystrophies from a multisystemic perspective.

Curr Opin Neurol 2021 May 14. Epub 2021 May 14.

Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.

Purpose Of Review: The multisystemic involvement of myotonic dystrophies (DMs) intricates disease monitoring, patients' care and trial design. This update of the multifaceted comorbidities observed in DMs aims to assist neurologists in the complex management of patients and to encourage further studies for still under-investigated aspects of the disease.

Recent Findings: We reviewed the most recent studies covering pathogenesis and clinical aspects of extra-muscular involvement in DM1 and DM2. Read More

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Efficacy and Safety of Intrathecal Pemetrexed Combined with Dexamethasone for Treating TKI-failed Leptomeningeal Metastases from EGFR-mutant NSCLC-A Prospective Open-label Single-arm Phase I/II Clinical Trial (unique identifier: ChiCTR1800016615).

J Thorac Oncol 2021 May 11. Epub 2021 May 11.

Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China. Electronic address:

Introduction: We aimed to examine the efficacy and safety of intrathecal pemetrexed (IP) for treating EGFR-mutant leptomeningeal metastases (LM) from EGFR-mutant non-small cell lung cancer (NSCLC).

Methods: EGFR-mutant NSCLC patients with LM who had failed tyrosine-kinase inhibitors (TKIs) were recruited. The dose of IP was escalated from 15 mg to 80 mg using an accelerated titration design in a Phase I study. Read More

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Molecular cloning and characterization of high-affinity potassium transporter (AlHKT2;1) gene promoter from halophyte Aeluropus lagopoides.

Int J Biol Macromol 2021 May 11. Epub 2021 May 11.

Division of Plant Omics, CSIR-Central Salt and Marine Chemicals Research Institute (CSIR-CSMCRI), Council of Scientific and Industrial Research (CSIR), Gijubhai Badheka Marg, Bhavnagar 364 002, Gujarat, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India. Electronic address:

HKT subfamily II functions as Na- K co-transporter and prevents plants from salinity stress. A 760 bp promoter region of AlHKT2;1 was isolated, sequenced and cloned. The full length promoter D1, has many cis-regulatory elements like MYB, MBS, W box, ABRE etc. Read More

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Endoscopic application of mussel-inspired phenolic chitosan as a hemostatic agent for gastrointestinal bleeding: A preclinical study in a heparinized pig model.

PLoS One 2021 14;16(5):e0251145. Epub 2021 May 14.

Department of Gastroenterology, CHA Gangnam Medical Center, College of Medicine, Cha University, Seoul, Republic of Korea.

Marine mussels secrete adhesive proteins to attach to solid surfaces. These proteins contain phenolic and basic amino acids exhibiting wet adhesion properties. This study used a mussel-inspired hemostatic polymer, chitosan-catechol, to treat gastrointestinal bleeding caused by endoscopic mucosal resection in a heparinized porcine model. Read More

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Non-Native Peptides Capable of Pan-Activating the Quorum Sensing System across Multiple Specificity Groups of .

ACS Chem Biol 2021 May 14. Epub 2021 May 14.

Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.

is a leading cause of hospital-acquired infections. Traditional antibiotics have significantly reduced efficacy against this pathogen due to its ability to form biofilms on abiotic surfaces and drug resistance. The accessory gene regulator () quorum sensing system is directly involved in pathogenesis. Read More

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Effect of Different Permeable Cryoprotectants on the Quality of Cat Epididymal Spermatozoa.

K Buranaamnuay

Cryo Letters 2020 Jul-Aug;41(4):237-244

Molecular Agricultural Biosciences Cluster, Institute of Molecular Biosciences (MB), Mahidol University, Nakhon Pathom 73170, Thailand.

Background: Permeable cryoprotectants (CPAs) are required for successful sperm cryopreservation.

Objective: To investigate the efficacy of adding different CPAs to a freezing extender on cat epididymal sperm quality.

Methods: Epididymal spermatozoa were suspended in Tris-glucose-citrate-egg yolk extender supplemented either with glycerol, methanol, formamide, ethylene glycol (EG), propylene glycol (PG) and dimethylsulfoxide (DMSO), all at 5% (v/v), and then cryopreserved. Read More

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Platelet-rich Plasma use for facial rejuvenation: a clinical trial and review of current literature.

Acta Biomed 2021 May 12;92(2):e2021187. Epub 2021 May 12.


Background And Aim Of The Work: Several studies have shown beneficial effects for Platelet-rich plasma (PRP). We aimed to assess the efficacy of pure PRP injection for facial rejuvenation in Iran.

Methods:  30 female consecutive participants were injected with PRP in two sessions with 3 month interval. Read More

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Effectiveness of Digital Interventions for Reducing Behavioral Risks of Cardiovascular Disease in Nonclinical Adult Populations: Systematic Review of Reviews.

J Med Internet Res 2021 May 14;23(5):e19688. Epub 2021 May 14.

Public Health England, London, United Kingdom.

Background: Digital health interventions are increasingly being used as a supplement or replacement for face-to-face services as a part of predictive prevention. They may be offered to those who are at high risk of cardiovascular disease and need to improve their diet, increase physical activity, stop smoking, or reduce alcohol consumption. Despite the popularity of these interventions, there is no overall summary and comparison of the effectiveness of different modes of delivery of a digital intervention to inform policy. Read More

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Monoclonal antibodies in type 2 asthma: an updated network meta-analysis.

Minerva Med 2021 May 14. Epub 2021 May 14.

Department of Bioanalysis, Pharmaceutical Care Unit, Ghent University, Ghent, Belgium -

Introduction: Novel treatments target eosinophilic inflammation in type 2 asthma. We aimed to evaluate and meta-analyze the efficacy of monoclonal antibodies to reduce exacerbation rate.

Evidence Acquisition: PubMed and Embase were searched for phase II and phase III randomized clinical trials with monoclonal antibodies targeting key mediators of type 2-associated asthma between 2019 and 2021 to update our previous meta-analysis covering studies published from 2005 to 2018. Read More

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Combined gene therapy via VEGF and mini-dystrophin synergistically improves pathologies in temporalis muscle of dystrophin/utrophin double knockout mice.

Hum Mol Genet 2021 May 13. Epub 2021 May 13.

Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15219, USA.

Duchenne muscular dystrophy (DMD) is a severe X-linked inherited muscular disorder characterized by the loss of dystrophin. We have previously shown that monogene therapy using the mini-dystrophin gene improves muscle function in DMD. However, chronic inflammation plays an important role in progressive muscle degeneration in DMD as well. Read More

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Exploring the concepts and practices of advanced breast cancer treatment: a narrative review.

Ann Transl Med 2021 Apr;9(8):721

Department of Medical Oncology (Breast Cancer), Cancer Hospital of the University of Chinese Academy of Sciences/Zhejiang Cancer Hospital, Hangzhou, China.

Objective: To explore the concepts and practices of advanced breast cancer treatment.

Background: Metastatic breast cancer (MBC) has become a chronic disease, with a median overall survival (OS) of around 3 years and a 5-year survival rate of about 25%. OS are strongly associated with the best available care, which consists of not only application of guidelines, but also multidisciplinary specialized care, the most efficacious medicines, and so on. Read More

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