66,912 results match your criteria efficacy early

Delinquency as a consequence of parental warmth and self-efficacy: Total sample and individual male and female mediation analyses.

Glenn D Walters

J Adolesc 2021 May 5;89:137-148. Epub 2021 May 5.

Kutztown University, United States. Electronic address:

Introduction: This study's purpose was to investigate the mediating effect of parental control self-efficacy on the parental warmth → child delinquency relationship in the mothers and fathers of early to mid-adolescent youth in a test of performance accomplishments as a prelude to parental self-efficacy.

Methods: Parental warmth and control self-efficacy estimates, representing parental support and control, respectively, were provided by the mothers and fathers of 3934 (2010 boys, 1924 girls) youth from the Longitudinal Study of Australian Children (LSAC) and self-reported delinquency was obtained from the child.

Results: As predicted, parental control self-efficacy mediated the relationship between parental warmth and child delinquency, whereas parental warmth did not mediate the relationship between parental self-efficacy and child delinquency. Read More

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Intravenous tranexamic acid reduce postoperative drainage and pain after open elbow arthrolysis: A randomized controlled trial.

J Shoulder Elbow Surg 2021 May 5. Epub 2021 May 5.

Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, P. R. China. Electronic address:

Background: Open elbow arthrolysis (OEA), which has become an established treatment for post-traumatic elbow stiffness (PTES), requires complete release of contracture tissue and wide excision of ectopic bone, which results in extensive bleeding. The aim of the present study is to evaluate the efficacy of intravenous tranexamic acid (TXA) on postoperative drainage, calculated blood loss and early clinical outcomes in patients undergoing OEA.

Methods: A double-blind, randomized, placebo-controlled trial including 96 patients undergoing OEA was undertaken. Read More

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Predictors of Colorectal Cancer Screening Among African American Men Living with HIV.

J Community Health 2021 May 8. Epub 2021 May 8.

University Pennsylvania Annenberg School of Communication, Philadelphia, USA.

African American men living with HIV are at high risk of colorectal cancer (CRC). Screening to detect CRC is associated with a reduced risk of CRC mortality. However, little is known about CRC screening predictors in this population. Read More

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Safety and efficacy of autologous whole cell vaccines in hematologic malignancies: A systematic review and meta-analysis.

Hematol Oncol 2021 May 8. Epub 2021 May 8.

Cancer Therapeutics Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Autologous cell vaccines use a patient's tumor cells to stimulate a broad antitumor response in vivo. This approach shows promise for treating hematologic cancers in early phase clinical trials, but overall safety and efficacy remain poorly described. We conducted a systematic review assessing the use of autologous cell vaccination in treating hematologic cancers. Read More

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[GCS score combined with CT score and serum S100B protein level Can evaluate severity and early prognosis of acute traumatic brain injury].

W Yin S Weng S Lai H Nie

Nan Fang Yi Ke Da Xue Xue Bao 2021 Apr;41(4):543-548

Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore the value of Glasgow Coma Scale (GCS) score and CT score combined with serum S100B protein level for evaluation of injury severity and predicting early prognosis of acute traumatic brain injury (TBI).

Objective: A total of 108 patients with TBI admitted within 24 h after injury in the Emergency Department of West China Hospital from May, 2019 to May, 2020 were enrolled in this study. The clinical data, laboratory test results, CT examination, GCS score, Full Outline of Unresponsiveness score, Fisher CT classification, Rotterdam CT score, and serum S100B protein level of the patients were collected upon admission. Read More

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Neurotoxicity prevention with a multimodal program (ATENTO) prior to cancer treatment versus throughout cancer treatment in women newly diagnosed for breast cancer: Protocol for a randomized clinical trial.

Res Nurs Health 2021 May 7. Epub 2021 May 7.

Department of Physiotherapy, Faculty of Health Sciences, University of Granada, Granada, Spain.

A current challenge in breast cancer (BC) patients is how to reduce the side effects of cancer and cancer treatments and prevent a decrease in quality of life (QoL). Neurotoxic side effects, especially from chemotherapy, are present in up to 75% of women with BC, which implies a large impact on QoL. There is a special interest in the preventive possibilities of therapeutic exercise (TE) for these neurological sequelae, and the benefits of TE could be improved when it is combined with vagal activation techniques (VATs). Read More

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A Trauma-Informed, Family-Centered, Virtual Home Visiting Program for Young Children: One-Year Outcomes.

Child Psychiatry Hum Dev 2021 May 7. Epub 2021 May 7.

Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, 760 Westwood Plaza, Room A8-225, Los Angeles, CA, 90024, USA.

Military-connected families face many challenges associated with military life transitions, including deployment separations. We report on a randomized controlled trial to evaluate the efficacy of Families OverComing Under Stress-Early Childhood (FOCUS-EC) delivered through an in-home, virtual telehealth platform. FOCUS-EC is a trauma-informed, family-centered preventive intervention designed to promote family resilience and well-being. Read More

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Bridging the gap: a pre-post feasibility study of embedding exercise therapy into a co-located cancer unit.

Support Care Cancer 2021 May 8. Epub 2021 May 8.

School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia.

Purpose: To establish the feasibility of embedding a flexible, exercise-based rehabilitation program into a cancer treatment unit to allow cancer survivors early exercise support.

Method: A pre-post study was conducted using Bowen's Framework to describe key domains of feasibility: demand (referrals), acceptability (uptake, attendance, satisfaction), implementation (resources), practicality (adverse events, costs) and limited-efficacy (function, quality of life, self-efficacy). Participants were medically stable, adult cancer survivors receiving curative or palliative treatment for cancer at the health service. Read More

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Mitochondria-targeted antioxidant MitoQ ameliorates ischaemia-reperfusion injury in kidney transplantation models.

Br J Surg 2021 May 8. Epub 2021 May 8.

Department of Surgery, University of Cambridge, Cambridge, UK.

Background: Ischaemia-reperfusion (IR) injury makes a major contribution to graft damage during kidney transplantation. Oxidative damage to mitochondria is an early event in IR injury. Therefore, the uptake, safety, and efficacy of the mitochondria-targeted antioxidant MitoQ were investigated in models of transplant IR injury. Read More

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A Review of Recent Research on the Role of MicroRNAs in Renal Cancer.

Med Sci Monit 2021 May 8;27:e930639. Epub 2021 May 8.

Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, China (mainland).

Renal cell carcinoma (RCC) is a most common type of urologic neoplasms; it accounts for 3% of malignant tumors, with high rates of relapse and mortality. The most common types of renal cancer are clear cell carcinoma (ccRCC), papillary renal cell carcinoma (pRCC), and chromophobe renal carcinoma (chRCC), which account for 90%, 6-15%, and 2-5%, respectively, of all renal malignancies. Although surgical resection, chemotherapy, and radiotherapy are the most common treatment method for those diseases, their effects remain dissatisfactory. Read More

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Early Fusion Rates After Direct Lateral Lumbar Interbody Fusion With Bone-Morphogenetic Protein.

Int J Spine Surg 2021 May 7. Epub 2021 May 7.

Department of Orthopaedic Surgery, Duke University Medical Center; Durham, North Carolina.

Background: Direct lateral (transpsoas) lumbar interbody fusion (LLIF) reportedly achieves union by 1 year postoperatively, but how soon fusion occurs after these minimally invasive procedures is unclear. This study investigated LLIF fusion progression at 6 months and 1 year in a large-scale cohort using bone morphogenetic protein (BMP) graft and examined risk factors associated with failed fusion.

Methods: Patients undergoing primary LLIF with a single surgical team from 2015 through 2016 with polyetheretherketone (PEEK) iimplants and BMP graft were identified. Read More

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Repurposing existing medications for coronavirus disease 2019: protocol for a rapid and living systematic review.

Syst Rev 2021 May 7;10(1):143. Epub 2021 May 7.

University of Sydney, Sydney, NSW, Australia.

Background: Coronavirus disease 2019 (COVID-19) has no confirmed specific treatments. However, there might be in vitro and early clinical data as well as evidence from severe acute respiratory syndrome and Middle Eastern respiratory syndrome that could inform clinicians and researchers. This systematic review aims to create priorities for future research of drugs repurposed for COVID-19. Read More

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Protocol for a family-centered behavioral intervention to reduce early childhood caries: the MySmileBuddy program efficacy trial.

BMC Oral Health 2021 May 7;21(1):246. Epub 2021 May 7.

Mailman School of Public Health, Columbia University Irving Medical Center, 1051 Riverside Drive, Unit 47, New York, NY, 10032, USA.

Background: Although largely preventable through diet management and topical fluoride use, early childhood caries (ECC) often progresses to severity that necessitates surgical repair. Yet repair often fails to mitigate caries progression. Needed is an effective behavioral intervention to address underlying behavioral causes. Read More

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Antiviral treatment selection for SARS-CoV-2 pneumonia.

Expert Rev Respir Med 2021 May 7. Epub 2021 May 7.

Department of Health Sciences, University of Genoa, Genoa, Italy.

Introduction: Therapy of coronavirus disease 2019 (COVID-19) involves evolving algorithms that include drugs aimed at reducing disease progression by counteracting two different, but intertwined processes: () the damage caused by the virus (with antivirals); () the damage caused by a dysregulated host response (with immunomodulatory agents).

Areas Covered: Herein, we discuss the available evidence on efficacy and safety of antiviral agents employed over the past months for the treatment of COVID-19, and the reasons to be considered for antiviral selection.

Expert Opinion: The available evidence from randomized controlled trials (RCT) currently discourage the use of lopinavir/ritonavir, hydroxychloroquine, and interferons, which did not show improved efficacy compared to standard care or placebo. Read More

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An automated approach to determine antibody endpoint titers for COVID-19 by an enzyme-linked immunosorbent assay.

Immunohematology 2021 Mar;37(1):33-43

Center for Transfusion Medicine and Cellular Therapies, and Department of Pathology and Laboratory Medicine, Emory University School of Medicine , 201 Dowman Drive, Atlanta, GA 30322 , and Joint Program in Transfusion Medicine, Department of Pathology, Brigham and Women's Hospital, Harvard Medical School , 630E New Research Building, 77 Avenue Louis Pasteur, Boston, MA 02115.

While a variety of therapeutic options continue to emerge for COVID-19 treatment, convalescent plasma (CP) has been used as a possible treatment option early in the pandemic. One of the most significant challenges with CP therapy, however, both when defining its efficacy and implementing its approach clinically, is accurately and efficiently characterizing an otherwise heterogenous therapeutic treatment. Given current limitations, our goal is to leverage a SARS antibody testing platform with a newly developed automated endpoint titer analysis program to rapidly define SARS-CoV-2 antibody levels in CP donors and hospitalized patients. Read More

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The safety profile and angioarchitectural changes after acute targeted embolization of ruptured arteriovenous malformations.

J Neurosurg 2021 May 7:1-10. Epub 2021 May 7.

2Division of Neuroradiology, Department of Medical Imaging, and.

Objective: The aim of this study was to 1) compare the safety and efficacy of acute targeted embolization of angiographic weak points in ruptured brain arteriovenous malformations (bAVMs) versus delayed treatment, and 2) explore the angioarchitectural changes that follow this intervention.

Methods: The authors conducted a retrospective analysis of a prospectively acquired database of ruptured bAVMs. Three hundred sixteen patients with ruptured bAVMs who presented to the hospital within 48 hours of ictus were included in the analysis. Read More

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A randomised evaluation of low-dose cytosine arabinoside (ara-C) plus tosedostat versus low-dose ara-C in older patients with acute myeloid leukaemia: results of the LI-1 trial.

Br J Haematol 2021 May 7. Epub 2021 May 7.

Department of Haematology, Nottingham University Hospitals, Nottingham, UK.

Older patients with acute myeloid leukaemia (AML) account for nearly half of those with the disease. Because they are perceived to be unfit for, unwilling to receive, or unlikely to benefit from conventional chemotherapy they represent an important unmet need. Tosedostat is a selective oral aminopeptidase inhibitor, which in phase I/II trials showed acceptable toxicity and encouraging efficacy. Read More

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Colchicine and the heart.

Eur Heart J 2021 May 7. Epub 2021 May 7.

GenesisCare, 3/140 Mounts Bay Rd, Perth, Western Australia, Australia.

Colchicine is a unique, sophisticated anti-inflammatory agent that has been used for decades for the prevention of acute inflammatory flares in gout and familial Mediterranean fever. In recent years, clinical trials have demonstrated its potential in a range of cardiovascular (CV) conditions. Colchicine is avidly taken up by leucocytes, and its ability to bind to tubulin and interfere with microtubular function affects the expression of cytokines and interleukins, and the ability of neutrophils to marginate, ingress, aggregate, express superoxide, release neutrophil extracellular traps, and interact with platelets. Read More

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Efficacy and safety of ceftobiprole in patients aged 65 years or older: a  analysis of three Phase III studies.

Future Microbiol 2021 May 7. Epub 2021 May 7.

Basilea Pharmaceutica International Ltd., Basel, Switzerland.

To evaluate the efficacy and safety of ceftobiprole in patients aged ≥65 years. We conducted a analysis of three randomized, double-blind, Phase III studies in patients with acute bacterial skin and skin structure infections, community-acquired pneumonia and hospital-acquired pneumonia. Findings for patients aged ≥65 years (n = 633) were consistent with those for the overall study populations, although a trend toward improved outcomes was reported in some subgroups, for example, patients aged ≥75 years with community-acquired pneumonia were more likely to achieve an early clinical response with ceftobiprole than comparator (treatment difference 16. Read More

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Bayesian adaptive design for clinical trials in Duchenne muscular dystrophy.

Stat Med 2021 May 7. Epub 2021 May 7.

Wave Life Sciences Ltd, Cambridge, Massachusetts.

A Bayesian adaptive design is proposed for a clinical trial in Duchenne muscular dystrophy. The trial was designed to demonstrate treatment efficacy on an ambulatory-based clinical endpoint and to identify early success on a biomarker (dystrophin protein levels) that can serve as a basis for accelerated approval in the United States. The trial incorporates placebo augmentation using placebo data from past clinical trials. Read More

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Circulating CD15 LOX-1 PMN-MDSCs are a potential biomarker for the early diagnosis of non-small cell lung cancer.

Int J Clin Pract 2021 May 6:e14317. Epub 2021 May 6.

Department of Laboratory Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu, China.

Aims: Non-small-cell lung cancer (NSCLC) is the most common clinical lung cancer. Polymorphonuclear-myeloid derived suppressor cells (PMN-MDSCs), which are the major population of MDSCs, are involved in NSCLC progression. Recently, it was found that lectin-type oxidized LDL receptor 1 (LOX-1) could identify human PMN-MDSCs. Read More

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Can Preoperative Axillary Ultrasound and Biopsy of Suspicious Lymph Nodes Be An Alternative To Sentinel Lymph Node Biopsy in Clinical Node Negative Early Breast Cancer?

Int J Clin Pract 2021 May 6:e14332. Epub 2021 May 6.

General Surgery Clinics of University of Health Sciences, Ankara Oncology Education and Research Hospital, Ankara, Turkey.

Aim: The aim of this study was to assess the efficacy of pre-operative axillary ultrasonography (AUS) and pre-operative axillary fine-needle aspiration biopsy (FNAB) from suspicious lymph nodes in clinically node-negative breast cancer to compare with radiologically positive and sentinel lymph node biopsy (SLNB) positive involvement.

Method: Clinically node-negative early-stage breast cancer patients were included in the study. These patients under went pre-operative AUS examination, suspicious lymph nodes were evaluated with FNAB. Read More

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High Content Image Analysis of Spatiotemporal Proliferation and Differentiation Patterns in 3D Embryoid Body Differentiation Model.

Olga Gordeeva

Methods Mol Biol 2021 May 7. Epub 2021 May 7.

Laboratory of Cell and Molecular Mechanisms of Histogenesis, Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.

The 3D embryoid body (EB) differentiation model is a promising tool for fundamental cell biology and drug discovery studies assessing the compound effects on mammalian and human development. This 3D cell model allows for analyzing spatiotemporal changes during morphogenesis and differentiation. A combination of confocal microscopy with high content image analysis (HCIA) can significantly improve the study of spatiotemporal patterns of early embryonic lineages and compound efficacy and toxicity testing by enhancing the identification and quantification of various cell types. Read More

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Laparoscopic Heller-Dor Is an Effective Treatment for Esophageal-Gastric Junction Outflow Obstruction.

J Gastrointest Surg 2021 May 6. Epub 2021 May 6.

Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, School of Medicine, Clinica Chirurgica 3, Azienda Ospedale Università di Padova, Padova, Italy.

Background: The treatment of esophagogastric junction outflow obstruction (EGJOO) currently mirrors that of achalasia, but this is based on only a few studies on small case series. The aim of this prospective, controlled study was to assess the outcome of laparoscopic Heller-Dor (LHD) in patients with EGJOO, as compared with patients with esophageal achalasia.

Materials And Methods: Between 2016 and 2019, patients with manometric diagnosis of idiopathic EGJOO and patients with radiological stage I achalasia, both treated with LHD, were compared. Read More

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Ground and Stem Sampling as Potential Detection Tools for the Wool of Adelges tsugae (Hemiptera: Adelgidae).

J Econ Entomol 2021 May 7. Epub 2021 May 7.

Natural Resources Canada Canadian Forest Service, Great Lakes Forestry Centre, Sault Ste. Marie, Ontario, Canada.

The wool of the invasive, non-native hemlock woolly adelgid, Adelges tsugae Annand (Hemiptera: Adelgidae), occurs mostly on hemlock (Tsuga sp.) twigs, but can be dislodged from the canopy and end up on the forest floor and tree stem underneath the canopy. Herein, we developed and tested the efficacy of two novel sampling techniques, which are based on a visual examination of the forest floor and the hemlock stem for A. Read More

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Impact of Ribosome Activity on SARS-CoV-2 LNP - Based mRNA Vaccines.

Front Mol Biosci 2021 20;8:654866. Epub 2021 Apr 20.

1st ENT Department, Hippocration Hospital, National and Kapodistrian University, Athens, Greece.

Coronavirus-related Severe Acute Respiratory Syndrome-2 (SARS-CoV-2) initially was detected in Wuhan, Hubei, China. Since early 2021, World Health Organization (WHO) has declared Coronavirus Disease 2019 (COVID-19) a pandemic due to rapidly transformed to a globally massive catastrophic viral infection. In order to confront this emergency situation, many pharmaceutical companies focused on the design and development of efficient vaccines that are considered necessary for providing a level of normalization in totally affected human social-economical activity worldwide. Read More

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SARS-CoV-2 transmission and control in a hospital setting: an individual-based modelling study.

R Soc Open Sci 2021 Mar 22;8(3):201895. Epub 2021 Mar 22.

Department of Mathematics, Applied Mathematics, and Statistics, Case Western Reserve University, Cleveland, OH 44106, USA.

Development of strategies for mitigating the severity of COVID-19 is now a top public health priority. We sought to assess strategies for mitigating the COVID-19 outbreak in a hospital setting via the use of non-pharmaceutical interventions. We developed an individual-based model for COVID-19 transmission in a hospital setting. Read More

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Comparison of three treatment protocols with intra-articular low or intermediate molecular weight hyaluronic acid in early symptomatic knee osteoarthritis.

Ther Adv Musculoskelet Dis 2021 20;13:1759720X21994024. Epub 2021 Apr 20.

Department of Clinical and Experimental Medicine, University of Florence and Department of Geriatric Medicine, Div. of Rheumatology AOUC, SOD Reumatologia, via delle Oblate 4, Firenze (FI), 50139, Italy.

Introduction: Viscosupplementation with hyaluronic acid (HA) is indicated for non-responders to non-pharmacological therapy, to analgesics or when non-steroidal anti-inflammatory drugs (NSAIDs) are contraindicated. The aim of this study is to compare the efficacy, safety and costs of three different HA treatments (, sinovial one and hyalgan).

Patients And Methods: Ninety patients with grade I/II Kellgren-Lawrence knee osteoarthritis were included in three groups, the first was treated with hyalgan (weekly for 5 weeks), the second with Sinovial® Forte (weekly for 3 weeks) and the third group with a single injection of sinovial one. Read More

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The Association Between Glucocorticoid Administration and the Risk of Impaired Efficacy of Axicabtagene Ciloleucel Treatment: A Systematic Review.

Front Immunol 2021 20;12:646450. Epub 2021 Apr 20.

Department of Neurosurgery, The First Affiliated Hospital, University of South China, Hengyang, China.

Background: Glucocorticoid is one of the common and important strategies for the treatment of chimeric antigen receptor T (CAR-T) cell therapy-related toxicity. However, there has been a theoretical concern about whether glucocorticoids use can impact the expansion of CAR-T cells and thus impair its efficacy. Hence, we reviewed studies related to the Axicabtagene ciloleucel (Axi-cel), a first-class and widely used CAR-T cell product, to elucidate the association between glucocorticoids administration and efficacy of Axi-cel. Read More

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Vaccine Inoculation Route Modulates Early Immunity and Consequently Antigen-Specific Immune Response.

Front Immunol 2021 20;12:645210. Epub 2021 Apr 20.

UMR1184 IMVA-HB, IDMIT Department, Université Paris-Saclay - INSERM U1184 - CEA, Fontenay-aux-Roses, France.

Vaccination is one of the most efficient public healthcare measures to fight infectious diseases. Nevertheless, the immune mechanisms induced by vaccination are still unclear. The route of administration, an important vaccination parameter, can substantially modify the quality of the response. Read More

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