114,813 results match your criteria efficacy antimicrobial


Hybrid donor-acceptor polymer nanoparticles and combination antibiotic for mitigation of pathogenic bacteria and biofilms.

J Microbiol Methods 2021 Sep 15:106328. Epub 2021 Sep 15.

Department of Plastic and Reconstructive Surgery, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA. Electronic address:

Biofilms pose a significant clinical problem in skin and soft tissue infections. Their resistance to antibiotics has spurred investigations into alternative treatments, such as nanoparticle-mediated photothermal ablation. Non-toxic Hybrid Donor- Acceptor (DA) Polymer nanoParticles (H-DAPPs) were developed for fluorescence imaging (using poly(3-hexylthiophene-2,5 diyl) (P3HT)) and rapid, near-infrared photothermal ablation (NIR- PTA) (using poly[4,4-bis(2-ethylhexyl)-cyclopenta[2,1-b;3,4-b']dithiophene-2,6-diyl-alt-2,1,3-benzoselenadiazole-4,7-diyl] (PCPDTBSe)). Read More

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September 2021

Antimicrobial Activity of Synthetic Antimicrobial Peptides Loaded in Poly-Ɛ-Caprolactone Nanoparticles Against Mycobacteria and their Functional Synergy with Rifampicin.

Int J Pharm 2021 Sep 14:121097. Epub 2021 Sep 14.

Experimental Animal Facility, ICMR-National JALMA Institute for Leprosy and Other Mycobacterial Diseases, Tajganj, Agra, India-282004. Electronic address:

Tuberculosis (TB) treatment has become a challenge because of the natural presence of multilayered cell wall rich in lipids which restrict antibiotic permeability within the bacteria. The development of mutations conferring resistance has aggravated the situation. Consequently, maximum pharmaceutical efforts are required to improve the treatment, and antimicrobial peptides (AMPs) with antimycobacterial activity can be exploited as a new treatment strategy against TB. Read More

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September 2021

Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial.

Lancet Infect Dis 2021 Sep 14. Epub 2021 Sep 14.

Université de Paris, IAME, INSERM, Paris, France; Département d'Épidémiologie, Biostatistique et Recherche Clinique, Hôpital Bichat, AP-HP, Paris, France.

Background: The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial. We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with standard of care alone in patients admitted to hospital with COVID-19, with indication of oxygen or ventilator support.

Methods: DisCoVeRy was a phase 3, open-label, adaptive, multicentre, randomised, controlled trial conducted in 48 sites in Europe (France, Belgium, Austria, Portugal, Luxembourg). Read More

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September 2021

Tebipenem as an oral alternative for the treatment of typhoid caused by XDR Salmonella Typhi.

J Antimicrob Chemother 2021 Sep 17. Epub 2021 Sep 17.

University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, UK.

Background: Antimicrobial therapy is essential for the treatment of enteric fever, the infection caused by Salmonella serovars Typhi and Paratyphi A. However, an increase in resistance to key antimicrobials and the emergence of MDR and XDR in Salmonella Typhi poses a major threat for efficacious outpatient treatments.

Objectives: We recently identified tebipenem, an oral carbapenem licensed for use for respiratory tract infections in Japan, as a potential alternative treatment for MDR/XDR Shigella spp. Read More

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September 2021

From plants to antimicrobials: Natural products against bacterial membranes.

Phytother Res 2021 Sep 16. Epub 2021 Sep 16.

Department of Pharmaceutical Control, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Bacterial membrane barrier provides a cytoplasmic environment for organelles of bacteria. The membrane is composed of lipid compounds containing phosphatide protein and a minimal amount of sugars, and is responsible for intercellular transfers of chemicals. Several antimicrobials have been found that affect bacterial cytoplasmic membranes. Read More

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September 2021

Discovery and Characterization of a Rapidly Fungicidal and Minimally Toxic Peptoid against .

ACS Med Chem Lett 2021 Sep 23;12(9):1470-1477. Epub 2021 Aug 23.

Department of Chemistry, Middle Tennessee State University, 1301 E. Main St., Murfreesboro, Tennessee 37132, United States.

A limited number of antifungals are available to treat infections caused by fungal pathogens such as and . Current clinical antifungals are generally toxic, and increasing resistance to these therapies is being observed, necessitating new, effective, and safe antifungals. Peptoids, or N-substituted glycines, have shown promise as antimicrobial agents against bacteria, fungi, and parasites. Read More

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September 2021

Antitumorigenic effect of insect-derived peptide poecilocorisin-1 in human skin cancer cells through regulation of Sp1 transcription factor.

Sci Rep 2021 Sep 16;11(1):18445. Epub 2021 Sep 16.

The Animal Molecular Genetics and Breeding Center, Jeonbuk National University, Jeonju, 54896, Republic of Korea.

Malignant melanoma is highly resistant to conventional treatments and is one of the most aggressive types of skin cancers. Conventional cancer treatments are limited due to drug resistance, tumor selectivity, and solubility. Therefore, new treatments with fewer side effects and excellent effects should be developed. Read More

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September 2021

Point-of-care antimicrobial coating protects orthopaedic implants from bacterial challenge.

Nat Commun 2021 Sep 16;12(1):5473. Epub 2021 Sep 16.

Department of Chemical and Biomolecular Engineering, University of California Los Angeles, Los Angeles, CA, United States.

Implant related infections are the most common cause of joint arthroplasty failure, requiring revision surgeries and a new implant, resulting in a cost of $8.6 billion annually. To address this problem, we created a class of coating technology that is applied in the operating room, in a procedure that takes less than 10 min, and can incorporate any desired antibiotic. Read More

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September 2021

Surveillance of Wisconsin Organisms for Trends in Antimicrobial Resistance and Epidemiology (SWOTARE): 2018-2019 Report on Clinical Isolates.

Clin Med Res 2021 Sep;19(3):123-131

College of Health Sciences, Marquette University, Milwaukee, Wisconsin USA

Both and have been regarded as important opportunistic pathogens for humans. Recent data have described the spread of multi-resistant strains of these organisms. Development of novel resistance phenotypes may result in a reduction in anti-infective efficacy, therefore making patient treatment decisions challenging. Read More

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September 2021

Potentiation of anti-Helicobacter pylori activity of clarithromycin by Pelargonium graveolens oil.

Arab J Gastroenterol 2021 Sep 13. Epub 2021 Sep 13.

Department of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt; Center for Drug Discovery Research and Development, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:

Background And Study Aim: Peptic ulcer is one of the most serious diseases in Egypt, affecting more than one-third of the population. Helicobacter pylori is the main organism responsible for peptic ulcer formation. These ulcers can lead to chronic active gastritis and lymphoma. Read More

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September 2021

Mitigating Nosema ceranae infection in western honey bee (Apis mellifera) workers using propolis collected from honey bee and stingless bee (Tetrigona apicalis) hives.

J Invertebr Pathol 2021 Sep 13:107666. Epub 2021 Sep 13.

Entomology and Nematology Department, University of Florida, Gainesville, FL, 32611 USA. Electronic address:

Beekeepers need sustainable control options to treat Nosema ceranae infection in colonies of western honey bees (Apis mellifera L.) they manage. Propolis is a natural product derived from plant resins and contains chemical compounds with potential antimicrobial activity against N. Read More

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September 2021

Challenges and solutions in polymer drug delivery for bacterial biofilm treatment: a tissue-by-tissue account.

Adv Drug Deliv Rev 2021 Sep 13:113973. Epub 2021 Sep 13.

Division of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham, NG7 2RD, UK. Electronic address:

To tackle the emerging antibiotic resistance crisis, novel antimicrobial approaches are urgently needed. Bacterial communities (biofilms) are a particular concern in this context. Biofilms are responsible for most human infections and are inherently less susceptible to antibiotic treatments. Read More

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September 2021

Mesenchymal stromal cell-secreted CCL2 promotes antibacterial defense mechanisms through increased antimicrobial peptide expression in keratinocytes.

Stem Cells Transl Med 2021 Sep 16. Epub 2021 Sep 16.

Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.

Mesenchymal stromal cells (MSCs) from both humans and horses, which represent a clinically relevant translation animal model for human cutaneous wound healing, were recently found to possess antimicrobial properties against planktonic bacteria, and in the case of equine MSCs, also against biofilms. This, together with previous findings that human and equine MSCs promote angiogenesis and wound healing, makes these cells an attractive approach to treat infected cutaneous wounds in both species. The anti-biofilm activities of equine MSC, via secretion of cysteine proteases, have only been demonstrated in vitro, thus lacking information about in vivo relevance. Read More

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September 2021

Carboxyboranylamino ethanol: unprecedented discovery of boron agents for neutron capture therapy in cancer treatment.

Chem Commun (Camb) 2021 Sep 16. Epub 2021 Sep 16.

Louis Pasteur Centre for Medical Research, 103-5 Nakamonzen-machi, Sakyo-ku, Kyoto 606-8225, Japan.

Carboxyboranylamino ethanol (MeN(BHCOH)CHCHOH, 1) was prepared in 75.0% yield by an amine-exchange reaction. Compound 1 shows lower cytotoxicity and higher anti-tumor efficacy towards the SCCVII cell line in comparison with 4-borono-L-phenylalanine (BPA) and methyl 2-hydroxyl-5-(1'--carbonylmethyl-1',2',3'-triazol-4'-yl)-benzonate (2). Read More

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September 2021

Antibacterial efficacy of in-house designed cell-penetrating peptide against multi-drug resistant strains of Salmonella Enteritidis and Salmonella Typhimurium.

Environ Microbiol 2021 Sep 16. Epub 2021 Sep 16.

Division of Veterinary Public Health, ICAR-Indian Veterinary Research Institute, Izatnagar, 243 122, Uttar Pradesh, India.

The in vitro antibacterial efficacy of an in-house designed cell-penetrating peptide (CPP) variant of Cecropin A (1-7)-Melittin (CAMA) (CAMA-CPP) against the characterized multi-drug resistant (MDR) field strains of and Salmonella Typhimurium were evaluated and compared with two identified CPPs namely, P7 and APP, keeping CAMA as control. Initially, the minimum inhibitory concentration (MIC) (μg/ml) of in-house designed CAMA-CPP, APP, and CAMA was determined to be 3.91, whereas that of P7 was 7. Read More

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September 2021

Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis.

Sci Rep 2021 Sep 15;11(1):18304. Epub 2021 Sep 15.

Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK.

Bacterial keratitis (BK) is a major cause of corneal blindness globally. This study aimed to develop a novel class of antimicrobial therapy, based on human-derived hybrid host defense peptides (HyHDPs), for treating BK. HyHDPs were rationally designed through combination of functional amino acids in parent HDPs, including LL-37 and human beta-defensin (HBD)-1 to -3. Read More

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September 2021

The efficacy of corticosteroids therapy in patients with moderate to severe SARS-CoV-2 infection: a multicenter, randomized, open-label trial.

Respir Res 2021 Sep 15;22(1):245. Epub 2021 Sep 15.

Student Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: We performed a multicenter, randomized open-label trial in patients with moderate to severe Covid-19 treated with a range of possible treatment regimens.

Methods: Patients were randomly assigned to one of three regimen groups at a ratio of 1:1:1. The primary outcome of this study was admission to the intensive care unit. Read More

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September 2021

The effect of additional antimicrobial therapy on the outcomes of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Respir Res 2021 Sep 15;22(1):243. Epub 2021 Sep 15.

Department of Internal Medicine, E-Da Cancer Hospital, Yan-Chao District, No. 21, Yida Road, Jiao-su Village, Kaohsiung, 824, Taiwan.

Background: The effect of additional antimicrobial agents on the clinical outcomes of patients with idiopathic pulmonary fibrosis (IPF) is unclear.

Methods: We performed comprehensive searches of randomized control trials (RCTs) that compared the clinical efficacy of additional antimicrobial agents to those of placebo or usual care in the treatment of IPF patients. The primary outcome was all-cause mortality, and the secondary outcomes were changes in forced vital capacity (FVC), diffusing capacity of the lung for carbon monoxide (DLCO), and the risk of adverse events (AEs). Read More

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September 2021

Unravelling the antimicrobial activity of peptide hydrogel systems: current and future perspectives.

Soft Matter 2021 Sep 15;17(35):8001-8021. Epub 2021 Sep 15.

Biofunctional Nanomaterials Group, School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast, N. Ireland, BT9 7BL, UK.

The use of hydrogels has garnered significant interest as biomaterial and drug delivery platforms for anti-infective applications. For decades antimicrobial peptides have been heralded as a much needed new class of antimicrobial drugs. Self-assembling peptide hydrogels with inherent antimicrobial ability have recently come to the fore. Read More

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September 2021

Bacteriophages against enteropathogens: rediscovery and refinement of novel antimicrobial therapeutics.

Curr Opin Infect Dis 2021 Oct;34(5):491-499

Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital.

Purpose Of Review: Alarming rates of antibiotic resistance in bacteria and gastrointestinal dysbiosis associated with traditional antimicrobial therapy have led to renewed interests in developing bacteriophages as novel therapeutics. In this review, we highlight some of the recent advances in bacteriophage therapeutic development targeting important enteropathogens of the gastrointestinal tract.

Recent Findings: Bacteriophages are viruses that infect bacteria, either to utilize the bacterial machinery to produce new progeny or stably integrate into the bacterial chromosome to ensure maintenance of the viral genome. Read More

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October 2021

Common Ophthalmic Preservatives in Soft Contact Lens Care Products: Benefits, Complications, and a Comparison to Non-Preserved Solutions.

Clin Optom (Auckl) 2021 7;13:271-285. Epub 2021 Sep 7.

School of Optometry, University of Alabama at Birmingham, Birmingham, AL, USA.

Purpose: Preservatives are essential for preventing contact lens (CL)-related microbial keratitis (MK). The purpose of this review is to summarize the current knowledge related to the use of common ophthalmic preservatives in CL care products with respect to both safety and efficacy.

Methods: Manuscripts written in English were obtained by searching PubMed. Read More

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September 2021

In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens.

J Antibiot (Tokyo) 2021 Sep 14. Epub 2021 Sep 14.

US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA.

Antimicrobial-resistance (AMR) has become an increasingly difficult issue to overcome for bacteria associated with both community- and hospital-acquired infections as well as potential biodefense threats. The need to identify new therapeutics of novel classes and/or with unique mechanisms is critical to combatting AMR in the coming years. GT-1 (LCB10-0200), a siderophore-linked cephalosporin, is one such novel option and is formulated to be used either alone or in combination with a novel broad-spectrum β-lactamase inhibitor, GT-055 (LCB18-055). Read More

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September 2021

A review: antimicrobial resistance data mining models and prediction methods study for pathogenic bacteria.

J Antibiot (Tokyo) 2021 Sep 14. Epub 2021 Sep 14.

Transportation and Economics Research Institute, China Academy of Railway Sciences Corporation Limited, Beijing, PR China.

Antimicrobials have paved the way for medical and social development over the last century and are indispensable for treating infections in humans and animals. The dramatic spread and diversity of antibiotic-resistant pathogens have significantly reduced the efficacy of essentially all antibiotic classes and is a global problem affecting human and animal health. Antimicrobial resistance is influenced by complex factors such as resistance genes and dosing, which are highly nonlinear, time-lagged and multivariate coupled, and the amount of resistance data is large and redundant, making it difficult to predict and analyze. Read More

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September 2021

Essential oils as alternative promising anti-Candidal agents: progress and prospects.

Curr Pharm Des 2021 Sep 14. Epub 2021 Sep 14.

Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurugram- 122413. India.

Candida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects as well as treatment costs are considered as major limitations for antifungal drugs. It has drawn scientists' attention to search for potential substitution and therapeutic reliable alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Read More

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September 2021

A Synergistic New Approach Toward Enhanced Antibacterial Efficacy via Antimicrobial Peptide Immobilization on a Nitric Oxide-Releasing Surface.

ACS Appl Mater Interfaces 2021 Sep 13. Epub 2021 Sep 13.

School of Chemical, Materials, and Biomedical Engineering, College of Engineering, University of Georgia, Athens, Georgia 30602, United States.

Despite technological advancement, nosocomial infections are prevalent due to the rise of antibiotic resistance. A combinatorial approach with multimechanistic antibacterial activity is desired for an effective antibacterial medical device surface strategy. In this study, an antimicrobial peptide, nisin, is immobilized onto biomimetic nitric oxide (NO)-releasing medical-grade silicone rubber (SR) via mussel-inspired polydopamine (PDA) as a bonding agent to reduce the risk of infection. Read More

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September 2021

Electrohydraulic Streamer Discharge Plasma-Enhanced Disinfection in Seed Sterilization.

ACS Appl Mater Interfaces 2021 Sep 12. Epub 2021 Sep 12.

Department of Electrical Engineering, Faculty of Engineering, Kasetsart University, 50 Ngam Wong Wan Road, Ladyaow, Chatuchak, Bangkok 10900, Thailand.

As emerging chemical-free and eco-friendly technologies, nonthermal (gas discharge) plasma and (liquid phase) plasma-activated water (PAW) offer exceptional microbial disinfection solutions for biological, medical, environmental, and agricultural applications. Herein, we present electrohydraulic streamer discharge plasma (ESDP), which combines streamer discharge plasma (SDP) and PAW generated at a gas-liquid interface, to sterilize Chinese kale ( var. alboglabra) seeds contaminated with (). Read More

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September 2021

Characterization and protective effects of lytic bacteriophage pAh6.2TG against a pathogenic multidrug-resistant Aeromonas hydrophila in Nile tilapia (Oreochromis niloticus).

Transbound Emerg Dis 2021 Sep 13. Epub 2021 Sep 13.

Department of Food, Agriculture and Bioresources, School of Environment, Resources and Development, Asian Institute of Technology, Pathum Thani, Thailand.

Bacteriophage (phage) is considered as one of the alternatives to antibiotics and an environmentally friendly approach to tackle antimicrobial resistance (AMR) in aquaculture. Here, we reported isolation, morphology and genomic characterizations of a newly isolated lytic phage, designated pAh6.2TG. Read More

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September 2021

Surviving Sepsis Campaign: Research Opportunities for Infection and Blood Purification Therapies.

Crit Care Explor 2021 Sep 7;3(9):e0511. Epub 2021 Sep 7.

Department of Surgery and Emory Critical Care Center, Emory University, Atlanta, GA.

Patients with infection can develop sepsis, and their mortality can be high. An important aspect in the treatment of sepsis is adequate management of the infection.

Data Sources: Using a modified Delphi approach, the Surviving Sepsis Campaign research committee recently published a series of 26 priorities for sepsis and septic shock. Read More

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September 2021

Comparative Study of Parenteral Penicillin G vs. Amoxicillin-Clavulanate for the Treatment of Dentoalveolar Abscess in Hospitalized Children.

Front Pediatr 2021 27;9:700188. Epub 2021 Aug 27.

Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

To compare the clinical efficacy and the safety profiles of parenteral penicillin G vs. amoxicillin-clavulanate for the treatment of dentoalveolar abscess (DA) in hospitalized pediatric patients. A retrospective cohort study that was conducted at the Schneider Children's Medical Center in Israel. Read More

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Is Single-Dose Antimicrobial Prophylaxis Sufficient to Control Infections in Gastrointestinal Oncological Surgeries?

Cureus 2021 Aug 6;13(8):e16939. Epub 2021 Aug 6.

Medicine, Vinayaka Mission's Kirupananda Variyar Medical College, Salem, IND.

Surgical site infections (SSIs) represent one of the most important complications occurring postoperatively following surgical procedures. The SSI incidence is higher following gastrointestinal (GI) surgeries compared to any other surgery. It contributes to the majority of morbidity and mortality in patients undergoing GI surgeries. Read More

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