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Efficacy and Safety of Awake CT-guided Percutaneous Balloon Compression of Trigeminal Ganglion for Trigeminal Neuralgia.

Pain Med 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, CA, 94305, USA.

Objectives: To describe the method and clinical efficacy of awake CT-guided percutaneous balloon compression (PBC) as a treatment for trigeminal neuralgia (TN).

Design: In this case-series, TN patients were treated with awake CT-guided PBC and followed for treatment efficacy and complications for 12 months.

Setting: A single-center study. Read More

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Comparative effectiveness and safety of 32 pharmacological interventions recommended by guidelines for coronavirus disease 2019: a systematic review and network meta-analysis combining 66 trials.

Chin Med J (Engl) 2021 Jul 27. Epub 2021 Jul 27.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing 100191, China Department of Clinical Epidemiology and EBM, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB18RN, UK Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton L8S4K1, Canada Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.

Background: The global pandemic coronavirus disease 2019 (COVID-19) has become a major public health problem and presents an unprecedented challenge. However, no specific drugs were currently proven. This study aimed to evaluate the comparative efficacy and safety of pharmacological interventions in patients with COVID-19. Read More

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The Emerging Role of Telehealth for Concussion Clinical Care During the Coronavirus (COVID-19) Pandemic.

J Head Trauma Rehabil 2021 Jul 26. Epub 2021 Jul 26.

Inova Sports Medicine Concussion Program, Fairfax, Virginia (Dr Womble); Baylor Scott & White Sports Concussion Program, Frisco, Texas (Dr Reynolds); Sports Medicine Concussion Program, Department of Orthopaedics, The University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania (Drs Kissinger-Knox, Collins, Kontos, and Eagle); Inova Sports Medicine, Fairfax, Virginia (Dr West); and Office for Sport Concussion Research, Department of Health, Human Performance and Recreation, University of Arkansas, Fayetteville (Dr Elbin).

The coronavirus disease 2019 (COVID-19) pandemic has substantially altered the delivery of healthcare for providers and their patients. Patients have been reticent to seek care for many diseases and injuries including concussion due to fears of potential exposure to COVID-19. Moreover, because of social distancing recommendations and stay-at-home orders, patient screening, evaluation, and delivery of care have become less efficient or impossible to perform via in-person clinic visits. Read More

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Escalating morphine dosage fails to elicit conditioned analgesia in a preclinical chronic neuropathic pain model.

Behav Pharmacol 2021 Jul 26. Epub 2021 Jul 26.

School of Medical Sciences (Neuroscience) and the Brain and Mind Centre, The University of Sydney, New South Wales, Australia.

Many people with chronic pain escalate their opioid dosage to counteract tolerance effects. A treatment regimen consisting of placebos admixed with opioids has been suggested as a possible therapeutic option that could reduce the harm of long-term opioid use. However, the analgesic efficacy of such a regimen requires further investigation before widespread adoption. Read More

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Long-Term Amnioinfusion through an Intrauterine Catheter in Preterm Premature Rupture of Membranes before 26 Weeks of Gestation: A Retrospective Multicenter Study.

Fetal Diagn Ther 2021 Jul 28:1-6. Epub 2021 Jul 28.

Department of Gynecology, Fertility, and Fetal Therapy, Polish Mother's Memorial Hospital Research Institute, Lodz, Poland.

Introduction: The objective of this study was to elucidate the efficacy of long-term amnioinfusion on perinatal outcomes in patients with preterm premature rupture of membranes (PPROM) before 26 weeks' gestation.

Material: A total of 31 patients with PPROM at a periviable gestational age (21 + 0-25 + 0 weeks) were enrolled. Long-term amnioinfusion was performed in 22 patients, and 9 patients did not receive amnioinfusion. Read More

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Comparative Efficacy and Acceptability of 3 Repetitive Transcranial Magnetic Stimulation Devices for Depression: A Meta-Analysis of Randomized, Sham-Controlled Trials.

Neuropsychobiology 2021 Jul 28:1-9. Epub 2021 Jul 28.

Department of Psychiatry, The Jikei University School of Medicine, Tokyo, Japan.

Introduction: Repetitive transcranial magnetic stimulation (rTMS) has been employed worldwide for therapy-resistant depression. The Food and Drug Administration has approved a number of therapeutic devices for treating major depressive disorder; however, no studies have examined the differences in efficacy and acceptability among commercially available stimulation devices. The aim of our study was to compare the efficacy and acceptability of 3 stimulation devices (NeuroStar, MagPro, and Magstim) for depressive disorders. Read More

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The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation.

Aging (Albany NY) 2021 Jul 28;13(undefined). Epub 2021 Jul 28.

Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Fraxetin, a natural product isolated and purified from the bark of , has anti-inflammatory, analgesic, and anti-dysenteric activities. This study aimed to investigate the anti-tumor effects of fraxetin in pancreatic ductal adenocarcinoma (PDA). The effects of fraxetin on the malignant biological behavior of PDA were evaluated. Read More

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Eco-friendly sunscreen formulation based on starches and PEG-75 lanolin increases the antioxidant capacity and the light scattering activity in the visible light.

J Photochem Photobiol B 2021 Jul 22;222:112264. Epub 2021 Jul 22.

Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Department of Dermatology, Venereology and Allergology, Charitéplatz 1, 10117 Berlin, Germany. Electronic address:

Most modern sunscreens contain physical filters, which scatter the sunlight, increasing the photons' pathway in the upper stratum corneum. This effect can lead to a better efficacy of the UV filters and improve the diffuse reflection. However, the addition of nanosized inorganic UV filters reduces the antioxidant capacity of sunscreen formulations. Read More

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Survival advantage of treosulfan plus fludarabine before allogeneic hematopoietic cell transplantation for older or comorbid patients with myeloid malignancies.

Transplant Cell Ther 2021 Jul 25. Epub 2021 Jul 25.

Hematology Department - BMT Unit, G Papanicolaou Hospital, Thessaloniki; Greece.

Background: We have previously shown an advantage of a myeloablative conditioning regimen with reduced toxicity (Fludarabine 150mg/m, Treosulfan 42g/m, FluTreo) compared to a reduced intensity regimen (RIC).

Objectives: We aimed to determine long-term safety and efficacy of FluTreo.

Study Design: We prospectively studied consecutive patients that received FluTreo in our center (2014-2019) based on age (≥50 years), hematopoietic cell transplantation comorbidity index/HCT-CI≥2, or both. Read More

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Molecular epidemiology and clinical risk factors for rifaximin-nonsusceptible Clostridioides difficile infection in South Korea: a prospective multicenter observational study.

J Glob Antimicrob Resist 2021 Jul 25. Epub 2021 Jul 25.

Department of Laboratory Medicine and Research Institute of Bacterial Resistance, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

Introduction: This study was designed to investigate the molecular epidemiology of Clostridioides difficile in South Korea, and to evaluate the risk factors of rifaximin-nonsusceptible C. difficile infections (CDI).

Methods: A total of 413 patients with CDI from two sentinel hospitals in South Korea were enrolled in this study. Read More

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Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding.

Cell Rep 2021 Jul 20:109493. Epub 2021 Jul 20.

Institut für Virologie, Freie Universität Berlin, Berlin, Germany. Electronic address:

Safe and effective vaccines are urgently needed to stop the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a series of live attenuated vaccine candidates by large-scale recoding of the SARS-CoV-2 genome and assess their safety and efficacy in Syrian hamsters. Animals were vaccinated with a single dose of the respective recoded virus and challenged 21 days later. Read More

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Rituximab for the Treatment of Refractory Cardiac Sarcoidosis-A Single Center Experience.

J Card Fail 2021 Jul 25. Epub 2021 Jul 25.

Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Division of Epidemiology, Department of Health Sciences Research, Rochester, MN, USA.

Objective: To examine the effect of anti-B cell therapy (rituximab) on cardiac inflammation and function in corticosteroid-refractory cardiac sarcoidosis.

Background: Cardiac sarcoidosis (CS) is a rare cause of cardiomyopathy characterized by granulomatous inflammation involving the myocardium. While typically responsive to corticosteroid treatment, there is a critical need for identifying effective steroid-sparing agents for disease control. Read More

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Risdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls.

N Engl J Med 2021 Jul;385(5):427-435

From the Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston (B.T.D.); the Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (R.M., G.B.), and the Center of Translational and Experimental Myology, IRCCS Istituto Giannina Gaslini, Genoa (C.B.) - both in Italy; the Department of Developmental Neurology, Medical University of Gdańsk, Gdańsk, Poland (M.M.-B.); the Paediatric Gait Analysis Service of New South Wales, the Children's Hospital at Westmead and the University of Sydney, Sydney (K.R.); the Department of Pediatrics, Peking University First Hospital, Beijing (H.X.), and Children's Hospital of Fudan University, Shanghai (Y.W.) - both in China; the Department of Neurology, Faculdade de Medicina, Universidade de São Paulo, São Paulo (E.Z.); the Dubowitz Neuromuscular Centre, National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, and Great Ormond Street Hospital for Children NHS Foundation Trust, London (G.B.), Roche Products, Welwyn Garden City (M.E.-K.), and the Muscular Dystrophy UK Oxford Neuromuscular Centre, the Department of Paediatrics, University of Oxford, Oxford (L.S.) - all in the United Kingdom; Russian Children Neuromuscular Center, Veltischev Clinical Pediatric Research Institute, Pirogov Russian National Research Medical University, Moscow (D.V.); Pharma Development, Safety (M.G.), Product Development Medical Affairs - Neuroscience and Rare Disease (K.G., P.F.), and Pharma Development Neurology (R.S.S.), F. Hoffmann-La Roche, and Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel (O.K., H.K.) - both in Basel, Switzerland; the Division of Child Neurology, Centre de Références des Maladies Neuromusculaires, the Department of Pediatrics, University Hospital Liege, University of Liege, Liege, Belgium (L.S.); and I-Motion, Institut de Myologie, Assistance Publique Hôpitaux de Paris, Hôpital Armand Trousseau, Paris (L.S.).

Background: Type 1 spinal muscular atrophy (SMA) is a progressive neuromuscular disease characterized by an onset at 6 months of age or younger, an inability to sit without support, and deficient levels of survival of motor neuron (SMN) protein. Risdiplam is an orally administered small molecule that modifies pre-messenger RNA splicing and increases levels of functional SMN protein in blood.

Methods: We conducted an open-label study of risdiplam in infants with type 1 SMA who were 1 to 7 months of age at enrollment. Read More

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Covid-19 Breakthrough Infections in Vaccinated Health Care Workers.

N Engl J Med 2021 Jul 28. Epub 2021 Jul 28.

From the Infection Prevention and Control Unit (M.B., T.G., C.C., E.G.L., C.R., I.T., M.Z., G.R.-Y.), the Department of Clinical Microbiology (S.A.), General Management (Y.K.), and the Central Virology Laboratory, Public Health Authority, Ministry of Health (Y.L., M.M., V.I., N.Z.), Sheba Medical Center Tel Hashomer, Ramat Gan, Sackler School of Medicine, Tel Aviv University, Tel Aviv (T.G., Y.L., M.M., E.G.L., Y.K., G.R.-Y.), and the Laboratory Wing, Asaf Harofe Medical Center, Be'er Ya'akov (A.B.-C.) - all in Israel; St. George's School of Medicine of London and Faculty of Medicine, University of Nicosia, Nicosia, Cyprus (M.B.); and Harvard T.H. Chan School of Public Health, Boston (M.L.).

Background: Despite the high efficacy of the BNT162b2 messenger RNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), rare breakthrough infections have been reported, including infections among health care workers. Data are needed to characterize these infections and define correlates of breakthrough and infectivity.

Methods: At the largest medical center in Israel, we identified breakthrough infections by performing extensive evaluations of health care workers who were symptomatic (including mild symptoms) or had known infection exposure. Read More

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Facing the wrath of enigmatic mutations: A review on the emergence of SARS-CoV-2 variants amid COVID-19 pandemic.

Environ Microbiol 2021 Jul 28. Epub 2021 Jul 28.

Molecular Biophysics Unit, Indian Institute of Science (IISc), Bengaluru, India.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging respiratory virus responsible for the ongoing coronavirus disease 19 (COVID-19) pandemic. More than a year into this pandemic, the COVID-19 fatigue is still escalating and takes hold of the entire world population. Driven by the ongoing geographical expansion and upcoming mutations, the COVID-19 pandemic has taken a new shape in the form of emerging SARS-CoV-2 variants. Read More

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Factors associated with the stone-free status after retrograde intrarenal surgery in children.

Int J Clin Pract 2021 Jul 28:e14667. Epub 2021 Jul 28.

Department of Urology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Introduction: Pediatric urolithiasis has a recurrent nature because it is frequently associated with metabolic or anatomical disorders or infectious conditions. The rising incidence of the disease with its recurrent nature emphasizes the need for minimally invasive therapeutic options. In this study, we aimed to evaluate efficacy and factors affecting the success of retrograde intrarenal surgery (RIRS) in children. Read More

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Efficacy of ixekizumab on nail psoriasis in pediatric patients with moderate-to-severe psoriasis: a post-hoc analysis from IXORA-PEDS.

J Eur Acad Dermatol Venereol 2021 Jul 28. Epub 2021 Jul 28.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Nail psoriasis (NP) has been proposed as a potential clinical predictor for a more severe disease course in children with psoriasis but data regarding NP in children is scarce. Ixekizumab (IXE), a high-affinity monoclonal antibody that selectively targets interleukin-(IL)-17A, is an EMA and FDA approved treatment for pediatric (≥6 years old) and adult patients with moderate-to-severe psoriasis and provides rapid clinically meaningful improvements in skin, itch and quality of life (QoL) outcomes at week 12. Read More

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Open-label follow-on study evaluating the efficacy, safety, and quality of life with extended daily oral immunotherapy in children with peanut allergy.

Allergy 2021 Jul 28. Epub 2021 Jul 28.

University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR, USA.

Background: The benefit of daily administration of Peanut (Arachis hypogaea) Allergen Powder-dnfp (PTAH)-formerly AR101-has been established in clinical trials, but limited data past the first year of treatment are available. This longitudinal analysis aimed to explore the impact of continued PTAH therapeutic maintenance dosing (300 mg/day) on efficacy, safety/tolerability, and food allergy-related quality of life.

Methods: We present a subset analysis of PALISADE-ARC004 participants (aged 4-17 years) who received 300 mg PTAH daily for a total of ~1. Read More

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Resistance to Bruton's Tyrosine Kinase Inhibitors: The Achilles Heel of Their Success Story in Lymphoid Malignancies.

Blood 2021 Jul 28. Epub 2021 Jul 28.

The University of Cincinnati, Cincinnati, Ohio, United States.

Bruton's tyrosine kinase inhibitors (BTKi) have significantly changed the treatment landscape for patients with B-cell malignancies including chronic lymphocytic leukemia (CLL), Waldenstrom's macroglobulinemia (WM), mantle cell lymphoma (MCL), and marginal zone lymphoma (MZL). Unfortunately, patients with BTKi resistant disease have shortened survival. Clinical and molecular risk factors, such as number of prior therapies and presence of TP53 mutations, can be used to predict patients at the highest risk of developing BTKi resistance. Read More

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Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis.

Rev Soc Bras Med Trop 2021 23;54:e00172021. Epub 2021 Jul 23.

Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA, Brasil.

Introduction: Tuberculosis (TB) is the leading cause of death worldwide caused by a single infectious disease agent. Brazil, Russia, India, China, and South Africa (BRICS) account for more than half of the world's TB cases. Bacillus Calmette-Guérin (BCG) remains the only vaccine available despite its variable efficacy. Read More

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Reconnection Sites in Redo Ablation after Cryoballoon Pulmonary Vein Isolation in Patients with Paroxysmal Atrial Fibrillation.

Arq Bras Cardiol 2021 Jul;117(1):100-105

Centro Medico Nacional 20 de Noviembre - Hemodinamia y Electrofisiologua, Ciudad de México - México.

Background: In paroxysmal atrial fibrillation (PAF), pulmonary vein isolation using cryoballoon (CB-PVI) has similar efficacy as radiofrequency ablation (RF-PVI) has. In redo ablation procedures following RF-PVI, PV reconnection is high, whereas in patients with redo following CB-PVI, information is scarce.

Objective: To determine the sites of PV reconnection in patients who underwent redo ablation after initial CB-PVI. Read More

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A comparative study to evaluate the effects of antibiotics, plant extracts and fluoride-based toothpaste on the oral pathogens isolated from patients with gum diseases in Pakistan.

Braz J Biol 2021 26;83:e242703. Epub 2021 Jul 26.

Hazara University Mansehra, Department of Biotechnology and Genetic Engineering , Hazara, Pakistan.

Oral diseases caused by various microorganisms are common around the world. Scientific research has now been focusing on novel medicines to overcome bacterial resistance and antibiotics side effects; therefore, the current study was designed to assess the efficacy of certain antibiotics, toothpaste, and medicinal plant extracts (Ajuga bracteosa and Curcuma longa) versus the bacterial pathogens isolated from the human oral cavity. A total of 130 samples were collected from Khyber Teaching Hospital Peshawar, Pakistan, among those 27 species isolated, and eight bacterial species were identified from the samples. Read More

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Efficacy of the Chinese version interpretation bias modification training in an unselected sample: A randomized trial.

PLoS One 2021 28;16(7):e0255224. Epub 2021 Jul 28.

Faculty of Psychology, Naval Medical University, Shanghai, China.

Training individuals to interpret ambiguous information in positive ways might be an effective method of reducing social anxiety. However, little research had been carried out in Chinese samples, and the effect of interpretation training on other processes such as attentional bias also remained unclear. This study examined the effect of interpretation bias modification program (IMP) on interpretation bias, social anxiety and attentional bias, and the possible mediation effects. Read More

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Host immunity increases Mycobacterium tuberculosis reliance on cytochrome bd oxidase.

PLoS Pathog 2021 Jul 28;17(7):e1008911. Epub 2021 Jul 28.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.

In order to sustain a persistent infection, Mycobacterium tuberculosis (Mtb) must adapt to a changing environment that is shaped by the developing immune response. This necessity to adapt is evident in the flexibility of many aspects of Mtb metabolism, including a respiratory chain that consists of two distinct terminal cytochrome oxidase complexes. Under the conditions tested thus far, the bc1/aa3 complex appears to play a dominant role, while the alternative bd oxidase is largely redundant. Read More

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Emergence of equine-like G3 strains as the dominant rotavirus among children under five with diarrhea in Sabah, Malaysia  during 2018-2019.

PLoS One 2021 28;16(7):e0254784. Epub 2021 Jul 28.

Faculty of Medicine and Health Sciences, Department of Pathobiology and Medical Diagnostics, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia.

Rotavirus infection is a dilemma for developing countries, including Malaysia. Although commercial rotavirus vaccines are available, these are not included in Malaysia's national immunization program. A scarcity of data about rotavirus genotype distribution could be partially to blame for this policy decision, because there are no data for rotavirus genotype distribution in Malaysia over the past 20 years. Read More

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Mathematical modeling of N-803 treatment in SIV-infected non-human primates.

PLoS Comput Biol 2021 Jul 28;17(7):e1009204. Epub 2021 Jul 28.

Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana, United States of America.

Immunomodulatory drugs could contribute to a functional cure for Human Immunodeficiency Virus (HIV). Interleukin-15 (IL-15) promotes expansion and activation of CD8+ T cell and natural killer (NK) cell populations. In one study, an IL-15 superagonist, N-803, suppressed Simian Immunodeficiency Virus (SIV) in non-human primates (NHPs) who had received prior SIV vaccination. Read More

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Acute Citrulline-Malate Supplementation Increases Total Work in Short Lower-Body Isokinetic Tasks for Recreationally Active Females During Menstruation.

J Strength Cond Res 2021 Jul 26. Epub 2021 Jul 26.

Department of Health, Human Performance, and Recreation, Exercise Science Research Center, University of Arkansas, Fayetteville, Arkansas; Neurotrack Technologies, Inc., Redwood City, California; Department of Kinesiology, Louisiana Tech University, Ruston, Louisiana; Department of Exercise Science, High Point University, High Point, North Carolina; and Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas.

Abstract: Gills, JL, Spliker, B, Glenn, JM, Szymanski, D, Romer, B, Lu, H-C, and Gray, M. Acute citrulline-malate supplementation increases total work in short lower-body isokinetic tasks for recreationally active females during menstruation. J Strength Cond Res XX(X): 000-000, 2021-Citrulline-Malate (CM) exhibits acute ergogenic benefits through nitric oxide production (NO) and augmentation of vasodilatory properties. Read More

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Long-term Results of Nd: YAG Goniopuncture on Viscocanalostomy and Phacoviscocanalostomy.

J Glaucoma 2021 Jul 28. Epub 2021 Jul 28.

Stanley Eye Unit, Abergele Hospital, Llanfair Road, Abergele, Conwy, Wales LL22 8DP Moorfields Eye Hospital, 162 City Rd, London EC1V 2PD.

Prcis: Laser goniopuncture is an effective outpatient procedure which has been shown to maintain reduced intraocular pressure 5 years following initial laser treatment in patients who have had viscocanalostomy (with or without phacoemulsification).

Purpose: To establish the long term (5 year) efficacy of neodymium-doped:yttrium aluminium-garnet laser goniopuncture to lower intraocular pressure following viscocanalostomy or phacoviscocanalostomy in patients with glaucoma.

Patients And Methods: This retrospective study analysed patients who underwent laser goniopuncture following viscocanalostomy+/-phacoemulsification between 2009 to 2012 at the Stanley Eye Unit in Abergele. Read More

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Induction Therapy With Antithymocyte Globulin and Delayed Calcineurin Inhibitor Initiation for Renal Protection in Liver Transplantation: A Multicenter Randomized Controlled Phase II-B Trial.

Transplantation 2021 Jul 27. Epub 2021 Jul 27.

Digestive Disease and Surgery Institute, Transplant Center, Cleveland Clinic, Cleveland, OH. Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH. Transplant Center, Cleveland Clinic Weston, Weston, FL. Division of Transplantation Surgery, Medical College of Wisconsin, Milwaukee, WI. Transplantation Institute, University of Chicago Medicine, Chicago, IL.

Background: Calcineurin inhibitor (CNI) based immunosuppression in liver transplantation (LTx) is associated with acute and chronic deterioration of kidney function. Delaying CNI initiation by using induction rabbit anti-thymocyte globulin (rATG) may provide kidneys with adequate time to recover from a perioperative insult reducing the risk of early post-LTx renal deterioration.

Methods: This was an open-label, multicenter, randomized controlled clinical trial comparing use of induction rATG with delayed CNI initiation (day-10) against upfront CNI commencement (SOC; standard of care) in those patients deemed at standard risk of postoperative renal dysfunction following LTx. Read More

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Machine Learning-Enabled High-Resolution Dynamic Deuterium MR Spectroscopic Imaging.

IEEE Trans Med Imaging 2021 Jul 28;PP. Epub 2021 Jul 28.

Deuterium magnetic resonance spectroscopic imaging (DMRSI) has recently been recognized as a potentially powerful tool for noninvasive imaging of brain energy metabolism and tumor. However, the low sensitivity of DMRSI has significantly limited its utility for both research and clinical applications. This work presents a novel machine learning-based method to address this limitation. Read More

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