889,857 results match your criteria efficacy


Polycystic ovary syndrome and infertility: an update.

Int J Adolesc Med Health 2021 Jul 22. Epub 2021 Jul 22.

Regional Research Institute of Unani Medicine, Srinagar, Jammu and Kashmir, India.

Polycystic ovarian syndrome is the most well-known endocrine condition among women of this generation (PCOS). Symptoms of hyperandrogenism, irregular menstrual periods, and insulin resistance are all traits associated with PCOS. In women with PCOS, the chance of having problems including infertility, insulin resistance, and type 2 diabetes increases. Read More

View Article and Full-Text PDF

Diagnostic accuracy of a novel artificial intelligence system for adenoma detection in daily practice: a prospective non-randomized comparative study.

Endoscopy 2021 Jul 22. Epub 2021 Jul 22.

Department of Gastroenterology and interventional Endoscopy, Krankenhaus Barmherzige Bruder Regensburg, Regensburg, Germany.

Background And Aims: Adenoma detection rate (ADR) varies significantly between endoscopists with up to 26% adenoma miss rate (AMR). Artificial intelligence (AI) systems may improve endoscopic quality and reduce the rate of interval cancer. We evaluated the efficacy of an AI system in real time colonoscopy and its influence on the AMR and the ADR. Read More

View Article and Full-Text PDF

Tocilizumab for the Management of Thyroid-Associated Orbitopathy.

Ophthalmic Plast Reconstr Surg 2021 Jul 21. Epub 2021 Jul 21.

The Pacific Center for Oculofacial and Aesthetic Plastic Surgery, San Francisco, California, U.S.A. California Pacific Medical Center, San Francisco, California, U.S.A. University of California San Francisco, San Francisco, California, U.S.A.

Purpose: To describe the efficacy of tocilizumab in the treatment of a cohort of patients with active thyroid-associated orbitopathy.

Methods: Patients were identified with active thyroid-associated orbitopathy who were intolerant of or had progression of disease despite systemic corticosteroids and subsequently were treated with tocilizumab between January 2015 and December 2020. Clinical Activity Score, Thyroid-Associated Ophthalmopathy Scale score, and thyroid-stimulating immunoglobulin levels were assessed prior to initiation of tocilizumab, following the first dose, and after the completion of treatment. Read More

View Article and Full-Text PDF

Intraoral Hirudotherapy for Venous Congestion following Free Flap Head and Neck Reconstruction: Novel Intraoral Technique.

ORL J Otorhinolaryngol Relat Spec 2021 Jul 22:1-4. Epub 2021 Jul 22.

Division of Otolaryngology - Head and Neck Surgery, Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

Intraoral hirudotherapy is traditionally used for venous congestion following head and neck free flap reconstruction. Many institutions and healthcare teams have been reluctant to use intraoral leech therapy due to risks such as migration into the airway, increased infection from intraoral manipulation, and patient discomfort. Several protocols recommend blocking the path to the oropharynx via gauze or leaving a tracheotomy in place to protect the airway. Read More

View Article and Full-Text PDF

Ferric Citrate Dosing in Iron Deficiency Anemia in Nondialysis-Dependent Chronic Kidney Disease.

Am J Nephrol 2021 Jul 22:1-10. Epub 2021 Jul 22.

Akebia Therapeutics, Inc., Cambridge, Massachusetts, USA.

Introduction: Ferric citrate (FC) is indicated as an oral iron replacement for iron deficiency anemia in adult patients with chronic kidney disease (CKD) not on dialysis. The recommended starting dose is one 1-g tablet three times daily (TID). This study investigated long-term efficacy and safety of different FC dosing regimens for treating anemia in nondialysis-dependent CKD (NDD-CKD). Read More

View Article and Full-Text PDF

Efficacy of double antibiotics in hydroxypropyl methylcellulose for bactericidal activity against Enterococcus faecalis and Streptococcus gordonii in biofilm.

Arch Oral Biol 2021 Jul 16;129:105210. Epub 2021 Jul 16.

Center of Excellence in Oral and Maxillofacial Biology, Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. Electronic address:

Objective: This study aimed to investigate the efficacy of double antibiotics, including ciprofloxacin and metronidazole, in a new vehicle, hydroxypropyl methylcellulose (HPMC), against Enterococcus faecalis and Streptococcus gordonii grown in biofilm.

Design: Human mandibular premolars were prepared and divided into four groups: (i) negative control, (ii) positive control, (iii) infected with E. faecalis and S. Read More

View Article and Full-Text PDF

Efficacy and tolerability of Melatonin vs Triclofos to achieve sleep for pediatric electroencephalography: A single blinded randomized controlled trial.

Eur J Paediatr Neurol 2021 Jul 7;34:14-20. Epub 2021 Jul 7.

Department of Pediatrics, Bharati Vidyapeeth Deemed University Medical College, Pune, India. Electronic address:

Purpose: To compare Melatonin with Triclofos for efficacy (proportion of successful EEG, need of augmentation, sleep onset latency (SOL), yield of discharges, duration of sleep, presence and grade of artifacts) and tolerability (adverse effect profile).

Methods: A randomized trial was performed (block randomization). All children were advised regarding sleep deprivation, EEG technician administered the drug. Read More

View Article and Full-Text PDF

The efficacy of acoustic therapy versus oral medication for chronic tinnitus: A meta-analysis.

Am J Otolaryngol 2021 Jun 18;42(6):103116. Epub 2021 Jun 18.

Department of Otorhinolaryngology-Head and Neck Surgery, The first hospital of Jilin University, Changchun, Jilin 130021, PR China.

Purpose: To compare the efficacy of acoustic therapy (AT) and drug therapy (DT) for chronic tinnitus.

Methods: We searched Pubmed, ScienceDirect, Chinese Journal Full-text Database (CNKI), Wanfang Database, Chinese Biomedical Literature Database (CBM), Embase, and Cochrane Library from the establishment of the database to December 2019. Meta-analysis was performed on the Tinnitus Handicap Inventory (THI) score and Visual Analogue Scale (VAS) with included literature using Revman 5. Read More

View Article and Full-Text PDF

Neurotransmitters and Neuropeptides decrease PD-1 in T cells of healthy subjects and patients with hepatocellular carcinoma (HCC), and increase their proliferation and eradication of HCC cells.

Neuropeptides 2021 May 12;89:102159. Epub 2021 May 12.

Institute of Gene Therapy, Hadassah Hebrew University Hospital, Ein Karem, Jerusalem 91120, Israel.

T cells of aged people, and of patients with either cancer or severe infections (including COVID-19), are often exhausted, senescent and dysfunctional, leading to increased susceptibilities, complications and mortality. Neurotransmitters and Neuropeptides bind their receptors in T cells, and induce multiple beneficial T cell functions. Yet, T cells of different people vary in the expression levels of Neurotransmitter and Neuropeptide receptors, and in the magnitude of the corresponding effects. Read More

View Article and Full-Text PDF

Leveraging unsupervised image registration for discovery of landmark shape descriptor.

Med Image Anal 2021 Jul 9;73:102157. Epub 2021 Jul 9.

Scientific Computing and Imaging Institute, 72 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA; School of Computing, 50 Central Campus Dr, University of Utah, Salt Lake City, Utah-84112, USA.

In current biological and medical research, statistical shape modeling (SSM) provides an essential framework for the characterization of anatomy/morphology. Such analysis is often driven by the identification of a relatively small number of geometrically consistent features found across the samples of a population. These features can subsequently provide information about the population shape variation. Read More

View Article and Full-Text PDF

3D Modeling in Training, Simulation, and Surgical Planning in Open Vascular and Endovascular Neurosurgery: A Systematic Review of the Literature.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Neurosurgery, University of Illinois at Chicago, Chicago, Illinois.

Background: The expanding use of three-dimensional (3D) printing in open vascular and endovascular neurosurgery presents a promising new tool in resident learning as well as operative planning. Recent studies have investigated the accuracy, efficacy, and practicality of 3D printed models of patient-specific pathology.

Objective: To review the current literature exploring 3D modeling in neurovascular and endovascular surgery for training, simulation, and surgical preparation. Read More

View Article and Full-Text PDF

Spinous process screw fixation: A salvage technique in sub-axial cervical spinal instrumentation.

World Neurosurg 2021 Jul 19. Epub 2021 Jul 19.

Department of Orthopaedics, Peking University Third Hospital, Beijing, China. Electronic address:

Objective: To evaluate the feasibility and efficacy of spinous process screws (SPS) in sub-axial cervical fixation.

Methods: A retrospective study was conducted on seven patients receiving posterior cervical instrumentation for sub-axial fracture dislocation or atlantoaxial dislocation from 2014 to 2015. Additionally, a biomechanical test was performed on seven fresh-frozen cadaveric spine samples (from the occiput to C7) from healthy human subjects with no history of spinal trauma. Read More

View Article and Full-Text PDF

Improving severity scoring of food-induced allergic reactions: a global "Best-Worst Scaling" exercise.

J Allergy Clin Immunol Pract 2021 Jul 19. Epub 2021 Jul 19.

National Heart & Lung Institute, Imperial College London, London, UK;. Electronic address:

Background: There is no current consensus on assigning severity to food-induced allergic reactions, for example to assess the efficacy of allergen immunotherapy. Existing severity scores lack the capability to discriminate between non-anaphylaxis reactions of different severities. Attempts are ongoing to develop a more discriminatory score, which should ideally be data-driven and validated in multiple cohorts. Read More

View Article and Full-Text PDF

Safety, efficacy, and serum concentration monitoring of bedaquiline in Chinese patients with multidrug-resistant tuberculosis.

Int J Infect Dis 2021 Jul 19. Epub 2021 Jul 19.

Affiliated Hangzhou Chest Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China. Electronic address:

Objectives: To determine the safety and efficacy of bedaquiline for Chinese multidrug-resistant tuberculosis patients based on serum concentration monitoring and identify factors associated with QTc prolongation occurring during treatment.

Methods: We collected data from 35 patients who received treatment regimens containing bedaquiline for multidrug-resistant tuberculosis (MDR-TB) from May 2018 to December 2020. Blood samples were collected, and serum concentrations of bedaquiline were measured using high-performance liquid chromatography-mass spectrometry. Read More

View Article and Full-Text PDF

Pembrolizumab for locally advanced and recurrent/metastatic cutaneous squamous cell carcinoma (KEYNOTE-629 Study): an open-label, nonrandomized, multicenter, phase 2 trial.

Ann Oncol 2021 Jul 19. Epub 2021 Jul 19.

Service de Dermatologie et Cancérologie Cutanée, Aix-Marseille University, Marseille, France.

Background: Pembrolizumab demonstrated clinically meaningful and durable antitumor activity with a manageable safety profile in recurrent/metastatic (R/M) cutaneous squamous cell carcinoma (cSCC).

Patients And Methods: KEYNOTE-629 was a global, open-label, nonrandomized, phase 2 trial of patients with locally advanced (LA) or R/M cSCC conducted at 59 centers. Eligible patients received intravenous pembrolizumab 200 mg every three weeks for up to 35 cycles. Read More

View Article and Full-Text PDF

The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognosis.

Crit Rev Oncol Hematol 2021 Jul 19:103429. Epub 2021 Jul 19.

NICM Health Research Institute, Western Sydney University, Penrith, NSW 2747, Australia. Electronic address:

The association between human gut microbiota and cancers has been an evolving field of biomedical research in recent years. The gut microbiota is composed of the microorganisms residing in the gastrointestinal system that interact with the host to regulate behaviours and biochemical processes within the gut. This symbiotic physiological interaction between the gut and the microbiota plays a significant role in the modulation of gut homeostasis, in which perturbations to the microbiota, also known as dysbiosis can lead to the onset of diseases, including cancer. Read More

View Article and Full-Text PDF

Nonoperative and Operative Soft-Tissue, Cartilage, and Bony Regeneration and Orthopaedic Biologics of the Shoulder: An Orthoregeneration Network (ON) Foundation Review.

Arthroscopy 2021 Jul 19. Epub 2021 Jul 19.

Midwest Orthopaedics at Rush, Chicago, IL, USA. Electronic address:

Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electro-magnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes. Read More

View Article and Full-Text PDF

Comparison of standing stability with different doses in epidural fentanyl among post-cesarean delivery women: a prospective trial.

Braz J Anesthesiol 2021 Jul 19. Epub 2021 Jul 19.

The Hospital for Sick Children, Department of Anesthesia and Pain Medicine, Toronto, Canada.

Background: The study purpose was to determine the safety and efficacy of different doses of epidural fentanyl plus local anesthetics on ambulation for patients who had elective cesarean delivery.

Methods: A prospective study at a single community hospital used posturography to compute Sway area for assessment of standing stability [ISRCTN14517337]. Continuous epidural infusion of 0. Read More

View Article and Full-Text PDF

Design and evaluation of GLP-1 receptor G-protein biased agonist with prolonged efficacy on diabetes.

Life Sci 2021 Jul 19:119844. Epub 2021 Jul 19.

Peking University Third Hospital, Beijing 100191, PR China. Electronic address:

Aim: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as potent drug development target for treating diabetes and obesity. Here, we designed and evaluated novel long-acting GLP-1R G protein biased agonist with potent clinical application.

Main Methods: GLP-1R G-protein biased sequences were screened via a high-throughput autocrine-based strategy and then fused to Exendin (9-39). Read More

View Article and Full-Text PDF

Cutaneous manifestations of chimeric antigen receptor T cell therapy: an introduction for dermatologists.

J Am Acad Dermatol 2021 Jul 19. Epub 2021 Jul 19.

Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. Electronic address:

Chimeric antigen receptor T cell therapy is an emerging immunotherapy with promising efficacy for the treatment of previously refractory or relapsed malignancies. As a personalized medicine approach, T cells are genetically engineered to express a receptor designed to bind a specific tumor antigen, leading to selective immune-mediated destruction of tumor cells. Due to the novelty of chimeric antigen receptor T cell therapy, the safety profile continues to evolve with limited information currently available on cutaneous adverse events. Read More

View Article and Full-Text PDF

A review of regulated self-organizing approaches for tissue regeneration.

Prog Biophys Mol Biol 2021 Jul 19. Epub 2021 Jul 19.

Department of Gynaecology and Obstetrics, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, 210004, China. Electronic address:

Tissue and organ regeneration is the dynamic process by which a population of cells rearranges into a specific form with specific functions. Traditional tissue regeneration utilizes tissue grafting, cell implantation, and structured scaffolds to achieve clinical efficacy. However, tissue grafting methods face a shortage of donor tissue, while cell implantation may involve leakage of the implanted cells without a supportive 3D matrix. Read More

View Article and Full-Text PDF

Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2.

J Control Release 2021 Jul 19. Epub 2021 Jul 19.

Institute of Inorganic Chemistry, Department of Chemistry, , University of Cologne, Greinstraße 6, 50939 Cologne, Germany.

The coronavirus disease-19 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has taken the world by surprise. To date, a worldwide approved treatment remains lacking and hence in the context of rapid viral spread and the growing need for rapid action, drug repurposing has emerged as one of the frontline strategies in the battle against SARS-CoV2. Repurposed drugs currently being evaluated against COVID-19 either tackle the replication and spread of SARS-CoV2 or they aim at controlling hyper-inflammation and the rampaged immune response in severe disease. Read More

View Article and Full-Text PDF

Is flow control in a space-constrained drainage network effective? A performance assessment for combined sewer overflow reduction.

Environ Res 2021 Jul 19:111688. Epub 2021 Jul 19.

Eawag, Swiss Federal Institute of Aquatic Science and Technology, 8600, Dübendorf, Switzerland; Environmental Systems Dynamics Laboratory, University of California Berkeley, CA, 94720, USA.

Recurring combined sewer overflows (CSOs) can have a significant impact on the ecological condition of receiving water bodies. There are several structural measures, like adding retention basins and switching to low impact development solutions, that have been proposed to reduce the number of sewage overflows. Besides, several flow control strategies have been discussed in scientific literature that take advantage of the space within urban drainage networks, which is assumed to be adequate, for temporary storage. Read More

View Article and Full-Text PDF

Efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in patients with type 2 diabetes (SUSTAIN FORTE): a double-blind, randomised, phase 3B trial.

Lancet Diabetes Endocrinol 2021 Jul 19. Epub 2021 Jul 19.

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC, USA.

Background: Semaglutide is an effective treatment for type 2 diabetes; however, 20-30% of patients given semaglutide 1·0 mg do not reach glycaemic treatment goals. We aimed to investigate the efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in adults with inadequately controlled type 2 diabetes on a stable dose of metformin with or without a sulfonylurea.

Methods: We did a 40-week, randomised, active-controlled, parallel-group, double-blind, phase 3B trial (SUSTAIN FORTE) at 125 outpatient clinics in ten countries. Read More

View Article and Full-Text PDF

The role of psychosocial factors in the decision to enroll in physical education courses at the state college level.

J Am Coll Health 2021 Jul 22:1-8. Epub 2021 Jul 22.

Department of Health Sciences, College of Health Professions and Sciences, University of Central Florida, Orlando, Florida, USA.

Objective: Physical education (PE) courses may provide young adults with opportunities to become active, however, enrollment in college PE courses remains low.

Participants: This study examined psychosocial factors related to PE enrollment in a sample of 177 college students (29.4% completed a PE course). Read More

View Article and Full-Text PDF

The effect of esketamine in patients with treatment-resistant depression with and without comorbid anxiety symptoms or disorder.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Department of Neuroscience, Janssen Research & Development, LLC, San Diego, California, USA.

Background: Comorbid anxiety is generally associated with poorer response to antidepressant treatment. This post hoc analysis explored the efficacy of esketamine plus an antidepressant in patients with treatment-resistant depression (TRD) with or without comorbid anxiety.

Methods: TRANSFORM-2, a double-blind, flexible-dose, 4-week study (NCT02418585), randomized adults with TRD to placebo or esketamine nasal spray, each with a newly-initiated oral antidepressant. Read More

View Article and Full-Text PDF

Efficacy of temporally intensified exposure for anxiety disorders: A multicenter randomized clinical trial.

Depress Anxiety 2021 Jul 22. Epub 2021 Jul 22.

Institute of Clinical Psychology & Psychotherapy, Technische Universität Dresden, Dresden, Germany.

Background: The need to optimize exposure treatments for anxiety disorders may be addressed by temporally intensified exposure sessions. Effects on symptom reduction and public health benefits should be examined across different anxiety disorders with comorbid conditions.

Methods: This multicenter randomized controlled trial compared two variants of prediction error-based exposure therapy (PeEx) in various anxiety disorders (both 12 sessions + 2 booster sessions, 100 min/session): temporally intensified exposure (PeEx-I) with exposure sessions condensed to 2 weeks (n = 358) and standard nonintensified exposure (PeEx-S) with weekly exposure sessions (n = 368). Read More

View Article and Full-Text PDF

Intensity-modulated radiation therapy and doxorubicin in thyroid cancer: A prospective phase 2 trial.

Cancer 2021 Jul 22. Epub 2021 Jul 22.

Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York.

Background: The use of external-beam radiotherapy for locally advanced nonanaplastic thyroid cancer remains controversial. This prospective study evaluated the efficacy and tolerability of intensity-modulated radiation therapy (IMRT) with or without concurrent chemotherapy in patients with locally advanced thyroid cancer.

Methods: The authors conducted a nonrandomized phase 2 trial of IMRT with or without concurrent doxorubicin in patients with gross residual or unresectable nonanaplastic thyroid carcinoma (ClinicalTrials. Read More

View Article and Full-Text PDF