183,163 results match your criteria effects ppgpp°

Removal of trace DNA toxic compounds using a Poly(deep eutectic solvent)@Biomass based on multi-physical interactions.

J Hazard Mater 2021 Jun 9;418:126369. Epub 2021 Jun 9.

College of Pharmaceutical Science, Institute of Life Science and Green Development, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Hebei University, Baoding 071002, China. Electronic address:

DNA toxic compounds (DNA-T-Cs), even in trace amounts, seriously threaten human health and must be completely eliminated. However, the currently used separation media face great challenges in removing trace DNA-T-Cs. Based on the functional advantages of deep eutectic solvents (DESs) and the natural features of biomass (BioM), a series of Poly(DES)@BioMs functioning as adsorbents were prepared for the removal of aromatic/hetero-atomic DNA-T-Cs at the ppm level. Read More

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Changes in molecular structure of extracellular polymeric substances (EPS) with temperature in relation to sludge macro-physical properties.

Water Res 2021 May 31;201:117316. Epub 2021 May 31.

School of Environmental Studies, China University of Geosciences, Wuhan 430074, Hubei, China; State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Extracellular polymeric substances (EPS) are important components of activated sludge, whose content and composition have important effects on the macro-physical properties of sludge. In this study, the response of EPS in sludge to temperature (-40-200 °C) was systematically investigated using XAD resin fractionation, variable-temperature infrared spectra (VTIS) and two-dimensional correlation spectroscopy (2D-COS). The relationships between the molecular structure of EPS and the macro-physical properties (rheological property and dewatering performance) of waste activated sludge (WAS) at varying temperature were also established. Read More

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Transcatheter aortic valve replacement in bicuspid valves: The synergistic effects of eccentric and incomplete stent deployment.

J Mech Behav Biomed Mater 2021 Jun 7;121:104621. Epub 2021 Jun 7.

Department of Mechanical and Materials Engineering, University of Denver, Denver, CO, USA. Electronic address:

Bicuspid aortic valve is a congenital cardiac anomaly and common etiology of aortic stenosis. Given the positive outcomes of transcatheter aortic valve replacement (TAVR) in low-risk patients, TAVR will become more prevalent in the future in the treatment of severe bicuspid valve stenosis. However, asymmetrical bicuspid valve anatomy and calcification can prevent the circular and complete expansion of transcatheter aortic valves (TAVs). Read More

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Quantitative analysis of the biomechanical response of semicircular canals and nystagmus under different head positions.

Hear Res 2021 Jun 6;407:108282. Epub 2021 Jun 6.

School of Information and Communication Engineering, Dalian University of Technology, Dalian 116024, China. Electronic address:

The semicircular canals (SCCs) in the vestibular system can sense angular motion of the head, which performs a crucial role in maintaining the human's sense of balance. The different spatial orientations of the head affect the response of human SCCs to rotational movement. In this study, we combined the numerical model of bilateral human SCCs with vestibulo-ocular reflex experiments, and quantitatively investigated the responses of SCCs to constant angular acceleration when the head was in different left-leaning positions, including the head tilted 0°, 15°, 30°, 45°, 60°, 70°, 80°, and 90° to the left. Read More

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The effect of oral omega-3 polyunsaturated fatty acid supplementation on muscle maintenance and quality of life in patients with cancer: A systematic review and meta-analysis.

Clin Nutr 2021 Apr 27;40(6):3815-3826. Epub 2021 Apr 27.

Bond University Nutrition and Dietetics Research Group, Faculty of Health Sciences and Medicine, Bond University, Gold Coast, QLD, Australia; Dietetics and Foodservices, Mater Health, South Brisbane, QLD, Australia; Mater Research Institute, University of Queensland, Brisbane, QLD, Australia.

Background & Aims: Omega-3 polyunsaturated fatty acid (PUFA) supplementation has been proposed as a potential therapy for cancer-related malnutrition, which affects up to 70% of patients with cancer. The aim of this systematic review and meta-analysis was to examine the effects of oral omega-3 PUFA supplementation on muscle maintenance, quality of life, body weight and treatment-related toxicities in patients with cancer.

Methods: Randomised controlled trials in patients with cancer aged ≥18 years were retrieved from 5 electronic databases: MEDLINE (via PubMed), EMBASE, CENTRAL, CINAHL (via EBSCOhost), and Web of Science, from database inception until 31st of December 2019. Read More

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Global Reach 2018: nitric oxide-mediated cutaneous vasodilation is reduced in chronic, but not acute, hypoxia independently of enzymatic superoxide formation.

Free Radic Biol Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA. Electronic address:

We tested the hypotheses that 1) cutaneous microvascular function is impaired by acute normobaric and chronic hypobaric hypoxia and 2) that the superoxide free radical (via NADPH oxidase or xanthine oxidase) contributes to this impairment via nitric oxide (NO) scavenging. Local heating-induced cutaneous hyperemia (39°C) was measured in the forearm of 11 male lowlanders at sea level (SL) and following 14-18 days at high altitude (HA; 4340 m in Cerro de Pasco, Peru), and compared to 11 highlanders residing permanently at this elevation. Cutaneous vascular conductance (CVC; laser-Doppler flux/mean arterial pressure) was not different during 39°C [control site: 73 (19) vs. Read More

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Evolution of an asymptomatic first stage of infection in a heterogeneous population.

J R Soc Interface 2021 Jun 16;18(179):20210175. Epub 2021 Jun 16.

Department of Molecular Biology, Princeton University, Princeton, NJ, USA.

Pathogens evolve different life-history strategies, which depend in part on differences in their host populations. A central feature of hosts is their population structure (e.g. Read More

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The impact of weather and increased atmospheric CO from 1892 to 2016 on simulated yields of UK wheat.

J R Soc Interface 2021 Jun 16;18(179):20210250. Epub 2021 Jun 16.

Computational and Analytical Sciences, Rothamsted Research, Harpenden, Hertfordshire AL5 2JQ, UK.

Climate change effects on UK winter wheat grain yield are complex: warmer temperature, negative; greater carbon dioxide (CO) concentration, positive; but other environmental variables and their timing also affect yield. In the absence of long-term experiments where temperature and CO concentration were manipulated separately, we applied the crop simulation model Sirius with long-term daily meteorological data (1892-2016) for Rothamsted, Hertfordshire, UK (2007-2016 mean growing season temperature 1.03°C warmer than 1892-1991), and CO concentration over this period, to investigate the separate effects of historic CO and weather on simulated grain yield in three wheat cultivars of the modern era. Read More

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Three-dimensional assessment of the spheno-occipital synchondrosis and clivus after tooth-borne and bone-borne rapid maxillary expansion.

Angle Orthod 2021 Jun 15. Epub 2021 Jun 15.

Objectives: To assess changes in spheno-occipital synchondrosis after rapid maxillary expansion (RME) performed with conventional tooth-borne (TB) and bone-borne (BB) appliances.

Materials And Methods: This study included 40 subjects with transverse maxillary deficiency who received TB RME or BB RME. Cone-beam computed tomography images (CBCT) were taken before treatment (T0), and after a 6-month retention period (T1). Read More

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Cement augmentation for trochanteric femur fractures: A meta-analysis of randomized clinical trials and observational studies.

PLoS One 2021 15;16(6):e0251894. Epub 2021 Jun 15.

Department of Orthopaedic and Trauma Surgery, Lucerne Cantonal Hospital, Lucerne, Switzerland.

Introduction: To date, it is unclear what the clinical benefit of cement augmentation in fixation for trochanteric fractures is. The aim of this meta-analysis is to compare cement augmentation to no augmentation in fixation of trochanteric femur fractures in the elderly patients (>65 years) following low energy trauma.

Methods: PubMed/Medline/Embase/CENTRAL/CINAHL were searched for both randomized clinical trials (RCT) and observational studies comparing both treatments. Read More

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Physiological Changes and Differential Gene Expression of Tea Plants ( (L.) Kuntze var. Q.H. Chen) Under Cold Stress.

DNA Cell Biol 2021 Jun 15. Epub 2021 Jun 15.

The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education), Institute of Agro-Bioengineering and College of Life Sciences, Guizhou University, Guiyang, China.

Low temperature is an important factor that affects the growth and reproduction of tea plants [ (L.) Kuntze]. In this study, Yunwu Tribute Tea cutting seedlings [ (L. Read More

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Fiber orientation distribution from diffusion MRI: Effects of inaccurate response function calibration.

J Neuroimaging 2021 Jun 15. Epub 2021 Jun 15.

Image Sciences Institute, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Background And Purpose: Diffusion MRI of the brain enables to quantify white matter fiber orientations noninvasively. Several approaches have been proposed to estimate such characteristics from diffusion MRI data with spherical deconvolution being one of the most widely used methods. Spherical deconvolution requires to define--or derive from the data--a response function, which is used to compute the fiber orientation distribution (FOD). Read More

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Role of meteorological factors in the transmission of SARS-CoV-2 in the United States.

Nat Commun 2021 06 14;12(1):3602. Epub 2021 Jun 14.

Department of Environmental Health Sciences, Yale School of Public Health, New Haven, CT, USA.

Improved understanding of the effects of meteorological conditions on the transmission of SARS-CoV-2, the causative agent for COVID-19 disease, is needed. Here, we estimate the relationship between air temperature, specific humidity, and ultraviolet radiation and SARS-CoV-2 transmission in 2669 U.S. Read More

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Biomechanical Effects of a 6-Week Change-of-Direction Technique Modification Intervention on Anterior Cruciate Ligament Injury Risk.

J Strength Cond Res 2021 Jun 11. Epub 2021 Jun 11.

Human Performance Laboratory, Directorate of Sport, Exercise, and Physiotherapy, University of Salford, Greater Manchester, United Kingdom; Department of Sport and Exercise Sciences, Musculoskeletal Science and Sports Medicine Research Centre, Manchester Metropolitan University, Manchester, United Kingdom; and Edith Cowan University, School of Medical and Health Science, Western Australia, Australia.

Abstract: Dos'Santos, T, Thomas, C, Comfort, P, and Jones, PA. Biomechanical effects of a 6-week change-of-direction technique modification intervention on anterior cruciate ligament injury risk. J Strength Cond Res XX(X): 000-000, 2021-The aim of this study was to evaluate the biomechanical effects of a 6-week change-of-direction (COD) technique modification intervention on anterior cruciate ligament (ACL) injury risk (i. Read More

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Development of predictive models evaluating the spoilage-delaying effect of a bioprotective culture on different yeast species in yogurt.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Dairy Bioprotection, Chr. Hansen A/S, Boege Allé 10-12, 2970 Hoersholm, Denmark.

Yeast spoilage of fermented dairy products causes challenges for the dairy industry, including economic losses due to wasted product. Food cultures with bioprotective effects are becoming more widely used to help ensure product quality throughout product shelf life. To assist the dairy industry when evaluating product quality throughout shelf life and the effect of bioprotective cultures, we aimed to build stochastic models that provide reliable predictions of yeast spoilage in yogurt with and without bioprotective culture. Read More

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Assessment of the response of indigenous microflora and inoculated Bacillus licheniformis endospores in reconstituted skim milk to microwave and conventional heating systems by flow cytometry.

J Dairy Sci 2021 Jun 11. Epub 2021 Jun 11.

Food Chemistry and Technology Department, Teagasc Food Research Centre, Moorepark, Fermoy, County Cork, P61 C996, Ireland. Electronic address:

Heat treatment is one of the most widely used processing technologies in the dairy industry. Its primary purpose is to destroy microorganisms, both pathogenic and spoilage, to ensure the product is safe and has a reasonable shelf life. In this study microwave volumetric heating (MVH) was compared with a conventional tubular heat exchanger (THE), in terms of the effects of each at a range of temperatures (75°C, 85°C, 95°C, 105°C, 115°C, and 125°C) on indigenous microflora viability and the germination of inoculated Bacillus licheniformis endospores in reconstituted skim milk. Read More

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Clinical Pharmacology of Hyperammonemia by Sodium Valproate and Carbamazepine in People Living with HIV.

CNS Spectr 2021 Apr;26(2):143

Argentine Society of Neuropsychopharmacology, Buenos Aires City, Buenos Aires, Argentina.

Introduction: Hyperammonaemia (HA) is observed in decompensated liver disease. The picture of hyperammonemic encephalopathy in non-cirrhotic patients was reported mostly associated with valproic acid. There are few reports of hyperammonemia in people living with human immunodeficiency virus (PLHIV) and they are associated with other comorbidities and few with antiretrovirals (HAART), but not as adverse drug reactions associated with psychotropic drugs associated with the virus. Read More

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Roles of Aryl-hydrocarbon Receptor in metabolism and proliferative behaviors of Bone Marrow MSCs: Implications for targeted therapy.

Curr Top Med Chem 2021 Jun 11. Epub 2021 Jun 11.

Department of Hematology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.

Background: Mesenchymal stromal cells (MSCs) due to convenient isolation and ex vivo expansion, multipotent differentiation, and migrating capacity into the inflammation sites and tumor microenvironments are interesting candidates in precise medicine. MSCs, as an important component of bone marrow microenvironment, can regulate hematopoiesis and immunity via direct contact or secretion of adhesion factors and hematopoietic chemokines. Recent evidence showed that aryl-hydrocarbon receptor (AHR) signal pathway plays a crucial role in hematopoiesis and immunity. Read More

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Vitrimers: directing chemical reactivity to control material properties.

Chem Sci 2020 Apr 16;11(19):4855-4870. Epub 2020 Apr 16.

Department of Organic and Macromolecular Chemistry, Polymer Chemistry Research Group, Center of Macromolecular Chemistry (CMaC), Faculty of Sciences, Ghent University Krijgslaan 281 (S4-bis) 9000 Ghent Belgium

The development of more sustainable materials with a prolonged useful lifetime is a key requirement for a transition towards a more circular economy. However, polymer materials that are long-lasting and highly durable also tend to have a limited application potential for re-use. This is because such materials derive their durable properties from a high degree of chemical connectivity, resulting in rigid meshes or networks of polymer chains with a high intrinsic resistance to deformation. Read More

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Solvent effects leading to a variety of different 2D structures in the self-assembly of a crystalline-coil block copolymer with an amphiphilic corona-forming block.

Chem Sci 2020 Apr 21;11(18):4631-4643. Epub 2020 Apr 21.

Department of Chemistry, University of Toronto Toronto Ontario M5S 3H6 Canada

We describe a polyferrocenyldimethylsilane (PFS) block copolymer (BCP), PFS--P(TDMA--OEGMA) (the subscripts refer to the mean degrees of polymerization), in which the corona-forming block is a random brush copolymer of hydrophobic tetradecyl methacrylate (TDMA) and hydrophilic oligo(ethylene glycol) methyl ether methacrylate (OEGMA). Thus, the corona is amphiphilic. This BCP generates a remarkable series of different structures when subjected to crystallization-driven self-assembly (CDSA) in solvents of different polarity. Read More

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Protective Effect of Calcium Dobesilate on Induced AKI in Severely Burned Mice.

Nephron 2021 Jun 14:1-15. Epub 2021 Jun 14.

Department of Nephrology, The Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou, China.

Background: Early acute kidney injury (AKI) predicts a high mortality rate in severely burned patients. However, the pathophysiology of early AKI induced by severe burn has not been well-defined. This study was designed to examine the protective effects of calcium dobesilate (CaD) against severe burn-induced early AKI in mice and explore the mechanism. Read More

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Characterization of chicken meat contaminated with Salmonella by fluorescence spectroscopy.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 21;261:119986. Epub 2021 May 21.

Institute of Environmental, Chemical and Pharmaceutical Sciences, Department of Biology, Federal University of Sao Paulo, Diadema, Sao Paulo, Brazil.

Contaminated poultry products as eggs and meat are the primary vehicles of Salmonella infection. Conventional methods for microorganisms detections involve multiple steps, and despite its accuracy, these assays are time-consuming. Biosensing methods have shown great potential for the rapid detection of foodborne pathogens. Read More

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Shifted mineral ions transport in the mollusk Unio pictorum exposed to environmental concentrations of diclofenac.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Jun 11:109107. Epub 2021 Jun 11.

Papanin Institute for Biology of Inland Waters, Russian Academy of Sciences (RAS), 152742 Borok, Yaroslavl Province, Russia.

Previous studies showed that diclofenac (DCF), when released in the environment, can be toxic to aquatic animals (fish and mollusks), affecting gills, which are the main organ of ionic regulation. This study focuses on detecting the effects of relevant environmental concentrations of DCF (0.1-1 μg L) on the transport of main mineral cations, i. Read More

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How does post-flowering heat impact grain growth and its determining processes in wheat?

J Exp Bot 2021 Jun 14. Epub 2021 Jun 14.

The University of Queensland, Queensland Alliance for Agriculture and Food Innovation (QAAFI), Toowoomba, Australia.

Wheat grain yield is anticipated to suffer from the increased temperatures expected under climate change. In particular, the effects of post-anthesis temperatures on grain growth and development must be better understood to improve crop models. Grain growth and development involve several processes and we hypothesized that some of the most important processes, i. Read More

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Knee Joint Line Obliquity Causes Tibiofemoral Subluxation That Alters Contact Areas and Meniscal Loading.

Am J Sports Med 2021 Jun 14:3635465211020478. Epub 2021 Jun 14.

The Biomechanics Group, Department of Mechanical Engineering, Imperial College London, London, UK.

Background: Little scientific evidence is available regarding the effect of knee joint line obliquity (JLO) before and after coronal realignment osteotomy.

Hypotheses: Higher JLO would lead to abnormal relative position of the femur on the tibia, a shift of the joint contact areas, and elevated joint contact pressures.

Study Design: Descriptive laboratory study. Read More

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Parametric analysis of landing injury : The effect of landing posture and joint displacement.

Phys Eng Sci Med 2021 Jun 14. Epub 2021 Jun 14.

Department of Mechanical Engineering, College of Engineering, University of Tehran, 1417466191, Tehran, Iran.

During landing, the lower limb joints work concertedly to reduce landing forces. Changing the biomechanics of one joint can alter landing strategies in other joints thus affecting the probability of injury. Therefore, understanding the mutual effects between the joints is crucial for the prevention of lower extremity injuries. Read More

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Purpose in life, loneliness, and protective health behaviors during the COVID-19 pandemic.

Gerontologist 2021 Jun 14. Epub 2021 Jun 14.

Annenberg School for Communication, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Background And Objectives: Social distancing, while effective in slowing the spread of the coronavirus disease 2019 (COVID-19), can increase social isolation. The current preregistered study examined purpose in life as a psychological resource that may buffer against loneliness and increase intentions to engage in health protective behaviors.

Research Design And Methods: During the COVID-19 pandemic, 517 adults (mean=37. Read More

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Short-term stress responses and recovery of giant kelp (Macrocystis pyrifera, Laminariales, Phaeophyceae) juvenile sporophytes to a simulated marine heatwave and nitrate scarcity.

J Phycol 2021 Jun 14. Epub 2021 Jun 14.

Universidad Autónoma de Baja California, Instituto de Investigaciones Oceanológicas, Km 106 Carretera Tijuana-Ensenada, Ensenada, Baja California, México, CP, 22860.

The frequency of marine heatwaves (MHWs) is increasing due to climate change. Although seaweeds are resilient to environmental changes, an increasing body of evidence shows that rising sea surface temperatures have deleterious effects on temperate kelp species. However, information on the vulnerability of juvenile kelp to these stressors and their population stability is limited. Read More

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Hydrolysis of Lignocellulosic Biomass in Hot-Compressed Water with Supercritical Carbon Dioxide.

ACS Omega 2021 Jun 27;6(22):14252-14259. Epub 2021 May 27.

Hokkaido High-Technology College, Megumino, Eniwa 061-1396, Japan.

This study investigated the decomposition behavior of bamboo under hydrothermal and hydrolysis conditions with HO/CO in a semicontinuous-flow reactor at 9.8 MPa. At 255 °C, with and without CO, xylan in bamboo completely decomposed into xylo-oligosaccharide (XOD). Read More

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Effects of Sonication and Hydrothermal Treatments on the Optical and Chemical Properties of Carbon Dots.

ACS Omega 2021 Jun 24;6(22):14174-14181. Epub 2021 May 24.

Department of Chemistry, National Changhua University of Education, No. 1 Jin-De Road, Changhua City 50058, Taiwan.

In our study, we have tested the effects of sonication and hydrothermal treatments on the properties of carbon dots synthesized from a microwave-assisted method (C-dots). When the carbon dots are sonicated in an aerobic environment, the fluorescence quantum yield decreases drastically because the molecular fluorophores attached to the surface of the carbon dots are oxidized during the sonication process. Meanwhile, the sonicated C-dots also lose their Hg ion sensing and photoreduction activity due to the oxidization of surface functional groups. Read More

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