6,955,386 results match your criteria effects pparγ


A state-of-the-art review of the current role of cardioprotective techniques in cardiac transplantation.

Interact Cardiovasc Thorac Surg 2021 May;32(5):683-694

Department of Cardiothoracic Surgery, Cork University Hospital, Cork, Ireland.

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Objectives: The use of 'extended criteria' donor hearts and reconditioned hearts from donation after circulatory death has corresponded with an increase in primary graft dysfunction, with ischaemia-reperfusion injury being a major contributing factor in its pathogenesis. Limiting ischaemia-reperfusion injury through optimising donor heart preservation may significantly improve outcomes. We sought to review the literature to evaluate the evidence for this. Read More

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Effects of Short- and Long-Term Aerobic-Strength Training and Determinants of Walking Speed in the Elderly.

Gerontology 2021 May 10:1-11. Epub 2021 May 10.

Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, University Science, Park for Biomedicine, Bratislava, Slovakia.

Background/aims: Walking speed (WS) is an objective measure of physical capacity and a modifiable risk factor of morbidity and mortality in the elderly. In this study, we (i) determined effects of 3-month supervised aerobic-strength training on WS, muscle strength, and habitual physical activity; (ii) evaluated capacity of long-term (21 months) training to sustain higher WS; and (iii) identified determinants of WS in the elderly.

Methods: Volunteers (F 48/M 14, 68. Read More

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Comparisons of Efficacy and Safety between Triple (Inhaled Corticosteroid/Long-Acting Muscarinic Antagonist/Long-Acting Beta-Agonist) Therapies in Chronic Obstructive Pulmonary Disease: Systematic Review and Bayesian Network Meta-Analysis.

Respiration 2021 May 10:1-13. Epub 2021 May 10.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Jongno-Gu, Seoul, Republic of Korea.

Background: Various combinations of inhaled corticosteroid (ICS), long-acting muscarinic antagonist (LAMA), and long-acting beta-agonist (LABA) have been used as triple therapy for stable chronic obstructive pulmonary disease (COPD).

Objective: Our study was conducted to answer whether there were significant differences among various combinations in efficacy, for reducing exacerbation or mortality, and in safety, for increasing cardiovascular events or pneumonia.

Method: We searched parallel-group randomized controlled trials (RCTs) comparing ICS/LAMA/LABA with other inhaled drugs in patients with stable COPD for at least 12 weeks in PubMed, EMBASE, the Cochrane Library, and clinical trial registries from inception to December 31, 2019. Read More

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Miniaturized scintillator dosimeter for small field radiation therapy.

Phys Med Biol 2021 May 10. Epub 2021 May 10.

Optics, Institut FEMTO - ST, Route de Gray, 25030 Besançon cedex, Besancon, FRANCE.

The concept of a miniaturized inorganic scintillator detector is demonstrated in the analysis of the small static photon fields used in external radiation therapy. Such a detector is constituted by a 0.25-millimeter diameter and 0. Read More

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The expression of mimecan in adrenal tissue plays a role in an organism's responses to stress.

Aging (Albany NY) 2021 May 10;13. Epub 2021 May 10.

The Core Laboratory in Medical Center of Clinical Research, Department of Molecular Diagnostic and Endocrinology, Shanghai Ninth People’s Hospital, State Key Laboratory of Medical Genomics, Shanghai Jiao tong University School of Medicine, Shanghai 200011, China.

Mimecan encodes a secretory protein that is secreted into the human serum as two mature proteins with molecular masses of 25 and 12 kDa. We found 12-kDa mimecan to be a novel satiety hormone mediated by the upregulation of the expression of interleukin (IL)-1β and IL-6 in the hypothalamus. Mimecan was found to be expressed in human pituitary corticotroph cells and was up-regulated by glucocorticoids, while the secretion of adrenocorticotropic hormone (ACTH) in pituitary corticotroph AtT-20 cells was induced by mimecan. Read More

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Experiences of responsiveness to exercise in people with chronic whiplash: A qualitative study.

Musculoskelet Sci Pract 2021 Apr 21;54:102380. Epub 2021 Apr 21.

Faculty of Medicine & Health, The University of Sydney, NSW, Australia; John Walsh Centre for Rehabilitation Research, Royal North Shore Hospital, NSW, Australia. Electronic address:

Exercise is recommended in clinical guidelines for the treatment of chronic whiplash associated disorders (WAD). However, randomised controlled trials have shown similar effects for comprehensive exercise programs and advice. To date, there is no clear understanding of why some individuals with WAD appear to respond to exercise whilst others do not. Read More

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Dietary protein source contributes to the risk of developing maternal syndrome in the Dahl salt-sensitive rat.

Pregnancy Hypertens 2021 May 5;24:126-134. Epub 2021 May 5.

Department of Physiology, Augusta University, United States.

Preeclampsia (PE) is a disorder of pregnancy, which is categorized by hypertension and proteinuria or signs of end-organ damage. Though PE is the leading cause of maternal and fetal morbidity and mortality, the mechanisms leading to PE remain unclear. The present study examined the contribution of dietary protein source (casein versus wheat gluten) to the risk of developing maternal syndrome utilizing two colonies of Dahl salt-sensitive (SS/JrHsdMcwi) rats. Read More

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Immunoenhancement effects of chitosan-modified ginseng stem-leaf saponins-encapsulated cubosomes as an ajuvant.

Colloids Surf B Biointerfaces 2021 Apr 29;204:111799. Epub 2021 Apr 29.

Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, PR China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, PR China. Electronic address:

Nanoparticle delivery of functional molecules and vaccine is a promising method for enhancing the immune response. The objective of this study was to design chitosan (CS)-modified ginseng stem-leaf saponins (GSLS)-encapsulated cubosomes (Cub-GSLS) as a vaccine delivery system and explore its immunologic activity and adjuvanticity. In this study, CS-modified GSLS-encapsulated cubosomes (Cub-GSLS) were prepared. Read More

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Effects of air pollution on mortality of patients with chronic kidney disease: A large observational cohort study.

Sci Total Environ 2021 Apr 30;786:147471. Epub 2021 Apr 30.

Institute of Health and Environment, Seoul National University, South Korea; Department of Public Health Science, School of Public Health, Seoul National University, South Korea. Electronic address:

Due to industrialization, the burden of diseases associated with air pollution is increasing. Although the risk associated with air pollution in the general population has been actively investigated, few studies have been conducted on the effects of exposure to air pollution in patients with chronic kidney disease (CKD) in East Asia. A total of 29,602 patients with CKD in Seoul participated in a retrospective cohort at three medical centers. Read More

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Impacts of neonicotinoid seed treatments on the wild bee community in agricultural field margins.

Sci Total Environ 2021 Apr 24;786:147299. Epub 2021 Apr 24.

Missouri Department of Conservation, Resource Science Division, Columbia, MO, USA.

Wild bees support global agroecosystems via pollination of agricultural crops and maintaining diverse plant communities. However, with an increased reliance on pesticides to enhance crop production, wild bee communities may inadvertently be affected through exposure to chemical residues. Laboratory and semi-field studies have demonstrated lethal and sublethal effects of neonicotinoids on limited genera (e. Read More

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Controlling factors of seasonal and spatial variation of riverine CO partial pressure and its implication for riverine carbon flux.

Sci Total Environ 2021 Apr 30;786:147332. Epub 2021 Apr 30.

Institute of Earth Sciences, China University of Geosciences (Beijing), Beijing 100083, China. Electronic address:

Global carbon cycle is closely related to the earth's energy budget, because CO plays an active role in the global climate change. The higher CO partial pressure (pCO) in inland water in comparison with atmosphere, causing a CO evasion from water to the air. However, the relationship between CO evasion, riverine carbon export, and hydrochemistry in watershed has remained largely unknown. Read More

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Statin use for the prevention of seizure and epilepsy in the patients at risk: A systematic review and meta-analysis of cohort studies.

Epilepsy Res 2021 May 4;174:106652. Epub 2021 May 4.

Department of Neurosurgery, Qinghai Provincial People's Hospital, Xining, Qinghai, 810007, PR China. Electronic address:

Objective: Statin use for the prevention of seizure and epilepsy had been suggested but remained controversial. We sought to search existing literature to determine whether prophylactic use of statin reduced the incidence of seizure and epilepsy in the patients at risk.

Methods: Three electronic databases were thoroughly searched to identify clinical studies investigating the effects of statin use on patients at the risk of seizure or epilepsy. Read More

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Thermal tolerance, safety margins and vulnerability of coastal species: Projected impact of climate change induced cold water variability in a temperate African region.

Mar Environ Res 2021 Apr 29;169:105346. Epub 2021 Apr 29.

South African Institute for Aquatic Biodiversity, Makhanda, 6140, South Africa; Department of Ichthyology and Fisheries Science, Rhodes University, Makhanda, 6140, South Africa.

Anthropogenic induced climate change is predicted to increase the thermal variability in coastal waters, which can have strong physiological effects on individuals and populations of marine ectotherms. The magnitude and direction of these thermal effects varies depending on species, life stage, biogeography, habitat and season. This study aimed to compare the thermal tolerance of a range of juvenile fish and adult macro-invertebrates from intertidal and estuarine habitats in a warm-temperate, thermally variable region on the south-east coast of South Africa. Read More

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Exposure to community violence and depressive symptoms: Examining community, family, and peer effects among public housing youth.

Health Place 2021 May 7;69:102579. Epub 2021 May 7.

School of Social Work, Adelphi University, Social Work Building Room 309, One South Avenue, Garden City, NY, 11530, USA.

Exposure to community violence is an epidemic problem that causes debilitating effects on youth mental health. However, the relationships between violence exposure and youth mental health remain unclear when examining co-occurring socioecological risk and protective factors. The purpose of this study is to clarify the observed gaps in knowledge by utilizing structural equation modeling (SEM) to examine the mediating role of community violence exposure on the relationship between perceived neighborhood risk factors, parental behaviors, and peers on depressive symptoms in a sample of urban youth in low-income public housing communities (n = 320). Read More

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Adverse childhood experiences and risk of cancer during adulthood: A systematic review and meta-analysis.

Child Abuse Negl 2021 May 7;117:105088. Epub 2021 May 7.

Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China. Electronic address:

Background: Research findings on the relationship between adverse childhood experiences (ACEs) and the risk of cancer were inconsistent.

Objective: The purpose of this study was to perform a quantitative synthesis of the preceding research findings.

Participants And Setting: System review and meta-analysis. Read More

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1,2,3-Triazole tethered 1,2,4‑trioxane trimer induces apoptosis in metastatic cancer cells and inhibits their proliferation, migration and invasion.

Bioorg Chem 2021 Apr 29;112:104952. Epub 2021 Apr 29.

Department of Chemistry, North-Eastern Hill University, Shillong 793022, India. Electronic address:

Artemisinin (ART) has been in use against different cancer cells and its derivatives and conjugates are more cytotoxic to iron-rich cancer cells. It is desirable to develop easily achievable synthetic 1,2,4-trioxanes having the same pharmacophore as that of ART. To explore more efficient compounds, a 1,2,3-triazole tethered 1,2,4‑trioxane trimer (4T) was synthesized and the anti-cancer effects of ART and 4T on MDA-MB-435 and MDA-MB-231 cells were investigated concerning regulation of osteopontin (OPN) expression, which is associated with cancer progression and malignancy. Read More

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The effects of hydraulic/pneumatic fracturing-enhanced remediation (FRAC-IN) at a site contaminated by chlorinated ethenes: A case study.

J Hazard Mater 2021 Apr 16;417:125883. Epub 2021 Apr 16.

Institute for Environmental Studies, Faculty of Science, Charles University, Benátská 2, CZ-128 01 Prague 2, Czech Republic; Institute of Microbiology Academy of Sciences of the Czech Republic, v.v.i., Vídeňská 1083, CZ-142 20 Prague 4, Czech Republic. Electronic address:

A low-permeability locality with heterogeneous geology contaminated primarily by tetrachloroethene (PCE) present partially in the free phase in the unsaturated zone was treated on a pilot scale via direct push pneumatic fracturing combined with the hydraulic delivery of a remediation suspension consisting of milled iron, sulphidated nanosized zerovalent iron and sand in guar gum solution. Afterwards, a whey solution was injected into the fractures as a carbon source for bacteria. The unsaturated and saturated zones were treated. Read More

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Evaluating the radioprotective effect of Cimetidine, IMOD, and hybrid radioprotectors agents: An in-vitro study.

Appl Radiat Isot 2021 May 6;174:109760. Epub 2021 May 6.

Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. Electronic address:

Introduction: There are various radioprotective agents with different mechanisms that help to decrease ionizing radiation side effects. The radioprotective effect of Cimetidine and IMOD was assessed individually and compared with the hybrid radioprotectors agents (HRPAs-IMOD and Cimetidine) on human lymphocyte cells.

Methods: Twenty healthy volunteers (ten men and ten women) participated in the present study. Read More

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miR-133b inhibits cell proliferation, migration, and invasion of lung adenocarcinoma by targeting CDCA8.

Pathol Res Pract 2021 Apr 28;223:153459. Epub 2021 Apr 28.

Department of Cancer Radiotherapy and Chemotherapy, Zhejiang Quhua Hospital, Quzhou, 324004, China. Electronic address:

Objective: Lung adenocarcinoma (LUAD) is the most common type of lung cancer. This study aims to explore the mechanism by which CDCA8 regulates cell proliferation, invasion, and migration of LUAD, and to generate novel insights into targeted therapy of LUAD.

Methods: Expression profiles of mature microRNAs (miRNAs) and mRNAs, along with clinical data of LUAD were downloaded from TCGA database for differential analysis and survival analysis to mine differentially expressed mRNAs. Read More

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Tumstatin attenuates the promotion effect of IL-17 secreted by Th17 cells on the stemness maintenance of glioma cells.

Pathol Res Pract 2021 May 5;223:153463. Epub 2021 May 5.

Department of Neurosurgery, Beilun District People's Hospital of Ningbo City, Ningbo, Zhejiang, 315800, China. Electronic address:

The presence and clinical significance of IL-17 and IL-17-expressing cells have been studied for several cancers, although their correlation with tumor development remains controversial. Peripheral blood was collected from healthy donors and glioma patients to isolate peripheral blood mononuclear cells (PBMCs). The percentage of IL-17-expressing cells and the production of inflammatory cytokines in PBMCs and tissues were measured. Read More

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LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species.

Redox Biol 2021 Apr 30;43:101998. Epub 2021 Apr 30.

Department of Otolaryngology Head & Neck Surgery, University of Alabama at Birmingham, Birmingham, AL, USA; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address:

Lipopolysaccharide (LPS) serves as the interface between gram-negative bacteria (GNB) and the innate immune response in respiratory epithelial cells (REC). Herein, we describe a novel biological role of LPS that permits GNB to persist in the respiratory tract through inducing CFTR and mucociliary dysfunction. LPS reduced cystic fibrosis transmembrane conductance regulater (CFTR)-mediated short-circuit current in mammalian REC in Ussing chambers and nearly abrogated CFTR single channel activity (defined as forskolin-activated Cl currents) in patch clamp studies, effects of which were blocked with toll-like receptor (TLR)-4 inhibitor. Read More

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How unintentional cues can bias threat assessments during shoot/don't-shoot simulations.

Appl Ergon 2021 May 7;95:103451. Epub 2021 May 7.

Naval Medical Research Unit Dayton, United States.

Objective: Identify whether contextual information may unintentionally alter decision-making during lethal force training.

Background: Lethal force decisions inherently involve a threat assessment, where an individual learns to identify a threat and use force commensurate to the situation. This decision is ultimately subject to numerous cognitive influences, particularly during training where artificial factors may bias decision-making. Read More

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How should external human-machine interfaces behave? Examining the effects of colour, position, message, activation distance, vehicle yielding, and visual distraction among 1,434 participants.

Appl Ergon 2021 May 7;95:103450. Epub 2021 May 7.

Faculty of Mechanical, Maritime and Materials Engineering, Delft University of Technology, Delft, the Netherlands.

External human-machine interfaces (eHMIs) may be useful for communicating the intention of an automated vehicle (AV) to a pedestrian, but it is unclear which eHMI design is most effective. In a crowdsourced experiment, we examined the effects of (1) colour (red, green, cyan), (2) position (roof, bumper, windshield), (3) message (WALK, DON'T WALK, WILL STOP, WON'T STOP, light bar), (4) activation distance (35 or 50 m from the pedestrian), and (5) the presence of visual distraction in the environment, on pedestrians' perceived safety of crossing the road in front of yielding and non-yielding AVs. Participants (N = 1434) had to press a key when they felt safe to cross while watching a random 40 out of 276 videos of an approaching AV with eHMI. Read More

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Effects of organic loading rate and hydraulic retention time on bioaugmentation performance to tackle ammonia inhibition in anaerobic digestion.

Bioresour Technol 2021 Apr 30;334:125246. Epub 2021 Apr 30.

Department of Hydraulics, Soil Science and Agricultural Engineering, School of Agriculture, Aristotle University of Thessaloniki, Thessaloniki GR-54124, Greece. Electronic address:

Three continuously stirred-tank reactors fed with manure operating under high ammonia levels (5.0 g NH-N L) and with increased organic loading rate (OLR), (2.09 R1, 3. Read More

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Core-shell ZVI@carbon composites reduce phosphate inhibition of ZVI dissolution and enhance methane production in an anaerobic sewage treatment.

Water Res 2021 Apr 29;199:117197. Epub 2021 Apr 29.

Textile Pollution Controlling Engineering Center of Ministry of Environmental Protection, College of Environmental Science and Engineering, Donghua University, Shanghai 201620, China; Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China. Electronic address:

Inhibitory effects of phosphate on zero-valent iron (ZVI) dissolution have been studied mainly focusing on a single chemical system. Little is known about inhibitory effects and the mechanism of phosphate on ZVI dissolution within a bioreactor during long-term operation. This study demonstrates the feasibility of achieving energy recovery from phosphate-containing domestic sewage using an efficient anaerobic reactor with micro-sized or nano-sized ZVI addition. Read More

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Increase of acidification of synthetic brines by ultrasound-treated Lactiplantibacillus plantarum strains isolated from olives.

Ultrason Sonochem 2021 May 4;74:105583. Epub 2021 May 4.

Department of Agriculture, Food, Natural Resources and Engineering (DAFNE), University of Foggia, Via Napoli 25, 71122 Foggia, Italy. Electronic address:

This paper focused on the evaluation of Ultrasound effect on the growth patterns (3-6% of salt and 45 °C), acidification (pH-decrease), interactions with microorganisms, and membrane permeability of nine strains of Lactiplantibacillus plantarum. Ultrasound treatment was applied at 20% of net power by modulating duration (2-10 min) and pulses (2-10 s). Viable count (7. Read More

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Whole transcriptome analysis of schinifoline treatment in Caenorhabditis elegans infected with Candida albicans.

Mol Immunol 2021 May 7;135:312-319. Epub 2021 May 7.

Nanjing Institute for Comprehensive Utilization of Wild Plants, Nanjing, 211100, China. Electronic address:

Candida albicans is an opportunistic fungal human pathogen that has been causing an increasing number of deaths each year. Due to the widespread use of broad-spectrum antibiotics and immunosuppressants, C. albicans resistance to these therapies has increased. Read More

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"Light cannabis" consumption in a sample of young adults: Preliminary pharmacokinetic data and psychomotor impairment evaluation.

Forensic Sci Int 2021 May 2;323:110822. Epub 2021 May 2.

Department of Medical and Surgical Sciences, Unit of Legal Medicine, University of Bologna, Via Irnerio 49, 40126 Bologna, Italy.

Introduction: In 2019, the Italian Supreme Court established that hemp cannot be commercialized for human use, when the "psychotropic effect" of the product or its "offensiveness" can be demonstrated. The aim of the present study is to assess Δ9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) blood concentrations after smoking cannabis with a low percentage of Δ9-THC, also referred as "light cannabis", and its effects on young adults' vigilance, cognitive and motor skills.

Materials And Methods: Eighteen young adults consumed three light cannabis cigarettes containing 400 mg of inflorescences each, with a percentage of 0. Read More

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The association between intended drinking contexts and alcohol expectancies in college students: A daily diary study.

Addict Behav 2021 Apr 30;120:106967. Epub 2021 Apr 30.

Department of Psychiatry and Behavioral Sciences, University of Washington, Center for the Study of Health and Risk Behaviors, 1100 NE 45th St., #300, Seattle, WA 98115, USA.

Background: Because of the role alcohol outcome expectancies play in subsequent drinking, it is important to understand factors that can shape alcohol expectancies to guide intervention efforts. This study examined among college students whether intended social contexts for drinking were associated with positive and negative alcohol expectancies at the daily-level.

Methods: Participants included in analyses were 323 students, ages 18 to 24 years, enrolled at a 4-year university in the Pacific Northwest. Read More

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Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF-κB/NLRP3 and PGC1a/SIRT3 pathways.

Int Immunopharmacol 2021 May 7;96:107728. Epub 2021 May 7.

Department of Endocrinology and Metabolism, Changzhou No.2 People's Hospital, Changzhou, Jiangsu 213003, China. Electronic address:

Diabetic cardiomyopathy (DCM) is a chronic multifactorial complication of type-2 diabetes mellitus, leading to heart failure. A combination of multifaceted therapeutics for the management of DCM is needed. Here, we investigated the combined effect of syringin and tilianin on DCM by evaluating cardiac function, inflammation, oxidative stress, apoptosis and mitochondrial function, and explored the contribution of TLR4/NF-κB/NLRP3 and PGC1α/SIRT3 pathways in diabetic rats and hyperglycemic-H9c2 cells. Read More

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