8 results match your criteria effects mir211

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The Paradoxical Behavior of microRNA-211 in Melanomas and Other Human Cancers.

Front Oncol 2020 8;10:628367. Epub 2021 Feb 8.

Cancer & Blood Disorder Institute, Johns Hopkins All Children's Hospital, South, St. Petersburg, FL, United States.

Cancer initiation, progression, and metastasis leverage many regulatory agents, such as signaling molecules, transcription factors, and regulatory RNA molecules. Among these, regulatory non-coding RNAs have emerged as molecules that control multiple cancer types and their pathologic properties. The human microRNA-211 (MIR211) is one such molecule, which affects several cancer types, including melanoma, glioblastoma, lung adenocarcinomas, breast, ovarian, prostate, and colorectal carcinoma. Read More

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February 2021

Role of the p53‑TRPM1/miR‑211‑MMP9 axis in UVB‑induced human melanocyte migration and its potential in repigmentation.

Int J Mol Med 2020 Apr 27;45(4):1017-1026. Epub 2020 Jan 27.

Department of Dermatology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Clinical studies have proven that ultraviolet B (UVB) based phototherapy can induce perifollicular and marginal repigmentation patterns in the skin of vitiligo patients. It is, however, difficult to conceive how melanocytes can easily exit from their tightly interconnected epidermal microenvironment to re‑enter a different location in the skin to establish a new network with neighboring keratinocytes. While it is known that matrix metalloprotease 9 (MMP9) is involved in the degradation of the extracellular matrix in physiological or pathological processes, little is known about whether MMP9 affects melanocyte migration in vitiligo repigmentation. Read More

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MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.

Autophagy 2019 03 16;15(3):375-390. Epub 2018 Oct 16.

a Sabanci University , Faculty of Engineering and Natural Sciences, Molecular Biology, Genetics and Bioengineering Program , Orhanli-Tuzla , Turkey.

Macroautophagy (autophagy) is an evolutionarily conserved recycling and stress response mechanism. Active at basal levels in eukaryotes, autophagy is upregulated under stress providing cells with building blocks such as amino acids. A lysosome-integrated sensor system composed of RRAG GTPases and MTOR complex 1 (MTORC1) regulates lysosome biogenesis and autophagy in response to amino acid availability. Read More

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microRNA‑211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1.

Mol Med Rep 2018 Jan 7;17(1):1275-1282. Epub 2017 Nov 7.

Department of Gynaecology, Songgang People's Hospital, Shenzhen, Guangdong 518105, P.R. China.

Of gynecological cancers, cervical cancer has the second highest incidence globally and is a major cause of cancer‑associated mortality in women. An increasing number of studies have reported that microRNAs (miRNAs) have important roles in cervical cancer carcinogenesis and progression through regulation of various critical protein‑coding genes. The aim of the present study was to investigate the expression and biological roles of miRNA‑211 (miR‑211) in cervical cancer and its underlying molecular mechanism. Read More

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January 2018

LPS‑induced downregulation of microRNA‑204/211 upregulates and stabilizes Angiopoietin‑1 mRNA in EA.hy926 endothelial cells.

Mol Med Rep 2017 Nov 30;16(5):6081-6087. Epub 2017 Aug 30.

Sun Yat‑sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, P.R. China.

Angiopoietin‑1 (ANG‑1), a ligand of the endothelial cell‑specific TIE2 surface receptor, acts in a complementary and coordinated manner with vascular endothelial growth factor during the process of angiogenesis. ANG‑1 can be used as a clinically informative biomarker of disease severity and outcome in severe sepsis. The epithelium‑specific Ets transcription factor 1 can activate ANG‑1 transcription in the setting of inflammation; however, relatively little is known about the regulation of ANG‑1 by microRNAs (miRs). Read More

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November 2017

Association of AKAP6 and MIR2113 with cognitive performance in a population-based sample of older adults.

Genes Brain Behav 2017 04 26;16(4):472-478. Epub 2017 Jan 26.

John Curtin School of Medical Research, Australian National University, Canberra, Australia.

Genetic factors make a substantial contribution to inter-individual variability in cognitive function. A recent meta-analysis of genome-wide association studies identified two loci, AKAP6 and MIR2113, that are associated with general cognitive function. Here, we extend this previous research by investigating the association of MIR2113 and AKAP6 with baseline and longitudinal non-linear change across a broad spectrum of cognitive domains in a community-based cohort of older adults without dementia. Read More

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[MiR-211 promotes invasion of hepatoma cells by targeting estrogen receptor alpha].

Zhonghua Gan Zang Bing Za Zhi 2015 Jul;23(7):527-32

Department of clinical laboratory, Huanhu Hospital of Tianjin, Tianjin 300060, China.

Objective: To investigate the regulatory functions and molecular mechanisms of miR211 in hepatocellular carcinoma (HCC).

Methods: Real-time reverse transcription-PCR was used to analyze the expression of miR-211 in 20 paired clinical specimens of HCC and adjacent noncancerous tissues.QGY7703 and HepG2 cells with stimulation or inhibition of miR-211 expression were used to evaluate the effects on malignant phenotypes with the transwell invasion assay. Read More

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Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer.

Cancer Res 2014 Dec 2;74(23):6890-902. Epub 2014 Oct 2.

State Key Laboratory for Oncogenes and Related Genes; Division of Gastroenterology and Hepatology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

It is increasingly evident that long noncoding RNAs (lncRNA) have causative roles in carcinogenesis. In this study, we report findings implicating a novel lncRNA in gastric cancer, termed GAPLINC (gastric adenocarcinoma predictive long intergenic noncoding RNA), based on the use of global microarray and in situ hybridization (ISH) analyses to identify aberrantly expressed lncRNA in human gastric cancer specimens. GAPLINC is a 924-bp-long lncRNA that is highly expressed in gastric cancer tissues. Read More

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December 2014
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