16,490 results match your criteria effects melatonin


Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway.

Aging (Albany NY) 2021 Jun 11;13. Epub 2021 Jun 11.

Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.

Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Read More

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Endogenous circadian regulation and phase resetting of clinical metabolic biomarkers.

J Pineal Res 2021 Jun 12:e12752. Epub 2021 Jun 12.

Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, 02115.

Shiftwork and circadian disruption are associated with adverse metabolic effects. Therefore, we examined whether clinical biomarkers of metabolic health are under endogenous circadian regulation using a 40-h constant routine protocol (CR; constant environmental and behavioral conditions) and evaluated the impact of typical daily conditions with periodic sleep and meals (baseline; 8-h sleep at night, four meals during a 16-h wake episode) on the phase and amplitude of these rhythms. Additionally, we tested whether these circadian rhythms are reset during simulated shiftwork. Read More

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Metabolic responses to polychromatic LED and OLED light at night.

Sci Rep 2021 Jun 11;11(1):12402. Epub 2021 Jun 11.

International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.

Light exposure at night has various implications for human health, but little is known about its effects on energy metabolism during subsequent sleep. We investigated the effects of polychromatic white light using conventional light-emitting diodes (LED) and an alternative light source, organic light-emitting diodes (OLED), producing reduced spectral content in the short wavelength of blue light (455 nm). Ten male participants were exposed to either LED, OLED (1000 lx), or dim (< 10 lx) light for 4 h before sleep in a metabolic chamber. Read More

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[Effects of noise, bright light and mechanical stimulation on sleep, blood-brain barrier and cognitive function in septic rats].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 May;33(5):529-534

Department of Critical Care Medicine, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology (Xiaogan Central Hospital), Xiaogan 432000, Hubei, China. Corresponding author: Yao Peng, Email:

Objective: To evaluate the effects of noise, bright light and mechanical stimulation on sleep, blood-brain barrier and cognitive function in septic rats.

Methods: Forty male Sprague-Dawley (SD) rats were selected and intraperitoneal injection of 10 mg/kg lipopolysaccharide (LPS) was used to establish sepsis model. 0, 30, 45, 60, 75 dB noise stimulation or 0, 50, 100, 200, 400 Lux light stimulation were given to rats (all n = 4). Read More

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Seasonal variation in neurohormones, mood and sleep in patients with primary open angle glaucoma - implications of the ipRGC-system.

Chronobiol Int 2021 Jun 10:1-11. Epub 2021 Jun 10.

Department of Ophthalmology, Rigshospitalet-Glostrup Hospital, Copenhagen, Denmark.

Primary open angle glaucoma is associated with an increased risk of mood and sleep disorders. These adversities have been suggested to relate to a disrupted function of the intrinsically photosensitive retinal ganglion cells (ipRGCs). The ipRGCs are key components in the nonvisual photoreceptive system that mediates light effects on mood, sleep and circadian rhythm. Read More

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Use of melatonin as an inhibitor of apoptotic process for cryopreservation of zebrafish (Danio rerio) embryos.

Braz J Biol 2021 2;82:e241081. Epub 2021 Jun 2.

Universidade Estadual de Maringá - UEM, Departamento de Zootecnia, Maringá, PR, Brasil.

This study investigated the use of melatonin to arrest the effects of apoptosis in vitrified zebrafish (D. rerio) embryos. Dechorionated embryos at 22-24 somite-stage were divided (n = 60/treatment) into a non-vitrified (Control Group, 0 M melatonin) and vitrified treatments with 0 M (T1), 1 µM (T2) and 1 mM of melatonin (T3). Read More

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Melatonin improves the antioxidant capacity in cardiac tissue of Wistar rats after exhaustive exercise.

Free Radic Res 2021 Jun 8:1-36. Epub 2021 Jun 8.

Federal University of Sao Paulo, Santos, SP, Brazil.

We investigated the effects of melatonin on the onset and resolution of the oxidative stress in the cardiac muscle in melatonin-treated and nontreated rats subjected to an exhaustive exercise session. Forty male rats were divided into: melatonin-treated (20 mg/kg supplemented for 10 days) and control. On the 10th day, each group was subdivided according to euthanasia moments: control or melatonin-treated not exercised (C0h and M0h); immediately after the exercise (CIA and MIA); and 2 h after exercise (C2h and M2h). Read More

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Possible benefits of exogenous melatonin for individuals on dialysis: a narrative review on potential mechanisms and clinical implications.

Naunyn Schmiedebergs Arch Pharmacol 2021 Jun 7. Epub 2021 Jun 7.

Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Prevention of oxidative stress and inflammation in chronic kidney disease patients (CKD) on dialysis may reduce dialysis-associated complications. Administration of powerful antioxidants may improve the consequences of peritoneal dialysis (PD) and hemodialysis (HD). This narrative review aimed to show the potential therapeutic effects of melatonin (MLT) on the consequences of CKD patients receiving HD or PD. Read More

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Evaluation of Medications Used for Hospitalized Patients With Sleep Disturbances: A Frequency Analysis and Literature Review.

J Pharm Pract 2021 Jun 7:8971900211017857. Epub 2021 Jun 7.

Department of Pharmacy, Erlanger Health-System, Chattanooga, TN, USA.

Purpose: Poor sleep during hospitalization is common and implicated in worse patient outcomes. Despite implementation of non-pharmacologic techniques, medications are still frequently required. The study objective is to assess the frequency of new medications administered for sleep in hospitalized patients and to review literature evaluating these drug therapies in the inpatient setting. Read More

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Melatonin Regulates the Neurotransmitter Secretion Disorder Induced by Caffeine Through the Microbiota-Gut-Brain Axis in Zebrafish ().

Front Cell Dev Biol 2021 20;9:678190. Epub 2021 May 20.

Key Laboratory of Food Nutrition and Functional Food of Hainan Province, College of Food Science and Engineering, Hainan University, Haikou, China.

Melatonin has been widely used as a "probiotic agent" capable of producing strong neurotransmitter secretion regulatory effects, and the microbiota-gut-brain axis-related studies have also highlighted the role of the gut microbiota in neuromodulation. In the present study, a zebrafish neural hyperactivity model was established using caffeine induction to explore the regulatory effects of melatonin and probiotic on neurotransmitter secretion disorder in zebrafish. Disorders of brain neurotransmitter secretion (dopamine, γ-aminobutyric acid, and 5-hydroxytryptamine) caused by caffeine were improved after interference treatment with melatonin or probiotic. Read More

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Novel function of in expression of innate immunity genes and its probable roles in maintenance of pluripotency state.

Iran J Basic Med Sci 2021 Apr;24(4):531-536

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Objectives: Cell-based therapeutic approaches have witnessed significant developments during the last decade especially after approval of MSCs based treatment of graft versus host disease. Several cell-based approaches have shown immunomodulatory behavior during regeneration following the unknown cascade of events but the exact mechanisms are yet to be defined. Clinical applications of cell-based drugs are hampered all over the world because of incomplete understanding of molecular mechanisms requiring the application of mechanistic approaches to solving the mystery. Read More

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Melatonin and melatonergic agents for the prevention of postoperative delirium: A meta-analysis of randomized placebo-controlled trials.

Asian J Surg 2021 Jun 3. Epub 2021 Jun 3.

Department of Anesthesiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China. Electronic address:

Studies on melatonin and melatonergic agents (MMA) for the prevention of postoperative delirium (POD) have produced inconsistent findings. We conducted a meta-analysis to assess the effect of perioperative MMA on the prevention for POD. This meta-analysis is registered in the PROSPERO (CRD42020164900). Read More

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Metabolic and hormonal effects of melatonin and/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.

Nutr Metab (Lond) 2021 Jun 6;18(1):57. Epub 2021 Jun 6.

Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders among women of reproductive age. This study was designed to investigate the effects of melatonin and/or magnesium supplementation on metabolic profile and levels of sex hormones in PCOS women.

Methods: In an 8-week randomized double-blind placebo-controlled trial, 84 subjects with PCOS aged 18-40 years were randomly assigned based on the random block procedure to take magnesium, melatonin, magnesium plus melatonin, and placebo. Read More

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Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate/GPR109A signaling pathway.

J Nanobiotechnology 2021 Jun 6;19(1):170. Epub 2021 Jun 6.

Department of Orthopaedics, The First Affiliated Hospital of Soochow University, Soochow University, No. 188 Shizi Street, Suzhou, 215006, Jiangsu, China.

Background: Inflammatory osteolysis after total joint replacement (TJR) may cause implant failure, periprosthetic fractures, and be a severe threat to global public health. Our previous studies demonstrated that melatonin had a therapeutic effect on wear-particles induced osteolysis. Gut microbiota is closely related to bone homeostasis, and has been proven to be affected by melatonin. Read More

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: novel validated open-access and open-source web platform for calculating and sharing physiologically relevant quantities for light and lighting.

Wellcome Open Res 2021 3;6:69. Epub 2021 Jun 3.

f.lux software LLC, Los Angeles, USA.

Light exposure has a profound impact on human physiology and behaviour. For example, light exposure at the wrong time can disrupt our circadian rhythms and acutely suppress the production of melatonin. In turn, appropriately timed light exposure can support circadian photoentrainment. Read More

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Exogenous melatonin decreases circadian misalignment and body weight among early types.

J Pineal Res 2021 Jun 6:e12750. Epub 2021 Jun 6.

Department of Health, Life Cycles and Society, School of Public Health, University of São Paulo, São Paulo, Brazil.

Shift workers experience chronic circadian misalignment, which can manifest itself in reduced melatonin production, and has been associated with metabolic disorders. In addition, chronotype modulates the effect of night shift work, with early types presenting greater circadian misalignment when working night shift as compared to late types. Melatonin supplementation has shown positive results reducing weight gain in animal models, but the effect of exogenous melatonin in humans on body weight in the context of shift work remains inconsistent. Read More

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Clock-controlled arylalkylamine N-acetyltransferase (aaNAT) regulates circadian rhythms of locomotor activity in the American cockroach, Periplaneta americana via melatonin/MT2-like receptor.

J Pineal Res 2021 Jun 6:e12751. Epub 2021 Jun 6.

Graduate School of Natural Science and Technology, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe, 657-8501, Japan.

Melatonin (MEL) orchestrates daily and seasonal rhythms (e.g., locomotion, sleep/wake cycles, and migration among other rhythms) in diverse organisms. Read More

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Investigation of the effect of training on serotonin, melatonin and hematologic parameters in adolescent basketball players.

Horm Mol Biol Clin Investig 2021 Jun 7. Epub 2021 Jun 7.

Department of Physiology, Faculty of Medicine, University of Adiyaman, Adiyaman, Turkey.

Objectives: Exercise can improve both health and mood. Some beneficial effects of exercise are attributed to endocrine status. This study aims to evaluate the effect of eight weeks of basketball training on melatonin, serotonin, and hematologic parameters in basketball players. Read More

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Fertility responses of melatonin-treated gilts before and during the follicular and early luteal phases when there are different temperatures and lighting conditions in the housing area.

Anim Reprod Sci 2021 Jul 15;230:106769. Epub 2021 May 15.

Department of Animal Science, University of Illinois, Urbana, IL, 61801, United States. Electronic address:

This study was conducted to determine whether exogenous melatonin affected gilt fertility when there were different housing temperature and lighting conditions. Prepubertal gilts (n = 72) were fed (MEL, 5 mg/day) or not fed (CON) melatonin while housed in rooms where temperatures (31.0 ± 1 °C) and daily lighting (240 lx) duration differed: 8 (8 H); 16 (16 H); or 24 (24 H) h in winter and summer replicates. Read More

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Exogenous melatonin reduces water deficit-induced oxidative stress and improves growth performance of Althaea rosea grown on coal mine spoils.

Environ Sci Pollut Res Int 2021 Jun 5. Epub 2021 Jun 5.

College of Economics and Management, Northwest A&F University, Yangling, 712100, Shaanxi, China.

Coal mining activities are responsible for significant land degradation and often long-term irreversible effects on ecosystem functioning. To better understand how coal mined sites could be re-vegetated and ecosystem functioning restored, we address the role of the signalling hormone melatonin, which controls plant growth and development under adverse environmental conditions. We assessed the effects of exogenous melatonin on the plant species Althaea rosea by measuring morphological growth attributes, photosynthetic efficiency, reactive oxygen species (ROS)-induced oxidative damage and antioxidant defence developed by the seedlings when grown on coal-mined spoils under various water regimes. Read More

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Molecular targets for the management of gastrointestinal cancer using melatonin, a natural endogenous body hormone.

Biomed Pharmacother 2021 Jun 1;140:111782. Epub 2021 Jun 1.

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address:

Gastrointestinal cancer is one of the most common cancers globally. Melatonin, a natural endogenous body hormone, has been of interest for years, due to its anti-cancer characteristics, such as antiproliferative, antimetastatic, and cytotoxic as well as apoptotic induction. Through regulating several proteins such as melatonin upregulated mRNAs and proteins of downregulated Bcl-2-associated X protein (Bax), and B-cell lymphoma 2 (Bcl-2), as well as cytoplasmic protein such as calcium-binding proteins calmodulin or tubulin, and nuclear receptors, including RORα/RZR, and acts by non-receptor-regulated mechanisms, melatonin can exert anti-cancer efficacy. Read More

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Melatonin reshapes the mitochondrial network and promotes intercellular mitochondrial transfer via tunneling nanotubes (TNTs) after ischemic-like injury in hippocampal HT22 cells.

J Pineal Res 2021 Jun 4:e12747. Epub 2021 Jun 4.

Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.

Mitochondrial dysfunction is considered one of the hallmarks of ischemia/reperfusion injury. Mitochondria are plastic organelles that undergo continuous biogenesis, fusion and fission. They can be transferred between cells through tunneling nanotubes (TNTs), dynamic structures that allow the exchange of proteins, soluble molecules and organelles. Read More

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Melatonin effects on bone: implications for use as a therapy for managing bone loss.

J Pineal Res 2021 Jun 4:e12749. Epub 2021 Jun 4.

Division of Pharmaceutical Sciences, Duquesne University School of Pharmacy, Pittsburgh, PA, 15282, USA.

Melatonin is the primary circadian output signal from the brain and is mainly synthesized in pinealocytes. The rhythm and secretion of melatonin is under the control of an endogenous oscillator located in the SCN or the master biological clock. Disruptions in circadian rhythms by shift work, aging, or light at night is associated with bone loss and increased fracture risk. Read More

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Agomelatine protects against obesity-induced renal injury by inhibiting endoplasmic reticulum stress/apoptosis pathway in rats.

Toxicol Appl Pharmacol 2021 May 31;425:115601. Epub 2021 May 31.

Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Center for Research and Development of Natural Products for Health, Chiang Mai University, Chiang Mai, Thailand. Electronic address:

Obesity is recognized as a risk for the development of chronic kidney disease. Excessive fat accumulation in obesity is associated with the overproduction of reactive oxygen species with the underproduction of antioxidant mechanisms generating oxidative stress together with chronic low-grade inflammation which subsequently leads to the development of several obesity-related complications. It has been suggested that the abnormal lipid accumulation can induce endoplasmic reticulum (ER) stress and cellular apoptosis in several tissue types. Read More

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Melatonin's neuroprotective role in mitochondria and its potential as a biomarker in aging, cognition and psychiatric disorders.

Transl Psychiatry 2021 Jun 2;11(1):339. Epub 2021 Jun 2.

Molecular Brain Science Research Department, Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON, Canada.

Melatonin is an ancient molecule that is evident in high concentrations in various tissues throughout the body. It can be separated into two pools; one of which is synthesized by the pineal and can be found in blood, and the second by various tissues and is present in these tissues. Pineal melatonin levels display a circadian rhythm while tissue melatonin does not. Read More

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The role of melatonin in preventing radiation-induced intestinal injury.

J BUON 2021 Mar-Apr;26(2):626-633

Ataturk University School of Medicine, Department of Radiation Oncology, Erzurum, Turkey.

Purpose: Despite the therapeutic effects of radiotherapy on tumor cells, it has potential severe adverse effects on the surrounding normal tissues. Acute or chronic intestinal adverse effects that are likely to occur in patients undergoing radiotherapy for pelvic and abdominal cancers lead to increased morbidity, significant impairment of the quality of life, and economic losses. Various biological, chemical and pharmacological agents are being tested to protect from and to treat radiation enteritis. Read More

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Implanting melatonin at lambing enhances lamb growth and maintains high fat content in milk.

Vet Res Commun 2021 Jun 2. Epub 2021 Jun 2.

Instituto de Investigación en Ciencias Ambientales de Aragón (IUCA), Universidad de Zaragoza, Miguel Servet, 177, 50013, Zaragoza, Spain.

Three experiments were designed to study the effects of melatonin implantation of ewes and lambs after lambing on the growth of lambs and milk quality throughout lactation. In experiment 1, 53 lambs either did (n = 28) or did not (n = 25) receive a subcutaneous 18-mg melatonin implant at the base of the left ear. In experiment 2, 55 lambs and their mothers either did (lambs: n = 28; ewes: n = 15) or did not (lambs: n = 27; ewes: n = 16) receive a melatonin implant. Read More

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Melatonin Induces Apoptosis and Modulates Cyclin Expression and MAPK Phosphorylation in Pancreatic Stellate Cells Subjected to Hypoxia.

Int J Mol Sci 2021 May 24;22(11). Epub 2021 May 24.

Institute of Molecular Pathology Biomarkers, University of Extremadura, 10003 Caceres, Spain.

In certain diseases of the pancreas, pancreatic stellate cells form an important part of fibrosis and are critical for the development of cancer cells. A hypoxic condition develops within the tumor, to which pancreatic stellate cells adapt and are able to proliferate. The consequence is the growth of the tumor. Read More

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Melatonin, Its Beneficial Effects on Embryogenesis from Mitigating Oxidative Stress to Regulating Gene Expression.

Int J Mol Sci 2021 May 30;22(11). Epub 2021 May 30.

Department of Neonatology, Saint-Petersburg State Pediatric Medical University, Litovskaya Str., 2, 194100 St. Petersburg, Russia.

Embryogenesis is a complex multi-stage process regulated by various signaling molecules including pineal and extrapineal melatonin (MT). Extrapineal MT is found in the placenta and ovaries, where it carries out local hormonal regulation. MT is necessary for normal development of oocytes, fertilization and subsequent development of human, animal and avian embryos. Read More

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Lipoic Acid Combined with Melatonin Mitigates Oxidative Stress and Promotes Root Formation and Growth in Salt-Stressed Canola Seedlings ( L.).

Molecules 2021 May 25;26(11). Epub 2021 May 25.

Department of Agronomy, Faculty of Agriculture, University of Kafrelsheikh, Kafr el-Sheikh 33516, Egypt.

Lipoic acid (LA) and melatonin (MT) are pleiotropic molecules participating in plant stress resistance by modulating cellular biochemical changes, ion homeostasis, and antioxidant enzyme activities. However, the combined role of these two molecules in counteracting the detrimental impacts of salinity stress is still unknown. In the present study, we determined the effects of exogenous LA (0. Read More

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