1,297 results match your criteria effectiveness non-pharmacological


Cytapheresis re-induces high-rate steroid-free remission in patients with steroid-dependent and steroid-refractory ulcerative colitis.

World J Gastroenterol 2021 Mar;27(12):1194-1212

Akita Health Care Center, Akita Red Cross Hospital, Akita 010-0001, Japan.

Background: It is a crucial issue for patients with refractory ulcerative colitis (UC), including steroid-dependent and steroid-refractory patients, to achieve and maintain steroid-free remission. However, clinical studies focused on the achievement of steroid-free remission in refractory UC patients are insufficient. Cytapheresis (CAP) is a non-pharmacological extracorporeal therapy that is effective for active UC with fewer adverse effects. Read More

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A randomized trial to evaluate the impact of exercise-based cardiac rehabilitation for the prevention of chemotherapy-induced cardiotoxicity in patients with breast cancer: ONCORE study protocol.

BMC Cardiovasc Disord 2021 Apr 7;21(1):165. Epub 2021 Apr 7.

Cardiology Department, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), University Clinical Hospital of Santiago de Compostela (SERGAS), A Choupana s/n, 15706, Santiago de Compostela, A Coruña, Spain.

Background: Anthracyclines and monoclonal antibodies against human epidermal growth factor receptor-2 (HER2) are frequently used to treat breast cancer but they are associated with risk of developing cardiotoxicity. Implementation of cardioprotective strategies as part of breast cancer treatment are needed. To date, a limited number of studies have examined the effectiveness of cardiac rehabilitation programs or exercise programs in the prevention of cardiotoxicity through an integral assessment of cardiac function. Read More

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Prevalence and impact of dysmenorrhea among University students in Ireland.

Pain Med 2021 Apr 3. Epub 2021 Apr 3.

Centre for Pain Research, National University of Ireland, Galway, Ireland.

Objective: Primary dysmenorrhea (PD), or painful menstruation, is a common gynaecological condition that can cause intense pain and functional disability in women of reproductive age. As a non-malignant condition, PD is relatively under-studied and poorly managed. The purpose of this study was to estimate the prevalence and impact of PD among third-level students in Ireland. Read More

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Portuguese multidisciplinary recommendations for non-pharmacological and non-surgical interventions in patients with rheumatoid arthritis.

Acta Reumatol Port 2021 Jan-Mar;46(1):40-54

Background: Patients with rheumatoid arthritis (RA) report significant levels of disease impact, which are improved, but not fully abrogated by immunosuppressive therapy, even when remission is achieved. This imposes the need for adjuvant interventions targeting the uncontrolled domains of disease impact. Non-pharmacological interventions are widely used for this purpose, but they have not been the object of professional recommendations or guidelines. Read More

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Tele-management of home isolated COVID-19 patients via oxygen therapy with non-invasive positive pressure ventilation and physical therapy techniques: A randomized clinical trial.

J Med Internet Res 2021 Apr 1. Epub 2021 Apr 1.

Faculty of Physical Therapy, Cardiovascular-Respiratory Disorders and Geriatrics, Laser Applications in Physical Medicine, Cairo University, Cairo, EG.

Background: With the enlarging stress on hospitals caused by the novel coronavirus disease 2019 (Covid-19) pandemic, the need for home based solutions has become a necessity to support these overwhelmed hospitals.

Objective: To compare two non-pharmacological respiratory treatment methods for home isolated Covid-19 patients using a new developed tele-management healthcare system.

Methods: In this randomized, single-blinded, clinical trial, sixty patients with stage one pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection were treated. Read More

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The effectiveness of physical exercise interventions in the management of neuropsychiatric symptoms in dementia patients: a systematic review.

Int Psychogeriatr 2021 Apr 5:1-14. Epub 2021 Apr 5.

Professor, First Department of Psychiatry, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.

Background: The management of neuropsychiatric symptoms (NPS) in patients with dementia is a major challenge. Since no effective therapy has been found to date and drug treatments are associatedwith significant side effects, there seems to be a pressing need for alternative non-pharmacological interventions.

Objectives: The current study aims to investigate and compare the effect of different types of physical exercise on the NPS. Read More

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A feasibility cluster randomised controlled trial of a paramedic-administered breathlessness management intervention for acute-on-chronic breathlessness (BREATHE).

ERJ Open Res 2021 Jan 29;7(1). Epub 2021 Mar 29.

Wolfson Palliative Care Research Group, Hull York Medical School, Hull, UK.

Chronic breathlessness, persistent and disabling despite optimal treatment of underlying causes, is a prevalent and frightening symptom and is associated with many emergency presentations and admission to hospital. Breathlessness management techniques used by paramedics may reduce the need for conveyance to hospital. The Breathlessness RElief AT HomE study (BREATHE) aims to explore the feasibility of conducting a definitive cluster randomised controlled trial (cRCT) for people with acute-on-chronic breathlessness who have called an ambulance, to evaluate the effectiveness and cost-effectiveness of a paramedic-administered non-pharmacological breathlessness intervention. Read More

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January 2021

Topical Treatments and Their Molecular/Cellular Mechanisms in Patients with Peripheral Neuropathic Pain-Narrative Review.

Pharmaceutics 2021 Mar 26;13(4). Epub 2021 Mar 26.

Department of Pain Research and Treatment, Jagiellonian University Medical College, 31-008 Krakow, Poland.

Neuropathic pain in humans results from an injury or disease of the somatosensory nervous system at the peripheral or central level. Despite the considerable progress in pain management methods made to date, peripheral neuropathic pain significantly impacts patients' quality of life, as pharmacological and non-pharmacological methods often fail or induce side effects. Topical treatments are gaining popularity in the management of peripheral neuropathic pain, due to excellent safety profiles and preferences. Read More

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Impact of non-pharmacological interventions on quality of life, anxiety, and depression scores in patients with colorectal cancer: a systematic review and meta-analysis of randomized controlled trials.

Support Care Cancer 2021 Mar 31. Epub 2021 Mar 31.

Mental Health Center of West China Hospital, Sichuan University, Chengdu, China.

Purpose: Different non-pharmacological interventions have been considered and applied to patients with colorectal cancer to improve their quality of life and distress symptoms; however, there is little evidence comparing the effectiveness of these strategies. This review aimed at assessing the effect of non-pharmacological interventions on quality of life, anxiety, and depression scores among patients with colorectal cancer.

Methods: A systematic search for articles published until August 1, 2020, in the English language was performed in Medline, EMBASE, Web of Science, and the Cochrane Library; the reference lists of eligible articles were scanned for other potentially eligible publications. Read More

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The effect of a quality improvement intervention on sleep and delirium in critically ill patients in a surgical intensive care unit.

Chest 2021 Mar 24. Epub 2021 Mar 24.

Division of Pulmonary, Critical Care and Sleep Medicine, UC San Diego School of Medicine, La Jolla, CA, USA.

Background: Delirium is a deleterious condition affecting up to 60% of patients in the surgical intensive care unit (SICU). Few SICU-focused delirium interventions have been implemented, including those addressing sleep-wake disruption, a modifiable delirium risk factor common in critically ill patients.

Research Question: What is the effect on delirium and sleep quality of a multicomponent non-pharmacological intervention aimed at improving sleep-wake disruption in patients in the SICU setting?

Study Design And Methods: Using a staggered pre-post design, we implemented a quality improvement intervention in two SICUs (general surgery/trauma and cardiovascular) in an academic medical center. Read More

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Tension-type headache.

Nat Rev Dis Primers 2021 03 25;7(1):24. Epub 2021 Mar 25.

Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.

Tension-type headache (TTH) is the most prevalent neurological disorder worldwide and is characterized by recurrent headaches of mild to moderate intensity, bilateral location, pressing or tightening quality, and no aggravation by routine physical activity. Diagnosis is based on headache history and the exclusion of alternative diagnoses, with clinical criteria provided by the International Classification of Headache Disorders, third edition. Although the biological underpinnings remain unresolved, it seems likely that peripheral mechanisms are responsible for the genesis of pain in TTH, whereas central sensitization may be involved in transformation from episodic to chronic TTH. Read More

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Pharmacological and non-pharmacological strategies for obese women with subfertility.

Cochrane Database Syst Rev 2021 Mar 25;3:CD012650. Epub 2021 Mar 25.

Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran.

Background: Clinicians primarily recommend weight loss for obese women seeking pregnancy. The effectiveness of interventions aimed at weight loss in obese women with subfertility is unclear.

Objectives: To assess the effectiveness and safety of pharmacological and non-pharmacological strategies compared with each other, placebo, or no treatment for achieving weight loss in obese women with subfertility. Read More

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Repetitive transcranial magnetic stimulation alone and in combination with motor control exercise for the treatment of individuals with chronic non-specific low back pain (ExTraStim trial): study protocol for a randomised controlled trial.

BMJ Open 2021 Mar 24;11(3):e045504. Epub 2021 Mar 24.

Faculté de médecine, Université Laval, Quebec, Quebec, Canada

Introduction: While multiple pharmacological and non-pharmacological interventions treating chronic non-specific low back pain (CLBP) are available, they have been shown to produce at best modest effects. Interventions such as repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, have exhibited promising results to alleviate chronic pain. However, evidence on the effectiveness of rTMS for CLBP is scarce due to limited rigorous clinical trials. Read More

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Role of the active cycle of breathing technique combined with phonophoresis for the treatment of patients with chronic obstructive pulmonary disease (COPD): study protocol for a preliminary randomized controlled trial.

Trials 2021 Mar 23;22(1):228. Epub 2021 Mar 23.

School of Nursing, Jilin University, No 965, Xin Jiang Avenue, Changchun, 130000, Jilin Province, China.

Background: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease characterized by coughing, the production of excess sputum, and dyspnea. Patients with excessively thick sputum may have frequent attacks or develop more serious disease. The guidelines recommend airway clearance for patients with excessive sputum who are hospitalized with COPD. Read More

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Study design and rationale for a randomized controlled trial to assess effectiveness of stochastic vibrotactile mattress stimulation versus standard non-oscillating crib mattress for treating hospitalized opioid-exposed newborns.

Contemp Clin Trials Commun 2021 Mar 11;21:100737. Epub 2021 Feb 11.

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15213, USA.

The incidence of Neonatal Abstinence Syndrome (NAS) continues to rise and there remains a critical need to develop non-pharmacological interventions for managing opioid withdrawal in newborns. Objective physiologic markers of opioid withdrawal in the newborn remain elusive. Optimal treatment strategies for improving short-term clinical outcomes and promoting healthy neurobehavioral development have yet to be defined. Read More

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Effectiveness of a Family Support Intervention on Caregiving Burden in Family of Elderly Patients With Cognitive Decline After the COVID-19 Lockdown.

Front Psychiatry 2021 4;12:590104. Epub 2021 Mar 4.

Alzheimer Center ASST Rhodense, Rho, Italy.

The coronavirus disease 2019 (COVID-19) pandemic had a great impact on patients with cognitive decline or dementia. The lockdown period may exacerbate behavioral disorders and worsen distress of caregivers. The aim of this study is to evaluate the effectiveness of a family support intervention on the negative effects that the COVID-19 lockdown may have on patients and related caregivers. Read More

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SARS-CoV-2 vaccines: A critical perspective through efficacy data and barriers to herd immunity.

Respir Med 2021 Mar 6;180:106355. Epub 2021 Mar 6.

Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy; Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

Non-pharmacological interventions and tracing-testing strategy proved insufficient to reduce SARS-CoV-2 spreading worldwide. Several vaccines with different mechanisms of action are currently under development. This review describes the potential target antigens evaluated for SARS-CoV-2 vaccine in the context of both conventional and next-generation platforms. Read More

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Evaluation of a structured skills training group for adolescents with attention-deficit/hyperactivity disorder: a randomised controlled trial.

Eur Child Adolesc Psychiatry 2021 Mar 15. Epub 2021 Mar 15.

Department of Neuroscience, Child and Adolescent Psychiatry Unit, Uppsala University, Akademiska Sjukhuset, 751 85, Uppsala, Sweden.

Attention-deficit/hyperactivity disorder (ADHD) in adolescence is associated with behavioural, emotional and interpersonal problems, and non-pharmacological treatments targeting these difficulties have been requested. The objective of this study was to evaluate the effectiveness and acceptance of an age-adapted structured skills training group (SSTG) for adolescents with ADHD. Adolescents (n = 184, ages 15-18 years) with a diagnosis of ADHD were randomly assigned to either the SSTG, which is based on dialectical behavioural therapy, or an active control group based on psychoeducation. Read More

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Effectiveness and Efficiency of Non-drug Therapy Among Community-Dwelling Adults With Hypertension in China: A Protocol for Network Meta-Analysis and Cost-Effectiveness Analysis.

Front Med (Lausanne) 2021 25;8:651559. Epub 2021 Feb 25.

Center for Pharmacoeconomics and Outcomes Research, China Pharmaceutical University, Nanjing, China.

The Chinese government has established a nationwide community-based chronic disease management program since 2009 with hypertension a vital part of it. Though drugs have been proven effective with hypertensive patients, they bring economic burden as well, especially for those who with elevated blood pressure and are potentially eligible for national programs. When the effectiveness of pharmacotherapy-only interventions remains uncertain on these patients, non-pharmacological interventions have demonstrated non-inferior effectiveness and may have economic advantages. Read More

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February 2021

A systematic review of behavioural and exercise interventions for the prevention and management of chemotherapy-induced peripheral neuropathy symptoms.

J Cancer Surviv 2021 Mar 12. Epub 2021 Mar 12.

Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) can result in functional difficulties. Pharmacological interventions used to prevent CIPN either show low efficacy or lack evidence to support their use and to date, duloxetine remains the only recommended treatment for painful CIPN. Non-pharmacological interventions such as exercise and behavioural interventions for CIPN exist. Read More

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COPD Management in Community Pharmacy Results in Improved Inhaler Use, Immunization Rate, COPD Action Plan Ownership, COPD Knowledge, and Reductions in Exacerbation Rates.

Int J Chron Obstruct Pulmon Dis 2021 2;16:519-533. Epub 2021 Mar 2.

Woolcock Institute of Medical Research, University of Sydney, Glebe, New South Wales, Australia.

Purpose: To evaluate the effectiveness of a pilot community pharmacy care model for patients with chronic obstructive pulmonary disease (COPD) to improve: 1) inhaler technique; 2) medication adherence; and 3) uptake of non-pharmacological treatment and prevention activities.

Patients And Methods: Forty "host" pharmacies in Sydney were invited to recruit eligible patients and to provide a counselling room/area in their pharmacy for service provision. Eligible patients were referred to two "consultant" pharmacists, specifically trained to deliver a specialized pharmacy COPD service which involved 3 in-pharmacy visits and 2 follow-up phone calls over a 6-month period. Read More

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Self-Management for Men With Lower Urinary Tract Symptoms: A Systematic Review and Meta-Analysis.

Ann Fam Med 2021 Mar-Apr;19(2):157-167

Institute for Evidence-Based Healthcare, Faculty of Health Sciences and Medicine, Bond University, Queensland, Australia.

Purpose: Lower urinary tract symptoms are very common in older men. We conducted a systematic review and meta-analysis to evaluate the effects of self-management interventions on these symptoms.

Methods: We included randomized controlled trials comparing the effect of self-management interventions (alone or combined with drug therapy) with usual care or drug therapy alone in men with lower urinary tract symptoms. Read More

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February 2020

Effectiveness of Mulligan manual therapy over exercise on headache frequency, intensity and disability for patients with migraine, tension-type headache and cervicogenic headache - a protocol of a pragmatic randomized controlled trial.

BMC Musculoskelet Disord 2021 Mar 3;22(1):243. Epub 2021 Mar 3.

School of Physiotherapy and Exercise Science, Curtin University, P.O. Box U1987, Perth, WA, 6845, Australia.

Background: Non - pharmacological management of migraine, tension-type headache (TTH), and cervicogenic headache (CGH) may include spinal manual therapy and exercise. Mulligan Manual Therapy (MMT) utilizes a protocol of headache elimination procedures to manage headache parameters and associated disability, but has only been evaluated in CGH. There is little evidence for its effectiveness in migraine and TTH. Read More

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Effects of a non-pharmacological approach for chronic pain management in patients with haemophilia: efficacy of cognitive-behavioural therapy associated with physiotherapy.

Haemophilia 2021 Mar 2. Epub 2021 Mar 2.

Haemostasis and Thrombosis Unit, University and Polytechnic Hospital La Fe, Valencia, Spain.

Introduction: More than half of adult patients with severe haemophilia (PWH) suffer pain daily, with chronic pain (CP) in more than 15% of cases, thereby reducing their quality of life (QoL). However, there are no evidence-based therapeutic guidelines for pain management.

Aim: To evaluate the effectiveness of a combined protocol based on psychology and physiotherapy in the improvement of CP self-efficacy in PWH with CP. Read More

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Effect of Mastiha supplementation on NAFLD: The MAST4HEALTH Randomised, Controlled Trial.

Mol Nutr Food Res 2021 Feb 24:e2001178. Epub 2021 Feb 24.

Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.

Scope: Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease with poor therapeutic strategies. Mastiha possesses antioxidant/anti- inflammatory and lipid lowering properties. We investigated the effectiveness of Mastiha as a non-pharmacological intervention in NAFLD. Read More

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February 2021

Cochrane corner: effectiveness of quarantine in reducing the spread of COVID-19.

Pan Afr Med J 2020 4;35(Suppl 2):18. Epub 2020 May 4.

Cochrane South Africa, South African Medical Research Council, Cape Town, South Africa.

Introduction: there is no effective vaccine against coronavirus disease 2019 (COVID-19) at present, so non-pharmacological interventions like quarantine are advocated to control its spread. Quarantine refers to the restriction of the movement of asymptomatic healthy people who have had contact with cases of a communicable disease. We highlight a Cochrane rapid review, published in April 2020, on the effectiveness of quarantine in limiting the spread of COVID-19. Read More

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Economic evaluations of educational, physical, and psychological treatments for fibromyalgia: a systematic review with meta-analysis.

Pain 2021 Feb 9. Epub 2021 Feb 9.

Masters and Doctoral Programs in Physical Therapy, Universidade Cidade de São Paulo, São Paulo, SP, Brazil Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health research institute, The Netherlands.

Non-pharmacological interventions are recommended for the treatment of fibromyalgia, but there is a lack of knowledge about the cost-effectiveness of these interventions. The aim of this study was to systematically review economic evaluations of educational, physical and psychological interventions for the treatment of fibromyalgia. Search were performed in PUBMED, EMBASE, CINAHL, Cochrane Library, PEDro, PsycINFO, EconLit, NHS EED and HTA. Read More

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February 2021

[Chondroitin sulfate role in the complex rehabilitation of elderly people with chronic pain syndrome].

Vopr Kurortol Fizioter Lech Fiz Kult 2021 ;98(1):71-78

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

The article presents the data of the latest domestic and foreign original studies, the results of a number of meta-analyses, conclusions of randomized clinical trials (RCTs), and other scientific studies that prove the effectiveness and necessity of mandatory inclusion in the treatment of chronic pain syndrome of the stage of non-invasive non-pharmacological therapy. One of the promising areas of pharmacotherapy for degenerative-dystrophic joint lesions is the use of chondroprotectors (CP), in particular chondroitin sulfate (CS). According to new Clinical Recommendations of Ministry Health (MH) of the Russian Federation (RF) «Chronic pain in patients of elderly and senile age» (2020), according to which the purpose of CS is recommended for patients older than 60 years with joint pain and contraindications to non-steroidal anti-inflammatory drugs (NSAIDs) or senile asthenia for the purpose of pain relief and the prevention of exacerbations of pain. Read More

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February 2021

Community-based non-pharmacological interventions for improving pain, disability and quality of life in pregnant women with musculoskeletal conditions: protocol for a systematic review with meta-analyses.

BMJ Open 2021 Feb 18;11(2):e042107. Epub 2021 Feb 18.

Medical Rehabilitation, University of Nigeria, Enugu, Enugu, Nigeria.

Introduction: Twenty five per cent of pregnant women with musculoskeletal pain have disabling symptoms that negatively influence quality of life. Studies have reported varying effects of non-pharmacological interventions including exercise, manipulation and pelvic belts for pregnant women with musculoskeletal problems. The overall effectiveness and acceptability of these interventions is uncertain due to lack of synthesised evidence. Read More

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February 2021