1,156 results match your criteria effectiveness bioactive

Biological importance, therapeutic benefit and analytical aspects of bioactive flavonoid pectolinarin in the nature.

Drug Metab Lett 2021 Jul 25. Epub 2021 Jul 25.

Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology and Sciences, Naini, Prayagraj, 211007, Uttar Pradesh, Poland.

Backgrounds: Plants and their derived products have been used in the traditional system of medicine for the treatment of various forms of human disorders since very ancient time. In the traditional system of medicine and modern allopathic medicine, numerous phytoconstituents have been used for the preparation of various types of formulation. Flavonoidal class phytochemicals are the main active phytoconstituents of plants, fruit, vegetables and beverages. Read More

View Article and Full-Text PDF

Evolution of anodised titanium for implant applications.

Heliyon 2021 Jul 26;7(7):e07408. Epub 2021 Jun 26.

Department of Manufacturing Engineering, Faculty of Mechanical and Manufacturing Engineering, UTHM Parit Raja 86400, Batu Pahat, Johor, Malaysia.

Anodised titanium has a long history as a coating structure for implants due to its bioactive and ossified surface, which promotes rapid bone integration. In response to the growing literature on anodised titanium, this article is the first to revisit the evolution of anodised titanium as an implant coating. The review reports the process and mechanisms for the engineering of distinctive anodised titanium structures, the significant factors influencing the mechanisms of its formation, bioactivity, as well as recent pre- and post-surface treatments proposed to improve the performance of anodised titanium. Read More

View Article and Full-Text PDF

Effectiveness of cell adhesive additives in different supramolecular polymers.

J Polym Sci (2020) 2021 Jun 29;59(12):1253-1266. Epub 2021 Mar 29.

Institute for Complex Molecular Systems Eindhoven University of Technology Eindhoven The Netherlands.

Supramolecular motifs in elastomeric biomaterials facilitate the modular incorporation of additives with corresponding motifs. The influence of the elastomeric supramolecular base polymer on the presentation of additives has been sparsely examined, limiting the knowledge of transferability of effective functionalization between polymers. Here it was investigated if the polymer backbone and the additive influence biomaterial modification in two different types of hydrogen bonding supramolecular systems, that is, based on ureido-pyrimidinone or bis-urea units. Read More

View Article and Full-Text PDF

Computational strategies for the discovery of biological functions of health foods, nutraceuticals and cosmeceuticals: a review.

Mol Divers 2021 Jul 14. Epub 2021 Jul 14.

ProtoQSAR SL, CEEI (Centro Europeo de Empresas Innovadoras), Parque Tecnológico de Valencia, Valencia, Spain.

Scientific and consumer interest in healthy foods (also known as functional foods), nutraceuticals and cosmeceuticals has increased in the recent years, leading to an increased presence of these products in the market. However, the regulations across different countries that define the type of claims that may be made, and the degree of evidence required to support these claims, are rather inconsistent. Moreover, there is also controversy on the effectiveness and biological mode of action of many of these products, which should undergo an exhaustive approval process to guarantee the consumer rights. Read More

View Article and Full-Text PDF

Drug-Induced Liver Injury in a Patient with Nonsmall Cell Lung Cancer after the Self-Administration of Fenbendazole Based on Social Media Information.

Case Rep Oncol 2021 May-Aug;14(2):886-891. Epub 2021 Jun 17.

Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan.

Fenbendazole is a benzimidazole anthelmintic agent, with a broad antiparasitic range in animals such as dogs and pigs. The agent is also reported to exert antitumor effects and inhibit microtubule-associated tubulin polymerization, but its safety and tolerability profile in humans remains unclear. An 80-year-old female patient with advanced nonsmall cell lung cancer (NSCLC) was started on pembrolizumab monotherapy. Read More

View Article and Full-Text PDF

Phytotherapic Drugs For Covid19 Treatment: A Scoping Review.

Curr Pharm Des 2021 Jul 5. Epub 2021 Jul 5.

School of Civil and Environmental Engineering, Yonsei University, Seoul 03722. Korea.

Background: The rapid eruption of Coronavirus at the end of 2019 has caused global health crisis and significant loss to the economy and social well-being. This created a massive shortage of advanced health facilities with inadequate medicinal supply, further deteriorating human health conditions. On the basis of adverse effects of the ongoing pandemic, this review is proposed to evaluate the antiviral efficacy of plant-based therapeutics against SARS-CoV-2 (commonly called COVID19) infection. Read More

View Article and Full-Text PDF

Microwave Pretreatment for the Extraction of Anthocyanins from Saffron Flowers: Assessment of Product Quality.

Antioxidants (Basel) 2021 Jun 29;10(7). Epub 2021 Jun 29.

BioEcoUva, Research Institute on Bioeconomy, High Pressure Processes Group, Department of Chemical Engineering and Environmental Technology, University of Valladolid, 47011 Valladolid, Spain.

The potential of saffron flowers as a source of polyphenols, and in particular anthocyanins, for the extraction of bioactive compounds and the production of a cyanic colorant was analyzed. A microwave pretreatment, prior to the conventional solid-liquid extraction process, was proposed as a feasible intensification step. The effectiveness of microwave pretreatment was assessed in terms of increased yield and improved quality of the final product. Read More

View Article and Full-Text PDF

Promising Antimicrobial Properties of Bioactive Compounds from Different Honeybee Products.

Molecules 2021 Jun 30;26(13). Epub 2021 Jun 30.

Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznan, Poland.

Bee products have been known for centuries for their versatile healing properties. In recent decades they have become the subject of documented scientific research. This review aims to present and compare the impact of bee products and their components as antimicrobial agents. Read More

View Article and Full-Text PDF

Lung Cancer Management with Silibinin: A Historical and Translational Perspective.

Pharmaceuticals (Basel) 2021 Jun 11;14(6). Epub 2021 Jun 11.

Girona Biomedical Research Institute (IDIBGI), 17190 Girona, Spain.

The flavonolignan silibinin, the major bioactive component of the silymarin extract of (milk thistle) seeds, is gaining traction as a novel anti-cancer therapeutic. Here, we review the historical developments that have laid the groundwork for the evaluation of silibinin as a chemopreventive and therapeutic agent in human lung cancer, including translational insights into its mechanism of action to control the aggressive behavior of lung carcinoma subtypes prone to metastasis. First, we summarize the evidence from chemically induced primary lung tumors supporting a role for silibinin in lung cancer prevention. Read More

View Article and Full-Text PDF

Mesoporous Silica Nanoparticles and Mesoporous Bioactive Glasses for Wound Management: From Skin Regeneration to Cancer Therapy.

Materials (Basel) 2021 Jun 17;14(12). Epub 2021 Jun 17.

Tissue Engineering Research Group (TERG), Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad 917794-8564, Iran.

Exploring new therapies for managing skin wounds is under progress and, in this regard, mesoporous silica nanoparticles (MSNs) and mesoporous bioactive glasses (MBGs) offer great opportunities in treating acute, chronic, and malignant wounds. In general, therapeutic effectiveness of both MSNs and MBGs in different formulations (fine powder, fibers, composites etc.) has been proved over all the four stages of normal wound healing including hemostasis, inflammation, proliferation, and remodeling. Read More

View Article and Full-Text PDF

Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2.

Pathogens 2021 Jun 15;10(6). Epub 2021 Jun 15.

Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt.

Until now, there has been no direct evidence of the effectiveness of repurposed FDA-approved drugs against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections. Although curcumin, hesperidin, and quercetin have broad spectra of pharmacological properties, their antiviral activities against SARS-CoV-2 remain unclear. Our study aimed to assess the in vitro antiviral activities of curcumin, hesperidin, and quercetin against SARS-CoV-2 compared to hydroxychloroquine and determine their mode of action. Read More

View Article and Full-Text PDF

Chemical composition, antioxidant activities and antibacterial activities of essential oil from Thunb. growing in South Africa.

Heliyon 2021 Jun 7;7(6):e07244. Epub 2021 Jun 7.

Department of Nature Conservation, Faculty of Natural Sciences, Mangosuthu University of Technology, P.O.Box 12363, Jacobs, 4026, Durban, Kwa-Zulu Natal, South Africa.

Introduction: Essential oils from plants are recognized as one of the most promising secondary metabolites for the development of cheap and safer drugs. While has been prominently used in folk medicine for the treatment of microbial infections, there is dearth of information on the pharmacological effectiveness and chemical composition of its essential oil. The study, therefore, aimed at identifying the chemical composition and biological activities of the essential oil of

Methods: In this study, the essential oil was extracted with all-glass Clevenger. Read More

View Article and Full-Text PDF

Classification-based strategies to simplify complex traditional Chinese medicine (TCM) researches through liquid chromatography-mass spectrometry in the last decade (2011-2020): Theory, technical route and difficulty.

J Chromatogr A 2021 Aug 4;1651:462307. Epub 2021 Jun 4.

Key Laboratory for Identification and Quality Evaluation of Traditional Chinese Medicine of Liaoning Province, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China. Electronic address:

The difficulty of traditional Chinese medicine (TCM) researches lies in the complexity of components, metabolites, and bioactivities. For a long time, there has been a lack of connections among the three parts, which is not conducive to the systematic elucidation of TCM effectiveness. To overcome this problem, a classification-based methodology for simplifying TCM researches was refined from literature in the past 10 years (2011-2020). Read More

View Article and Full-Text PDF

Assessment of the effect of experimental bleaching agent with nano-bioactive material on postoperative sensitivity: A randomized, triple blind clinical trial.

J Esthet Restor Dent 2021 07 23;33(5):764-774. Epub 2021 Jun 23.

School of Dentistry, Department of Restorative Dentistry, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.

Objectives: This clinical study aimed to evaluate the effect of incorporating bioactive nanoparticles (n-Bm) inside an in-office bleaching gel on the risk and intensity of tooth sensitivity (TS) and on bleaching effectiveness.

Materials And Methods: Sixty-six participants were selected and randomly assigned into two groups: control-only in-office gel and experimental-in-office gel with n-Bm. Teeth were bleached in two sessions (3 × 15-min). Read More

View Article and Full-Text PDF

Methods to improve efficacy of orally administered bioactive peptides using bovine colostrum as an exemplar.

PLoS One 2021 17;16(6):e0253422. Epub 2021 Jun 17.

Centre for Immunobiology, Blizard Institute, Barts and The London School of Medicine, Queen Mary, University of London, London, United Kingdom.

Background: Oral administration of bioactive peptides has potential clinical advantages, but its applicability is limited due to gastric and pancreatic enzyme proteolysis.

Objective: To examine whether the co-packaging of bovine colostrum (BC), a rich source of IgG, immune and growth factors, with the food additives trehalose (carbohydrate), stearine (fat), casein (protein present in BC) or soy flour (plant based with high protease inhibitory activity) enhances the stability of BC against digestion.

Design: Samples alone and in combination (BC+ 10% wt/wt trehalose, stearine, casein or soy) were exposed to HCl/pepsin, followed by trypsin and chymotrypsin ("CT"). Read More

View Article and Full-Text PDF

Potential use of essential oils in cosmetic and dermatological hair products: A review.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Institute of Physics, University of São Paulo, São Paulo, Brazil.

Background: Essential oils have great interest among the increasing demand for herbal cosmetics in the market. They are natural sources of biologically active ingredients due to the wide application of such compounds as well as their particular chemical composition. Several researches have evaluated the effectiveness of these bioactive ingredients for use in cosmeceuticals, mainly in both hair scalp and shaft hair damage repair. Read More

View Article and Full-Text PDF

Recent advancements in encapsulation of bioactive compounds as a promising technique for meat preservation.

Meat Sci 2021 Nov 29;181:108585. Epub 2021 May 29.

Department of Food Science and Nutrition, Faculty of Food Engineering, University of Campinas (UNICAMP), 13083-862 Campinas, São Paulo, Brazil. Electronic address:

Encapsulation is currently considered as one the most valuable methods for preserving aromatic compounds or hiding odors, enhancing their thermal and oxidative stability, and expanding their food applications. Indeed, this current article was aimed to provide an overview regarding the encapsulation of plant bioactive compounds and the spray-drying and extrusion processes with a focused discussion regarding the encountered challenges for meat and meat product preservation. Furthermore, different ranges of carbohydrates as wall materials (carriers) besides the process conditions' effects on the encapsulation effectiveness and the particle size of the encapsulated bioactive compounds have been discussed. Read More

View Article and Full-Text PDF
November 2021

Anti-seizure activity of African medicinal plants: The identification of bioactive alkaloids from the stem bark of Rauvolfia caffra using an in vivo zebrafish model.

J Ethnopharmacol 2021 Jun 10;279:114282. Epub 2021 Jun 10.

Department of Pharmaceutical Sciences, Tshwane University of Technology, Pretoria, 0001, South Africa. Electronic address:

Ethnopharmacological Relevance: Epilepsy is one of the major chronic diseases that does not have a cure to date. Adverse drug reactions have been reported from the use of available anti-epileptic drugs (AEDs) which are also effective in only two-thirds of the patients. Accordingly, the identification of scaffolds with promising anti-seizure activity remains an important first step towards the development of new anti-epileptic therapies, with improved efficacy and reduced adverse effects. Read More

View Article and Full-Text PDF

Extraction of bioactive compounds from using emergent technologies.

3 Biotech 2021 Jun 21;11(6):284. Epub 2021 May 21.

Laboratory of Agroindustrial Processes Engineering (LAPE), Federal University of Santa Maria, 1040 Sete de Setembro st., Center DC, Cachoeira do Sul, RS 96508-010 Brazil.

Several plant species synthesize biologically active secondary metabolites. Pyrrolizidine alkaloids are a large group of biotoxins produced by thousands of plant species to protect against the attack of insects and herbivores, but they are highly toxic for humans and animals. In this study, extracts from the aerial part of were obtained using different technologies: ultrasound-assisted extraction (UAE), pressurized liquid extraction (PLE), and microwave hydrodiffusion and gravity (MHG). Read More

View Article and Full-Text PDF

The traditional uses, phytochemistry and pharmacology of spearmint (Mentha spicata L.): A review.

J Ethnopharmacol 2021 Oct 1;278:114266. Epub 2021 Jun 1.

Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Lucknow, 226015, India. Electronic address:

Ethnopharmacology Relevance: Mentha spicata L. (Lamiaceae), commonly called Spearmint, is wildly cultivated worldwide for its remarkable aroma and commercial value. In addition to traditional foods flavouring agent, M. Read More

View Article and Full-Text PDF
October 2021

Bioactive peptides from microalgae: Focus on anti-cancer and immunomodulating activity.

Physiol Plant 2021 Jun 3. Epub 2021 Jun 3.

Division of Biotechnology and Plant Health, Norwegian Institute of Bioeconomy Research (NIBIO), Ås, Norway.

In addition to the rapidly expanding field of using microalgae for food and feed, microalgae represent a tremendous potential for new bioactive compounds with health-promoting effects. One field where new therapeutics is needed is cancer therapy. As cancer therapy often cause severe side effects and loose effect due to development of drug resistance, new therapeutic agents are needed. Read More

View Article and Full-Text PDF

Bioactive nanoparticle reinforced alginate/gelatin bioink for the maintenance of stem cell stemness.

Mater Sci Eng C Mater Biol Appl 2021 Jul 19;126:112193. Epub 2021 May 19.

Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department, PLA General Hospital, 51 Fu Cheng Road, Beijing 100048, PR China. Electronic address:

Mesenchymal cells (MSCs) are an attractive option as seed cells for bioprinting. However, loss of stemness and undesired differentiation reduces their effectiveness. In this study, 12 nm bioactive nanoparticles (BNPs) which could release silicon (Si) ions were used to enhance the properties of alginate/gelatin hydrogel bioink to maintain MSC stemness. Read More

View Article and Full-Text PDF

Extracellular vesicles in the tumor immune microenvironment.

Cancer Lett 2021 Sep 31;516:48-56. Epub 2021 May 31.

State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, 361102, China. Electronic address:

Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved in various essential physiological and pathological processes. They are secreted by almost all cell types and carry bioactive materials, such as proteins, lipids and nucleic acids, that can be transmitted from host cells to recipient cells, thereby eliciting phenotypic and functional alterations in the recipient cells. Recent evidence shows that EVs play essential roles in remodeling the tumor immune microenvironment (TIME). Read More

View Article and Full-Text PDF
September 2021

Cordycepin Inhibits Virus Replication in Dengue Virus-Infected Vero Cells.

Molecules 2021 May 23;26(11). Epub 2021 May 23.

Division of Molecular Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

Dengue virus (DENV) infection causes mild to severe illness in humans that can lead to fatality in severe cases. Currently, no specific drug is available for the treatment of DENV infection. Thus, the development of an anti-DENV drug is urgently required. Read More

View Article and Full-Text PDF

Antimicrobial Activity of Selected Essential Oils against Selected Pathogenic Bacteria: In Vitro Study.

Antibiotics (Basel) 2021 May 8;10(5). Epub 2021 May 8.

Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.

The worldwide problem of infectious diseases has appeared in recent years, and antimicrobial agents are crucial in reducing disease emergence. Nevertheless, the development and distribution of multidrug-resistant (MDR) strains in pathogenic bacteria, such as , , and , has become a major society health hazard. Essential oils could serve as a promising tool as a natural drug in fighting the problem with these bacteria. Read More

View Article and Full-Text PDF

Bioactive Components of and Their Potential Antidiabetic Properties: A Review.

Molecules 2021 May 20;26(10). Epub 2021 May 20.

Nutrition, Metabolism and Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health, Malaysia, No.1, Jalan Setia Murni U13/52, Seksyen U13 Setia Alam, Shah Alam 40170, Malaysia.

The utilization of therapeutic plants is expanding around the globe, coupled with the tremendous expansion of alternative medicine and growing demand in health treatment. Plants are applied in pharmaceuticals to preserve and expand health-physically, mentally and as well as to treat particular health conditions and afflictions. There are more than 600 families of plants identified so far. Read More

View Article and Full-Text PDF

Impact of Commercial Seaweed Liquid Extract (TAM) Biostimulant and Its Bioactive Molecules on Growth and Antioxidant Activities of Hot Pepper ().

Plants (Basel) 2021 May 21;10(6). Epub 2021 May 21.

Botany Department, Faculty of Science, Tanta University, Tanta 31527, Egypt.

Bioactive molecules derived from seaweed extracts are revolutionary bio-stimulants used to enhance plant growth and increase yield production. This study evaluated the effectiveness of a commercially available seaweed liquid extract, namely, True-Algae-Max (TAM), as a plant growth stimulant on nutritional, and antioxidant activity of . Three concentrations of TAM (0. Read More

View Article and Full-Text PDF

Hemostatic and Tissue Regeneration Performance of Novel Electrospun Chitosan-Based Materials.

Biomedicines 2021 May 21;9(6). Epub 2021 May 21.

Medical Institute, Sumy State University, 40007 Sumy, Ukraine.

The application of chitosan (Ch) as a promising biopolymer with hemostatic properties and high biocompatibility is limited due to its prolonged degradation time, which, in turn, slows the repair process. In the present research, we aimed to develop new technologies to reduce the biodegradation time of Ch-based materials for hemostatic application. This study was undertaken to assess the biocompatibility and hemostatic and tissue-regeneration performance of Ch-PEO-copolymer prepared by electrospinning technique. Read More

View Article and Full-Text PDF

Cancer Initiation, Progression and Resistance: Are Phytocannabinoids from L. Promising Compounds?

Molecules 2021 May 2;26(9). Epub 2021 May 2.

Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università della Campania "Luigi Vanvitelli", Via G. Vivaldi 42, 81100 Caserta, Italy.

L. is a source of over 150 active compounds known as phytocannabinoids that are receiving renewed interest due to their diverse pharmacologic activities. Indeed, phytocannabinoids mimic the endogenous bioactive endocannabinoids effects through activation of CB1 and CB2 receptors widely described in the central nervous system and peripheral tissues. Read More

View Article and Full-Text PDF

Enhanced biomaterials: systematic review of alternatives to supplement spine fusion including silicon nitride, bioactive glass, amino peptide bone graft, and tantalum.

Neurosurg Focus 2021 Jun;50(6):E10

4William Beaumont School of Medicine, Oakland University, Rochester, Michigan.

Objective: Spinal fusions are among the most common and effective spinal surgical practices; however, the current model presents some cost and safety concerns within the patient population. Therefore, enhanced biomaterials have been presented to be an innovative yet underutilized tool to supplement the success of spinal fusion surgery. Herein, the authors discuss these biomaterials, their compositions, clinical outcomes, and cost analysis through a systematic review of the literature to date. Read More

View Article and Full-Text PDF