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Neorectal mucosal prolapse after intersphincteric resection for low lying rectal cancer: a case report.

Ann Coloproctol 2021 Apr 22. Epub 2021 Apr 22.

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea.

Radical resection for low rectal cancer is the mainstay among the treatment modalities. Intersphincteric resection (ISR) is considered a relatively new but effective surgical treatment for low-lying rectal tumor. As the sphincter preserving techniques get popularized, we notice uncommon complication associated with it in the form of rectal mucosal prolapse. Read More

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Management of patients with X-linked hypophosphatemic rickets during Covid-19 pandemic lockdown.

J Pediatr Endocrinol Metab 2021 Apr 23. Epub 2021 Apr 23.

Division of Pediatrics, Department of Obstetrics, Gynecology and Pediatrics, University-Hospital, Pisa, Italy.

Objectives: To identify a safe pathway for management and treatment of patients with X-linked hypophosphatemic rickets (XLH) during Covid-19 pandemic lockdown.

Methods: Twenty-six patients with XLH (age 3.1-25. Read More

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The Effect of Shoulder Abduction Angle on Trapezius Muscle Activity During Scapular Retraction Exercise.

J Athl Train 2021 Apr 22. Epub 2021 Apr 22.

1Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Sihhiye, 06100, Ankara, Turkey.

Context: Scapular retraction exercises are often prescribed to enhance scapular stabilization.

Objectives: To investigate the upper trapezius (UT), middle trapezius (MT), lower trapezius (LT) activities, and UT/MT and UT/LT ratios during scapular retraction exercise with elastic resistance at different shoulder abduction angles.

Design: Descriptive laboratory study. Read More

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Prediction of Covid-19 spreading and optimal coordination of counter-measures: From microscopic to macroscopic models to Pareto fronts.

PLoS One 2021 22;16(4):e0249676. Epub 2021 Apr 22.

Zuse Institute Berlin, Berlin, Germany.

The Covid-19 disease has caused a world-wide pandemic with more than 60 million positive cases and more than 1.4 million deaths by the end of November 2020. As long as effective medical treatment and vaccination are not available, non-pharmaceutical interventions such as social distancing, self-isolation and quarantine as well as far-reaching shutdowns of economic activity and public life are the only available strategies to prevent the virus from spreading. Read More

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Topical 15% Resorcinol Is Associated with High Treatment Satisfaction in Patients with Mild to Moderate Hidradenitis Suppurativa.

Dermatology 2021 Apr 22:1-4. Epub 2021 Apr 22.

Department of Dermatology, Alicante University General Hospital, Alicante, Spain.

Background: Topical 15% resorcinol is commonly used in clinical practice for the treatment of nodules and abscesses in patients with hidradenitis suppurativa (HS). It has been shown to be clinically effective in some small studies, but data on satisfaction perceived by patients are lacking. The Treatment Satisfaction Questionnaire for Medication (TSQM) version 1. Read More

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Subcutaneous Allergen Immunotherapy in Children: Real Life Compliance and Effect of COVID-19 Pandemic on Compliance.

Int Arch Allergy Immunol 2021 Apr 22:1-6. Epub 2021 Apr 22.

Department of Pediatric Allergy, Hacettepe University School of Medicine, Ankara, Turkey.

Background: Subcutaneous allergen immunotherapy (SCIT) is an effective treatment for allergic rhinitis, asthma, and venom allergy. Compliance is essential for SCIT to obtain maximal benefit as it is a long-term treatment.

Objectives: This study aimed to determine the level of real-life SCIT compliance in pediatric patients and the associated factors. Read More

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Clinical Features of Patients with Active Eosinophilic Granulomatosis with Polyangiitis Successfully Treated with Mepolizumab.

Int Arch Allergy Immunol 2021 Apr 22:1-13. Epub 2021 Apr 22.

Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Background: In some patients with eosinophilic granulomatosis with polyangiitis (EGPA), remission cannot be induced, despite treatment with corticosteroids and immunosuppressants. We evaluated the clinical features of patients with EGPA in whom mepolizumab was effective.

Methods: There were 59 EGPA patients treated at Hiratsuka City Hospital, Japan, between April 2018 and September 2020, and 30 of them received mepolizumab. Read More

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Incidence of Neo-Intimal Hyperplasia in Anterior Circulation Aneurysms Following Pipeline Flow Diversion.

J Stroke Cerebrovasc Dis 2021 Apr 19;30(7):105794. Epub 2021 Apr 19.

Department of Neurosurgery, New York Medical College, Westchester Medical Center, Valhalla, NY, USA.

Introduction: Flow diversion of the distal anterior circulation cerebral vasculature may be used for management of wide necked aneurysms not amenable to other endovascular approaches. Follow-up angiography sometimes demonstrates neo-intimal hyperplasia within or adjacent to the stent, however there is limited evidence in the literature examining the incidence in MCA and ACA aneurysms. We present our experience with flow diversion of the distal vasculature and evaluate the incidence of neo-intimal hyperplasia. Read More

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Quantification of the flexural rigidity of peripheral arterial endovascular catheters and sheaths.

J Mech Behav Biomed Mater 2021 Mar 30;119:104459. Epub 2021 Mar 30.

Center for Innovation in Neuroscience and Technology, Washington University in St. Louis, Missouri, USA; McKelvey School of Engineering, Washington University in St. Louis, St. Louis, Missouri, USA; Section of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address:

Endovascular catheter-based technologies have revolutionized the treatment of complex vascular pathology. Catheters and endovascular devices that can be maneuvered through tortuous arterial anatomy have enabled minimally invasive treatment in the peripheral arterial system. Although mechanical factors drive an interventionalist's choice of catheters and sheaths, these decisions are mostly made qualitative and based on personal experience and procedural pattern recognition. Read More

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Application of GCMS-pyrolysis to estimate the levels of microplastics in a drinking water supply system.

J Hazard Mater 2021 Mar 23;416:125708. Epub 2021 Mar 23.

IVAR Iks, Breiflåtveien 16/18, 4017 Stavanger, Norway.

Communities value water and aquatic environments for a many diverse reasons. Ensuring safe drinking water is prioritized on the political agenda with a dedicated focus on safe and affordable drinking water under the 6th of the UN sustainable development goals. The occurrence of micron sized plastic fragments has been confirmed even in very remote areas. Read More

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Downregulation of PDGFRß Signaling Overcomes Crizotinib Resistance in a TYRO3 and ALK Mutated Neuroendocrine-Like Tumor.

Transl Oncol 2021 Apr 19;14(7):101099. Epub 2021 Apr 19.

Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, 1600 7th Ave. South, Lowder, Room 300, Birmingham, AL 35233, United States. Electronic address:

Patient-derived xenografts provide significant advantages over long-term passage cell lines when investigating efficacy of treatments for solid tumors. Our laboratory encountered a high-grade, metastatic, neuroendocrine-like tumor from a pediatric patient that presented with a unique genetic profile. In particular, mutations in TYRO3 and ALK were identified. Read More

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The clinical effect of early enteral nutrition in liver-transplanted patients: a systematic review and meta-analysis.

Clin Res Hepatol Gastroenterol 2021 Apr 19;45(3):101594. Epub 2021 Apr 19.

Nursing Department, Huashan Hospital Affiliated to Fudan University, No.12 Urumqi Middle Road, Jing'an District, Shanghai 200040, China. Electronic address:

Background: Appropriate nutritional support is critical for patients undergoing liver transplantation (LT). Early enteral nutrition (EEN) has been considered effective in critically ill patients. However, the clinical effect of EEN on liver-transplanted patients is unclear. Read More

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A narrative review of exercise and obsessive-compulsive disorder.

Gen Hosp Psychiatry 2021 Apr 2;71:1-10. Epub 2021 Apr 2.

Department of Psychiatry, University of Toronto, Sunnybrook Health Sciences Centre, Canada.

Objective: Individuals with obsessive-compulsive disorder (OCD) suffer significant distress due to their condition; however, there can be multiple barriers to treatment. Even following OCD-tailored treatment, symptoms often remain. Exercise may be an effective and available approach to managing OCD, and yet, there are no specifically dedicated reviews, limiting integration into clinical practice. Read More

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The Subscapularis Sparing Windowed Anterior Technique (SWAT) Total Shoulder Arthroplasty.

J Shoulder Elbow Surg 2021 Apr 19. Epub 2021 Apr 19.

Florida Orthopedic Institute / Foundation for Orthopaedic Research & Education (FOI/FORE), 13020 Telecom Pkwy N, Tampa, FL 33637, USA.

Background: Traditionally, total shoulder arthroplasty (TSA) involves detaching the subscapularis tendon either through tenotomy or lesser tuberosity osteotomy. A subscapularis sparing approach avoids detachment, but may make recreation of the anatomy more difficult because of limited exposure. The primary aim of this study was to evaluate the ability to recreate the proximal humeral geometry and to assess for osteophyte removal with this technique. Read More

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An update on recent randomized clinical trials in systemic sclerosis.

Joint Bone Spine 2021 Apr 19:105184. Epub 2021 Apr 19.

Department of Rheumatology, Université de Paris, Cochin Hospital, Paris, France; INSERM U1016, Institut Cochin, CNRS UMR8104, Paris, France. Electronic address:

Systemic sclerosis (SSc) is an autoimmune disorder characterized by a remarkable clinical heterogeneity and variable disease course. In this multifactorial condition, the interaction of several pathogenic pathways related to inflammation, vasculopathy and fibrosis promote organ damage. The understanding of the pathogenesis of SSc has improved in recent years leading to the identification of relevant therapeutic targets. Read More

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Micelle-contained and PEGylated Hybrid Liposomes of Combined Gemcitabine and Cisplatin Delivery for enhancing antitumor activity.

Int J Pharm 2021 Apr 19:120619. Epub 2021 Apr 19.

Department of Pharmaceutics Science, Shenyang Pharmaceutical University, Shenyang 110116, China.

Combination, synergistic chemotherapy with gemcitabine (GEM) and cisplatin (CDDP) is a common strategy, and has been recommended for tumor treatment due to its promoted therapeutic effect and reduced systemic toxicity. However, this process involves the intravenous infusion of GEM prior to that of CDDP, which is inconvenient for patients and staff. Here, a novel hybrid nano-carrier system comprised of micelles encapsulated within PEGylated liposomes is proposed, in order to combine the unique strengths of each component. Read More

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Protective effect of melatonin entrapped PLGA nanoparticles on radiation-induced lung injury through the the miR-21/TGF-β1/Smad3 pathway.

Int J Pharm 2021 Apr 19:120584. Epub 2021 Apr 19.

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, No.30 Gaotanyan Street, Shapingba District, Chongqing, 400038, China. Electronic address:

Radiation-induced lung injury (RILI) is a complication commonly found in victims suffering from nuclear accidents and patients treated with chest tumor radiotherapy, and drugs are limited for effective prevention and treatment. Melatonin (MET) has an anti-radiation effect, but its metabolic period in the body is short. In order to prolong the metabolism period of MET, we prepared MET entrapped poly (lactic-co-glycolic acid) nanoparticles (MET/PLGANPS) for the treatment of RILI. Read More

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Fibroblastic Differentiation of Mesenchymal Stem/Stromal Cells (MSCs) is Enhanced by Hypoxia in 3D Cultures Treated with Bone Morphogenetic Protein 6 (BMP6) and Growth and Differentiation Factor 5 (GDF5).

Gene 2021 Apr 19:145662. Epub 2021 Apr 19.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, United States of America; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America. Electronic address:

Introduction: Culture conditions and differentiation cocktails may facilitate cell maturation and extracellular matrix (ECM) secretion and support the production of engineered fibroblastic tissues with applications in ligament regeneration. The objective of this study is to investigate the potential of two connective tissue-related ligands (i.e. Read More

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Safety and immunogenicity of SARS-CoV-2 recombinant protein vaccine formulations in healthy adults: interim results of a randomised, placebo-controlled, phase 1-2, dose-ranging study.

Lancet Infect Dis 2021 Apr 19. Epub 2021 Apr 19.

Sanofi Pasteur, Swiftwater, PA, USA. Electronic address:

Background: CoV2 preS dTM is a stabilised pre-fusion spike protein vaccine produced in a baculovirus expression system being developed against SARS-CoV-2. We present interim safety and immunogenicity results of the first-in-human study of the CoV2 preS dTM vaccine with two different adjuvant formulations.

Methods: This phase 1-2, randomised, double-blind study is being done in healthy, SARS-CoV-2-seronegative adults in ten clinical research centres in the USA. Read More

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Simultaneous Delivery of Multiple Antimicrobial Agents by Biphasic Scaffolds for Effective Treatment of Wound Biofilms.

Adv Healthc Mater 2021 Apr 22:e2100135. Epub 2021 Apr 22.

Department of Surgery-Transplant and Mary and Dick Holland Regenerative Medicine Program, University of Nebraska Medical Center, Omaha, NE, 68198, USA.

Biofilms pose a major challenge to control wound-associated infections. Due to biofilm impenetrability, traditional antimicrobial agents are often ineffective in combating biofilms. Herein, a biphasic scaffold is reported as an antimicrobial delivery system by integrating nanofiber mats with dissolvable microneedle arrays for the effective treatment of bacterial biofilms. Read More

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Combination therapy with plasma exchange and glucocorticoid may be effective for severe COVID-19 infection. -A retrospective observational study.

Ther Apher Dial 2021 Apr 22. Epub 2021 Apr 22.

Department of General Medicine, Faculty of Medicine, Juntendo University.

We retrospectively analyzed the characteristics and outcomes of five patients with COVID-19 who were received glucocorticoid (with or without pulse therapy) and therapeutic plasma exchange. The efficacy of the treatment was determined by whether the patient was able to be transferred from the COVID-19 exclusive ICU to the general ward. In comparing patients who received prednisolone pulse therapy (3 cases) with those who did not (2 cases), 2/3 (66%) and 0/2 (0%) patients could be discharged from the COVID-19 dedicated ICU, respectively. Read More

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