248,541 results match your criteria effective factors


Efficient recovery of phosphorus and sulfur from Anaerobic Membrane Bioreactor (AnMBR) permeate using chemical addition of iron and evaluation of its nutrient availability for plant uptake.

Sci Total Environ 2021 Apr 1;783:146850. Epub 2021 Apr 1.

Department of Civil Engineering, Kansas State University, 2118 Fiedler Hall, 1701C Platt St., Manhattan, KS 66506, USA.

Anaerobic membrane bioreactors (AnMBRs) represent an emerging environmental biotechnology platform with the potential to simultaneously recover water, energy, and nutrients from concentrated wastewaters. The removal and beneficial capture of nutrients from AnMBR permeate has yet to be fully explored, therefore this study sought to foster iron phosphate recovery through a tertiary coagulation process, as well as characterize the recovered nutrient product (RNP) and assess its net phosphorus release, diffusion, and availability for plant uptake. One of the primary goals of this study was to optimize the dose of the coagulant, ferric chloride, and coagulant aid, aluminum chlorohydrate (ACH), for continuous application to the coagulation-flocculation-sedimentation (CFS) unit of an AnMBR pilot plant treating municipal wastewater, through controlled bench-scale jar tests. Read More

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Implementing practices focused on workplace health and psychological wellbeing: A systematic review.

Soc Sci Med 2021 Apr 1;277:113888. Epub 2021 Apr 1.

Employment Systems and Institutions Group, Norwich Business School, University of East Anglia, NR4 7TJ, United Kingdom.

Rationale: Workplace health and wellbeing practices (WHWPs) often fail to improve psychological health or wellbeing because of implementation failure. Thus, implementation should be evaluated to improve the effectiveness of WHWPs.

Objective: We conducted a systematic review to identify critical success factors for WHWP implementation and gaps in the evidence. Read More

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Predicting why people engage in pro-sustainable behaviors in Portland Oregon: The role of environmental self-identity, personal norm, and socio-demographics.

J Environ Manage 2021 Apr 14;289:112538. Epub 2021 Apr 14.

Department of Kinesiology, College of Nursing and Health Innovations, The University of Texas at Arlington, TX, USA. Electronic address:

This study aims to identify factors influencing people's participation in frequent and effective pro-sustainable behaviors (PSB) in Portland, Oregon, using value-belief-norm theory and a modified value-identity-personal-norm (VIP) model. Drawing from a resident survey (n = 484) and applying a series of regression and mediation analyses, we tested the power of the VIP model in our sample to examine the influence of values, environmental self-identity, and personal norms on PSB while adjusting for socio-demographic factors. Our study revealed participants who held altruistic values (i. Read More

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High levels of Tim-3Foxp3Treg cells in the tumor microenvironment is a prognostic indicator of poor survival of diffuse large B cell lymphoma patients.

Int Immunopharmacol 2021 Apr 14;96:107662. Epub 2021 Apr 14.

Department of Geriatrics, Gastroenterology Ward, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China. Electronic address:

Foxp3Treg cells display phenotypic and functional heterogeneity, which express high levels of T cell immunoglobulin and mucin-domain containing-3 (Tim-3) in the tumor microenvironment (TME) of colorectal and lung cancer. High abundance of Tim-3Foxp3Treg (TFT) cells are associated with poor prognosis in these patients. However, the expression patterns and roles of TFT cells in TME of diffuse large B cell lymphoma (DLBCL) remain to be established. Read More

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An automated room disinfection system using ozone is highly active against surrogates for SARS-CoV-2.

J Hosp Infect 2021 Apr 14. Epub 2021 Apr 14.

Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Background: The presence of coronaviruses on surfaces in the patient environment is a potential source of indirect transmission. Manual cleaning and disinfection measures do not always achieve sufficient removal of surface contamination. This increases the importance of automated solutions in the context of final disinfection of rooms in the hospital setting. Read More

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Factors associated with influenza vaccination acceptance in Mexican healthcare workers: A multicenter cross-sectional study.

Prev Med 2021 Apr 14:106560. Epub 2021 Apr 14.

Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Vasco de Quiroga 15, Col. Belisario Domínguez Sección XVI, Tlalpan, Mexico City 14080, Mexico.

Adherence of healthcare workers (HCWs) to influenza vaccination is far from optimal despite its being the most effective intervention for preventing influenza. In order to evaluate factors associated with influenza vaccination acceptance among Mexican HCWs during the 2017-2018 influenza season, a multicenter cross-sectional study spanning public and private hospitals was conducted. Participants were consecutively invited to answer a self-administered questionnaire. Read More

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A novel method for the detection and diagnosis of virus infections in honey bees.

J Virol Methods 2021 Apr 14:114163. Epub 2021 Apr 14.

U.S. Department of Agriculture - Agricultural Research Service (USDA-ARS) Bee Research Laboratory, Beltsville, MD, 20705, USA. Electronic address:

In terms of infectious diseases caused by a variety of microorganisms, the ability to promptly and accurately identify the causative agents is the first step on the path to all types of effective management of such infections. Among the various factors that are affecting global bee health, viruses have often been linked to honey bee colony losses and they pose a serious threat to the fraction of agriculture that depends on the service of pollinators. Over the past few decades, PCR-based molecular methods have provided powerful tools for rapid, specific, and sensitive detection and the quantification of difficult-to-grow pathogenic microorganisms such as viruses in honey bees. Read More

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[Central neurocytomas: long-term treatment outcomes].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):5-16

Burdenko Neurosurgical Center, Moscow, Russia.

Central neurocytoma is a rare benign brain tumor. These tumors may be giant and accompanied by compression of ventricular system and surrounding structures. Modern treatment of brain neurocytoma includes extended resection and restoration of normal CSF circulation. Read More

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January 2021

Assessing the Outbreak Risk of Epidemics Using Fuzzy Evidential Reasoning.

Risk Anal 2021 Apr 17. Epub 2021 Apr 17.

School of Maritime and Mechancial Engineering, John Moores Liverpool University, Liverpool, UK.

Epidemic diseases (EDs) present a significant but challenging risk endangering public health, evidenced by the outbreak of COVID-19. Compared to other risks affecting public health such as flooding, EDs attract little attention in terms of risk assessment in the current literature. It does not well respond to the high practical demand for advanced techniques capable of tackling ED risks. Read More

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Factors Associated with HIV and Vulnerability Contexts for Women in Brazil.

Arch Sex Behav 2021 Apr 16. Epub 2021 Apr 16.

Department of Collective Health, School of Nursing, Federal University of Rio Grande do Sul, 90620-110, Porto Alegre, Brazil.

The purpose of this study was to identify factors associated with HIV and vulnerability contexts for women in Porto Alegre, Brazil. The participants were 1326 women recruited by complex sampling design, divided into two groups: 640 women with HIV (WLH) and 686 women who did not have HIV (WNLH). Gross and weighted statistical analyses were performed. Read More

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Evaluation of the Mawid mobile healthcare application in delivering services during the COVID-19 pandemic in Saudi Arabia.

Int Health 2021 Apr 16. Epub 2021 Apr 16.

College of Business Administration, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Purpose: The purpose of this study is to evaluate MAWID mobile application developed by the Ministry of Health, Saudi Arabia, which is used for primary care hospitals appointments management and for tracking and tracing COVID-19.

Participants And Methods: An online questionnaire-based survey was used for collecting data related to three major factors including Ease of Use, Satisfaction, and Benefits of MAWID application among its users. Out of total 2542 participants, 345 participants completed only a part of the survey, and 204 participants did not use the application. Read More

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Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes.

Pediatr Res 2021 Apr 16. Epub 2021 Apr 16.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Children with congenital heart disease (CHD) are living longer due to effective medical and surgical management. However, the majority have neurodevelopmental delays or disorders. The role of the placenta in fetal brain development is unclear and is the focus of an emerging field known as neuroplacentology. Read More

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A prognostic dynamic model applicable to infectious diseases providing easily visualized guides: a case study of COVID-19 in the UK.

Sci Rep 2021 Apr 16;11(1):8412. Epub 2021 Apr 16.

Department of Pharmacology, University of Oxford, Oxford, OX1 3QT, UK.

A reasonable prediction of infectious diseases' transmission process under different disease control strategies is an important reference point for policy makers. Here we established a dynamic transmission model via Python and realized comprehensive regulation of disease control measures. We classified government interventions into three categories and introduced three parameters as descriptions for the key points in disease control, these being intraregional growth rate, interregional communication rate, and detection rate of infectors. Read More

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Effect of perioperative bronchodilator therapy on postoperative pulmonary function among lung cancer patients with COPD.

Sci Rep 2021 Apr 16;11(1):8359. Epub 2021 Apr 16.

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Chronic obstructive pulmonary disease (COPD), an established risk factor for lung cancer, remains largely undiagnosed and untreated before lung cancer surgery. We evaluated the effect of perioperative bronchodilator therapy on lung function changes in COPD patients who underwent surgery for non-small cell lung cancer (NSCLC). From a database including NSCLC patients undergoing lung resection, COPD patients were identified and divided into two groups based on the use of bronchodilator during the pre- and post-operative period. Read More

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uPAR antibody (huATN-658) and Zometa reduce breast cancer growth and skeletal lesions.

Bone Res 2020 Apr 17;8(1):18. Epub 2020 Apr 17.

Department of Medicine, McGill University, Montréal, QC, H4A3J1, Canada.

Urokinase plasminogen activator receptor (uPAR) is implicated in tumor growth and metastasis due to its ability to activate latent growth factors, proteases, and different oncogenic signaling pathways upon binding to different ligands. Elevated uPAR expression is correlated with the increased aggressiveness of cancer cells, which led to its credentialing as an attractive diagnostic and therapeutic target in advanced solid cancer. Here, we examine the antitumor effects of a humanized anti-uPAR antibody (huATN-658) alone and in combination with the approved bisphosphonate Zometa (Zoledronic acid) on skeletal lesion through a series of studies in vitro and in vivo. Read More

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High-resolution genomic comparisons within serotypes derived from beef feedlot cattle: parsing the roles of cattle source, pen, animal, sample type and production period.

Appl Environ Microbiol 2021 Apr 16. Epub 2021 Apr 16.

Department of Veterinary Pathobiology, Texas A&M University, College Station, Texas, USA;

is a major foodborne pathogen, and contaminated beef products have been identified as one of the primary sources of -related outbreaks. Pathogenicity and antibiotic resistance of are highly serotype- and subpopulation-specific, which makes it essential to understand high-resolution population dynamics in cattle. Time of year, source of cattle, pen, and sample type(i. Read More

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Clinical Effectiveness of Second-line Sunitinib Following Immuno-oncology Therapy in Patients with Metastatic Renal Cell Carcinoma: A Real-world Study.

Clin Genitourin Cancer 2021 Mar 17. Epub 2021 Mar 17.

Tom Baker Cancer Centre, University of Calgary, Department of Oncology, Calgary, Canada. Electronic address:

Background: Limited data exist on the clinical effectiveness of second-line (2L) vascular endothelial growth factor (receptor) targeted inhibitor (VEGF(R)i) sunitinib after first-line (1L) immuno-oncology (IO) therapy for patients with metastatic renal cell carcinoma (mRCC) in real-world settings.

Methods: A retrospective cohort study among adult patients with mRCC treated with 2L sunitinib following 1L IO was conducted from select International mRCC Database Consortium (IMDC) centers. All analyses were performed overall and by 1L ipilimumab + nivolumab (IPI+NIVO) or 1L IO+VEGF(R)i. Read More

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Factors associated with patient activation in a socially deprived population: Evidence from Germany.

Patient Educ Couns 2021 Apr 6. Epub 2021 Apr 6.

Department of Health Care Management, Hamburg Center for Health Economics (HCHE), University of Hamburg, Esplanade 36, 20354 Hamburg, Germany. Electronic address:

Objective: Patient activation has been identified as a crucial determinant of health, but little is known about its own determinants, particularly in low socioeconomic status populations. To address this research gap, we analyzed factors that might explain variation in patient activation in such a population.

Methods: We conducted a cross-sectional patient survey (n = 582) in a low socioeconomic status urban district in Germany in 2017. Read More

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Factors associated with sexually transmitted infections among care-seeking adults in the African Cohort Study.

BMC Public Health 2021 Apr 16;21(1):738. Epub 2021 Apr 16.

U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA.

Objectives: Sexually transmitted infections (STIs) are a major cause of morbidity. Understanding drivers of transmission can inform effective prevention programs. We describe STI prevalence and identify factors associated with STIs in four African countries. Read More

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Psychosocial functionality in depressive workers: A study on associated factors.

Int J Soc Psychiatry 2021 Apr 16:207640211011195. Epub 2021 Apr 16.

Ribeirão Preto Medical School, University of São Paulo, Brazil.

Background: Major Depressive Disorder (MDD) has been shown a high prevalence and debilitating mental health. Most of the burden comes from reduced work functioning and frequent or long-term absenteeism.

Aims: Describe psychosocial functionality in sample of workers with MDD and observe associated factors with sick-leave. Read More

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Multitype branching and graph product theory of infectious disease outbreaks.

Authors:
Alexei Vazquez

Phys Rev E 2021 Mar;103(3):L030301

German Aerospace Center (DLR), Institute for the Protection of Terrestrial Infrastructures, Rathausallee 12, 53757 Sankt Augustin, Germany.

The heterogeneity of human populations is a challenge to mathematical descriptions of epidemic outbreaks. Numerical simulations are deployed to account for the many factors influencing the spreading dynamics. Yet, the results from numerical simulations are often as complicated as the reality, leaving us with a sense of confusion about how the different factors account for the simulation results. Read More

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Efficiency of aminolevulinic acid (ALA)-photodynamic therapy based on ALA uptake transporters in a cell density-dependent malignancy model.

J Photochem Photobiol B 2021 Apr 13;218:112191. Epub 2021 Apr 13.

School of Life Science and Technology, Tokyo Institute of Technology, 4259 B47, Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan. Electronic address:

The effectiveness of the conventional chemotherapy for cancer are compromised as the cancer cells advances in their malignancy level as they acquired drug resistance. In this study, we aimed to evaluate the efficiency of aminolevulinic acid-photodynamic therapy (ALA-PDT) against cancer of various malignancy levels, indicated by the expression level of receptor associated nuclear factor-κB ligand (RANKL), through the expression levels of ALA uptake transporters. We established a malignancy model by gradually increasing the cell density of cancer cells. Read More

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Characteristics of Patients with Severe Asthma Who Experienced Treatment Failure with Omalizumab.

Pulm Pharmacol Ther 2021 Apr 13:102032. Epub 2021 Apr 13.

Department of Respiratory Medicine, Tokyo Women's Medical University School of Medicine, Tokyo, Japan; Allergy Medical Center, Tokyo Women's Medical University Hospital, Tokyo, Japan. Electronic address:

Background: Omalizumab, an anti-IgE antibody, has been widely used in many countries, including Japan. However, some patients do not respond to omalizumab, and the cause of treatment failure has not been fully elucidated.

Objective: This study aimed to evaluate the characteristics of adult asthma patients who failed to achieve disease control with omalizumab in a real-world setting. Read More

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Cardiovascular risks of periodontitis and oral hygiene indicators in patients with diabetes mellitus.

Diabetes Metab 2021 Apr 13:101252. Epub 2021 Apr 13.

Department of Neurology, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin-si, South Korea. Electronic address:

Aim: Periodontitis is a common chronic inflammatory disease prevalent in diabetes. The aim of this study was to evaluate periodontitis and poor oral hygiene as independent risk factors for either cerebral or myocardial infarction in the diabetes population.

Methods: This retrospective cohort study included 17,009 patients with diabetes who had participated in a nationwide health-screening programme, including oral health examination, during 2002-2003 in South Korea. Read More

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Rules of nature's Formula Run: Muscle mechanics during late stance is the key to explaining maximum running speed.

J Theor Biol 2021 Apr 13:110714. Epub 2021 Apr 13.

Computational Biophysics and Biorobotics, Institute for Modelling and Simulation of Biomechanical Systems, Universität Stuttgart, Nobelstraße 15, 70569 Stuttgart, Germany; Stuttgart Center for Simulation Science (SC SimTech), Universität Stuttgart, Pfaffenwaldring 5a, 70569 Stuttgart, Germany.

The maximum running speed of legged animals is one evident factor for evolutionary selection-for predators and prey. Therefore, it has been studied across the entire size range of animals, from the smallest mites to the largest elephants, and even beyond to extinct dinosaurs. A recent analysis of the relation between animal mass (size) and maximum running speed showed that there seems to be an optimal range of body masses in which the highest terrestrial running speeds occur. Read More

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Debridement, antibiotics, irrigation and retention in prosthetic joint infection : predictive tools of failure.

Acta Orthop Belg 2020 Dec;86(4):636-643

Debridement, antibiotic, irrigation and retention of the implant (DAIR) is an attractive treatment for periprosthetic joint infection (PJI). The purpose of this study is to determine predictive factors of failure. We reviewed all DAIR procedures for hip PJI performed between 2002-2017 (n=69). Read More

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December 2020

Sex-specific actuarial and reproductive senescence in zoo-housed tiger (Panthera tigris): The importance of sub-species for conservation.

Zoo Biol 2021 Apr 16. Epub 2021 Apr 16.

Conservation, Research, and Veterinary Department, Wildlife Reserves Singapore, Singapore, Singapore.

A fifth of all known species are currently classified as threatened in the wild: the rate of biodiversity loss is rapid, continuous, and mostly due to anthropogenic activities. To slow down this decline, the accurate estimation of demographic parameters for threatened species is critical. With this aim, zoo institutions play an important role, giving access to data on zoo-housed animals, which aids researchers working on species life-history traits and intrinsic factors influencing the fitness of both sexes, such as age. Read More

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Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies.

PLoS One 2021 16;16(4):e0249305. Epub 2021 Apr 16.

Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Jacksonville, Florida, United States of America.

Genetic studies have shifted to sequencing-based rare variants discovery after decades of success in identifying common disease variants by Genome-Wide Association Studies using Single Nucleotide Polymorphism chips. Sequencing-based studies require large sample sizes for statistical power and therefore often inadvertently introduce batch effects because samples are typically collected, processed, and sequenced at multiple centers. Conventionally, batch effects are first detected and visualized using Principal Components Analysis and then controlled by including batch covariates in the disease association models. Read More

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A Multicenter, 10-Year Experience With Hepatocellular Adenoma: Risk Factors and Disease Course.

Am Surg 2021 Apr 16:31348211011084. Epub 2021 Apr 16.

Department of Surgery, Kaiser Permanente Los Angeles Medical Center, Los Angeles, CA, USA.

Background: Management of hepatocellular adenoma (HA) is marked by a paucity of recent studies. Long-term follow-up data from an equal access health care system may facilitate our understanding of the natural disease course of HA and identify modifiable risk factors.

Methods: A multi-institutional, retrospective review of patients with HA from 2008-2017 was performed. Read More

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Forecasting Future Asthma Hospital Encounters of Patients With Asthma in an Academic Health Care System: Predictive Model Development and Secondary Analysis Study.

J Med Internet Res 2021 Apr 16;23(4):e22796. Epub 2021 Apr 16.

Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, WA, United States.

Background: Asthma affects a large proportion of the population and leads to many hospital encounters involving both hospitalizations and emergency department visits every year. To lower the number of such encounters, many health care systems and health plans deploy predictive models to prospectively identify patients at high risk and offer them care management services for preventive care. However, the previous models do not have sufficient accuracy for serving this purpose well. Read More

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