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Bio-activation of soil with beneficial microbes after soil fumigation reduces soil-borne pathogens and increases tomato yield.

Environ Pollut 2021 Apr 14;283:117160. Epub 2021 Apr 14.

Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, 100193, China; Beijing Innovation Consortium of Agriculture Research System, Beijing, 100029, China. Electronic address:

Soil-borne diseases have become increasingly problematic for farmers producing crops intensively under protected agriculture. Although soil fumigants are convenient and effective for minimizing the impact of soil-borne disease, they are most often detrimental to beneficial soil microorganisms. Previous research showed that bio-activation of soil using biological control agents present in biofertilizers or organic fertilizers offered promise as a strategy for controlling soil-borne pathogens when the soil was bio-activated after fumigation. Read More

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Manipulating antigen presentation for antigen-specific immunotherapy of autoimmune diseases.

Curr Opin Immunol 2021 Apr 17;70:75-81. Epub 2021 Apr 17.

Institute of Immunology and Immunotherapy, University of Birmingham, B15 2TT, United Kingdom. Electronic address:

Current treatments for autoimmune diseases do not address the immune pathology underlying their initiation and progression and too often rely on non-specific immunosuppressive drugs for control of symptoms. Antigen-specific immunotherapy aims to induce tolerance selectively among the cells causing the disease while leaving the rest of the adaptive immune system capable of protecting against infectious diseases and cancers. Here we describe how novel approaches for antigen-specific immunotherapy are designed to manipulate antigen presentation and promote tolerance to specific self-antigens. Read More

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Noise Suppression for Ultrasound Attenuation Coefficient Estimation based on Spectrum Normalization.

IEEE Trans Ultrason Ferroelectr Freq Control 2021 Apr 20;PP. Epub 2021 Apr 20.

Ultrasound attenuation coefficient estimation (ACE) has great diagnostic potential for fatty liver detection and assessment. In a previous study, we proposed a reference-phantom-free ACE method, called reference frequency method (RFM), which does not require a calibrated phantom for normalization. The power of each frequency component can be normalized by the power of an adjacent frequency component in the spectrum to cancel system-dependent effects such as focusing and time gain compensation (TGC). Read More

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Impact of sodium vanadium oxide (NaVO, NVO) material synthesis conditions on charge storage mechanism in Zn-ion aqueous batteries.

Phys Chem Chem Phys 2021 Apr 26;23(14):8607-8617. Epub 2021 Mar 26.

Institute for Electrochemically Stored Energy, State University of New York at Stony Brook, Stony Brook, New York 11794, USA.

The electrochemical charge storage of sodium vanadate (NaVO or NVO) cathodes in aqueous Zn-ion batteries has been hypothesized to be influenced by the inclusion of structural water for facilitating ion transfer in the material. Materials properties considered important (morphology, crystallite and particle size, surface area) are systematically studied herein through investigation of two NVO materials, NaVO·0.34HO [NVO(300)] and NaVO·0. Read More

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Role of p53-miRNAs circuitry in immune surveillance and cancer development: A potential avenue for therapeutic intervention.

Semin Cell Dev Biol 2021 Apr 16. Epub 2021 Apr 16.

Molecular Cancer Genetics & Translational Research Lab, Section of Genetics, Department of Zoology, Aligarh Muslim University, Aligarh 202002, India. Electronic address:

The genome's guardian, p53, is a master regulatory transcription factor that occupies sequence-specific response elements in many genes and modulates their expression. The target genes transcribe both coding RNA and non-coding RNA involved in regulating several biological processes such as cell division, differentiation, and cell death. Besides, p53 also regulates tumor immunology via regulating the molecules related to the immune response either directly or via regulating other molecules, including microRNAs (miRNAs). Read More

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An isothermal recombinase polymerase amplification and lateral flow strip combined method for rapid on-site detection of Vibrio vulnificus in raw seafood.

Food Microbiol 2021 Sep 15;98:103664. Epub 2020 Oct 15.

School of Pharmacy, Jiangsu Ocean University, Lianyungang, 222005, China. Electronic address:

Vibrio vulnificus is an important foodborne pathogenic bacterium that mainly contaminates seafood. Rapid and accurate technologies that suitable for on-site detection are critical for effective control of its spreading. Conventional detection methods and polymerase chain reaction (PCR)-based and qPCR-based approaches have application limitations in on-site scenarios. Read More

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September 2021

[Clinical effects of retrograde anterolateral thigh perforator flaps assisted with CT angiography in repairing skin and soft tissue defects around the knee or in proximal lower leg].

Zhonghua Shao Shang Za Zhi 2021 Mar 24;37:1-7. Epub 2021 Mar 24.

Department of orthopedics, Jizhong Energy Xingtai Mig General Hospital, Xingtai 054000, China.

To investigate the clinical effects of retrograde anterolateral thigh perferator flaps assisted with CT angiography (CTA) in repairing skin and soft tissue defects around the knee or in proxiamal lower leg. A retrospective cohort study was conducted. From May 2015 to October 2019, 17 patients with skin and soft tissue defects around the knee or in proximal lower leg were admitted to Department of orthopedics of Jizhong Energy Xingtai Mig General Hospital, including 12 males and 5 females, aged 16-65 years, with an average age of 35 years. Read More

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Desiccation as the active principle in heat-stimulated seed germination of Leucospermum R. Br. (Proteaceae) in fynbos.

New Phytol 1993 Oct;125(2):397-403

National Botanical Institute, Private Bag X7, Claremont 7735.

A new seed biological phenomenon in the myrmecochorous, fire-recruiting fynbos species Leucospermum cordifolium (Salisb. ex Knight) Fourcade is reported. This is the extensive breaking, following desiccation treatment, of the seed testa which in intact, soil-stored seeds imposes dormancy on the embryo by means of oxygen exclusion. Read More

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October 1993

Secretory tissues in vascular plants.

Abraham Fahn

New Phytol 1988 Mar;108(3):229-257

Department of Botany, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

Secretory tissues occur in most vascular plants. Some of these tissues, such as hydathodes, salt glands and nectaries, secrete unmodified or only slightly modified substances supplied directly or indirectly by the vascular tissues. Other tissues secreting, for instance, polysaccharides, proteins and lipophilic material, produce these substances in their cells. Read More

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New Phytol 1986 Jan;102(1):133-142

The Environmental Research Laboratory, Department of Biology North East London Polytechnic, Romford Road, London E1 5 4LZ, UK.

Detailed germination responses to temperature and light in two populations of Dactylis glomerata L. originating from S.E. Read More

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January 1986

Case study of pipeline failure analysis from two automated vacuum collection system.

Waste Manag 2021 Apr 16;126:643-651. Epub 2021 Apr 16.

Departament de Ciència de Materials i Química Física, Universitat de Barcelona, C/ Martí i Franquès 1, 08028 Barcelona, Spain. Electronic address:

Conventional municipal waste management systems based on collecting and storing waste for future management are cost-effective and flexible. These systems present significant problems such as odours, plagues and hygiene problems caused by their storage and greenhouse gas emissions from garbage trucks used for the transport of waste. The Automated Waste Collection System (AWCS) and Automated Vacuum Waste Collection (AVWC) systems, in which waste is transported directly underground to the processing plants, are efficient collection systems and respectful of the environment as alternatives to traditional systems. Read More

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Fabrication of plasmonic cotton gauze-Ag composite as versatile SERS substrate for detection of pesticides residue.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 31;257:119766. Epub 2021 Mar 31.

School of Petrochemical Engineering, Liaoning Petrochemical University, Fushun, Liaoning 113001, PR China. Electronic address:

Plasmonic cotton gauze-Ag composite were fabricated through a simple, instant and cost-effective way, in which the Ag NPs were immobilized on the surface of cotton gauze through in-situ growth process. The in-situ growth of Ag NPs was started from electroless-immobilized Ag seeds on the surface of cotton fiber, which could form numerous hot spots for SERS compared with current method. The cotton gauze-Ag composite was employed as versatile substrate in surface-enhanced Raman scattering (SERS) spectroscopy. Read More

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A Multi-Herb-Combined Remedy to Overcome Hyper-Inflammatory Response by Reprogramming Transcription Factor Profile and Shaping Monocyte Subsets.

Pharmacol Res 2021 Apr 16:105617. Epub 2021 Apr 16.

Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Dongcheng District, Beijing 100700, China. Electronic address:

Traditional Chinese multi-herb-combined prescriptions usually show better performance than a single agent since a group of effective compounds interfere multiple disease-relevant targets simultaneously. Huang-Lian-Jie-Du decoction is a remedy made of four herbs that are widely used to treat oral ulcers, gingivitis, and periodontitis. However, the active ingredients and underlying mechanisms are not clear. Read More

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Rationale, design, and methods of a two-site randomized controlled trial: Comparative effectiveness of two treatments for posttraumatic stress disorder in veterans.

Contemp Clin Trials 2021 Apr 16:106408. Epub 2021 Apr 16.

Department of Psychiatry, Georgetown University Medical School, Washington, DC, United States of America.

PTSD is associated with serious problems in interpersonal functioning, including higher rates of marital conflict and divorce, disrupted relationships with family and friends, estrangement from others and social isolation. Cognitive behavioral and trauma focused treatments are effective for treating PTSD symptoms, but a substantial proportion of individuals, particularly veterans, with PTSD, do not engage, complete, or fully respond to these treatments. The effects of these treatments on interpersonal functioning are unknown. Read More

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Changing Health-Related Behaviors 2: On Improving the Value of Health Spending.

Methods Mol Biol 2021 ;2249:553-569

Quality of Care NL, Faculty of Medicine, Memorial University, St. John's, NL, Canada.

The quantity of health spending does not equate directly to the quality of healthcare. Social spending and nonmedical determinants of health impact on health outcomes. The value of health spending in the United States is limited by the high cost of goods and labor, and administrative costs, high use of low-level care, and lack of basic healthcare coverage in a substantial minority of the population. Read More

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January 2021

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.

Cochrane Database Syst Rev 2021 Apr 19;4:CD011535. Epub 2021 Apr 19.

Department of Dermatology, Hôpital Henri Mondor, Créteil, France.

Background: Psoriasis is an immune-mediated disease for which some people have a genetic predisposition. The condition manifests in inflammatory effects on either the skin or joints, or both, and it has a major impact on quality of life. Although there is currently no cure for psoriasis, various treatment strategies allow sustained control of disease signs and symptoms. Read More

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A serum microRNA sequence reveals fragile X protein pathology in amyotrophic lateral sclerosis.

Brain 2021 Apr 19. Epub 2021 Apr 19.

Department of Neurology, Ulm University, Ulm, Germany.

Knowledge about converging disease mechanisms in the heterogeneous syndrome amyotrophic lateral sclerosis (ALS) is rare, but may lead to therapies effective in most ALS cases. Previously, we identified serum microRNAs downregulated in familial ALS, the majority of sporadic ALS patients, but also in presymptomatic mutation carriers. A 5-nucleotide sequence motif (GDCGG; D = G, A or U) was strongly enriched in these ALS-related microRNAs. Read More

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Safe and effective HeRO graft placement: Technique and results.

J Vasc Access 2021 Apr 19:11297298211008085. Epub 2021 Apr 19.

Dialysis Access Institute, Regional Medical Center of Orangeburg and Calhoun Counties, Charleston, SC, USA.

Objectives: Hemodialysis Reliable Outflow (HeRO) grafts are used when venous outflow is inadequate to support conventional access. These have been perceived as complex to implant and being associated with high risk. We have evolved a defined protocol for insertion that minimizes morbidity and maximizes efficiency. Read More

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Biocontrol of invasive pheretimoid earthworms using .

PeerJ 2021 7;9:e11101. Epub 2021 Apr 7.

Plant and Soil Science, University of Vermont, Burlington, VT, USA.

Background: Invasive species cause enormous costs of over $120 billion to the U.S. economy. Read More

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Highly sensitive FET sensors for cadmium detection in one drop of human serum with a hand-held device and investigation of the sensing mechanism.

Biomicrofluidics 2021 Mar 12;15(2):024110. Epub 2021 Apr 12.

Institute of Nanoengineering and Microsystems, National Tsing Hua University, Hsinchu 300, Taiwan.

As the heavy metal contamination is becoming worse, monitoring the heavy metal content in water or human body gets more and more important. In this research, a cadmium ion-selective field effect transistor (Cd-ISFET) for rapidly detecting cadmium ions has been developed and the mechanism of the sensor is also investigated in depth. Our Cd-ISFET sensor exhibits high sensitivity beyond the ideal Nernst sensitivity, wide dynamic range, low detection limit (∼10M), which is comparable with inductively coupled plasma mass spectrometry, and easy operation enabling people to detect cadmium ion by themselves. Read More

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A Novel Biomarker Identification Approach for Gastric Cancer Using Gene Expression and DNA Methylation Dataset.

Front Genet 2021 25;12:644378. Epub 2021 Mar 25.

School of Computer and Information Engineering, Henan University, Kaifeng, China.

As one type of complex disease, gastric cancer has high mortality rate, and there are few effective treatments for patients in advanced stage. With the development of biological technology, a large amount of multiple-omics data of gastric cancer are generated, which enables computational method to discover potential biomarkers of gastric cancer. That will be very important to detect gastric cancer at earlier stages and thus assist in providing timely treatment. Read More

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Clinical Efficacy and Cost-Effectiveness of Imagery Rescripting Only Compared to Imagery Rescripting and Schema Therapy in Adult Patients With PTSD and Comorbid Cluster C Personality Disorder: Study Design of a Randomized Controlled Trial.

Front Psychiatry 2021 19;12:633614. Epub 2021 Mar 19.

Sinai Centrum, Amstelveen, Netherlands.

Posttraumatic stress disorder (PTSD) is a serious and relatively common mental disorder causing a high burden of suffering. Whereas evidence-based treatments are available, dropout and non-response rates remain high. PTSD and Cluster C personality disorders (avoidant, dependent or obsessive-compulsive personality disorder; CPD) are highly comorbid and there is evidence for suboptimal treatment effects in this subgroup of patients. Read More

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MicroRNA-223 restricts liver fibrosis by inhibiting the TAZ-IHH-GLI2 and PDGF signaling pathways via the crosstalk of multiple liver cell types.

Int J Biol Sci 2021 11;17(4):1153-1167. Epub 2021 Mar 11.

Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.

Liver fibrosis is a common consequence of chronic liver injury and is characterized by the accumulation of extracellular matrix mainly generated from activated hepatic stellate cells (HSCs). At present, the mechanisms underlying liver fibrogenesis remain obscure and effective pharmacological therapies are lacking. Neutrophil-specific microRNA-223 (miR-223) plays an important role in controlling the development of various liver diseases; however, its role in HSC activation and liver fibrosis remains unclear. Read More

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Low dose versus standard dose four factor prothrombin complex concentrate for factor-Xa inhibitor reversal in spontaneous and traumatic intracranial hemorrhage.

Pharmacotherapy 2021 Apr 18. Epub 2021 Apr 18.

Department of Surgery, Dell Seton Medical Center, University of Texas, 1500 Red River St, Austin, 78701.

Introduction: Current neurocritical care guidelines recommend 50 IU/kg four factor prothrombin complex concentrate (4PCC) for factor Xa inhibitor (FXaI) reversal in intracranial hemorrhage (ICH) based on few clinical studies conducted among non-ICH subjects. Two recent studies suggest that low dose (25 IU/kg) 4PCC may be similar to 50 IU/kg in reversal of FXaI in ICH, and both 25 and 50 IU/kg doses are used in clinical practice for this indication. To our knowledge, no studies have directly compared 25 IU/kg versus 50 IU/kg 4PCC for FXaI reversal in ICH. Read More

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16α-Bromoepiandrosterone as a new candidate for experimental diabetes-tuberculosis comorbidity treatment.

Clin Exp Immunol 2021 Apr 18. Epub 2021 Apr 18.

Experimental Pathology Section, Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

Tuberculosis (TB) is the leading cause of death from a single bacterial infectious agent and is one of the most relevant issues of public health. Another pandemic disease is type 2 diabetes mellitus (T2D) that is estimated to affect half-billion people in the world. T2D is directly associated with obesity and a sedentary lifestyle and frequently associated with immunosuppression. Read More

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Interruption of MDM2 signaling augments MDM2-targeted T cell-based antitumor immunotherapy through antigen-presenting machinery.

Cancer Immunol Immunother 2021 Apr 18. Epub 2021 Apr 18.

Department of Otolaryngology-Head & Neck Surgery, Asahikawa Medical University, Asahikawa, 078-8510, Japan.

Identification of immunogenic tumor antigens, their corresponding T cell epitopes and the selection of effective adjuvants are prerequisites for developing effective cancer immunotherapies such as therapeutic vaccines. Murine double minute 2 (MDM2) is an E3 ubiquitin-protein ligase that negatively regulates tumor suppressor p53. Because MDM2 overexpression serves as a poor prognosis factor in various types of tumors, it would be beneficial to develop MDM2-targeted cancer vaccines. Read More

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Evidence that loneliness can be reduced by a whole-of-community intervention to increase neighbourhood identification.

Soc Sci Med 2021 Apr 6;277:113909. Epub 2021 Apr 6.

Relationships Australia National, Canberra, ACT, 2604, Australia.

Rationale: Social identification with the people in one's neighbourhood has a wide variety of benefits for individual and community health and wellbeing. In particular, previous research shows that residents' social identification with their neighbourhood is protective of mental health. However, researchers are only just beginning to design and evaluate interventions that directly target social identification on health grounds. Read More

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Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts.

Bioorg Med Chem Lett 2021 Apr 15:128045. Epub 2021 Apr 15.

Department of Traditional Chinese Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, 510515, China. Electronic address:

Inhibiting myocardial fibrosis can help prevent cardiovascular diseases, including heart failure. Magnolol (Mag), a natural component of Magnoliae officinalis, has been reported to inhibit fibrosis. However, the mechanism of Mag activity and its effects on myocardial fibrosis remain unclear. Read More

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Identification of new Anopheles gambiae transcriptional enhancers using a cross-species prediction approach.

Insect Mol Biol 2021 Apr 17. Epub 2021 Apr 17.

Department of Biochemistry, University at Buffalo-State University of New York, Buffalo, NY.

The success of transgenic mosquito vector control approaches relies on well-targeted gene expression, requiring the identification and characterization of a diverse set of mosquito promoters and transcriptional enhancers. However, few enhancers have been characterized in Anopheles gambiae to date. Here, we employ the SCRMshaw method we previously developed to predict enhancers in the A. Read More

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Efficacy of motivational interviewing on enhancing self-care behaviors among patients with chronic heart failure: a systematic review and meta-analysis of randomized controlled trials.

Heart Fail Rev 2021 Apr 17. Epub 2021 Apr 17.

Health Professions Research and Development Unit, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Although motivational interviewing (MI) seems to be promising for enhancing self-care behaviors (i.e., daily disease management and responses to symptoms) in patients with heart failure (HF), no quantitative pooling of effect sizes has been described to summarize and test its efficacy on self-care. Read More

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